89
28
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0234 |
Methicillin sodium salt
Methicillin sodium,Meticillin sodium,甲氧西林钠 |
Antibacterial; Antibiotic | Microbiology/Virology |
Methicillin sodium salt 是β-内酰胺抗生素,抑制参与肽聚糖合成的青霉素结合蛋白。 | |||
T6622 |
Oxacillin sodium monohydrate
苯唑西林钠一水合物,Stapenor monohydrate,苯唑青霉素钠,Sodium oxacillin monohydrate,Methicillin,Bactocill monohydrate |
Others; Antibacterial; Antibiotic | Microbiology/Virology; Others |
Oxacillin sodium monohydrate (Stapenor monohydrate) 是一种抗生素,可研究耐药性葡萄球菌感染,类似 Flucloxacillin。 | |||
T73859 | Methicillin sodium hydrate | ||
Methcillin sodium hydrate 是一种窄谱 β-内酰胺类抗生素,通过抑制青霉素结合蛋白 (penicillin-binding proteins,PBP) 发挥作用。Methcillin sodium hydrate 对青霉素耐药性的金黄色葡萄球菌Staphylococcus aureu 和表皮葡萄球菌Staphylococcus epidermidis 有活性。Methcillin sodium hydrate 可用于研究皮肤感染、骨髓炎和心内膜炎等疾病。 | |||
T33359 |
Meticillin
Staphcillin,Methicillin,Dimethoxyphenyl Penicillin,Metin |
||
Methicillin is a narrow-spectrum beta-lactam antibiotic of the penicillin-like family, used to treat infections caused by susceptible gram-positive bacteria, in particular penicillase-producing organisms such as Staphylococcus aureus. | |||
T1312 |
Nafcillin sodium monohydrate
CL 8491,萘夫西林钠,nafcillin sodium |
Antibacterial; Antibiotic | Microbiology/Virology |
Nafcillin sodium monohydrate (CL 8491) 是一种抗生素,是可逆的β-lactamase 抑制剂。它用于治疗由耐青霉素的葡萄球菌菌株引起的感染。 | |||
T40475 |
Ceftobiprole medocaril
BAL5788,头孢比普酯 |
Antibacterial | Microbiology/Virology |
Ceftobiprole medocaril (BAL5788) 是 Ceftobiprole 的前药。Ceftobiprole 是一种广谱的头孢菌素,对耐甲氧西林金黄色葡萄球菌具有活性。 | |||
TQ0077 |
Ceftobiprole
Ro 63-9141,BAL 9141,头孢吡普 |
Antibacterial | Microbiology/Virology |
Ceftobiprole (Ro 63-9141) 是一种广谱头孢菌素,对甲氧西林耐受的金黄色葡萄球菌的MIC90值为 2 μg/mL。 | |||
T4208 |
Targocil
|
Antibacterial | Microbiology/Virology |
Targocil 是一种磷壁酸生物合成的抑菌抑制剂,可抑制甲氧西林敏感金黄色葡萄球菌 (MSSA) 和耐甲氧西林金黄色葡萄球菌 (MRSA) 的生长,对于 MRSA 和 MSSA 的MIC90值都为 2 μg/mL。 | |||
T21358 |
Dalbavancin
BI 397,BI-397,VER 001,A-A 1,BI397,VER-001,Dalbavancin HCl,达巴万星 |
Antibacterial; Antibiotic | Microbiology/Virology |
Dalbavancin (BI-397) HCl 是一种半合成的脂糖肽抗生素,对革兰氏阳性细菌有杀菌活性。Dalbavancin 抑制金黄色葡萄球菌和炭疽芽孢杆菌的 MIC90分别为 0.06 μg/mL 和 0.25 μg/mL。 | |||
T15237 |
Eperezolid
PNU-100592 |
Antibacterial; Antibiotic | Microbiology/Virology |
Eperezolid (PNU-100592) 是一种在体外表现出良好抑制活性的恶唑烷酮类抗生素。 | |||
T64316 |
VP-4604
1-((4-Nitrophenyl)sulfonyl)piperidine |
||
VP-4604是一种有效的抗耐甲氧西林金黄色葡萄球菌(MRSA)化合物。VP-4604对金黄色葡萄球菌展现出显著的抑制微生物生长的作用,MIC 为4-8μg/mL。VP-4604抑制耐甲氧西林金黄色葡萄球菌的生长,其生长抑制率达到95%以上。 | |||
TN6672 |
Cyclo(L-Phe-L-Pro)
|
Free radical scavengers; COX; Antibacterial; Antifungal | Immunology/Inflammation; Microbiology/Virology; Neuroscience; oxidation-reduction |
Cyclo(L-Phe-L-Pro) 具有广谱抗菌和抗真菌活性。 Cyclo(L-Phe-L-Pro) 对耐甲氧西林金黄色葡萄球菌和棉子肠球菌具有活性。 | |||
