50
8
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T64722 | IP Lysis Buffer | ||
IP Lysis Buffer 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T64722。 | |||
T64696 | NP-40 Cell Lysis Buffer | ||
NP-40 Cell Lysis Buffer 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T64696。 | |||
T8129 |
Potassium acetate
Diuretic salt,Potassium ethanoate,乙酸钾 |
Antifungal | Microbiology/Virology |
Potassium acetate (Diuretic salt) 是一种钾盐,能够用于补充电解质,恢复水电解质平衡,也能用于制备细菌碱性裂解的中和液,以及纯化 DNA 和蛋白质。 | |||
T6622 |
Oxacillin sodium monohydrate
苯唑西林钠一水合物,Stapenor monohydrate,苯唑青霉素钠,Sodium oxacillin monohydrate,Methicillin,Bactocill monohydrate |
Others; Antibacterial; Antibiotic | Microbiology/Virology; Others |
Oxacillin sodium monohydrate (Stapenor monohydrate) 是一种抗生素,可研究耐药性葡萄球菌感染,类似 Flucloxacillin。 | |||
T30099 | Aplysistatin | ||
Aplysistatin is a bromosesquiterpene derived from sea mollusks. | |||
T60442 |
NLRP3/AIM2-IN-3
|
NOD; AIM2 | Immunology/Inflammation; NF-κB |
NLRP3/AIM2-IN-3 是一种独特的分子,能以物种特异性的方式抑制 NLRP3 和 AIM2 炎性体的激活。它对细胞裂解的 IC50 值为 0.077 ± 0.008 μ M。NLRP3/AIM2-IN-3是一种 NLRP3 和 AIM2 炎症体依赖性细胞裂解的强效抑制剂,对细胞裂解的 IC50 值为 0.077 ± 0.008 μ M。NLRP3/AIM2-IN-3 可抑制 LPS/nigericin 刺激的 THP-1 巨噬细胞的细胞裂解,其 IC50 值为 0.077 ± 0.008 μM。NLRP3/AIM2-IN-3 干扰了 NLRP3 或 AIM2 与桥接蛋白 ASC 的相互作用,抑制了 ASC 的寡聚。 | |||
T23764 |
AZ3976
AZ 3976,AZ-3976 |
PAI-1 | Metabolism |
AZ3976 是一种纤溶酶原激活物抑制剂-1抑制剂,在血浆凝块溶解试验中的 IC50为16μM。AZ3976 显示促纤维蛋白溶解活性。 | |||
T12470 |
Picloxydine
|
Antibacterial | Microbiology/Virology |
Picloxydine 是一种杂环双胍,有抗细菌和牙菌斑活性。 | |||
T7338L |
DHBP
紫外线吸收剂,Benzoresorcinol |
Others | Others |
DHBP (Benzoresorcinol) 是一种 WalKR TCS 激活剂。它通过靶向行走和选择性地促进纽曼野生型菌株的溶葡萄球菌素诱导的裂解活性起作用。 | |||
T1625 |
Lomefloxacin hydrochloride
Lomefloxacin HCl,盐酸洛美沙星,Okacyn,Maxaquin |
Topoisomerase; Antibacterial; Antibiotic | DNA Damage/DNA Repair; Microbiology/Virology |
Lomefloxacin hydrochloride (Okacyn) 是一种广谱喹诺酮类抗生素,具有抗菌活性。它可研究支气管炎、尿路感染、结膜炎、外耳炎和中耳炎。 | |||
T22831 |
Protein kinase inhibitor H-7 dihydrochloride
H-7 dihydrochloride |
PKC | Chromatin/Epigenetic; Cytoskeletal Signaling |
Protein kinase inhibitor H-7 dihydrochloride(H-7 dihydrochloride0) 是一种有效的蛋白激酶 C(PKC)抑制剂。Protein kinase inhibitor H-7 dihydrochloride(100 μM)显著抑制 TPA (皮肤肿瘤启动子,12-O-tetradecanoylphorbol-13-acetate) 和磷脂酶 C 促使的 ODC (鸟氨酸脱羧酶),抑制 PMA 诱导的混杂细胞溶解活性。 | |||
T1497 |
Liranaftate
Piritetrate,利拉萘酯,M-732 |
Antifungal | Microbiology/Virology |
Liranaftate (Piritetrate) 是一种具有抗真菌活性的硫代氨基甲酸酯和角鲨烯环氧酶抑制剂,可研究皮肤癣菌。 | |||
T1005L |
Amoxicillin trihydrate
Amoxycillin trihydrate,Amoxil trihydrate,Amoxipen trihydrate,阿莫西林三水物,Moxaline trihydrate |
Antibacterial; Antibiotic | Microbiology/Virology |
