9
2
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1939 |
DMOG
Dimethyloxalylglycine,Dimethyloxallyl Glycine,Dimethyloxaloylglycine,二甲基草酰甘氨酸 |
HIF/HIF Prolyl-Hydroxylase; HIF; Autophagy | Angiogenesis; Autophagy; Chromatin/Epigenetic; Metabolism |
DMOG (Dimethyloxalylglycine) 是 α-酮戊二酸辅因子的拮抗剂,是一种 HIF 脯氨酰羟化酶抑制剂,可导致蛋白HIF-1α的积聚和稳定,诱导细胞自噬。它是一种促血管生成剂,在结肠炎和腹泻动物模型中起保护作用。 | |||
T12644L |
(S)-Thalidomide
(S)-(-)-Thalidomide |
Apoptosis | Apoptosis |
(S)-Thalidomide ((S)-(-)-Thalidomide) 是 Thalidomide 的 S 型异构体,具有免疫调节,抗炎,抗癌,抗血管生成活性和促凋亡活性,可用于研究麻风结节性红斑和骨髓瘤。 | |||
T1185 |
Rofecoxib
MK 966,罗非昔布,罗非考昔,MK-0966 |
COX | Immunology/Inflammation; Neuroscience |
Rofecoxib (MK 966) 是可口服的 COX-2特异性抑制剂,具有抗炎、解热和镇痛特性以及潜在的抗肿瘤特性。在人骨肉瘤细胞和中国仓鼠卵巢细胞中,对人 COX-2 的 IC50值分别为 26 和 18 nM。 | |||
T69599 |
ABT-510
|
||
ABT-510 is synthetic peptide that mimics the anti-angiogenic activity of the endogenous protein thrombospondin-1 (TSP-1). ABT-510 inhibits the actions of several pro-angiogenic growth factors important to tumor neovascularization; these pro-angiogenic growth factors include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF)), hepatocyte growth factor (HGF), and interleukin 8 (IL-8). | |||
T11325 | Frondoside A | Others | Others |
possesses anticancer, anti-invasive, anti-metastasis, anti-angiogenic and pro-apoptosis properties with high safety.Frondoside A, a natural glycoside extracted from the sea cucumber, Cucumaria frondosa, | |||
T82633 |
Cys-Asp-Pro-Gly-Tyr-Ile-Gly-Ser-Arg-NH2
|
||
Cys-Asp-Pro-Gly-Tyr-Ile-Gly-Ser-Arg-NH2是源自层粘连蛋白B1链的线性肽,能够干预肿瘤细胞对基底膜的附着与侵袭,且表现出抗血管生成活性。 | |||
T28874 |
SU11652
SU-11652,SU 11652 |
||
SU11652 is a potent cell-permeable pyrrole-indolinone compound. SU11652 acts as an ATP-competitive tyrosine kinase receptor and angiogenic inhibitor with greater selectivity for PDGFR-β (PDGFRβ, IC50 = 3 nM), Flk-1 (VEGFR2, IC50 = 27 nM), FGFR1 (IC50= 170 | |||
T69223 | CC-1088 | ||
CC-1088 is an analog of thalidomide with potential antineoplastic activity that belongs to the functional class of agents called selective cytokine inhibitory drugs (SelCIDs). SelCIDs inhibit phosphodiesterase-4 (PDE 4), an enzyme involved in tumor necrosis factor alpha (TNF alpha) production. CC-1088 inhibits production of the cytokines vascular endothelial growth factor (VEGF) (a pro-angiogenic factor) and interleukin-6 (IL-6). | |||
T69555 |
XUN49524
|
||
XUN49524 also known as Vezf1-IN-T4, is an inhibitor of the pro-angiogenic activity of the zinc finger transcription factor Vezf1. XUN49524 was first reported in Molecules (2018), 23(7), 1615/1-1615/15 . This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming). |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3843 |
Pinosylvin
银松素,3,5-stilbenediol,5-Styrylresorcinol |
Apoptosis; Others; Antibacterial; Autophagy | Apoptosis; Autophagy; Microbiology/Virology; Others |
Pinosylvin (5-Styrylresorcinol) 是从Pinus spp 的心材中分离出来的一种白藜芦醇类似物,可诱导白血病细胞凋亡和自噬。它是一种感染前的类苯乙烯类毒素,具有抗菌活性。 | |||
T36715 |
Tetrac
Tetraiodothyroacetic acid,3,3',5,5'-Tetraiodothyroacetic acid |
Apoptosis; EGFR | Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Tetrac (Tetraiodothyroacetic acid)是L-甲状腺素(T4)的衍生物,是一种甲状腺整合素受体拮抗剂。Tetrac通过阻断EGFR介导的结直肠癌细胞信号传导来诱导抗增殖。Tetrac 可阻断 T4 和 3,5,3'-triiodo-L-thyronine (T3)在细胞表面甲状腺素整合素 αvβ3 受体上的作用。Tetra 具有抗血管生成、抗肿瘤活性和促凋亡活性。 |