T22269 |
Benzyldodecyldimethylammonium Chloride Dihydrate
|
Antibacterial | Microbiology/Virology |
Benzyldodecyldimethylammonium chloride dihydrate 可以用作杀虫试剂,可以靶向耐药性细菌,如耐甲氧西林金黄色葡萄球菌、耐多药铜绿假单胞菌等,且具有浓度依赖性。 | |||
T0391 |
Linezolid
PNU-100766,雷奈佐利 |
MAO; Antibacterial; Antibiotic | Metabolism; Microbiology/Virology; Neuroscience |
Linezolid (PNU-100766) 是恶唑烷酮类合成抗生素,抑制细菌蛋白质合成的起始阶段,具有抗感染作用。 | |||
T10579 |
BO3482
|
Others | Others |
BO3482 is an antimicrobial compound and can inhibit the growth of methicillin-resistant Staphylococci (MIC90: 6.25 mg/mL). | |||
T30509 |
BMS-247243
BMS247243,UNII-KG8365V22L |
||
BMS-247243 is a novel cephalosporin inhibitor that is mainly active against Gram-positive bacteria and also against methicillin-resistant Staphylococcus. | |||
T69995 |
Chlorhexidine-d8 HCl
|
||
Chlorhexidine-d8 is intended for use as an internal standard for the quantification of chlorhexidine by GC- or LC-MS. Chlorhexidine is a bis(biguanide) antimicrobial disinfectant and antiseptic agent. It inhibits growth of clinical methicillin-resistant S. aureus (MRSA) isolates (MIC90 = 4 μg/ml). It is also active against canine isolates of MRSA, methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. pseudintermedius (MRSP), and methicillin-susceptible S. pseudintermedius (MSSP; MIC... | |||
T26256 |
Teicoplanin aglycone
TD-A3 |
||
Teicoplanin aglycone is an antibacterial glycopeptide antibiotic used in the prophylaxis and treatment of serious infections caused by Gram-positive bacteria, including Enterococcus faecalis and methicillin-resistant Staphylococcus aureus. | |||
T26162 |
Rubradirin
|
||
Rubradirin is an antibiotic with a complex chemical structure that is active vs. methicillin resistant staphylococci. It is a selective enzymatic peptide initiation inhibitor. | |||
T37729 |
IMP-1700
|
||
IMP-1700 is an inhibitor of bacterial DNA repair.1It potentiates the activity of the quinolone antibiotic ciprofloxacin against methicillin-resistantS. aureus(MRSA) with a combination index value of 0.7. IMP-1700 inhibits the ciprofloxacin-induced bacterial SOS response, a process that repairs DNA damage, in a reporter assay in a concentration-dependent manner. It is also active againstE. coli, as well as methicillin-resistant and -sensitive S. aureus, when used alone (EC50s = 0.5, 0.21, and 3.8... | |||
T60525 |
VP-4556
|
||
VP-4556 是一种有效的抗耐甲氧西林金黄色葡萄球菌 (MRSA) 剂,对金黄色葡萄球菌 (ATCC 43300) 具有显著的生长抑制作用,MIC 为 8 μg/mL。VP-4556 对于耐甲氧西林金黄色葡萄球菌(MRSA)的生长抑制率达 95% 以上。 | |||
T37465 |
CAY10742
|
||
