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Search Results for " promyelocytic "

9

抑制剂 & 化合物

11

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1843	XMD8-92	ERK; BMI-1; Epigenetic Reader Domain	Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK
	XMD8-92 是 ERK5 (BMK1)/BRD4的有效抑制剂，Kd 分别为80和190 nM。它抑制 DCAMKL2、PLK4 和 TNK1的 Kd 分别为190、600和890nm，具有抗癌活性。
T14982	Clofilium tosylate	Potassium Channel	Membrane transporter/Ion channel
	Clofilium tosylate 是一种钾通道阻滞剂，可诱导人早幼粒细胞白血病细胞凋亡，具有抗心律失常作用。
T35554	GSK-3β inhibitor 3	Apoptosis; GSK-3	Apoptosis; PI3K/Akt/mTOR signaling; Stem Cells
	GSK-3β inhibitor 3 是一种糖原合成酶激酶 3β（GSK-3β）共价抑制剂（ IC50 ： 6.6 μM），具有强效性、选择性和不可逆性。GSK-3β inhibitor 3 可用于研究急性早幼粒细胞白血病。
T31002	Colletochlorin B
	Colletochlorin B is a natural differentiation inducer of human promyelocytic leukemia cells.
T36575	HDAC3 Inhibitor
	HDAC3 inhibitor is an allosteric inhibitor of histone deacetylase 3 (HDAC3; Ki = 0.16 nM). It is selective for HDAC3 over HDAC1 and HDAC2 (IC50s = 0.95, 11.81, and 95.45 nM, respectively, using recombinant HDACs). In addition, it is selective for acute myeloid, monocytic, and lymphoblastic leukemia cell lines (EC50s = 36.37, 76.64, and 151.7 nM, respectively) over chronic myeloid, acute promyelocytic, and acute lymphoblastic cells (EC50s = 2,160, >10,000, and >10,000 nM, respectively).
T37056	D-erythro-MAPP
	D-erythro-MAPP is a derivative of ceramide and an inhibitor of alkaline ceramidase (Ki = 2-13 μM; IC50 = 1-5 μM). It is selective for alkaline ceramidase over acid ceramidase (IC50 = >500 μM) as well as the serine/threonine protein phosphatase CAPP at concentrations up to 10 μM. D-erythro-MAPP increases intracellular ceramide levels, induces cell cycle arrest at the G0/G1 phase, and inhibits growth of HL-60 promyelocytic leukemia cells in a time- and concentration-dependent manner.
T19228	Calcitriol Impurities D 24-Homo Calcitriol,24-Homo-1,25-dihydroxyvitamin D3	Antiviral	Immunology/Inflammation
	Calcitriol Impurities D (24-Homo Calcitriol) 是维生素的一种激素形式，可促进HL-60人早幼粒细胞白血病细胞分化为单核细胞。Calcitriol Impurities D 具有骨吸收活性，抑制人类免疫缺陷病毒在人体细胞中的复制。Calcitriol Impurities D 具有抗病毒活性们可以用于治疗艾滋病和病毒感染。
T36418	O-Desmethyl-N-deschlorobenzoyl Indomethacin
	O-Desmethyl-N-deschlorobenzoyl indomethacin is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor indomethacin .1It is formed from indomethacin in isolated rabbit hepatocytes. O-Desmethyl-N-deschlorobenzoyl indomethacin (600 μM) decreases the viability of HL-60 leukemia cells when cultured with glucose oxidase.2It has also been used in the synthesis of prostaglandin D2receptor antagonists.3 1.Evans, M.A., Papazafiratou, C., Bhat, R., et al.Indomethacin metabolism ...
T36199	AZD 1152 (hydrochloride)
	AZD 1152 is an orally bioavailable prodrug of AZD 1152-HQPA, a selective inhibitor of Aurora kinase B (IC50= 0.36 nM).1AZD 1152 is converted to AZD 1152-HQPA in plasma. Inhibition of Aurora B results in disruption of spindle checkpoint functions and chromosome alignment, resulting in inhibition of cytokinesis followed by apoptosis.2,3AZD 1152 inhibits tumor xenograft growthin vivo.4,5 1.Mortlock, A.A., Foote, K.M., Heron, N.M., et al.Discovery, synthesis, and in vivo activity of a new class of p...

