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42

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T16939	Stains-All	Others	Others
	Stains-All 是一种能够研究钙调蛋白 (CaM) 和相关钙结合蛋白 (CaBP) 的各个钙结合位点的结构特征的便捷探针，是一种阳离子碳菁染料。
TP1938	RS 09	TLR	Immunology/Inflammation
	RS 09 是一种 LPS 肽模拟物，是 TLR4 激动剂佐剂，可在疫苗环境中增加抗体产量。
T7417	Avatrombopag YM477,AKR-501,1-[3-氯-5-[[[4-(4-氯-2-噻吩基)-5-(4-环己基-1-哌嗪基)-2-噻唑基]氨基]羰基]-2-吡啶基]-4-哌啶羧酸,E5501	Thrombin; Thrombopoietin Receptor	Immunology/Inflammation; Proteases/Proteasome
	Avatrombopag (YM477) 是一种新型口服血小板生成素 (TPO) 受体激动剂，可激活 TPO 受体并增加巨核细胞增殖/分化和血小板生成。
T6966	RGD RGD (Arg-Gly-Asp) Peptides,Arg-Gly-Asp,RGD Peptides	Integrin	Cytoskeletal Signaling
	RGD (RGD (Arg-Gly-Asp) Peptides) 是一种细胞粘附基序，可以模拟细胞粘附蛋白并与整合素结合。
T13932	TLR1 N-[(1S)-2-甲基-1-(1-吡咯烷羰基)丙基]-苯丙酰胺	Others; MyD88	Immunology/Inflammation; Others
	TLR1 是细胞穿透 Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop 的小分子模拟物，能够阻碍 IL-1 受体介导的反应。
T13587	BT18	Others	Others
	BT18 是一种功能类似于胶质细胞源神经营养因子的分子模拟物。它能够影响 GDNF 家族受体 GFRα1 和 RET 受体酪氨酸激酶 RetA 的功能。
T9597	H2S Donor 5a N-(苯甲酰基硫基)苯甲酰胺	Endogenous Metabolite	Metabolism
	H2S Donor 5a 是一种稳定的、半胱氨酸活化的的 H2S 供体。它是研究 H2S 的有用工具。
T16044	Methoprene 烯虫酯,ZR-515	Others	Others
	Methoprene (ZR-515) 是一种保幼激素模拟物和一种生物杀虫剂。Methoprene 作为昆虫生长调节剂，干扰昆虫的生命周期并阻止其成熟或繁殖。
TP1911L	CALP3 acetate(261969-05-5 free base)	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	CALP3 acetate(261969-05-5 free base) 是一种有效的 Ca2+ 通道阻滞剂，可激活 Ca2+ 结合蛋白的 EF 手基序。它可以通过调节钙调蛋白 (CaM)、Ca2+ 通道和泵的活性在功能上模拟增加的 [Ca2+]i。
T38836L	Protease-Activated Receptor-1, PAR-1 Agonist acetate	Protease-activated Receptor	GPCR/G Protein
	Protease-Activated Receptor-1, PAR-1 Agonist acetate 是一种选择性蛋白酶激活受体 1 (PAR-1) 激动剂肽。它对应于 PAR1 栓系配体，可以选择性地模拟凝血酶通过该受体的作用。
TP2207	Pasireotide Acetate	Somatostatin	GPCR/G Protein
	Pasireotide acetate 是长效的环己肽生长激素抑制素类似物，具有抗分泌、抗增殖和促凋亡活性。它可抑制 GH、IGF-I 和 ACTH 的分泌，可用于研究肢端肥大症和库欣病。它还可以提高生长抑素受体的激动剂活性，对sst1、2、3、4、5的pKi 分别为 8.2、9.0、9.1、小于7.0 和 9.9。
T9085	JFD01307SC [(1,1-DIOXIDOTETRAHYDROTHIEN-3-YL)AMINO]	Antibacterial	Microbiology/Virology
	JFD01307SC ([(1,1-DIOXIDOTETRAHYDROTHIEN-3-YL)AMINO]) 是一种谷氨酰胺合成酶抑制剂。它是抗结核剂，可作为 L-谷氨酸盐的模拟物，靶向参与谷氨酰胺生物合成的酶。
T9120	HBC Benzeneacetonitrile, 4-cyano-α-[[4-[(2-hydroxyethyl)methylamino]phenyl]methylene]-,HBC 530	Others	Others
	HBC (HBC 530) 530 是绿色荧光蛋白 (GFP) 类荧光团的合成染料，具有结构刚性的电子受体和强电子供体。它能够用于 RNA 定位的检测。