CAY10742 is an orally bioavailable oxadiazole antibiotic.1It is active against the Gram-positive bacteriaS. aureus,S. epidermidis,S. haemolyticus,B. cereus,B. licheniformis,E. faecalis, andE. faecium(MICs = 1-4 μg/ml), including laboratory strains and clinical isolates with varying degrees of resistance to methicillin, vancomycin, linezolid, and other antibiotics. CAY10742 (40 mg/kg) reduces the number of bacteria in mouse neutropenic thigh models of linezolid-sensitive or -resistant methicillin... | |||
T61274 |
PC190723
|
||
PC190723 (Compound 2) 是一种细菌细胞分裂蛋白 FtsZ 抑制剂,IC50值为 55 ng/ml。FtsZ-IN-3 具有抗葡萄球菌活性,对 MSSA 和 MRSA 的MIC 值均为 1 μg/ml。 | |||
T37546 |
TPU-0037C
|
||
TPU-0037C is a metabolite of the marine actinomycete S. platensis that is structurally similar to lydicamycin . It is active against Gram-positive bacteria (MICs = 0.39-3.13 μg/ml), including methicillin-resistant S. aureus strains (MIC = 3.13 μg/ml), but is ineffective against Gram-negative bacteria (MICs = >50 μg/ml). | |||
T36032 | Desotamide | ||
Desotamide is a cyclic hexapeptide antibiotic originally isolated from Streptomyces. It is active against S. aureus, S. pneumoniae, and methicillin-resistant S. epidermidis (MRSE; MICs = 16, 12.5, and 32 μg/ml, respectively). | |||
T1747L |
Tedizolid phosphate disodium salt
Torezolid phosphate sodium salt,DA 7218,TR-701,TR 701 |
||
Tedizolid phosphate is a novel antibacterial prodrug. Tedizolid phosphate is a next-generation oxazolidinone with activity against both methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus spp. It also has effective activity a | |||
T61624 |
Antibacterial agent 106
|
||
Antibacterial agent 106 (compound 8) is a highly effective orally active antibacterial compound with antibiofilm activity. It demonstrates potent antibacterial effects against multi-drug resistant (MDR)-Gram-positive pathogens, including the eradication of 99.7% of intracellular methicillin-resistant S. aureus (MRSA) harbored within macrophages [1]. | |||
T36706 |
Bottromycin A2
|
||
Bottromycin A2is an antibiotic originally isolated fromStreptomyces.1It blocks the binding of aminoacyl-tRNA to the A site of the 50S ribosome, inhibiting protein synthesis.2Bottromycin A2is active against clinical isolates of methicillin-resistantStaphylococcus aureus(MRSA) and vancomycin-resistantEnterococciwith MIC values of 1 and 0.5 μg/ml, respectively. 1.Nakamura, S., Yajima, T., Lin, Y., et al.Isolation and characterization of bottromycins A2, B2, C2J. Antibiot. (Tokyo)20(1)1-5(1967) 2.Go... | |||
T74715 | Antibacterial agent 136 | ||
Antibacterial agent 136 (compound 3) 是恶二唑酮类抗生素。Antibacterial agent 136 对 Staphylococcus aureus(MRSA) 具有很高的抗菌效力,MIC50值为 0.8 μM。 | |||
T39816 |
Ceftaroline fosamil inner salt
TAK-599 free acid,PPI0903freeacid |
||
Ceftaroline fosamil (TAK-599) inner salt, a cephalosporin derivative, is an N-phosphono prodrug of anti-methicillin-resistant Staphylococcus aureus (MRSA) T-91825. Ceftaroline fosamil inner salt can be used for the research of MRSA infection. | |||