化合物

Cat.No: T1843

Target: ERK, BMI-1, Epigenetic Reader Domain

Clofilium tosylate

Cat.No: T14982

Target: Potassium Channel

GSK-3β inhibitor 3

Cat.No: T35554

Target: Apoptosis, GSK-3

Colletochlorin B

Cat.No: T31002

HDAC3 Inhibitor

Cat.No: T36575

Cat.No: T37056

Calcitriol Impurities D

Cat.No: T19228

Synonym: 24-Homo Calcitriol,24-Homo-1,25-dihydroxyvitamin D3

Target: Antiviral

O-Desmethyl-N-deschlorobenzoyl Indomethacin

Cat.No: T36418

AZD 1152 (hydrochloride)

Cat.No: T36199

Cat. No.	Product Name	Target	Signaling Pathways
TN1684	Ginsenoside F5 人参皂苷 F5,人参皂苷F5	Apoptosis	Apoptosis
	Ginsenoside F5 是从人参中提取的一种天然产物，通过凋亡途径显着抑制 HL-60 细胞的生长。
TJS0328	Nordalbergin 6,7-dihydroxy-4-phenylcoumarin,6,7-Dihydroxy-4-Phenylchromen-2-One,6,7-二羟基-4苯基香豆素	Others	Others
	Nordalbergin 是一种香豆素，分离自Dalbergia sissoo 的木皮中。它能够显著性的诱导 HL-60 细胞的分化。
TMS0484	Episyringaresinol 4'-O-β-D-glncopyranoside (-)-丁香树脂酚-4-O-β-D-葡萄糖苷,(-)-Syringaresinol 4-O-β-D-glucopyranosi	Others	Others
	Episyringaresinol 4'-O-β-D-glncopyranoside ((-)-Syringaresinol 4-O-β-D-glucopyranosi) 是一种天然的潜在神经炎症抑制剂，分离自鼠尾草 (Alhagi sparsifoliaShap) 。
T6S0234	Toosendanin	Others	Others
	Toosendanin 是一种从杜鹃花果实皮中提取的三萜，具有杀虫和抗炎活性，可用于研究缓解疼痛。
T14304	Aphidicolin	Others	Others
	Aphidicolin is a potent inhibitor of cellular deoxyribonucleic acid synthesis and inhibits the growth of herpes simplex virus[2]. Aphidicolin is an inhibitor of DNA polymerase α and δ, prevents mitotic cell division by interfering with the activity of DNA
TJS0487	(-)-Syringaresinol DL-Syringaresinol,Lirioresinol b,(-)-丁香脂素	Others	Others
	(-)-Syringaresinol (DL-Syringaresinol) 来源于番荔枝 Annona Montana 的茎。 (-)-Syringaresinol 通过 G1 期阻滞和诱导细胞凋亡来抑制人早幼粒细胞 HL-60 细胞的增殖，并具有抗癌活性。
TN2318	Yadanziolide C	Others	Others
	Yadanziolide C induces differentiation with cultured HL-60 promyelocytic leukemia cells.
TN6054	Norglaucine hydrochloride
	(+)-Norglaucine shows cytotoxic activity toward the tumor cell lines B16-F10 (mouse melanoma), HepG2 (human hepatocellular carcinoma), K562 (human chronic myelocytic leukemia) and HL-60 (human promyelocytic leukemia) and non-tumor peripheral blood mononuc
TN3799	Dehydrocrebanine	Antifection	Microbiology/Virology
	Dehydrocrebanine has strong activity against promyelocytic leukemia cells (HL-60) with an IC50 of 2.14 ug/mL. It also shows potent antimalarial activity with an IC50 value of 70 ng/ml.
TN3838	Desmethylrocaglamide	Others	Others
	Desmethylrocaglamide is a novel inducer of cellular differentiation using HL-60 promyelocytic cells, it may be a drug for the prevention and therapy of cancer. It also has insecticidal activity.
T37442	Aspergillin PZ
	Aspergillin PZ is a fungal metabolite originally isolated from A. awamori. It induces morphological deformation of P. oryzae conidia when used at a concentration of 89 nM. Aspergillin PZ is active against S. epidermidis (MIC = 20 μM) but not S. aureus, E. coli, or B. cereus (MICs = >20 μM). It is cytotoxic to HL-60 promyelocytic leukemia cells (IC50 = 56.61 μM) but not THP-1 acute monocytic leukemia or PC3 prostate cancer cells (IC50s = >80 μM).

天然产物

Cat.No: TN1684

Synonym: 人参皂苷 F5,人参皂苷F5

Target: Apoptosis

Cat.No: TJS0328

Synonym: 6,7-dihydroxy-4-phenylcoumarin,6,7-Dihydroxy-4-Phenylchromen-2-One,6,7-二羟基-4苯基香豆素

Target: Others

Episyringaresinol 4'-O-β-D-glncopyranoside

Cat.No: TMS0484

Synonym: (-)-丁香树脂酚-4-O-β-D-葡萄糖苷,(-)-Syringaresinol 4-O-β-D-glucopyranosi

Target: Others

Cat.No: T6S0234

Target: Others

Cat.No: T14304

Target: Others

(-)-Syringaresinol

Cat.No: TJS0487

Synonym: DL-Syringaresinol,Lirioresinol b,(-)-丁香脂素

Target: Others

Cat.No: TN2318

Target: Others

Norglaucine hydrochloride

Cat.No: TN6054

Dehydrocrebanine

Cat.No: TN3799

Target: Antifection

Desmethylrocaglamide

Cat.No: TN3838

Target: Others

Cat.No: T37442

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