Amoxicillin trihydrate (Moxaline trihydrate) 是一种中谱β内酰胺抗菌素。 | |||
T0932 |
Cefixime
FK-027,头孢克肟,Cefspan,Cefiximum,Cephoral,FR-17027,CL-284635 |
Antibacterial; Antibiotic | Microbiology/Virology |
Cefixime (FR-17027) 是一种头孢菌素类抗生素, 可研究一些细菌感染。 | |||
T1213 |
Piperacillin sodium
哌拉西林钠,Sodium piperacillin,CL227193,Piperacillin sodium salt |
Antibacterial; Antibiotic | Microbiology/Virology |
Piperacillin sodium salt(CL227193) )是一种β-内酰胺类广谱抗生素。 | |||
T1005 |
Amoxicillin
Amoxycillin,阿莫西林 |
Antibacterial; Antibiotic | Microbiology/Virology |
Amoxicillin (Amoxycillin) 是一种具有广谱抗菌活性和良好口服吸收的抗生素。 | |||
T0953 |
Cefazolin sodium
Ancef,头孢唑啉钠,头孢唑林钠,Cefazolin sodium salt,Sodium cephazolin,cephazolin sodium,cefazoline sodium,Sodium cefazolin |
Others; Antibacterial; Antibiotic | Microbiology/Virology; Others |
Cefazolin sodium (cephazolin sodium) salt 是一种头孢类抗生素, 可研究多种细菌感染。 | |||
T1122 |
Cephalothin sodium
头孢噻吩钠,Cefalotin sodium,Cephalothin,Cefalotin |
Antibacterial; Antibiotic | Microbiology/Virology |
Cephalothin sodium (Cefalotin) 是一种头孢类抗生素, 具有广泛的抗菌活性,抑制革兰氏阳性和阴性菌。 | |||
T1224 |
Cefuroxime sodium
Anaptivan,头孢呋辛钠,Cefuroxime sodium salt,Biociclin |
Antibacterial; Antibiotic | Microbiology/Virology |
Cefuroxime sodium (Cefuroxime sodium salt) 是一种具有口服活性的头孢菌素抗生素,增加了对 β-内酰胺酶的稳定性。 | |||
T1228 |
Cefonicid sodium
Monocid sodium,头孢尼西钠,Cefonicid disodium salt |
Antibacterial; Antibiotic | Microbiology/Virology |
Cefonicid sodium (Monocid sodium) 是一种广谱头孢类抗生素, 能抑制细菌细胞壁的形成。 | |||
T1187 |
Bifonazole
联苯苄唑,Bay H-4502 |
P450; Antibiotic; Antifungal | Metabolism; Microbiology/Virology |
Bifonazole (Bay H-4502) 是咪唑类抗真菌剂。 | |||
T1063 |
Ticarcillin disodium
Ticarpen,Ticarcillin disodium salt,替卡西林二钠 |
Antibacterial; Antibiotic | Microbiology/Virology |
Ticarcillin disodium (Ticarpen) 主要用于抗革兰氏阴性菌, 特别是绿脓杆菌, 也是少数可研究嗜麦芽感染的抗生素。 | |||
T3934 |
Isavuconazonium sulfate
|
Antifungal | Microbiology/Virology |
Isavuconazonium sulfate 是一种口服活性抗真菌药,是活性三唑类抗真菌药物 Isavuconazole 的前药,可用于侵袭性曲霉菌病和毛霉菌病。 | |||
T69454 | Cephradine dihydrate | ||
Cephradine dihydrate is the hydrate form of Cephradine (free base), a semi-synthetic cephalosporin antibiotic. Cefradin inhibits the last stage of bacterial cell wall synthesis by binding to certain penicillin-binding proteins which results in cell lysis. Cell lysis is mediated by bacterial cell wall autolytic enzymes. Cefradin may interfere with autolysin inhibitors. | |||
T22600 |
BC 11 hydrobromide
|
Others | Others |
The compound is a selective urokinase inhibitor (IC50 = 8.2 μM). It also inhibits clot lysis with no effect on clot formation. | |||
T69070 |
Cephradine sodium
|
||
