22
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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1406 |
Amantadine hydrochloride
盐酸金刚烷胺,1-adamantanamine HCl,1-Adamantanamine hydrochloride,Symmetrel,CI-719,Amantadine HCl,1-Adamantylamine hydrochloride |
Dopamine Receptor; Influenza Virus | GPCR/G Protein; Microbiology/Virology; Neuroscience |
Amantadine hydrochloride (CI-719) 是一种抗病毒药物,用于预防或对症治疗甲型流感和帕金森病。它阻断质子流通过 M2 离子通道,从而阻止病毒 RNA 释放到感染细胞的细胞质中。 | |||
T34435 |
RU 47213
RU-47213,Itameline,RU47213 |
Others | Others |
RU 47213 可用于抑制东莨菪碱诱导的大鼠工作记忆障碍。 | |||
T77678 |
TZ3O
|
AChR | Neuroscience |
TZ3O是一种具有神经保护活性的抗胆碱能化合物。TZ3O 在Scopolamine诱导的阿尔茨海默型模型中改善大鼠记忆障碍与认知衰减,可用于研究阿兹海默症。 | |||
TP1570 |
Cortistatin-14
|
Somatostatin | GPCR/G Protein |
Cortistatin-14 是一种与生长抑素-14结构相似的神经肽,具有抗惊厥和神经保护作用,通过激活 sst(2)、生长素释放肽和 GABA(A/B) 受体损害小鼠的识别记忆巩固,可用于研究脓毒症引发的认知障碍。 | |||
T21792 |
CGP 3466B maleate
马来酸CGP3466B,Omigapil (Maleate),Omigapil maleate |
Apoptosis | Apoptosis |
CGP 3466B maleate (Omigapil maleate) 是一种口服有效的 GAPDH 亚硝基化抑制剂,可消除 Aβ1-42 诱导的小鼠 tau 乙酰化,记忆障碍和运动功能障碍,Omigapil maleate 具有研究阿尔茨海默症的潜力。Omigapil maleate (CGP3446B maleate) 是一种有效的凋亡 (apoptosis) 抑制剂。Omigapil maleate 可用于研究先天性肌营养不良 (CMD)。 | |||
T62899 |
Tau-aggregation and neuroinflammation-IN-1
|
Microtubule Associated; NO Synthase | Cytoskeletal Signaling; Immunology/Inflammation |
Tau-aggregation and neuroinflammation-IN-1 是一种有效的 Tau 蛋白聚集体抑制剂, 对 AcPHF6 和全长 tau 蛋白聚集体显示出显著的抑制活性。Tau-aggregation and neuroinflammation-IN-1具有抗炎活性且可减少 NO 释放。Tau-aggregation and neuroinflammation-IN-1 对 LSP 刺激的 BV2 细胞具有低细胞毒性。Tau-aggregation and neuroinflammation-IN-1 可逆转冈田酸诱导的大鼠记忆障碍。 | |||
T38192 |
Unifiram
|
Others | Others |
Unifiram 是一种认知增强剂。 Unifiram 诱导大鼠海马 CA1 区场兴奋性突触后电位 (fEPSP) 幅度的持久增加 (EC50= 27 nM) 并增加大鼠大脑皮层中乙酰胆碱 (ACh) 的释放。 | |||
T69314 | T-82 | ||
T-82 is an acetylcholinesterase inhibitor that may ameliorate the impairment of memory induced by acetylcholinergic dysfunction. | |||
T39384 |
Exendin (5-39)
|
||
Exendin (5-39) is a powerful antagonist of the glucagon-like peptide 1 (GLP-1) receptor with the ability to ameliorate memory impairment in rats treated with β-amyloid protein. | |||
T33424 |
MK-0952
MK 0952 |
||
MK-0952 is a selective PDE4 inhibitor used to treat long-term memory loss and mild cognitive impairment. It is an intrinsically potent inhibitor and has shown limited whole blood activity. | |||
T61684 |
S 17092
|
||
S 17092 (S 17092-1) is a highly effective inhibitor of cerebral prolyl-endopeptidase (PEP), displaying an IC50 value of 1.2 nM. It is utilized in research focused on understanding memory impairment and cognitive disorders associated with cerebral aging [1]. | |||
T21470 |
Davunetide
AL-208,AL 208,AL 108,AL-108 |
||
Davunetide is an eight amino acid peptide (NAPVSIPQ) with potent neuroprotection in vitro and in vivo. Davunetide has been shown to enhance functional daily behaviors in schizophrenia patients and to increase memory scores in patients suffering from amnes | |||
T80071 |
PKCζ/ι pseudosubstrate inhibitor
|
||
PKCζ/ι偽基質抑制劑對PKC酶家族表現廣譜抑制作用,並可能促成記憶功能障礙。 | |||
