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55

抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T9189	Iptacopan hydrochloride Iptacopan HCl,LNP023 hydrochloride	Complement System	Immunology/Inflammation
	Iptacopan hydrochloride (LNP023 hydrochloride) 是一种可口服、高效和高选择性的因子 B 抑制剂，IC50 为 10 nM。 LNP023 显示与人因子 B 的直接、可逆和高亲和力结合，KD 为 7.9 nM。
T40276	GS-621763	SARS-CoV	Microbiology/Virology
	GS-621763 是具有口服活性的 GS-441524 前药，在小鼠体内具有抗SARS-CoV-2病毒活性。
T19508	Peroxidase	Others	Others
	Peroxidase 来自辣根，在先天免疫、氧化活性氧、激素生物合成和多种疾病的发病机制等方面具有重要作用。
T40109	APOL1-IN-1 APOL1-IN-1	Others	Others
	APOL1-IN-1是一种有效的载脂蛋白 L1(APOL1) 的抑制剂，可用于研究局灶节段性肾小球硬化 (FSGS) 和非糖尿病肾病 (NDKD) 的发病原理，促进对此类疾病的研究。
T1993	J-147 J147	Epigenetic Reader Domain; Dopamine Receptor; Monoamine Oxidase	Chromatin/Epigenetic; GPCR/G Protein; Neuroscience
	J-147 是一种高效的、具有口服活性的、可透过血脑屏障神经保护剂，可增强认知能力。它抑制单胺氧化酶 B 和多巴胺转运体，EC50分别为 1.88 μM 和 0.649 μM。它有研究阿尔茨海默氏症的潜力。
TP1359L	Amyloid β Peptide (42-1)(human) acetate Amyloid β Peptide (42-1)(human) acetate(317366-82-8 free base)	Beta Amyloid	Neuroscience
	Amyloid β Peptide (42-1)(human) acetate 是淀粉样蛋白 β 肽 (1-42) 的无活性形式。Amyloid β Peptide (42-1)(human) acetate 是由 42 个氨基酸组成的肽，其在阿尔茨海默病的发病机制中起关键作用。
TP1390	CEP dipeptide 1
	CEP dipeptide 1, a potent angiogenic compound, exhibits robust activity in promoting angiogenesis. This compound is specifically implicated in the pathogenesis of age-related macular degeneration (AMD).
T32392	Sonlicromanol KH-176,KH 176,KH176
	KH-176 is an effective intracellular REDOX regulator that targets reactive oxygen species, which are important in the pathogenesis of mitochondrial oxidative phosphorylation disorders and may be used to treat mitochondrial diseases.
T69441	NSC66098
	NSC66098 is a novel potent inhibitor of Huntington's disease (HD) pathogenesis via targeting CAG repeats RNA and Poly Q protein.
TP1359	β-Amyloid (42-1), human Amyloid β Peptide (42-1)(human)
	β-Amyloid (42-1), human is the inactive form of Amyloid β Peptide (1-42) which plays a key role in the pathogenesis of Alzheimer disease.
T36638	[Des-His1,Glu9]-Glucagon amide TFA [Des-His1,Glu9]-Glucagon amide TFA
	[Des-His1,Glu9]-Glucagon amide TFA is a potent peptide antagonist targeting the glucagon receptor, featuring a pA2 value of 7.2. It holds potential utility in diabetes pathogenesis research[1].
TP1007	β-Amyloid (1-42), human 大豆肽,β-Amyloid (1-42), human,Amyloid β-Peptide (1-42) human	Beta Amyloid	Neuroscience
	β-Amyloid (1-42), human 是一种由 42 个氨基酸组成的肽，在阿尔茨海默病的发病机制中起关键作用。
T61064	nAChR antagonist 1
	nAChR antagonist 1 (compound B15) is a highly effective antagonist of α7 nAChR, demonstrating an IC50 value of 3.3 μM. Its versatility makes it an ideal candidate for investigating the pathogenesis of schizophrenia, Alzheimer's disease, and inflammatory disorders [1].
T38521	Patamostat mesylate E-3123 mesylate