Cephradine sodium is the salt form of Cephradine (free base), a semi-synthetic cephalosporin antibiotic. Cefradin inhibits the last stage of bacterial cell wall synthesis by binding to certain penicillin-binding proteins which results in cell lysis. Cell lysis is mediated by bacterial cell wall autolytic enzymes. Cefradin may interfere with autolysin inhibitors. | |||
T36049 |
Linearmycin B
|
||
Linearmycin B is a polyene antibiotic that has been found inStreptomyces.1It induces lysis and degradation ofB. subtilisas a component ofStreptomycesMg1 extract.2 1.Sakuda, S., Guce-Bigol, U., Itoh, M., et al.Novel linear polyene antibiotics: LinearmycinsJ. Chem. Soc., Perkin Trans. 1182315-2319(1996) 2.Stubbendieck, R.M., and Straight, P.D.Escape from lethal bacterial competition through coupled activation of antibiotic resistance and a mobilized subpopulationPLoS Genet.11(12)e1005722(2015) | |||
T28882 |
Sultosilic acid, piperazine salt
A-585,Mimedran,piperazine-sultosylate,A585,A 585 |
||
Sultosilic acid piperazine salt is a drug with lowering lipid activity. It causes significant shortening of the euglobulin lysis time and a significant diminution of platelet adhesiveness, as well as statistically significant decrease of triglycerides, to | |||
T77878 |
Desthiobiotin-Iodoacetamide
|
||
Desthiobiotin-Iodoacetamide 可应用于ADC Linker。该化合物亦可作为探针,用于标记经草甲素(Oridonin)处理的细胞裂解物。 | |||
T81517 |
PEP1
|
||
PEP1为具生物活性的肽类化合物。它在低浓度时能够与POPC SLB结合,在高浓度下则会引起POPC SLB的裂解。 | |||
T81338 |
Pyrromethene 556
PM556 |
||
Pyrromethene 556 (PM556) 是一种绿色荧光极性示踪染料。它应用于膜融合、溶解和隙缝连接通信的研究,以及探测细胞或脂质体体积变化。 | |||
T35579 | PKSI-527 | ||
PKSI-527 is an inhibitor of plasma kallikrein (Ki = 0.81 μM). It is selective for plasma kallikrein over glandular kallikrein, plasmin, thrombin, urokinase, and Factor Xa (Kis = >500, 390, >500, 200, and >500 μM, respectively). PKSI-527 reduces bradykinin generation induced by kaolin and λ-carrageenan ex vivo in human plasma. It also prolongs partial thromboplastin and euglobulin clot lysis times. In vivo, PKSI-527 (300 mg/kg per day) reduces hyperplasia, pannus formation, and infiltration of in... | |||
T36048 |
Linearmycin A
|
||
Linearmycin A is a polyene antibiotic that has been found inStreptomyces.1It is active against the bacteriaS. aureusandE. coli(MICs = 3.1 and 1.6 μg/disc, respectively), the fungiS. cerevisiaeandC. albicans(MICs = 0.1 and 1.6 μg/disc, respectively), and the plant pathogenic fungusA. nigerin disc assays (MIC = 0.2 μg/disc). Linearmycin A induces lysis and degradation ofB. subtilisas a component ofStreptomycesMg1 extract.2 1.Sakuda, S., Guce-Bigol, U., Itoh, M., et al.Novel linear polyene antibiot... | |||
