Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TD0098 |
Direct Red 80
Sirius Red,天狼猩红,Sirius Red F 3BA,C.I. direct red 80 |
Others | Others |
Direct Red 80 (Sirius Red) 是一种聚偶氮染料,在降解时不会释放联苯胺,比许多传统的直接染料更安全,主要用于胶原蛋白和淀粉样蛋白的染色方法。 | |||
T7460 |
α-Cyano-4-hydroxycinnamic acid
α-Cyano-4-hydroxycinnamic acid(α-CHCA),2-氰基-4-羟基 |
Monocarboxylate transporter | Membrane transporter/Ion channel |
α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamic acid(α-CHCA)) 是非竞争性单羧酸盐转运蛋白 (MCTs) 抑制剂,可抑制线粒体丙酮酸转运蛋白,Ki 值为 6.3 μM。它可作为基质辅助激光解吸电离-飞行时间质谱 (MALDI-TOF) 分析的基质,可以促进肽离子化。 | |||
T3338 |
Ceralasertib
AZD6738 |
ATM/ATR | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
Ceralasertib (AZD6738) 是一种具有口服活性的选择性 ATR 激酶抑制剂,IC50 为 1 nM。 | |||
T6019 |
Volasertib
BI 6727,伏拉塞替 |
Apoptosis; PLK | Apoptosis; Cell Cycle/Checkpoint |
Volasertib (BI 6727) 是一种具有口服活性的高效ATP 竞争性Polo 样激酶 1 抑制剂。它抑制 PLK2 和 PLK3,IC50分别为 5 和 56 nM。它是二氢蝶呤酮衍生物,有抗肿瘤活性,可诱导有丝分裂停滞和细胞凋亡。 | |||
T32577 |
Laserpitin
NSC-109434,NSC 109434,NSC109434 |
||
Laserpitin is a coumarin compound from Angelica keiskei. | |||
T124156 |
Laserine oxide
|
||
Laserine oxide 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T124156,CAS号为 82433-10-1。 | |||
T32576 |
Laserolide
|
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Laserolide is a sesquiterpene lactone. | |||
T26981 |
Ceralasertib formate
Ceralasertib,AZD-6738,AZD 6738,AZD6738 |
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Ceralasertib is an orally available inhibitor of ataxia telangiectasia and rad3 related (ATR) kinase. Ceralasertib selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine protein kinase CHK1. This prevents ATR- | |||
T12795 |
(S)-Ceralasertib
(S)-AZD6738 |
Others | Others |
(S)-Ceralasertib is a potent and selective inhibitor of sulfoximine morpholinopyrimidine ATR with excellent preclinical physicochemical and pharmacokinetic (PK) characteristics. . | |||
T125424 |
Laserine
|
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Laserine 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T125424,CAS号为 19946-83-9。 | |||
T41100 |
Volasertib trihydrochloride
BI6727trihydrochloride,伏拉塞替三盐酸盐 |
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Volasertib (BI 6727) trihydrochloride is a dihydropteridinone derivative that exhibits potent and selective inhibition of Polo-like kinase 1 (PLK1), PLK2, and PLK3. It acts as an orally active ATP-competitive inhibitor with an IC50 of 0.87 nM against PLK1. Additionally, Volasertib trihydrochloride demonstrates IC50 values of 5 nM and 56 nM against PLK2 and PLK3, respectively. Its mechanism of action includes inducing mitotic arrest and apoptosis. Furthermore, Volasertib trihydrochloride has been... | |||
T126023 |
d-Laserpitin
|
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d-Laserpitin 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T126023。 | |||
T19063 |
Sulforhodamine B sodium salt
Acid Red 52,Kiton Red 620,磺酰罗丹明B |
Others | Others |
Sulforhodamine B sodium salt (Acid Red 52) 是一种能够定量测定培养细胞的细胞蛋白量的荧光染料,。 | |||
T16744 |
Rhodamine 6G
Basic Red 1,罗丹明6G,罗丹明 6G |
Others | Others |
Rhodamine 6G (Basic Red 1) 是一种罗丹明类似物,可用于表征 MRP1 介导的流出的动力学,测定 Pgp 的流出,可用作激光染料和潜在的线粒体探针。 | |||
T3316 |
Fluorometholone
氟米龙,Fluoromethalone,Cortilet,Oxylone,Delmeson |
Glucocorticoid Receptor | Endocrinology/Hormones |
