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Cat. No.	Product Name	Target	Signaling Pathways
T4635	Ralinepag APD811	Others; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Others
	Ralinepag (APD811) 是一种可口服的非前列腺素前列环素 (IP) 受体激动剂，对人和大鼠 IP 受体以及人 DP1 受体的 EC50 分别为 8.5、530 和 850 nM。
T15718	Latanoprost acid	GPR	Endocrinology/Hormones; GPCR/G Protein
	Latanoprost acid 是前列腺素受体的选择性激动剂，通过抑制 c-fos/NFATc1 通路抑制 RANKL 诱导的破骨细胞生成和功能。拉坦前列素酸可用于降低眼内压力的研究。
T1978	GW627368 GW 627368X	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	GW627368 (GW 627368X) 是一种新型、强效和选择性的前列腺素 EP4 受体拮抗剂，还对血栓素受体TP 有亲和力。对人 EP4 和 TP 的pKi 值分别为 7.0 和 6.8。
T2528	Latanoprost Xalatan,PHXA41,拉坦前列腺素,拉坦前列素	GPR; Prostaglandin Receptor; RAR/RXR	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Metabolism
	Latanoprost (Xalatan) 是前列腺素 F2α 类似物，是一种前列腺素受体激动剂，能够降低眼内压。
T2664	Timapiprant OC000459	GPR; Prostaglandin Receptor	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation
	Timapiprant (OC000459) 是一种有效的选择性 D 前列腺素受体 2(DP2) 拮抗剂，IC50为 13 nM。它抑制肥大细胞激活 Th2 淋巴细胞和嗜酸性粒细胞，有效地置换来自人重组 DP2、大鼠重组 DP2 和人天然 DP2 的 [3H] PGD2。
T17232	Vidupiprant AMG 853	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Vidupiprant (AMG 853) 是一种有效的 CRTH2 和前列腺素 D 受体双重拮抗剂，在人源血浆中的 IC50 分别为 8 nM 和 35 nM。 Vidupiprant 可用于治疗哮喘的研究。
T11211	EP4 receptor antagonist 1	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	EP4 receptor antagonist 1 是一种有效的特异性前列腺素 EP4受体拮抗剂，对人和小鼠 EP4受体的 IC50分别为6.1 nM 和16.2 nM。 EP4 receptor antagonist 1 可用于癌症免疫治疗的研究。
T69229	ONO-8539
	ONO-8539 is a prostanoid EP1 receptor antagonist.
T69602	ONO-DI-004
	ONO-DI-004 is a selective EP1 Prostanoid receptor agonist.
T27875	LY 150310 LY150310,LY-150310
	LY 150310, a histamine H1-receptor antagonist, can alter prostanoid concentrations in vitro and in vivo.
T29734	AH 19437 AH-19437,AH19437
	AH 19437 is a prostanoid receptor.
T26578	AH13205 AH-13205,AH 13205
	AH13205 is an agonist of EP2 prostanoid receptor.
T15689	L-798106 CM9,GW671021	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	L-798106 is a highly selective prostanoid EP3 receptor antagonist (Ki=0.3 nM). It also has micromolar activities at EP4, EP1, and EP2 receptors (Ki: 916 nM, >5000 nM, and >5000 nM at EP4, EP1, and EP2, respectively).
T23332	SC 51322	Others	Others
	SC 51322 is an EP1 prostanoid receptor antagonist.
T16389	Omidenepag	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Omidenepag is a pharmacologically active form of Omidenepag Isopropyl and is a selective, non-prostanoid EP2 receptor agonist (EC50: 1.1 nM). Omidenepag displays binding affinities (IC50: 10 nM for h-EP2).
T19660	QCC-374 QCC374
	QCC-374 is a prostanoid agonist. It potentially for the treatment of pulmonary arterial hypertension.
T20644	Unoprostone isopropyl UF021,Rescula,UF-021,UF 021
	Unoprostone isopropyl, a prostanoid and synthetic docosanoid, is approved for the treatment of ocular hypertension and open-angle glaucoma.
T27765	L-644,698
	L-644,698 is a selective agonist of human prostanoid DP receptor.
T17099	Timapiprant sodium OC000459 sodium	Others	Others
	Timapiprant sodium inhibits mast cell activation of Th2 lymphocytes and eosinophils. Timapiprant sodium is a potent and selective D prostanoid receptor 2 antagonist. Timapiprant sodium potently displaces [3H] PGD2 from human recombinant DP2 (Ki=13 nM), ra
T39165	Treprostinil palmitil Treprostinil palmitil,INS-1009
	Treprostinil Palmitil (TP), a prodrug of the DP1 and EP2 agonist Treprostinil (UT-15), exhibits EC50 values of 0.6 and 6.2 nM, respectively. It is a pure prodrug without any inherent binding affinity for G-protein coupled receptors, including prostanoid receptors.
T28651	S-5751 S 5751
	S-5751, a prostanoid DP (DP1) antagonist, is used potentially for the treatment of bronchial asthma.
T29813	AL-3138 AL3138,AL 3138,11-Deoxy-16-fluoro PGF2alpha
	AL-3138 is a prostaglandin F2alpha (PGF2alpha) analogue which antagonizes FP prostanoid receptor-mediated inositol phosphates generation.
T28032	MF266-1 MF 266-1,MF-266-1
	MF266-1, a selective E prostanoid receptor 4 antagonist, relieves joint inflammation and pain in rodent models of osteoarthritis and rheumatoid.
T16069	MF498	Others	Others
	MF498 is a novel and selective E prostanoid receptor 4 (EP4 receptor) antagonist, displayed a strong binding affinity for the EP4 receptor (Ki: 0.7 nM).
T15690	L-902688	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	L-902688 is an orally active EP4 receptor agonist (Ki: 0.38 nM; EC50: 0.6 nM). L-902688 displays >4,000-fold selective for EP4 over other EP and prostanoid receptors.
T11821	Latanoprost lactone diol	Others	Others