T74803 | Levonadifloxacin | ||
Levonadifloxacin ((S)-(-)-Nadifloxacin; WCK 771),作为一种宽谱抗葡萄球菌药物,对甲氧西林敏感金黄色葡萄球菌(MSSA)及对甲氧西林耐药金黄色葡萄球菌(MRSA)显示出显著的抗菌活性,并能有效减少THP-1单核细胞对MRSA和MSSA菌株的吞噬。 | |||
T39319 |
Actinomycin X2
放线菌素X2;放线菌素V,Actinomycin V |
||
Actinomycin X2 (Actinomycin V) is a compound synthesized by various species of Streptomyces. It displays potent inhibition against methicillin-resistant Staphylococcus aureus (MRSA), with a minimum inhibitory concentration (MIC) of 0.25 μg/mL. Actinomycin X2 possesses potential applications in the treatment of both cancer and bacterial infections. | |||
T64315 |
VP-4509
|
||
VP-4509 是一种抗耐甲氧西林金黄色葡萄球菌 (MRSA) 剂 (MIC: 49.3 μM)。VP-4509 对革兰氏阴性细菌铜绿假单胞菌 (ATCC9027) 表现出高抗菌效果。 | |||
T83097 | Antibacterial agent 165 | ||
Antibacterialagent 165 (compound 3) 是一种有效针对细菌 (bacterial) 的羟基喹啉衍生物抑制剂,具备抗耐甲氧西林金黄色葡萄球菌 (MRSA) 的能力。 | |||
T60546 | Anti-MRSA agent 6 | ||
Anti-MRSA agent 6 (compound 3q6) 是一种有效的抗耐甲氧西林金黄色酿脓葡萄球菌(anti-MRSA)剂,对 MCF-7、A549 细胞具有低细胞毒性。 | |||
T83098 | Antibacterial agent 163 | ||
Antibacterialagent 163 (compound 1) 是一种羟基喹啉衍生物,能有效抑制细菌 (bacterial)。该化合物特别针对耐甲氧西林金黄色葡萄球菌 (MRSA) 表现出抑制作用。 | |||
T27964 |
Voxvoganan
LTX109,Lytixar,LTX-109,LTX 109 |
||
Lytixar is a Synthetic Antimicrobial Peptide, it shows activity against Daptomycin-Nonsusceptible, Methicillin-Resistant, Vancomycin-Intermediate, Vancomycin-Resistant, and Linezolid-Nonsusceptible Staphylococcus aureus. LTX-109 demonstrated a MIC range o | |||
T38102 |
Decatromicin B
|
||
Decatromicin B is a bacterial metabolite that has been found in Actinomadura. It is active against Gram-positive bacteria, including several strains of S. aureus (MICs = 0.39-0.78 μg/ml), two strains of methicillin-resistant S. aureus (MRSA; MICs = 0.39 and 0.78 μg/ml), as well as M. luteus, B. subtilis, and C. bovis (MICs = 0.78, 0.78, and 6.25 μg/ml, respectively). | |||
T37731 |
TPU-0037A
|
||
TPU-0037A is an antibiotic and a congener of lydicamycin . It inhibits the growth of Gram-positive bacteria, including methicillin-resistant S. aureus (MRSA), B. subtilis, and M. luteus (MICs = 1.56-12.5 μg/ml), but not Gram-negative E. coli, P. mirabilis, P. vulgaris, or P. aeruginosa strains (MICs = >50 μg/ml). | |||
T60302 |
4,4'-Dicyanostilbene
|
||
4,4'-Dicyanostilbene (化合物 43) 是一种有效的抗疟药,可抗 Dd2 菌株,EC50值为 27 nM。4,4'-Dicyanostilbene 对耐甲氧西林金黄色葡萄球菌具有体内功效。 | |||
T38009 |
Kocurin
|
||
Kocurin is a thiazolyl peptide originally isolated fromK. palustrisand has antibiotic activity.1It is active against methicillin-resistantS. aureus(MRSA; MIC = 0.25 μg/ml), as well asB. subtilisandE. faeciumin a solid agar test when used at a concentration of 8 μg/ml. Kocurin is also active againstE. faecium,E. faecalis,S. epidermidis, and clinical isolates of vancomycin-resistant enterococci (MICs = 0.004-1.025 μg/ml).2In vivo, kocurin (2.5, 5, and 10 mg/ml) increases survival in a mouse model ... | |||