Fluorometholone (Fluoromethalone) 是合成糖皮质激素,具有抗炎和抗过敏作用。它可用作糖皮质激素受体激动剂,能够用于干眼症的研究。 | |||
T14050 |
5-FAM
5-羧基荧光素,5-Carboxyfluorescein |
Others | Others |
5-FAM (5-Carboxyfluorescein) 是一种绿色荧光探针(Ex/Em 为 490 nm/520 nm),可用于肽,蛋白质和核苷酸的标记。 | |||
T36466 |
Chlorin E6
Ce6,Chlorin e6,CE6 |
Parasite | Microbiology/Virology |
Chlorin E6 (CE6) 是一种第二代光敏剂,在与辐照结合使用时具有抗肿瘤活性。在植入性纤维肉瘤的小鼠模型中,Chlorin E6(2.5-10 毫克/千克,静脉注射,50-200 焦耳/平方厘米的辐照)在不同程度的辐照后会导致肿瘤完全消失。在一项针对支气管源性早期浅表鳞状细胞癌患者的 I 期临床研究中,对包括 Chlorin E6 在内的制剂进行了测试,结果良好(40 毫克/平方米,静脉注射,100 焦耳/平方厘米的激光辐照)。在一项针对早期肺癌患者的二期临床试验中,同样的给药模式使 82.9% 的患者获得了完全应答。Chlorin E6 已被研究为一种纳米技术给药工具。 | |||
T16743L |
Rhodamine 123 free base
|
||
The laser dye rhodamine 123 inhibit mitochondrion function. | |||
T20664 |
LD 490
C 6H,C-6H,LD-490,LD490,C6H |
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LD 490 is a laser dye. | |||
T32616 |
LD-473
LD 473 |
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LD-473 is a laser dye. | |||
T82195 |
HITCI
|
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HITCI作为具有正电荷的商业化吲哚碳菁染料,常用于近红外(NIR)激光染料应用场合。 | |||
T37090 |
Indo-1 (potassium salt)
|
||
Indo-1 is a ratiometric fluorescent calcium indicator. It is ideal for analyses using flow cytometry, as it uses a single excitation source, typically 349-364 nm light from an argon-ion laser. The emission maximum shifts from 475-485 nm without calcium to 400-410 nm when indo-1 binds calcium. Indo-1 is prone to photobleaching, which limits its usefulness in methods involving microscopy. | |||
TD0029 |
Super Fluor 750
|
||
Super Fluor 750 dye is a bright, near-IR–fluorescent dye with excitation ideally suited for the 633 nm laser line or dye-pumped laser excitation. Super Fluor 750 dye is pH-insensitive over a wide molar range, helping ensure that you get stable signals in | |||
T78089 |
FITC-labeled ODN 1018 sodium
|
||
FITC-labeled ODN 1018 (sodium) 作为TLR9激动剂,其细胞内摄取和定位可通过共聚焦激光扫描显微镜(激发/发射光波长:495/520 nm)或流式细胞术进行评估。 | |||
T67840 |
5-TAMRA Azide
TAMRA Azide, isomer 5 |
Others | Others |
5-TAMRA Azide (TAMRA Azide, isomer 5) 是一种橙色荧光探针,兼容各种激发源,包括汞弧灯,钨弧灯和氙弧灯,氦氖激光544 nm 线和532 nm 绿激光线。它主要用于检测末端炔标记的生物分子通过铜催化的点击反应(CuAAC)。 | |||
T37317 |
Fluo-3 (sodium salt)
|
||
Fluo-3 is a fluorescent calcium indicator commonly used in flow cytometry and cell-based experiments to detect changes in intracellular calcium levels. Its absorption maximum at 506 nm makes it compatible with excitation at 488 nm by argon-ion laser sources. Fluo-3 provides intense fluorescence upon binding calcium, detected at a maximum emission at 526 nm which can be monitored by FL1 (green, 525 nm band pass) sensors in flow cytometry. | |||
T78457 |
Pyrromethene 597
|
||
Pyrromethene 597 是一种具有宽波长调谐范围及高光稳定性的 BODIPY 激光染料,可作为热探针使用。 | |||
T74601 | Antitumor photosensitizer-3 | ||
Antitumor photosensitizer-3(Compound I)是一种二氢卟酚衍生物,能在650 nm激光照射下诱导肿瘤细胞的凋亡和坏死。与阳性参考m-THPC相比,Antitumor photosensitizer-3在体内的皮肤光毒性较低。 | |||
T78996 |
FITC-labeled ODN 2088 sodium
|
||
FITC-labeled ODN 2088 (sodium) 作为TLR3、TLR7和TLR9的抑制剂,可用于评估CpG ODN在细胞内的摄取与定位。通过共聚焦激光扫描显微镜(激发/发射光波长:495/520 nm)或流式细胞术进行检测。 | |||
TD0025 |
Super Fluor 647
|
||
Super Fluor 647 dye is a bright, far-red–fluorescent dye with excitation ideally suited for the 594 nm or 633 nm laser lines. For stable signal generation in imaging and flow cytometry, Super Fluor 647 dye is pH-insensitive over a wide molar range.Probes | |||