	Patamostat mesylate (E-3123) is a highly potent protease inhibitor, displaying strong inhibitory activity against trypsin, plasmin, and thrombin, with IC 50 values of 39 nM, 950 nM, and 1.9 μM, respectively. This compound, Patamostat mesylate, shows promising potential in suppressing the pathogenesis and development of acute pancreatitis.
T76464	FITC-β-Ala-Amyloid β-Protein (1-42) (ammonium)
	FITC-β-Ala-Amyloid β-Protein (1-42) ammonium 是一种关键于阿尔茨海默病发病机制中的 FITC 标记 Aβ1-42 单体肽。
T81725	Mz325	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Mz325为HDAC与Sirt2的双重抑制剂，针对Sirt2展现9.7 μM的IC50，其在癌症和神经退行性疾病的发病机制中扮演关键角色。
T76797	Anti-Human IL-17A
	Anti-HumanIL-17A 是一种全人抗白细胞介素 17A 单克隆抗体。Anti-HumanIL-17A 可用于银屑病发病机制研究。
T80035	Biotin-β-Amyloid (1-42), human TFA Biotin-amyloid β-peptide (1-42) (human) TFA
	Biotin-β-Amyloid (1-42), human TFA（Biotin-Amyloid β-Peptide (1-42) (human) TFA）是一种标记有生物素的β-Amyloid (1-42)肽，由42个氨基酸构成，对阿尔茨海默病的发病机理有重要作用。
T69830	GSK2239633
	GSK2239633 is a potent CC-chemokine receptor 4 antagonist with pIC50 of 7.9. The CC-chemokine receptor 4 (CCR4) is thought potentially to play a critical role in asthma pathogenesis due to its ability to recruit type 2 T-helper lymphocytes to the inflamed airways. Therefore, CCR4 provides an excellent target for anti-inflammatory therapy.
T83557	(3S,4S)-Tivantinib ARQ 198,(3S,4S)-ARQ 197
	“(3S,4S)-Tivantinib 为高效、高选择性c-MET受体酪氨酸激酶抑制剂，同时作用于新靶点GSK3α和GSK3β，这些在非小细胞肺癌(NSCLC)的细胞机制中具有关键作用。”
T40043	RORγt Inverse agonist 10
	RORγt Inverse agonist 10 is a highly potent and orally bioavailable compound that acts as an antagonist for the retinoic acid receptor-related orphan nuclear receptor gamma t (RORγt). With an IC50 of 51 nM, it effectively inhibits the activity of RORγt, a prominent transcription factor involved in the regulation of genes associated with the pathogenesis of psoriasis, including IL-17A, IL-22, and IL-23R.
T73001	eIF4A3-IN-9
	eIF4A3-IN-9 是silvestrol 类似物。eIF4A3-IN-9 干扰eIF4F 翻译复合体组装，对 myc-LUC，tub-LUC 和抑制 MBA-MB-231 细胞生长的EC50值分别为 29，450 和 80 nM。eIF4A3-IN-9 可用于人类肿瘤发病机制的研究。
T78370	Myelin Basic Protein(87-99) TFA
	Myelin Basic Protein(87-99) TFA 为诱导神经碱性蛋白特异性T细胞增殖的致脑肽。该化合物能在外周血单核细胞中诱导Th1极化，与多发性硬化症(MS)的发病机制相关。
T36097	TNF-α-IN-2
	TNF-α-IN-2 is a highly potent and orally bioavailable inhibitor of tumor necrosis factor alpha (TNFα), exhibiting an IC50 of 25 nM in the HTRF assay. It exerts its inhibitory effects by inducing conformational changes in the TNFα trimer upon binding, resulting in disrupted signaling when the trimer interacts with TNFR1. TNF-α-IN-2 holds promise as a valuable tool for investigating the pathogenesis of rheumatoid arthritis[1].
T82297	GluN1(356-385)
	GluN1 (356-385) 是抗NMDAR脑炎抗原肽，能够降低海马神经元表面NMDAR簇密度。该肽段用于探讨抗NMDAR脑炎病理机制。
T82260	Grisnilimab WT1
	Grisnilimab (WT1)为IgG2a亚型的单克隆抗体（抗CD7），与Wilms' tumor发病相关的肿瘤抑制因子。该抗体能够调控多个靶基因的转录活性，并可能涉及RNA的转录后修饰过程。
T71184	ARQ-736