T81337 |
Pyrromethene 650
PM650 |
||
Pyrromethene 650 (PM650)为一种绿色荧光偏振示踪染料,常用于膜融合、裂解及隙缝结通讯的研究,并可检测细胞或脂质体的体积变化。 | |||
T83490 |
[Lys3]-Bombesin
|
||
[Lys3]-Bombesin 是具有生物活性的肽类化合物,用于 PET(正电子发射断层扫描)成像检测 GRPR(胃泌素释放肽受体)阳性的前列腺癌。此外,[Lys3]-Bombesin 及其单克隆抗体的免疫缀合物能特异性诱导 CD64 依赖的单核细胞和中性粒细胞介导的小细胞肺癌细胞裂解。 | |||
T76881 | Teclistamab | ||
Teclistamab 是一种人源化的 BCMA 和 CD3双特异性抗体,可识别靶细胞上的 BCMA 和 T 细胞上的 CD3,诱导 T 细胞介导的细胞毒性,导致 T 细胞的活化和随后的靶细胞裂解。Teclistamab 可用于多发性骨髓瘤等相关疾病研究。 | |||
T77127 | Pacanalotamab | ||
Pacanalotamab (AMG 420;BI-836909) 是一种双特异性 T 细胞接合剂 (BiTE),靶向 BCMA 和 CD3ɛ。BCMA 是指 B 细胞成熟抗原,而 Pacanalotamab 会将 T 细胞重定向到细胞表面的 BCMA 表达细胞。Pacanalotamab 可对人多发性骨髓瘤 (MM) 细胞系进行 T 细胞重定向裂解。 | |||
T38296 |
Alamethicin F50
Alamethicin F50 |
||
Alamethicin F50 is a peptaibol isolated from Trichoderma. It is a polymer of 20 amino acids that includes modified and non-proteinogenic amino acids. Alamethicin F50 is a mixture of 13 different peptides, with the most abundant designated as alamethicin F50/5. Alamethicin F50 forms voltage-dependent ion channels in lipid membranes and acts as a lytic agent. It induces lysis of leukocytes (IC50 = 54 and 80 μM for rat mast cells and mouse spleen lymphocytes, respectively) and exhibits antibacteria... | |||
T69350 | Ethionamide HCl | ||
Ethionamide HCl is the salt form of Ethionamide, a second-line antitubercular agent that inhibits mycolic acid synthesis. Ethionamide is a nicotinamide derivative, with antibacterial activity, used to treat tuberculosis. Although the exact mechanism of action of ethionamide is unknown, it may inhibit the synthesis of mycolic acid, a saturated fatty acid found in the bacterial cell wall, thereby inhibiting bacterial cell wall synthesis. This eventually leads to bacterial cell wall disruption and ... | |||
T38103 |
Defensin HNP-3 (human) (trifluoroacetate salt)
|
||
Defensin HNP-3 is a peptide secreted by human polymorphonuclear leukocytes (PMNs) that has antimicrobial properties. It induces lysis of mammalian cells when used at a concentration of 25 μg/mL. It also inhibits growth of E. faecalis (ED50 = 100 nM) and clinical isolates of P. aeruginosa (MIC90 = 4 μM). HNP-3 binds to recombinant HIV-1 envelope glycoprotein (gp120) and human CD4 (Kds = 52.8 and 34.9 nM, respectively). It also binds to recombinant, immobilized human surfactant protein D (SP-D; Kd... | |||
T76880 | Tepoditamab | ||
Tepoditamab (MCLA-117) 是一种双特异性的单克隆抗体,可以与骨髓细胞的 CLEC12A 和细胞毒性 T 细胞的 CD3结合。其中,CLEC12A 是一种骨髓分化抗原。Tepoditamab (MCLA-117) 可以杀死 AML 白血病母细胞和 AML 白血病干细胞,诱导 T 细胞介导的急性髓细胞增殖裂解,可用于急性骨髓性白血病(AML)研究。 | |||
T80762 |
XmAb 5592
|
||