T64672 |
Colivelin TFA
|
||
Colivelin (sequence SALLRSIPAPAGASRLLLLTGEIDLP) is composed of activity-dependent neurotrophic factor (ADNF) C-terminally fused to AGA-(C8R)HNG17, a potent HN derivative. It works as a neuroprotective peptide and activator of STAT3. Colivelin-induced neuroprotection has been confirmed to occur via two neuroprotective pathways: one mediated by Ca2+/calmodulin-dependent protein kinase IV, triggered by ADNF, and one mediated by signal transducer and activator of transcription 3, triggered by HN. Co... | |||
T28653 |
S-8510 free base
SB 737552,SB-737552,S8510,SB737552,S-8510,S 8510 |
||
S-8510 is a GABA-A receptor inverse agonist. S-8510 selectively potentiated pentylenetetrazol-induced convulsion without affecting minimal electroconvulsive shock- or strychnine-induced convulsion in ddY mice. S-8510 ameliorated memory impairment induced | |||
T74195 | 4′-Demethylnobiletin | ||
4′-Demethylnobiletin 是一种生物活性代谢物,可以激活PKA/ERK/CREB 信号通路,增强海马神经元中 CRE 介导的转录,并通过刺激ERK 信号逆转与 NMDA 受体拮抗相关的记忆障碍。 | |||
T72874 |
sEH/AChE-IN-2
|
||
sEH/AChE-IN-2 是可溶性环氧化物水解酶 (sEH) 和乙酰胆碱酯酶 (AChE) 的双重抑制剂。sEH/AChE-IN-2 提供对抗神经炎症和记忆障碍的累积效应。sEH/AChE-IN-2具有研究阿尔茨海默病 (AD) 的潜力。 | |||
T81335 | PZ-1922 | 5-HT Receptor | GPCR/G Protein; Neuroscience |
PZ-1922(Compound 16),是能穿透大脑屏障的5-HT6R/5-HT3R拮抗剂,其Ki值分别为17 nM和0.45 nM。该化合物还能可逆地抑制MAO-B(pIC50:8.93)。在大鼠的新物体识别(NOR)测试中,PZ-1922逆转了Scopolamine (SCOP)诱导的记忆缺陷;同样,在T迷宫测试中,它防止了Aβ诱发的记忆衰退。 | |||
T64181 |
sEH/AChE-IN-1
|
||
sEH/AChE-IN-1 (Compound 12a) 是一种可溶性环氧化物水解酶 (sEH) 和乙酰胆碱酯酶 (AChE) 的双重抑制剂。sEH/AChE-IN-1 具有对抗神经炎症和记忆障碍的累积效应。sEH/AChE-IN-1 对阿尔茨海默病 (AD) 表现出研究潜力。 | |||
T76022 |
Chemerin-9 (149-157) (TFA)
|
||
Chemerin-9 (149-157) TFA 作为趋化因子样受体1 (CMKLR1) 的有效激动剂,展现出抗炎活性,并能促进Akt与ERK磷酸化及活性氧生成,进而改善Aβ1-42诱发的记忆障碍。此外,该化合物还参与调节免疫反应、脂肪细胞分化以及糖代谢。 | |||
T61930 | Yhhu-3792 | ||
Yhhu-3792 激活 Notch 信号通路并促进 Hes3 和 Hes5 的表达。Yhhu-3792 增强神经干细胞 (NSC) 的自我更新能力,扩大了 NSC 池并促进了小鼠海马齿状回部分 (DG) 的内源性神经形成。Yhhu-3792 可提高小鼠的情景和空间记忆能力。 Yhhu-3792 在记忆障碍相关 DG 功能障碍中具有研究潜力。 | |||
T79666 |
WLB-89462
|
Sigma receptor | GPCR/G Protein |
WLB-89462(Compound 20c)是一种高选择性σ2受体配体(Ki:13 nM),展示出神经保护活性,并能有效改善由Aβ肽引发的大鼠短期记忆障碍。该化合物拥有出色的ADMET特性,包含良好的溶解度、无CYP抑制作用、优异的代谢稳定性、高渗透性、脑部可渗透性以及在啮齿类动物中经口服途径高暴露量。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7060 |
Amantadine
1-Aminoadamantane,1-金刚烷胺,金刚烷胺,1-Adamantanamine,1-Adamantylamine |
Others | Others |
Amantadine (1-Aminoadamantane) 是抗病毒药物,也是是 NMDA 型谷氨酸受体的弱拮抗剂,能促进高多巴胺的释放,并阻断多巴胺的再摄取。 | |||
TN2230 |
Soyasaponin Ba
大豆皂苷 BA,大豆皂苷Ba |
Others | Others |
Soyasaponin Ba 是一种大豆皂苷,分离自菜豆类,可用作醛糖还原酶抑制剂。 | |||
T4956 |
Tetrahydroxystilbene-2-O-β-D-glucoside
tetrahydroxyl diphenylethylene-2-o-gluco,何首乌苷,EH-201 |
Others | Others |
Tetrahydroxystilbene-2-O-β-D-glucoside (EH-201) 是一种低分子量的促红细胞生成素诱导剂。 | |||
T5702 |
Tenuifoliside B
|
Dehydrogenase | Metabolism |
Tenuifoliside B 是一种分离自Polygalae Radix 中的成分,能够抑制氰化钾引起的缺氧和东莨菪碱引起的记忆障碍。它有成为 AD 先导化合物的潜力。它具有潜在的认知改善和脑保护作用。 | |||
T6S2227 |
Spinosin
斯皮诺素,Flavoayamenin |
Others | Others |
Spinosin (Flavoayamenin) 是一种具有神经保护作用的 C-糖苷类黄酮,从 Zizyphus jujube 种子分离得到,能够激活 Nrf2/HO-1 通路,并抑制 Aβ1-42的产生和聚合。 |