T28314 |
PD 117588
PD117588,PD-117588 |
||
PD 117588 is a quinolone against bacterial isolates from cancer patients. PD 117558 has a broad antimicrobial spectrum with excellent activity against all Gram-positive isolates (including methicillin-resistant Staphylococcus aureus, coagulase-negative st | |||
T79778 |
Anti-MRSA agent 8
|
||
Anti-MRSA agent 8(Compound 7g)为DAPG衍生物,展现出显著的抗菌活性,主要通过作用于细菌细胞膜以发挥效能。此化合物可应用于耐甲氧西林Staphylococcus aureus(MRSA)的研究领域。 | |||
T80414 |
ASP-1
|
||
ASP-1是一种活性强的抗葡萄球菌肽,其对金黄色葡萄球菌及耐甲氧西林金黄色葡萄球菌(MRSA)的最低抑制浓度(mic)范围为2μg/mL至64μg/mL。 | |||
T35737 |
Emeguisin A
|
||
Emeguisin A is a depsidone fungal metabolite originally isolated fromE. unguis.1It is active against the bacteriaS. aureusand methicillin-resistantS. aureus(MRSA; MIC = 0.5 μg/ml for both), the fungusC. neoformans(MIC = 0.5 μg/ml), and the protozoanP. falciparum(IC50= 2.2 μM).2 1.Kawahara, N., Nozawa, K., Nakajima, S., et al.Isolation and structures of novel fungal depsidones, emeguisins A, B, and C, from Emericella unguisJ. Chem. Soc., Perkin Trans. 12611-2614(1988) 2.Klaiklay, S., Rukachaisiri... | |||
T74529 | Antibacterial agent 86 | ||
Antibacterial agent 86 (Compound A11) 活性较强,对耐甲氧西林金黄色葡萄球菌具有抑菌活性,MIC 值低至 0.00191 μg/mL,比市售抗生素泰妙菌素和瑞他莫林分别低 162 倍和 32 倍。 | |||
T74527 | Anti-MRSA agent 4 | ||
Anti-MRSA agent 4 (compound 7a) 为针对耐甲氧西林金黄色葡萄球菌 (MRSA) 的革兰氏阳性菌强效选择性生长抑制剂,具有MIC≤ 0.26 µM的显著效力。此外,该化合物在HEK293细胞中未显示细胞毒性和溶血活性。 | |||
T80275 |
Lynronne-2
|
||
Lynronne-2是抗菌肽,对革兰氏阳性细菌,包含MDR菌株具有活性(耐甲氧西林MRSA菌株MIC: 32-256 μg/mL)。该化合物亦对P. aeruginosa感染展现效用。 | |||
T70798 |
Benastatin B
|
||
Benastatin B is a polyketide synthase-derived benastatin that has been found in Streptomyces and has diverse biological activities. It inhibits glutathione S-transferase (GST; Ki = 3.7 µM for the rat liver enzyme).2 Benastatin B also inhibits the transglycosylase activity of A. baumannii, C. difficile, E. coli, and S. aureus recombinant penicillin-binding proteins (PBPs; IC50s = 16, 53.3, 30.7, and 31.6 µM, respectively).3 It is active against several bacteria, including methicillin-resistant S.... | |||
T36541 |
Nornidulin
|
||
Nornidulin is a depsidone originally isolated from A. nidulans that has antibacterial activity against M. tuberculosis and M. ranoe as well as antifungal activity against T. tonsurans and M. audouini. It also inhibits the growth of methicillin-resistant S. aureus (MRSA; MIC = 2 μg/ml) and has larvicidal activity toward Artemia (LC50 = 1.7 μg/ml). Nornidulin has cytotoxic activity in MOLT-3 cells (IC50 = 35.7 μM) but not HuCCA-1, HepG2, or A549 cells (IC50s = >116.4 μM). |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1524 |