XmAb 5592 是一款人源化Fc工程化的抗HM1.24抗体,通过增强与 FcγRIIIa 及 FcγRIIIb 受体的结合能力,增强了对HM1.24特异性多发性骨髓瘤(MM)细胞的抗体依赖性细胞毒性(ADCC)和抗体依赖性细胞吞噬(ADCP)作用,从而促进了体外裂解效果。 | |||
T79738 |
CYP51/PD-L1-IN-1
|
||
CYP51/PD-L1-IN-1(compound L11)是一种具有抗真菌活性的喹唑啉化合物,作为CYP51(IC50: 0.884 μM)和PD-L1(IC50: 0.083 μM)的双重抑制剂,能够在细胞周期早期引发真菌细胞的凋亡。该化合物还能有效减少IL-2、NLRP3、NF-κBp65等蛋白的细胞内水平,诱导线粒体损伤及ROS积聚,进而导致真菌细胞的破裂和死亡。 | |||
T72113 |
6-Aminocaproic acid hydrochloride
EACA hydrochloride,EACA hydrochloride ; Epsilon-Amino-n-caproic Acid hydrochloride ; 6-Aminohexanoic acid hydrochloride,6-Aminohexanoic acid hydrochloride,Epsilon-Amino-n-caproic Acid hydrochloride |
||
6-Aminocaproic acid hydrochloride,一种单氨基羧酸,作为有效及口服活性的纤溶酶和纤溶酶原抑制剂,具备显著的抗纤溶能力。通过竞争性结合纤溶酶原上的赖氨酸残基,6-Aminocaproic acid hydrochloride 阻止血块溶解,抑制纤溶酶生成,减少纤维蛋白溶解,用于出血性疾病研究。 | |||
T79740 |
CYP51/PD-L1-IN-3
|
||
CYP51/PD-L1-IN-3(compound L21)是一种具有抗真菌活性的喹唑啉化合物。作为CYP51(IC50: 0.205 μM) 和PD-L1(IC50: 0.039 μM) 的双重抑制剂,它能够引发真菌细胞在细胞周期早期的凋亡。此外,CYP51/PD-L1-IN-3 还能显著降低IL-2、NLRP3、NF-κBp65 蛋白的细胞内水平,并诱导线粒体损害及ROS 聚集,进而导致真菌细胞的裂解与死亡。 | |||
T79739 |
CYP51/PD-L1-IN-2
|
||
CYP51/PD-L1-IN-2(compound L20)是一种具有抗真菌活性的喹唑啉化合物。它作为CYP51(IC50:0.263 μM)和PD-L1(IC50:0.017 μM)的双重抑制剂,能够在细胞周期的早期引发真菌细胞凋亡。CYP51/PD-L1-IN-2进一步显著降低IL-2、NLRP3、NF-κBp65等蛋白水平,触发线粒体损伤及ROS积累,终致真菌细胞裂解和死亡。 | |||
T82252 |
GTPγS tetralithium
|
||
GTPγS (tetralithium) 是一种G蛋白激活剂,能够通过酪氨酸激酶依赖性机制刺激GLUT4的转位,并促进磷脂酶活化和肌动蛋白的聚合,从而可以作为蛋白质抑制蛋白酶介导降解的保护剂。此外,GTPγS (tetralithium) 在研究G蛋白α亚单位功能和激酶活性时可以与其结合使用,并可用作裂解缓冲液中的一个组分。 | |||
T69266 | Cefcanel free acid | ||
Cefcanel is a semisynthetic third-generation cephalosporin with antibacterial activity. Cefcanel is active against the species E. coli, K. aerogenes and Proteus mirabilis; H. influenzae and M. catarrhalis has reasonable susceptibility. Cefcanel inhibits 90% of S. aureus strains at 2 µg/ml, irrespective of the presence of a β-lactamase. Cefcanel binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the te... | |||
T76843 | Tebentafusp | ||
Tebentafusp (IMCgp100) 是靶向 gp100(一种黑色素瘤相关抗原)的双特异性融合蛋白。该药物通过其 T 细胞受体 (TCR) 高亲和力结合域以及抗 CD3 T 细胞接合域,指引 T 细胞针对表达 gp100 的肿瘤细胞进行杀伤。进一步,Tebentafusp 促进炎症细胞因子和细胞溶解酶的释放,直接导致肿瘤细胞裂解。 | |||
T37873 | CAP 3 | ||
CAP 3 is a cholic acid-peptide conjugate (CAP) with antibacterial activity. It is active against the Gram-negative bacteria E. coli, K. pneumoniae, and A. baumanii (MIC99s = 8, 16, and 16 μM, respectively). CAP 3 increases the fluidity of model Gram-negative bacterial membranes and binds to LPS in vitro. It reduces the biomass and number of colony-forming units in E. coli biofilms in a concentration-dependent manner. CAP 3 inhibits E. coli biofilm formation on catheters implanted in mice infecte... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5239 |
