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Search Results for " keratinocyte "

19

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1328	TB500	Others	Others
	TB500 是一种胸腺素β4活性区域的合成分子。它可促进内皮细胞分化，角质形成细胞迁移，真皮组织中的血管生成，胶原沉积和减少炎症。
T20158	Phenformin Debeone,N-Phenethylbiguanide,Insoral,BRN 1977317,Azucaps	Apoptosis	Apoptosis
	Phenformin (BRN 1977317) 是一种双胍化合物，具有抗癌和抗血糖活性，抑制皮肤肿瘤生长并促进角质形成细胞分化，促进细胞凋亡。
T10687	Casein Kinase II Inhibitor IV	Casein Kinase	Metabolism; Stem Cells
	Casein Kinase II Inhibitor IV 是一种小分子诱导剂，可诱导表皮角质形成细胞分化。
T27710	K6PC-5 K6PC5,K6PC 5	S1P Receptor	GPCR/G Protein
	K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels. With its potential applications in skin diseases associated with abnormal keratinocyte function, as well as in studies on neurodegeneration and virus infection, K6PC-5 presents a promising compound for research purposes.
T6696	Tazarotene 他扎罗汀,Tazorac,AGN 190168,Zorac	Retinoid Receptor; Autophagy	Autophagy; Metabolism
	Tazarotene (Zorac) 是一种选择性视黄酸受体激动剂，用于研究寻常痤疮和斑块状银屑病。
TP2308	TB500 acetate(885340-08-9 free base) Frag17-23 Acetate,TB500 Acetate	Others	Others
	TB500 acetate(885340-08-9 free base) (Frag17-23 Acetate) 是胸腺素 β4 活性区域的合成版本。它促进内皮细胞分化、真皮组织中的血管生成、角质形成细胞迁移、胶原沉积和减少炎症。
TP2497	Myristoyl Tetrapeptide-12 Acetate 醋酸肉蔻酰四胜肽-12,Myristoyl Tetrapeptide-12 Acetate(959610-24-3 Free base)	Others	Others
	Myristoyl Tetrapeptide-12 Acetate (Myristoyl Tetrapeptide-12 Acetate (959610-24-3 Free base)) 是肉豆蔻酸和 Tetrapeptide-12 的反应产物，是一种刺激头发和睫毛生长并增强睫毛和/或眉毛外观的肽。 Myristoyl tetrapeptide-12 可以增加角质形成细胞的增殖，改善外观、紧致弹性和皮肤厚度。
T30526	BMS-480404 BMS 480404,BMS480404,UNII-T78485CEYD
	BMS-480404 is an effective small molecule inhibitor, which can bind to human keratinocyte fatty acid-binding protein.
T26958	CAY10583 CAY 10583,CAY-10583
	CAY10583 is an agonist of leukotriene B4 receptor type 2 (BLT2). CAY10583 directly promotes keratinocyte migration and indirectly enhances fibroblast proliferation by increasing keratinocyte production of bFGF1 and TGF-β, leadng to accelerate wound closur
T62055	NVS-BET-1
	NVS-BET-1 是 BET 溴结构域抑制剂。NVS-BET-1可以调节角质形成细胞可塑性。
T81330	Q-Peptide
	Q-Peptide（QHREDGS），是血管生成素-1的衍生肽。在糖尿病小鼠模型中，它通过增加角质形成细胞迁移来改善伤口愈合，并加速伤口闭合。
T35524	(1S)-Calcitriol
	(1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3) is a natural metabolite of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3). (1S)-Calcitriol exhibits potent vitamin D receptor (VDR)-mediated actions such as inhibition of keratinocyte growth or suppression of parathyroid hormone secretion[1]. 3‐epi‐Calcitroic acid is an end product of (1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3; 3‐epi‐1a,25(OH)2D3) metabolism by rat CYP24A1[1]. [1]. Steve Y Rhieu, et al. Metabolic stability of 3-epi-1α,25-dihydr...
T10687L	Casein Kinase II Inhibitor IV Hydrochloride Casein Kinase II Inhibitor IV Hydrochloride (863598-09-8 free base)	Others	Others
	Casein Kinase II Inhibitor IV Hydrochloride 是一种表皮角质形成细胞分化的小分子诱导剂，可用于机制研究，并具有治疗皮肤过度增生性疾病的研究潜力。
T37158	8(S)-HETE