	ARQ 736 is a potent and selective BRAF inhibitor. ARQ 736 is selectively potent in killing cancer cell lines harboring at least one mutated BRAF allele. BRAF mutations were detected in over 60% of melanomas and may account for a significant proportion of colon cancer patients whose tumors are resistant to anti-EGFR therapy. The B-Raf protein is a key signaling molecule in the mitogen activated protein kinase (MAPK) signaling pathway and has been implicated in the pathogenesis of a variety of ca...
T80700	β Amyloid(17-28) human
	β Amyloid(17-28) human 为β-淀粉样肽(Abeta)的一段核心片段，其结构受脂质诱导。本化合物能够促进β Amyloid40全长肽段的聚集，导致阿尔茨海默病(AD)中具毒性的聚集体形成。
T78344	Pectinase
	果胶酶(Pectinase)为水解果胶的酶混合物，广泛存在于微生物与高等植物中。该酶涉及细胞壁代谢，并影响细胞生长、衰老、果实成熟及发病与脱落过程。
T61394	Neuraminidase-IN-5
	Neuraminidase-IN-5 (Compound 5b) 是一种有效的 neuraminidase 抑制剂，IC50为 0.02 μM。神经氨酸酶（NA）是开发抗流感药物的有希望的靶点。Neuraminidase-IN-5 是一种二氢呋喃香豆素衍生物化合物。
T9670	Patamostat
	Patamostat (E-3123)是一种有效的蛋白酶抑制剂，对胰蛋白酶、纤溶酶和凝血酶具有显著抑制效果，其IC50值分别为39 nM、950 nM和1.9 μM。Patamostat可能在急性胰腺炎的发病机制和发展中发挥抑制作用。
T72943	eIF4A3-IN-17
	eIF4A3-IN-17 是 silvestrol 类似物。eIF4A3-IN-17 干扰 eIF4F 翻译复合体组装，对 myc-LUC，tub-LUC 和抑制 MBA-MB-231 细胞生长的 EC50值分别为 0.9，15 和 1.8 nM。eIF4A3-IN-17 可用于人类肿瘤发病机制的研究。
T60271	SARS-CoV-2 nsp3-IN-2
	SARS-CoV-2 nsp3-IN-2 是一种 SARS-CoV-2 nsp3 Mac1抑制剂，IC50值为 180 μM。SARS-CoV-2 nsp3 宏结构域是一种 ADP-核糖基水解酶，对冠状病毒的复制和发病机制至关重要。 SARS-CoV-2 nsp3-IN-2 是一种小分子化学探针，可用于研究病毒。
T72944	eIF4A3-IN-18
	eIF4A3-IN-18 是silvestrol 类似物。eIF4A3-IN-18 干扰eIF4F 翻译复合体组装，对 myc-LUC，tub-LUC 和抑制 MBA-MB-231 细胞生长的EC50值分别为 0.8、35 和 2 nM。eIF4A3-IN-18 对 RMPI-8226 细胞具有细胞毒性，LC50值为 0.06 nM。eIF4A3-IN-18 可用于人类肿瘤发病机制的研究。
T73652	Eritoran
	Eritoran是一种Toll样受体4 (TLR4) 拮抗剂，能够保护小鼠免受包括埃博拉病毒(EBOV)、马尔堡病毒(MARV)在内的致命流感病毒感染。该化合物通过降低粒细胞增多水平，可能有助于减轻“细胞因子风暴”的严重程度，抑制丝状病毒感染的发病机制。
T39168L	Epsilon-(gamma-glutamyl)-lysine acetate (17105-15-6 Free base)
	Epsilon-(gamma-glutamyl)-lysine acetate (17105-15-6 Free base) 是一种 N(6)-酰基-L-赖氨酸衍生物，可在组织转谷氨酰胺酶的帮助下在细胞外基质 (ECM) 成分之间形成键（tTg）。这些键与某些疾病（如非糖尿病肾病和青光眼滤过）的发病机制有关。
T80699	β Amyloid(28-35) human
	β Amyloid(28-35) human 是一种具有神经毒性的β-淀粉样肽，能够与神经元膜结合，影响其二级结构并加剧阿尔茨海默病的神经毒性。该肽段对酸性磷脂DPH表现出非均向性作用，从而增加脂质膜双层内部的流动性。该核心片段由脂质诱导形成。
T35802	ML-345
	Insulin-degrading enzyme (IDE) is a thiol-sensitive zinc-metallopeptidase that acts as the major insulin-degrading protease in vivo, mediating the termination of insulin signaling. [1] In addition to regulating insulin action in diabetes pathogenesis, IDE plays a role in Varicella-Zoster virus infection and degradation of amyloid-β, a peptide implicated in Alzheimer's disease. ML-345 is a small molecule inhibitor that selectively targets cysteine819 in IDE with an EC50 value of 188 nM. [2] It de...
T37620	Leukotriene C4 methyl ester
	Leukotriene C4 (LTC4) is the parent cysteinyl-leukotriene produced by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, and mast cells, and by transcellular metabolism in platelets. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute all...