TP1736L	Fibrinogen-Binding Peptide 137235-80-4(fb-acetate)	Others	Others
	Fibrinogen-Binding Peptide 137235-80-4(fb-acetate) 是纤维蛋白原受体上玻连蛋白结合位点的推定肽模拟物。它结合纤维蛋白原并抑制血小板与纤维蛋白原的粘附和血小板聚集，还抑制血小板与玻连蛋白的粘附
T77457	Emicizumab ACE 910,RO 5534262	Others	Others
	Emicizumab(ACE 910) 是一种人源化单克隆抗体，桥接活化因子 IX 和激活因子 X，以模拟活化因子 VIII 的功能。Emicizumab 可用于预防和治疗血友病 A 。
T16263	N6-Cyclopentyladenosine UK-80882,CPA	Adenosine Receptor	GPCR/G Protein; Neuroscience
	N6-Cyclopentyladenosine (CPA) 是一个选择性的腺苷A1 受体 (Adenosine A1 receptor)的激动剂，可用于模拟腺苷A1受体的作用，对人A1、A2A 和 A3 受体的Ki 分别为 2.3 nM、790 nM 和 43 nM。N6-Cyclopentyladenosine (CPA) 可用于调节细胞信号传导、神经递质释放和其他生物学过程。
T41142	EM 163	IL Receptor; p38 MAPK; MyD88	Immunology/Inflammation; MAPK
	EM 163是一种 TIR-TIR 相互作用抑制剂，它是MyD88蛋白的TIR（Toll/白细胞介素-1受体）结构域拟态。EM 163针对IL-1受体中的TIR 结构域，阻断与MyD88的相互作用。EM 163抑制葡萄球菌肠毒素B（SEB）引起的体内炎症细胞因子的产生。EM 163能保护小鼠免受SEB 冲击引起的死亡。在体外的大鼠海马神经元中，EM 163阻断p38的激活和IL-1β对化学诱导的长期电位（LTP）引发的蛋白质合成的抑制作用。
T29371	2PyG 2-PyG,2 PyG
	2PyG is a highly fluorescent guanosine mimic for folding and energy transfer studies.
T29702	AG 85-12 AG-85-12,AG85-12
	AG 85-12 is a mimic of the C-terminal portion of angiotensin I.
T13811	Pasireotide ditrifluoroacetate SOM230 ditrifluoroacetate,Pasireotide ditrifluoroacetate (396091-73-9 free base),Pasireotide TFA salt	Others	Others
	Pasireotide is a stable cyclohexapeptide somatostatin mimic.
T25844	N4Py N-4-Py,N 4 Py
	N4Py is a good synthetic mimic of the Bleomycins (BLMs), which are a family of natural antibiotics used clinically in the treatment of certain cancers.
T40846	3,5-Difluoro-L-tyrosine
	3,5-Difluoro-L-tyrosine is a functional and tyrosinase-resistant mimic of tyrosine, commonly utilized for evaluating the substrate specificity of protein tyrosine phosphatases (PTPs).
T39295	Remlarsen MRG-201
	Remlarsen (MRG-201), a miR-29b mimic, functions as a miR-29b agonist with the potential to prevent the formation of fibrotic scars or cutaneous fibrosis.
T30546	BMX-010 AEOL-10113
	BMX-010, also known as AEOL-10113, is Porphyrin-Based SOD Mimic.
T12368	Pasireotide L-aspartate salt 帕瑞肽天门冬氨酸盐,SOM230 L-aspartate	Others	Others
	Pasireotide L-aspartate salt is a stable cyclohexapeptide somatostatin mimic that exhibits unique high-affinity binding to human somatostatin receptors (subtypes sst1/2/3/4/5, pKi=8.2/9.0/9.1/<7.0/9.9 respectively).