Continentalic acid
|
NOS; COX; Antibacterial; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience |
Continentalic acid 是来自 Aralia continentalis 的,对金黄色葡萄球菌的 MIC 约为 8-16 µg/mL,包括对甲氧西林敏感的金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌标准菌株。 | |||
TN4943 |
Sanguisorbigenin
地榆皂苷元,Tomentosolic acid,3β-Hydroxyurs-12,19-dien-28-oic acid,19-Dehydroursolic acid,Ursa-12,19-dien-28-oic acid |
Antibacterial | Microbiology/Virology |
Sanguisorbigenin (Tomentosolic acid) 抑制耐甲氧西林金黄色葡萄球菌,是一种天然抗菌剂。 | |||
TN1527 |
(-)-Corynoxidine
Corynoxidine |
Antibacterial; AChE; Antifection | Microbiology/Virology; Neuroscience |
(-)-Corynoxidine 是一种源自 Stephania succifera 块茎的 AChE 抑制剂。 Corynoxidine 对金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌具有不同程度的抗菌活性。 | |||
TN1204 |
2,3-Dehydrokievitone
2,3-脱氢维酮 |
Antifungal | Microbiology/Virology |
2,3-Dehydrokievitone 是一种从刺桐属植物 Erythrina sacleuxii 中提取的一种异黄酮,具有抗菌活性,可通过降低α-溶血素表达来对抗耐甲氧西林金黄色葡萄球菌感染。 | |||
TN2281 |
Sinapaldehyde
trans-3,5-Dimethoxy-4-hydroxy cinnamaldehyde,TRANS-3,5-二甲氧基-4-羟基肉桂醛,芥子醛 |
Antibacterial | Microbiology/Virology |
Sinapaldehyde (trans-3,5-Dimethoxy-4-hydroxy cinnamaldehyde) 对耐甲氧西林的金黄色葡萄球菌和大肠杆菌有抗菌作用,MIC 值都为 128 μg/mL。 | |||
T8724 |
6-Methoxydihydrosanguinarine
|
Others | Others |
6-Methoxydihydrosanguinarine 是一种从M. cordata 果实中分离出的生物碱,它对 MCF-7 细胞系(IC50:0.61 μM)和 SF-268 细胞系(IC50:0.54 μM)具有强的细胞毒性。 | |||
TN6010 |
Picrasidine S
|
||
Picrasidine S shows the potent cytotoxicity against human HeLa cervical, gastric MKN-28, and mouse melanoma B-16 cancer cells, it also shows the potent antibacterial activity against two strains of pathogenic bacteria methicillin-resistant Staphylococcus | |||
T73207 |
Laburnetin
|
||
Laburnetin 是一种异黄酮类抗菌剂 (antibacterial agent)。Laburnetin 对真菌、S. vesicarium 具有抗菌活性。Laburnetin 增强了耐甲氧西林 (Methicillin) 金黄色葡萄球菌 (MRSA) 菌株对甲氧西林的敏感性。Laburnetin 可用于控制栽培物种的虫害。 | |||
T2S0058 |
6-Ethoxychelerythrine
乙氧基白屈菜红碱,Ethoxychelerythrin |
Antibacterial | Microbiology/Virology |
6-Ethoxychelerythrine (Ethoxychelerythrin) 具有抗菌活性,对烟曲霉和耐甲氧西林金黄色葡萄球菌 (MRSA) 表现出很强的活性。 | |||
TN1444 |
Bis(dihydrochelerythrinyl)amine
bis[6-(5,6-dihydrochelerythrinyl)]amine |
Antifection | Microbiology/Virology |
BIS-[6-(5,6-dihydro-chelerythrinyl)] ether shows strong activity against Aspergillus fumigatus and methicillin-resistant Staphylococcus aureus (MRSA). | |||
TN2278 |
Torachrysone
决明柯酮 |
Antifection | Microbiology/Virology |
Torachrysone shows promising antioxidant activity. Torachrysone, toralactone , aloe-emodin, rhein and emodin show noticeable antibacterial effects on four strains of methicillin-resistant Staphylococcus aureus with a minimum inhibitory concentration of 2- | |||