TP2177	Amyloid Precursor C-Terminal Peptide	Others	Others
	Amyloid precursor c-terminal peptide has the amino acid sequence Gly-Tyr-Glu-Asn-Pro-Thr-Tyr-Lys-Phe-Phe-Glu-Gln-Met-Gln-Asn. APP is best known as the precursor molecule whose proteolysis generates beta-amyloid (Aβ), a 37 to 49 amino acid peptide whose am
T82316	GIP, rat TFA
	GIP, rat TFA 是一种源自大鼠的生物活性肽。GIP（Glucose-dependent Insulinotropic Polypeptide，又名 Gastric Inhibitory Polypeptide）是由十二指肠与空肠中的K细胞在摄食后释放的一种含42个氨基酸的多肽。作为肠促胰岛素激素肽家族的一部分，GIP和GLP（Glucagon-Like Peptide）共同调控胰岛β细胞的胰岛素分泌，并可能促进β细胞扩增及存活。此外，近期研究显示GIP参与调节脂质平衡，并可能在肥胖的病理生理中扮演角色。
T37737	N-cis-octadec-9Z-enoyl-L-Homoserine lactone
	Quorum sensing is a regulatory process used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which gene...
T37336	N-3-oxo-hexadec-11(Z)-enoyl-L-Homoserine lactone
	Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which gener...
T37745	N-pentadecanoyl-L-Homoserine lactone
	Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which gener...
T35498	β-Amyloid (1-14),mouse,rat
	β-Amyloid (1-14),mouse,rat is a 1 to 14 fragment of Amyloid-β peptide. β-Amyloid (1-14),mouse,rat is produced through the proteolytic processing of a transmembrane protein, amyloid precursor protein (APP), by β- and γ-secretases. β-Amyloid (1-14),mouse,rat accumulation in the brain is proposed to be an early toxic event in the pathogenesis of Alzheimer’s disease, which is the most common form of dementia associated with plaques and tangles in the brain[1]. [1]. Chen GF, et al. Amyloid beta: stru...
T37878	N-tridecanoyl-L-Homoserine lactone
	Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which gener...
T37879	N-undecanoyl-L-Homoserine lactone
	Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which gener...
T37738	N-cis-tetradec-9Z-enoyl-L-Homoserine lactone
	Quorum sensing is a regulatory process used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which gene...
T38128	Leukotriene D4 Leukotriene D4 MaxSpec® Standard,LTD4
	Leukotriene D4 (LTD4) is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase. It is the first cysteinyl-leukotriene metabolite of LTC4 . Like LTC4, LTD4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity. LTD4 is equipotent to LTC4 in its biological activities, except that LTD4 is nearly 100-fold more effective in the contraction of...
T37582	Ganglioside GM1 Mixture (ovine) (ammonium salt)
	Ganglioside GM1is a monosialylated ganglioside and the prototypic ganglioside for those containing one sialic acid residue.1,2It is found in a large variety of cells, including immune cells and neurons, and is enriched in lipid rafts in the cell membrane.3It associates with growth factor receptors, including TrkA, TrkB, and the GDNF receptor complex containing Ret and GFRα, and is required for TrkA expression on the cell surface. Ganglioside GM1interacts with other proteins to increase calcium i...