T12369	Pasireotide pamoate SOM230 pamoate	Others	Others
	Pasireotide pamoate is a stable cyclohexapeptide somatostatin mimic. Pasireotide pamoate exhibits antisecretory, antiproliferative, and proapoptotic activity.
T34718	StG
	StG is a highly fluorescent guanosine mimic for folding and energy transfer studies.
T29443	4PVG 4 PVG,4-PVG
	4PVG is a highly fluorescent guanosine mimic for folding and energy transfer studies.
T11058	DM3 Maytansinoid DM3	Others	Others
	DM3 (Maytansinoid DM3) is a maytansine mimic containing disulfide or thiol groups and a tubulin inhibitor. It is the cytotoxic part of antibody-drug conjugates (ADCs) .
T20382	Diglycyl-histidine NSC334195,NSC-334195,Gly-gly-his,Glycylglycyl-L-histidine,NSC 334195
	Diglycyl-histidine is a tripeptide complexed with cupric ion designed to mimic specific Cu(II) transport site of ascorbate on albumin molecule.
T6990	SNAP8 Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-Nh2,SNAP 8,SNAP-8	Others	Others
	SNAP8 (Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-Nh2) 是 SNAP-25 N 末端的模拟物，它与 SNAP-25 竞争 SNARE 复合物中的位置，从而调节其形成。
TP2170	CALP3 TFA（261969-05-5 free base) CALP3 TFA	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	CALP3 TFA is a potent Ca2+ channel blocker that activates EF-hand motifs of Ca2+-binding proteins. It can functionally mimic increased [Ca2+]i by modulating the activity of Calmodulin, Ca2+ channels, and pumps.
TP1736	Fibrinogen-Binding Peptide
	Fibrinogen-Binding Peptide (designed by anticomplementarity hypothesis) is a presumptive peptide mimic of the vitronectin binding site on the fibrinogen receptor. Fibrinogen, a soluble plasma protein, is a cofactor in platelet activation. It is converted
T12370	Pasireotide SOM 230,SOM 320,帕瑞肽	Others	Others
	Pasireotide(SOM 230) is a stable cyclohexapeptide somatostatin mimic that exhibits unique high-affinity binding to human somatostatin receptors (subtypes sst1/2/3/4/5, pKi=8.2/9.0/9.1/<7.0/9.9 respectively).
T16450	PDK1-IN-RS2	PDK	PI3K/Akt/mTOR signaling
	PDK1-IN-RS2 inhibits the activation of the downstream kinases S6K1 by PDK1. PDK1-IN-RS2 is a mimic of the peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor (Kd: 9 μM).
T35980	Bilirubin Conjugate (sodium salt)