TD0027 |
Super Fluor 680
|
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Super Fluor 680 dye is a bright, near-IR fluorescent dye with excitation ideally suited for the 633 nm laser line. For stable signal generation in imaging and flow cytometry, Super Fluor 680 dye is pH-insensitive over a wide molar range.The fluorescence q | |||
T78998 |
FITC-labeled ODN 2216 sodium
|
||
FITC-labeled ODN 2216 (sodium) 为TLR9激动剂,其细胞摄取与定位可通过共聚焦激光扫描显微镜(激发/发射光波长:495/520 nm)或流式细胞术评估。 | |||
T82391 |
Fluo-3
|
||
Fluo-3及其相关化合物Fluo3/AM作为细胞内钙(Ca2+)的荧光指示剂。Fluo-3可用于可见光激发(与波长为488 nm的氩离子激光光源兼容)的流式细胞术和共聚焦激光扫描显微镜研究。与钙结合后,荧光强度可增加约40倍。 | |||
T78665 |
FITC-labeled ODN 1826 sodium
|
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FITC-labeled ODN 1826(sodium)为B类CpG ODN,兼作TLR9激动剂。该化合物的细胞摄取和定位可通过共聚焦激光扫描显微镜(激发/发射光波长:495/520 nm)及流式细胞术进行评估。 | |||
T37316 |
Fluo-3 (potassium salt)
|
||
Fluo-3 (potassium salt) is a fluorescent calcium indicator commonly used in flow cytometry and cell-based experiments to detect changes in intracellular calcium levels. Its absorption maximum at 506 nm makes it compatible with excitation at 488 nm by argon-ion laser sources. Fluo-3 provides intense fluorescence upon binding calcium, detected at a maximum emission at 526 nm which can be monitored by FL1 (green, 525 nm band pass) sensors in flow cytometry. | |||
T78663 |
FITC-labeled Agatolimod sodium
|
||
FITC-labeled Agatolimod (sodium) 是一种B类CpG ODN,兼具TLR9激动剂功能。该化合物应用共聚焦激光扫描显微镜(激发/发射光波长:495/520 nm)或流式细胞术,可以评估CpG ODN在细胞内的摄取及定位情况。 | |||
T83482 |
1,1',3,3,3',3'-Hexamethylindotricarbocyanine perchlorate
HITC |
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1,1',3,3,3',3'-Hexamethylindotricarbocyanine perchlorate (HITC)为一种长波长染料,对膜电位具有敏感性。该化合物作为电位计荧光素表现出缓慢的反应性,并用作红外激光器中的激光染料。 | |||
T78992 |
FITC-labeled ODN 1585 sodium
|
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FITC-labeled ODN 1585 (sodium) 为B类CpG ODN同时兼作TLR9激动剂。通过共聚焦激光扫描显微镜(激发/发射光波长:495/520 nm)或流式细胞术,可评估其细胞内摄取和定位情况。 | |||
T78994 |
FITC-labeled ODN 1668 sodium
|
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FITC-labeled ODN 1668 (sodium) 是B类CpG ODN,兼具TLR9激动剂功能。该化合物能借助共聚焦激光扫描显微镜(激发/发射光波长:495/520 nm)及流式细胞术,用于评估CpG ODN在细胞内的摄取及定位情况。 | |||
T37091 |
Indo-1 (sodium salt)
|
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Indo-1 is a ratiometric fluorescent calcium indicator. It is ideal for analyses using flow cytometry, as it uses a single excitation source, typically 349-364 nm light from an argon-ion laser. The emission maximum shifts from 475-485 nm without calcium to 400-410 nm when indo-1 binds calcium. Indo-1 is prone to photobleaching, which limits its usefulness in methods involving microscopy. | |||
T79000 |
FITC-labeled ODN 2395 sodium
|
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FITC-labeled ODN 2395 (sodium) 是C类CpG ODN,具有TLR9激动剂功能。该化合物的细胞摄取和定位可通过共聚焦激光扫描显微镜(激发/发射光波长:495/520 nm)或流式细胞术进行评估。 | |||
T37315 |
Fluo-3 (ammonium salt)
|
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Fluo-3 (ammonium salt) is a fluorescent calcium indicator commonly used in flow cytometry and cell-based experiments to detect changes in intracellular calcium levels. [1] Its absorption maximum at 506 nm makes it compatible with excitation at 488 nm by argon-ion laser sources. Fluo-3 provides intense fluorescence upon binding calcium, detected at a maximum emission at 526 nm which can be monitored by FL1 (green, 525 nm band pass) sensors in flow cytometry. | |||