Cholesteryl sulfate sodium
Cholesterol 3-Sulfate Sodium Salt,胆固醇硫酸酯钠盐,Sodium Cholesteryl Sulfate |
Endogenous Metabolite; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism |
Cholesteryl sulfate sodium (Sodium Cholesteryl Sulfate) 是内源性代谢产物的一种。 | |||
T0881 |
6-Aminocaproic acid
氨基己酸,EACA,6-氨基己酸,6-Aminohexanoic acid,Epsilon-Amino-n-caproic Acid,(6-)ε-Aminocaproic acid |
Others | Others |
6-Aminocaproic acid (EACA) 是一种单氨基羧酸,是一种有效的、具有口服活性的纤溶酶和纤溶酶原的抑制剂。它是一种有效的抗纤维蛋白溶解剂,能够竞争性结合纤溶酶原上的赖氨酸残基,防止血块溶解,并抑制纤溶酶的形成,减少纤维蛋白溶解。它可用于出血性疾病的研究。 | |||
T5060 |
2-Oxobutanoic acid
2-酮丁酸,alpha-Ketobutyric Acid,2-Oxobutyric acid,Propionylformic acid |
Others; Endogenous Metabolite | Metabolism; Others |
2-Oxobutanoic acid (alpha-Ketobutyric Acid) 是一种胱硫醚的酶促裂解产物。它也是苏氨酸的降解产物之一。 它能够转化为丙酰辅酶A,从而进入柠檬酸循环。 | |||
TN6909 |
Polyporusterone B
猪苓酮B,(1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R)-2,3-dihydroxy-6-methyl-5-methylideneheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one |
Others | Others |
Polyporusterone B ((1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R)-2,3-dihydroxy-6-methyl-5-methylideneheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one) 是一种三萜羧酸,从Polyporus umbellatusFries 中分离得到。它对自由基诱导的红细胞裂解 (溶血) 具有抑制作用。 | |||
T1165 |
Ethionamide
Bayer 5312,乙硫异烟胺,2-ethylthioisonicotinamide,Ethinamide |
Dehydrogenase; CAT; Antibacterial; Antibiotic | Metabolism; Microbiology/Virology; oxidation-reduction |
Ethionamide (2-ethylthioisonicotinamide) 是一种抗结核抗生素。 | |||
T4889 |
2,6-Diaminoheptanedioic acid
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Others; Endogenous Metabolite | Metabolism; Others |
2,6-Diaminoheptanedioic acid 是内源性代谢产物的一种。 | |||
T19565 | Streptolysin O | Others | Others |
Streptolysin O causes both lysis of cells and cardiotoxicity. Streptolysin O is widely used for the controlled permeabilization of cell membranes. Streptolysin O exists in two forms, a reduced active state and an oxidized reversibly inactive state . | |||
T35750 |
Trypacidin
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Trypacidin is a fungal metabolite originally isolated fromA. fumigatus.1It is active againstB. subtilisandM. bovis(MICs = 12.5 and 1.25 μg/ml, respectively), as well asT. cruziandT. gondii(MICs = 5-10 and 10-20 μg/ml, respectively).1,2It reduces viability and induces lysis of A549 human lung cancer cells (IC50s = 7.4 μM for both).3Trypacidin increases survival in a mouse model ofT. gondiiinfection when administered in six doses of 12.5 mg/kg each.1 1.Balan, J., Ebringer, L., Nemec, P., et al.Ant... |