	Latanoprost lactone diol is an important intermediate compound in the synthesis of Latanoprost. Latanoprost, classified as a prostaglandin F2α analogue, functions as an agonist for the FP prostanoid receptor, resulting in a reduction in intraocular pressure (IOP).
T71088	AM-211 sodium
	AM-211 sodium is a novel and potent antagonist of the prostaglandin D2 receptor type 2. AM-211 is active in animal models of allergic inflammation. AM211 has high affinity for human, mouse, rat, and guinea pig DP2 and it shows selectivity over other prostanoid receptors and enzymes. AM211 exhibits good oral bioavailability in rats and dogs and dose-dependently inhibits 13,14-dihydro-15-keto-PGD(2)-induced leukocytosis in a guinea pig pharmacodynamic assay.
T38389	Prostaglandin D2 Ethanolamide Prostaglandin D2 Ethanolamide
	Prostaglandin D2 ethanolamide (PGD2-EA) is a bioactive lipid produced by the sequential metabolism of anandamide (arachidonoyl ethanolamide) by cyclooxygenase (COX) enzymes, in particular by COX-2, and PGD synthase. The biosynthesis of PGD2-EA from anandamide can also be increased when anandamide metabolism is diminished by deletion of fatty acid amide hydrolase. PGD2-EA is inactive against recombinant prostanoid receptors, including the D prostanoid receptor. It increases the frequency of minia...
T37724	Lumula
	There are currently four prostaglandin (PG) derivatives which have been approved for human clinical use for the treatment of glaucoma. The names of the PGs and the concentrations of the approved doses are: travoprost (40 μg/ml), latanoprost (50 μg/ml), bimatoprost (300 μg/ml), and unoprostone (1,500 μg/ml). All of these compounds are modified at C-1 in order to act as lipophilic prodrugs in the eye. All have also been postulated to function via activation of the prostanoid FP receptor. Unoprosto...
T14139	Aganepag AGN 210937	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Aganepag, a potent Prostanoid EP2 receptor agonist, exhibits remarkable selectivity with an EC50 of 0.19 nM, demonstrating no activity at the EP4 receptor. Its applications are primarily in the fields of wound healing, scar reduction, scar prevention, and the treatment and prevention of wrinkles.
T38171	Ro 1138452 hydrochloride
	Selective prostacyclin IP receptor antagonist (pKi = 8.3). Exhibits no affinity at other prostanoid receptors (EP1-4, FP and TP) in a radioligand binding assay. Demonstrates analgesic activity in rats. Orally bioavailable. Clark et al (2004) Discovery and SAR development of 2-(phenylamino) imidazolines as prostacyclin receptor antagonists. Bioorg.Med.Chem.Lett. 14 1053 PMID:15013022 \|Jones et al (2006) Investigation of the prostacyclin (IP) receptor antagonist RO1138452 on isolated blood vessel ...
T37441	KMN-80
	The prostaglandin E receptor 4 (EP4) is one of four G protein-coupled receptors that mediate the actions of prostaglandin E2 . Binding of PGE2 to the EP4 receptor causes an increase in intracellular cyclic AMP, which plays important roles in bone formation and resorption, cancer, and atherosclerosis. KMN-80 is a substituted γ-lactam (pyrrolidinone) derivative of PGE1 that acts as a selective and potent agonist of EP4 with an IC50 value of 3 nM (IC50 = 1.4 μM for EP3 and > 10 μM for all other pro...
T37383	1,2,3-Trilinoelaidoyl-rac-glycerol
	1,2,3-Trilinoelaidoyl-rac-glycerol is a triacylglycerol that contains linoelaidic acid at the sn-1, sn-2, and sn-3 positions. Dietary administration of 1,2,3-trilinoelaidoyl-rac-glycerol (0.6-6.3% w/w) lowers serum levels of thromboxane B2 , prostaglandin F2 (PGF2), and PGE in rats.1 \|1. Bruckner, G., Goswami, S., and Kinsella, J.E. Dietary trilinoelaidate: Effects on organ fatty acid composition, prostanoid biosynthesis and platelet function in rats. J. Nutr. 114(1), 58-67 (1984).

化合物

Ralinepag

Cat.No: T4635

Synonym: APD811

Target: Others, Prostaglandin Receptor

Synonym: GW 627368X

Target: Prostaglandin Receptor

Latanoprost

Cat.No: T2528

Synonym: Xalatan,PHXA41,拉坦前列腺素,拉坦前列素

Target: GPR, Prostaglandin Receptor, RAR/RXR

Timapiprant

Cat.No: T2664

Synonym: OC000459

Target: GPR, Prostaglandin Receptor

Vidupiprant

Cat.No: T17232

Synonym: AMG 853

Target: Prostaglandin Receptor

EP4 receptor antagonist 1

Cat.No: T11211

Synonym:

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Cat. No.	Product Name	Target	Signaling Pathways
T1626	Prostaglandin E1 前列地尔,PGE1,列腺素E1,Alprostadil	Endogenous Metabolite; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism
	Prostaglandin E1 (Alprostadil) 是一种前列腺素受体配体，对小鼠 EP1、EP2、EP3、EP4和 IP 的 Ki 值分别为 36、10、1.1、2.1 和 33 nM。它诱导血管舒张并抑制血小板聚集，可作为血管扩张剂用于外周血管疾病的研究。

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