TD0021 |
Super Fluor 488
|
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Super Fluor 488 dye is a bright, green-fluorescent dye with excitation ideally suited to the 488 nm laser line. For stable signal generation in imaging and flow cytometry, Super Fluor 488 dye is pH-insensitive over a wide molar range.Probes with high fluo | |||
T79002 |
FITC-labeled ODN TTAGGG sodium
|
||
FITC-labeled ODN TTAGGG (sodium) 作为一种寡核苷酸抑制剂,对TLR9、AIM2及cGAS具有拮抗作用。通过共聚焦激光扫描显微镜(激发/发射光波长:495/520 nm)或流式细胞术,可以评估CpG ODN在细胞内的摄取及定位情况。 | |||
T41209 |
DPNB-ABT 594
|
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DPNB-ABT 594 is a nitrobenzyl-caged ABT 594, a selective α4β2 nAChR agonist. One-photon uncaging evokes large inward currents and Ca2+transients on cell bodies and dendrites of medial habenular neurons in mouse brain slices. Two-photon uncaging induces fast nAChR-mediated currents. Photolyzed with high quantum yield of 0.20. Effective photolysis occurs using one- or two-photon excitation; one-photon uncaging requires illumination at 410 nm for 1.5-3 ms; two-photon uncaging requires illumination ... | |||
T36908 |
Bimatoprost grenod
15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α |
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Bimatoprost grenod(15-(6-nitroxyhexanoyl)-17-phenyl trinor PGF2α) is a nitric oxide-donating derivative of 17-phenyl trinor PGF2α.1It increases cGMP levels in rabbit aqueous humor and iris ciliary body when topically administered at a concentration of 0.042%. Topical administration of 15-(6-nitroxylhexanoyl)-17-phenyl trinor PGF2α(0.14%) reduces intraocular hypertension (IOP) in a rabbit model of hypertonic saline-induced transient ocular pressure. It also reduces IOP in a cynomolgus monkey mode... | |||
T34112 |
Porfimer Sodium
DHE,dihematoporphyrin ether,CL184116,CL-184116,CL 184116,Porfimer |
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Porfimer sodium is t he sodium salt of a mixture of oligomers formed by ether and ester linkages of up to eight porphyrin units with photodynamic activity. Absorbed selectively by tumor cells, porfimer produces oxygen radicals after activation by 630 nm w | |||
T35494 | (±)11(12)-EET | ||
(±)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes.[1][2][3[]A higher proportion of 11(R),12(S)-EET is produced by the CYP450 isoforms CYP2C23 and CYP2C24 while CYP2B2 produces a higher proportion of 11(S),12(R)-EET.[3]11(12)-EET has been shown, along with 8(9)-EET to play a role in the recovery of depleted calcium pools in cultured smooth muscle cells[4] It also inhibits basolateral 18-pS potassium channels in t... | |||
T36364 |
Flutax-2
|
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Green fluorescent taxol derivative. Used for microtubule imaging. Binds microtubules with high affinity (Ka ~ 107M-1). Excitation/emission maximum λ ~ 496/526 nm. Lillo et al (2002) Location and properties of the Tax. binding center in microtubules: a picosecond laser study with fluorescent taxoids. Biochemistry. 41 12436 PMID:12369834 |Diaz et al (2000) Molecular recognition of Tax. by microtubules. Kinetics and thermodynamics of binding of fluorescent Tax. derivatives to an exposed site. J.Bio... |