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Search Results for " longevity "

6

抑制剂 & 化合物

7

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP2312	MOTS-c(Human) Acetate（1627580-64-6 free）	Others; AMPK	Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling
	MOTS-c(Human) Acetate（1627580-64-6 free）是一种线粒体衍生肽。它诱导 AMP 类似物 AICAR 的积累，增加 AMPK 的激活和其下游 GLUT4 的表达。它可诱导葡萄糖摄取并提高胰岛素敏感性。它对调节肥胖、糖尿病、运动和长寿有重要意义。
T28898	T145 T 145,T-145
	T145 inhibits growth of Enterococcus faecalis, Staphylococcus aureus and Mycobacterium tuberculosis (Mtb) with sub μg/ml potencies that are potentially therapeutically valuable. T145 minimizes selection of spontaneous resistant mutants, a trait that prolo
T18061	KB02-SLF	Others; PROTACs	Others; PROTAC
	KB02-SLF is a PROTAC-based nuclear FKBP12 degrader, known as a molecular glue. It facilitates the degradation of nuclear FKBP12 by covalently modifying DCAF16, an E3 ligase. Moreover, KB02-SLF enhances the longevity of protein degradation in biological systems. The compound SLF acts as a linker, binding to the ubiquitin E3 ligase ligand KB02, resulting in the formation of KB02-SLF[1].
T74139	MPEG-2000-DSPE
	MPEG-2000-DSPE 是一种磷脂-聚乙二醇偶联物，具有亲水性和疏水性。MPEG-2000-DSPE 被用于脂质体的合成，增加脂质体表面的亲水性，从而延长脂质体在血液循环中的寿命，用于抗癌和抗疟活性分子的研究。
T76039	MOTS-c(human) acetate
	MOTS-c(human) acetate 是一种线粒体衍生的肽，可诱导 AMP 类似物AICAR 的积累，增加AMPK 的激活及其下游GLUT4的表达。MOTS-c(human) acetate 可诱导葡萄糖摄取并改善胰岛素敏感性，对肥胖，糖尿病，运动和长寿的调节具有影响。
T74672	Sirtuin modulator 5
	Sirtuinmodulator 5 是一种sirtuin 调节剂。Sirtuinmodulator 5 可以激活SIRTl，DC50值 <50 μM。Sirtuinmodulator 5 可用于增加细胞的寿命并用于研究多种疾病，包括例如与衰老或压力、糖尿病、肥胖症、神经退行性疾病、心血管疾病、凝血障碍、炎症、癌症和/或潮红以及将受益于线粒体活性增加的疾病或病症。

化合物

MOTS-c(Human) Acetate（1627580-64-6 free）

Cat.No: TP2312

Target: Others, AMPK

Cat.No: T28898

Synonym: T 145,T-145

Cat.No: T18061

Target: Others, PROTACs

Cat.No: T74139

MOTS-c(human) acetate

Cat.No: T76039

Sirtuin modulator 5

Cat.No: T74672

Cat. No.	Product Name	Target	Signaling Pathways
T7909	α-Terpinene 松油烯,α-松油烯	Others; Parasite; Antifungal	Microbiology/Virology; Others
	α-Terpinene 是存在于多种食品和芳香植物的精油中的一种单萜。它具有杀螨、抗真菌、抗氧化和抗原生动物特性，可研究锥虫病。
T9257	1,3-BUTANEDIOL	Others; Endogenous Metabolite	Metabolism; Others
	1,3-Butanediol 是乙醇二聚体，能够为人体营养提供热量来源，在体内转化为 β-羟基丁酸酯，并具有脑保护和降血糖作用。
T2745	18α-Glycyrrhetinic acid 18-α-甘草次酸,甘草次酸,Enoxolone,Glycyrrhetinic acid	Apoptosis; NF-κB; Proteasome	Apoptosis; NF-κB; Proteases/Proteasome; Ubiquitination
	18α-Glycyrrhetinic acid (Enoxolone) 是 NF-kB 的抑制剂和蛋白酶体的激活剂，在多细胞生物中起到促进长寿和抗聚集因子的作用。它诱导细胞凋亡。
TN4410	Lappaol C	P-gp; JNK	MAPK; Membrane transporter/Ion channel; Neuroscience
	Lappaol C has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol C also has potential chemosensitizing activity, it may be candidates for developing novel adjuvant an
TN5044	Specioside	Others	Others
	Specioside has antioxidant, analgesic, anti-dyspeptic, astringent, liver stimulating and wound healing activities. It ameliorates oxidative stress and promotes longevity in Caenorhabditis elegans.
TN1072	Lappaol A	P-gp; JNK	MAPK; Membrane transporter/Ion channel; Neuroscience
	Lappaol A has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol A also has potential chemosensitizing activity, it may be candidates for developing novel adjuvant an
TN4411	Lappaol F	CDK; P-gp; JNK	Cell Cycle/Checkpoint; MAPK; Membrane transporter/Ion channel; Neuroscience
	1. Lappaol F has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. <br/> 2. Lappaol F has potential chemosensitizing activity, it may be candidates for developing novel adju

天然产物

Cat.No: T7909

Synonym: 松油烯,α-松油烯

Target: Others, Parasite, Antifungal

Cat.No: T9257

Target: Others, Endogenous Metabolite

18α-Glycyrrhetinic acid

Cat.No: T2745

Synonym: 18-α-甘草次酸,甘草次酸,Enoxolone,Glycyrrhetinic acid

Target: Apoptosis, NF-κB, Proteasome

Cat.No: TN4410

Target: P-gp, JNK

Cat.No: TN5044

Target: Others

Cat.No: TN1072

Target: P-gp, JNK

Cat.No: TN4411

Target: CDK, P-gp, JNK

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