	Bilirubin conjugate is a stable, water-soluble ditaurate derivative of bilirubin meant to mimic endogenous bilirubin glucuronide derivatives. In vivo, bilirubin circulates in the plasma and is taken up by hepatocytes and conjugated to one or two glucuronic acids in a reaction catalyzed by UDP glucuronidase to form bilirubin mono or diglucuronide. This water-soluble form is then excreted from the liver in bile in the feces or is converted to urobilinogen and excreted in the urine. In addition to ...
T73544	MPM-1
	MPM-1 是海洋生物 Eusynstyelamides 模拟物，是一种有效的抗癌剂。MPM-1 可通过诱导坏死样死亡，在体外快速杀死癌细胞。MPM-1具有诱导免疫原性细胞死亡的能力。MPM-1在癌细胞中干扰细胞自噬 (autophagy) 和溶酶体膨胀。
T76378	RGD-4C
	RGD-4C（ACDCRGDCFC）是一种携带Arg-Gly-Asp（RGD）序列的肽，具备与αv整合素结合的能力，用于模拟细胞外基质蛋白的整合素识别特性。作为αv整合素的配体，它能够与生物活性分子进行偶联，进而在动物模型中展现出抗肿瘤活性。
T75789	CALP3 TFA
	CALP3 TFA 是一种模拟 Ca2+ 的有效肽类 Ca2+ 通道阻断剂，能够激活 EF 手的 Ca2+ 结合蛋白。它通过影响钙调蛋白 (CaM)、Ca2+ 通道及泵的功能来模拟 [Ca2+]i 的增加，从而具备在控制 HIV 或缺血性神经元损伤等情况下调控细胞凋亡的能力。
T7037	7-Acetoxy-4-methylcoumarin 7-乙酰氧基-4-甲基香豆素,MU-Ac	Others	Others
	7-Acetoxy-4-methylcoumarin 是羧酸酯酶的荧光底物，在切割时会产生蓝色荧光溶液。该化合物已用于非质子介质（一种细胞膜环境模拟物），以研究分散在水介质中的模型生物膜的超氧化物和相关的氧自由基反应。由于 AchE 能够裂解和激活 7-Acetoxy-4-methylcoumarin，因此荧光底物已被用于研究 AchE 抑制剂 Tacrine·HCl (sc-200172)。该化合物也已从 Trigonella foenum graceum 中分离出来。
T36498	CAY10762 CAY10762
	CAY10762 is an inhibitor of monoacylglycerol lipase (MAGL; IC50= 34.1 nM).1It reduces hydrogen peroxide-induced lactate dehydrogenase (LDH) release from Neuro2a cells when used at a concentration of 1 μM. CAY10762 (10 mg/kg) increases levels of 2-arachidonoyl glycerol in mouse brain. 1.Castelli, R., Scalvini, L., Vacondio, F., et al.Benzisothiazolinone derivatives as potent allosteric monoacylglycerol lipase inhibitors that functionally mimic sulfenylation of regulatory cysteinesJ. Med. Chem.63(...
T36800	EN219
	EN219 is a synthetic recruiter of the E3 ubiquitin ligase RNF114.1It binds to cysteine 8 (C8) in the intrinsically disordered region of RNF114 (RNF114-C8; IC50= 470 nM) and inhibits RNF114-induced autoubiquitination and p21 ubiquitination in a cell-free assay when used at a concentration of 50 μM. EN219 (1 μM) also interacts with cysteine residues in the tubulin β1 chain (TUBB1), heat shock protein 60 (Hsp60), also known as Hsp family D member 1 (HspD1), and histone H3.1 (HIST1H3A) in 231MFP hum...