TN4670 |
Norlichexanthone
|
Antibacterial; Parasite | Microbiology/Virology |
Norlichexanthone 具有治疗和/或预防生活方式相关疾病的潜力,例如 2 型糖尿病、代谢综合征、动脉粥样硬化和心血管疾病。 它具有抗菌和抗疟活性,对枯草芽孢杆菌有很强的活性,IC50范围为1-5uM,对耐甲氧西林金黄色葡萄球菌的生长也有很强的抑制作用,IC50为20.95±1.56uM。 | |||
TN3216 |
(3R)-7,4’-Dihydrohomoisoflavanone
7,4'-Dihydroxyhomoisoflavanone |
Antibacterial | Microbiology/Virology |
(3R)-7,4’-Dihydrohomoisoflavanone 是一种天然化合物,对金黄色葡萄球菌和耐甲氧西林金黄色葡萄菌(MRSA)都具有强大的抗菌性能。 | |||
T74206 |
Kalimantacin A
|
||
Kalimantacin A是具有针对葡萄球菌(包括耐甲氧西林金黄色葡萄球菌)抗菌活性的有效抗生素。 | |||
T38349 |
Talaromycesone A
|
||
Talaromycesone A is a fungal metabolite originally isolated fromTalaromyces.1It is active againstS. epidermidisand methicillin-resistantS. aureus(MRSA) bacteria (IC50s = 3.70 and 5.48 μM, respectively). Talaromycesone A inhibits acetylcholinesterase (AChE) in a cell-free assay (IC50= 7.49 μM for the human enzyme). 1.Wu, B., Ohlendorf, B., Oesker, V., et al.Acetylcholinesterase inhibitors from a marine fungus Talaromyces sp. strain LF458Mar. Biotechnol. (NY)17(1)110-119(2015) | |||
TN3907 |
Pinosylvin monomethyl ether
(E)-3-Hydroxy-5-methoxystilbene |
Antifection | Microbiology/Virology |
(E)-3-Hydroxy-5-methoxystilbene possesses inhibitory activity against several Gram-positive bacteria, including isolates of methicillin-resistant Staphylococcus aureus (MRSA), Mycobacterium bovis BCG, and avirulent Bacillusanthracis (Sterne strain), among | |||
TN1165 |
(Rac)-Myrislignan
1-(3,4-dimethoxyphenyl)-2-(4-allly-2,6-dimethoxyphenoxy)propan-1-ol,rac-myrislignan,ALPHA-[1-[2,6-二甲氧基-4-(2-丙烯-1-基)苯氧基]乙基]-4-羟 |
Others | Others |
1-(3,4-Dimethoxyphenyl)-2-(4-allly-2,6-dimethoxyphenoxy)propan-1-ol shows anti-staphylococcal activity against a total of five multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus strains and the minimum inhibitory concentrations (MIC | |||
TN4308 |
Isolupalbigenin
|
Antifection | Microbiology/Virology |
Isolupalbigenin shows promising cytotoxic effects toward HL-60 cells (IC50 4.3 ± 0.7 to 18.0 ± 1.7 uM), it also shows in vitro inhibitory activity toward human glyoxalase I. Isolupalbigenin shows two different antibacterial activities against MRSA: direct growth inhibition and intensification of methicillin sensitivity, it could lead to the development of compounds for new approaches against MRSA infection. | |||
TN1526 |
Corydalmine
|
P450; Antifection | Metabolism; Microbiology/Virology |
Corydalmine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains.1-Corydalmine significantly inhibits spore germination of all the fungi at 100 to 1500 ppm. l-Corydalmine also exhibits potent analgesic activity in preclinical models, it is under development as an oral analgesic agent. | |||
TN3573 |
Camaric acid