化合物

Iptacopan hydrochloride

Cat.No: T9189

Synonym: Iptacopan HCl,LNP023 hydrochloride

Target: Complement System

Cat.No: T40276

Target: SARS-CoV

Cat.No: T19508

Target: Others

Cat.No: T40109

Synonym: APOL1-IN-1

Target: Others

Cat.No: T1993

Synonym: J147

Target: Epigenetic Reader Domain, Dopamine Receptor, Monoamine Oxidase

Amyloid β Peptide (42-1)(human) acetate

Cat.No: TP1359L

Synonym: Amyloid β Peptide (42-1)(human) acetate(317366-82-8 free base)

Target: Beta Amyloid

CEP dipeptide 1

Cat.No: TP1390

Cat.No: T32392

Synonym: KH-176,KH 176,KH176

Cat.No: T69441

β-Amyloid (42-1), human

Cat.No: TP1359

Synonym: Amyloid β Peptide (42-1)(human)

[Des-His1,Glu9]-Glucagon amide TFA

Cat.No: T36638

Synonym: [Des-His1,Glu9]-Glucagon amide TFA

β-Amyloid (1-42), human

Cat.No: TP1007

Synonym: 大豆肽,β-Amyloid (1-42), human,Amyloid β-Peptide (1-42) human

Target: Beta Amyloid

nAChR antagonist 1

Cat.No: T61064

Patamostat mesylate

Cat.No: T38521

Synonym: E-3123 mesylate

FITC-β-Ala-Amyloid β-Protein (1-42) (ammonium)

Cat.No: T76464

Cat.No: T81725

Target: HDAC

Anti-Human IL-17A

Cat.No: T76797

Biotin-β-Amyloid (1-42), human TFA

Cat.No: T80035

Synonym: Biotin-amyloid β-peptide (1-42) (human) TFA

Cat.No: T69830

(3S,4S)-Tivantinib

Cat.No: T83557

Synonym: ARQ 198,(3S,4S)-ARQ 197

RORγt Inverse agonist 10

Cat.No: T40043

Cat.No: T73001

Myelin Basic Protein(87-99) TFA

Cat.No: T78370

Cat.No: T36097

Cat.No: T82297

Cat.No: T82260

Synonym: WT1

Cat.No: T71184

β Amyloid(17-28) human

Cat.No: T80700

Cat.No: T78344

Neuraminidase-IN-5

Cat.No: T61394

Cat.No: T9670

Cat.No: T72943

SARS-CoV-2 nsp3-IN-2

Cat.No: T60271

Cat.No: T72944

Cat.No: T73652

Epsilon-(gamma-glutamyl)-lysine acetate (17105-15-6 Free base)

Cat.No: T39168L

β Amyloid(28-35) human

Cat.No: T80699

Cat.No: T35802

Leukotriene C4 methyl ester

Cat.No: T37620

Amyloid Precursor C-Terminal Peptide

Cat.No: TP2177

Target: Others

Cat.No: T82316

N-cis-octadec-9Z-enoyl-L-Homoserine lactone

Cat.No: T37737

N-3-oxo-hexadec-11(Z)-enoyl-L-Homoserine lactone

Cat.No: T37336

N-pentadecanoyl-L-Homoserine lactone

Cat.No: T37745

β-Amyloid (1-14),mouse,rat

Cat.No: T35498

N-tridecanoyl-L-Homoserine lactone

Cat.No: T37878

N-undecanoyl-L-Homoserine lactone

Cat.No: T37879

N-cis-tetradec-9Z-enoyl-L-Homoserine lactone

Cat.No: T37738

Cat.No: T38128

Synonym: Leukotriene D4 MaxSpec® Standard,LTD4

Ganglioside GM1 Mixture (ovine) (ammonium salt)

Cat.No: T37582

Cat. No.	Product Name	Target	Signaling Pathways
T41242	Uric acid sodium	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Uric acid sodium 是氧自由基 (oxygen radical) 的清除剂，是一种有效的、常见的抗氧化剂，有助于维持机体血压稳定和抗氧化应激。Uric acid sodium 能清除活性氧 (ROS)，如单线态氧和过氧亚硝酸盐，对脂质过氧化有抑制作用，与痛风性关节病的发病机理和草酸钙结石的形成有关。
TN4822	Prehelminthosporol	Antifection	Microbiology/Virology
	Prehelminthosporol is a phytotoxin, it may play an important role in pathogenesis by killing or weakening plant cells in advance of the growing hyphae and facilitating nutrient uptake and further growth of the fungus in plant tissue.
T39168	Epsilon-(gamma-glutamyl)-lysine Epsilon-(gamma-glutamyl)-lysine,γ-Glu-ε-Lys,H-Glu(H-Lys-OH)-OH
	Epsilon-(gamma-glutamyl)-lysine is an N(6)-acyl-L-lysine derivative that forms bonds between extracellular matrix (ECM) components with the assistance of the enzyme tissue transglutaminase (tTg). These bonds are implicated in the pathogenesis of certain diseases like non-diabetic kidney and glaucoma filtration.

天然产物

Uric acid sodium

Cat.No: T41242

Target: Reactive Oxygen Species

Prehelminthosporol

Cat.No: TN4822

Target: Antifection

Epsilon-(gamma-glutamyl)-lysine

Cat.No: T39168

Synonym: Epsilon-(gamma-glutamyl)-lysine,γ-Glu-ε-Lys,H-Glu(H-Lys-OH)-OH

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