化合物

Cat.No: T16939

Target: Others

Cat.No: TP1938

Target: TLR

Cat.No: T7417

Synonym: YM477,AKR-501,1-[3-氯-5-[[[4-(4-氯-2-噻吩基)-5-(4-环己基-1-哌嗪基)-2-噻唑基]氨基]羰基]-2-吡啶基]-4-哌啶羧酸,E5501

Target: Thrombin, Thrombopoietin Receptor

Cat.No: T6966

Synonym: RGD (Arg-Gly-Asp) Peptides,Arg-Gly-Asp,RGD Peptides

Target: Integrin

Cat.No: T13932

Synonym: N-[(1S)-2-甲基-1-(1-吡咯烷羰基)丙基]-苯丙酰胺

Target: Others, MyD88

Cat.No: T13587

Target: Others

Cat.No: T9597

Synonym: N-(苯甲酰基硫基)苯甲酰胺

Target: Endogenous Metabolite

Cat.No: T16044

Synonym: 烯虫酯,ZR-515

Target: Others

CALP3 acetate(261969-05-5 free base)

Cat.No: TP1911L

Target: Calcium Channel

Protease-Activated Receptor-1, PAR-1 Agonist acetate

Cat.No: T38836L

Target: Protease-activated Receptor

Pasireotide Acetate

Cat.No: TP2207

Target: Somatostatin

Cat.No: T9085

Synonym: [(1,1-DIOXIDOTETRAHYDROTHIEN-3-YL)AMINO]

Target: Antibacterial

Cat.No: T9120

Synonym: Benzeneacetonitrile, 4-cyano-α-[[4-[(2-hydroxyethyl)methylamino]phenyl]methylene]-,HBC 530

Target: Others

Fibrinogen-Binding Peptide 137235-80-4(fb-acetate)

Cat.No: TP1736L

Target: Others

Cat.No: T77457

Synonym: ACE 910,RO 5534262

Target: Others

N6-Cyclopentyladenosine

Cat.No: T16263

Synonym: UK-80882,CPA

Target: Adenosine Receptor

Cat.No: T41142

Target: IL Receptor, p38 MAPK, MyD88

Cat.No: T29371

Synonym: 2-PyG,2 PyG

Cat.No: T29702

Synonym: AG-85-12,AG85-12

Pasireotide ditrifluoroacetate

Cat.No: T13811

Synonym: SOM230 ditrifluoroacetate,Pasireotide ditrifluoroacetate (396091-73-9 free base),Pasireotide TFA salt

Target: Others

Cat.No: T25844

Synonym: N-4-Py,N 4 Py

3,5-Difluoro-L-tyrosine

Cat.No: T40846

Cat.No: T39295

Synonym: MRG-201

Cat.No: T30546

Synonym: AEOL-10113

Pasireotide L-aspartate salt

Cat.No: T12368

Synonym: 帕瑞肽天门冬氨酸盐,SOM230 L-aspartate

Target: Others

Pasireotide pamoate

Cat.No: T12369

Synonym: SOM230 pamoate

Target: Others

Cat.No: T34718

Cat.No: T29443

Synonym: 4 PVG,4-PVG

Cat.No: T11058

Synonym: Maytansinoid DM3

Target: Others

Diglycyl-histidine

Cat.No: T20382

Synonym: NSC334195,NSC-334195,Gly-gly-his,Glycylglycyl-L-histidine,NSC 334195

Cat.No: T6990

Synonym: Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-Nh2,SNAP 8,SNAP-8

Target: Others

CALP3 TFA（261969-05-5 free base)

Cat.No: TP2170

Synonym: CALP3 TFA

Target: Calcium Channel

Fibrinogen-Binding Peptide

Cat.No: TP1736

Cat.No: T12370

Synonym: SOM 230,SOM 320,帕瑞肽

Target: Others

Cat.No: T16450

Target: PDK

Bilirubin Conjugate (sodium salt)

Cat.No: T35980

Cat.No: T73544

Cat.No: T76378

Cat.No: T75789

7-Acetoxy-4-methylcoumarin

Cat.No: T7037

Synonym: 7-乙酰氧基-4-甲基香豆素,MU-Ac

Target: Others

Cat.No: T36498

Synonym: CAY10762

Cat.No: T36800

Cat. No.	Product Name	Target	Signaling Pathways
TN6848	Piperonylic acid 胡椒酸,2H-1,3-benzodioxole-5-carboxylic acid	P450	Metabolism
	Piperonylic acid (2H-1,3-benzodioxole-5-carboxylic acid) 是一种具有亚甲二氧基活性的天然分子，与反式肉桂酸结构相似，可作为选择性反式肉桂酸 4-羟化酶的灭活剂。
T32326	Juvabione
	Juvabione is the methyl ester of todomatuic acid, both of which are sesquiterpenes (C15) found in the wood of true firs of the genus Abies. They exist as part of a mixture of sesquiterpenes based on the bisabolane scaffold. Sesquiterpenes of this family,

天然产物

Piperonylic acid

Cat.No: TN6848

Synonym: 胡椒酸,2H-1,3-benzodioxole-5-carboxylic acid

Target: P450

Cat.No: T32326

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