|
Antifection | Microbiology/Virology |
Camaric acid shows antibacterial activity against Staphylococcus aureus and methicillin resistant S. aureus with IC50 values 8.74 and 8.09 uM, respectively, it also shows moderate antileishmanial activity and highly potent antitrypanosomal activity. Camar | |||
T79943 |
6-C-Methylquercetin-3,4'-dimethyl ether
|
Antibiotic | Microbiology/Virology |
6-C-Methylquercetin-3,4'-dimethyl etheris 是一种黄酮醇衍生物,提取自Bauhinia thonningii Schum叶。本化合物对多重耐药的革兰氏阴性细菌及耐甲氧西林金黄色葡萄球菌(MRSA)表现出抗菌活性。 | |||
T38394 | PSMα3 | ||
PSMα3 is a peptide compound that can be utilized to induce tolerance in dendritic cells (DCs) for DC vaccination strategies. It effectively penetrates and modulates human monocyte-derived DCs by modifying the maturation process induced by TLR2 or TLR4. Additionally, PSMα3 inhibits the production of both pro- and anti-inflammatory cytokines and decreases antigen uptake. Notably, PSMα3 is a significant virulence factor released by the most pathogenic strains of methicillin-resistant Staphylococcus... | |||
T75523 | Wychimicin A | ||
Wychimicin A 是一种螺旋藻酸聚酮,可从罕见的放线菌 Actinocrispum wychmicini 菌株 MI503-AF4 中分离得到。Wychimicin A 具有强抗菌活性,显著抑制耐甲氧西林的金黄色葡萄球菌Staphylococcus. aureus(IC50=0.125-0.5 μg/mL) 和 肠球菌Enterococcus. Faecalis/faecium(IC50=0.25 μg/mL)。 | |||
T75522 | Wychimicin C | ||
Wychimicin C为源自罕见放线菌Actinocrispum wychmicini菌株MI503-AF4的螺旋藻酸聚酮类化合物。此化合物展现出卓越的抗菌效果,尤其对耐甲氧西林的Staphylococcus. aureus(IC50=0.125-0.5 μg/mL)和Enterococcus. Faecalis/faecium(IC50=0.125-0.25 μg/mL)展现显著的抑制活性。 | |||
T75560 | 4(1H)-Quinolinone, 1-methyl-2-(5Z)-5-undecen-1-yl- | ||
4(1H)-Quinolinone, 1-methyl-2-(5Z)-5-undecen-1-yl- (化合物2) 是一种从蛇床子提取的喹诺酮类生物碱。该化合物对耐甲氧西林金黄色葡萄球菌(MRSA)表现出活性,其最小抑制浓度(MIC)值对ATCC 33591和ATCC 25923株分别为32 μg/mL和16 μM/mL。 | |||
T75278 | Pristinamycin | ||
Pristinamycin, 一种 Streptomyces pristinaespiralis 产生的口服活性链霉素样抗生素,由化学上不相关的两部分组成:Pristinamycin I (PI) 与 Pristinamycin II (PII)。该药物对包括耐甲氧西林金黄色葡萄球菌 (MRSA)、万古霉素耐药金黄色葡萄球菌 (VRSA) 和粪肠球菌 (VREF) 在内的多种抗生素耐药革兰氏阳性菌表现出强大活性。 | |||
T75555 | (6E,12E)-Tetradecadiene-8,10-diyne-1,3-diol | ||
'(6E,12E)-Tetradecadiene-8,10-diyne-1,3-diol' 是从白术根中分离出的一种具有抗菌活性的化合物,对 MRSA 显示出 4 - 32 μg/mL 的最小抑菌浓度(MIC),表现出对抗性细菌感染研究的潜力。 | |||
T36000 |
3-Hydroxyterphenyllin
|
||
3-Hydroxyterphenyllin is a p-terphenyl fungal metabolite originally isolated from A. candidus that has diverse biological activities, including antioxidant, antiproliferative, antibacterial, and antiviral properties.1,2,3,4 It has a 96% scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radicals when used at a concentration of 100 μg/ml.2 3-Hydroxyterphenyllin inhibits the growth of HeLa cervical, A549 lung, and HepG2 liver cancer cells (IC50s = 23, 36, and 32 μM, respectively), as well as methi... |