	8(S)-HETE is a major lipoxygenase product in PMA-treated murine epidermis. It activates mouse keratinocyte protein kinase C with an IC50 of 100 μM. 8(S)-HETE also activates PPARα selectively at concentrations as low as 0.3 μM. Stereochemical assignment of the (S) enantiomer is based on comparison of chiral HPLC retention times to published results.
T61996	Antiproliferative agent-6
	Antiproliferative agent-6 (compound 8a) 是有效的抗肿瘤化合物。Antiproliferative agent-6 具有抗增殖活性，抑制癌细胞系 HCT116、MCF-7、H460 和非肿瘤非整倍体永生角质细胞 HaCaT 的 GI50分别为 0.5 μM、2 μM、0.7 μM 和 3.5 μM。
T37547	trans-Urocanic Acid
	trans-Urocanic acid is a major epidermal chromophore for the immunosuppressive effects of UV radiation that is produced in mammalian stratum corneum by the action of histidine ammonialyase on L-histidine. It contributes to the acidification of the surface of the stratum corneum, and its function has been proposed as that of an endogenous sunscreen, endowing a low-level of protection (SPF ~ 1.5) against UV-induced DNA damage and excessive keratinocyte apoptosis. Upon UVB exposure, trans-urocanic ...
T36531	PAR2 (1-6) (mouse, rat) PAR2 (1-6) (mouse, rat)
	PAR2 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 2 (PAR2) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of mouse and rat PAR2. It also corresponds to residues 39-44 and 37-42 of the mouse and rat full-length sequences, respectively. PAR2 (1-6) induces relaxation in precontracted rat arteries in a concentration-dependent manner, an effect that can be reduced by the nitric oxide synthase inhibitor L-NNA . It inhibits keratinocyte growth i...
T35671	Salazinic Acid
	Salazinic acid is a depsidone lichen metabolite that has been found in P. sulcata.1 It is active against B. cereus, B. subtilis, S. aureus, P. aeruginosa, S. typhimurium, C. albicans, and A. niger in vitro (MICs = 3.9-30.8 mM). Salazinic acid is cytotoxic to MM98, A431, and HaCaT cells in crystal violet (EC50s = 159, 2,870, and 48 μM, respectively) and neutral red uptake assays (EC50s = 1,925, 1,913, and 907 μM, respectively).2 It increases the wound closure rate in scratch-wounded HaCaT monolay...
T35451	β-Defensin-2 (human) (trifluoroacetate salt)
	β-Defensin-2 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1It inhibits the growth of periodontopathogenic and cariogenic bacteria, includingP. gingivalisandS. salivarius.2β-Defensin-2 (30 μg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes.3It also stimulates calcium mobilization, migration, and proliferation of keratinocytes whe...

化合物

Cat.No: TP1328

Target: Others

Cat.No: T20158

Synonym: Debeone,N-Phenethylbiguanide,Insoral,BRN 1977317,Azucaps

Target: Apoptosis

Casein Kinase II Inhibitor IV

Cat.No: T10687

Target: Casein Kinase

Cat.No: T27710

Synonym: K6PC5,K6PC 5

Target: S1P Receptor

Cat.No: T6696

Synonym: 他扎罗汀,Tazorac,AGN 190168,Zorac

Target: Retinoid Receptor, Autophagy

TB500 acetate(885340-08-9 free base)

Cat.No: TP2308

Synonym: Frag17-23 Acetate,TB500 Acetate

Target: Others

Myristoyl Tetrapeptide-12 Acetate

Cat.No: TP2497

Synonym: 醋酸肉蔻酰四胜肽-12,Myristoyl Tetrapeptide-12 Acetate(959610-24-3 Free base)

Target: Others

Cat.No: T30526

Synonym: BMS 480404,BMS480404,UNII-T78485CEYD

Cat.No: T26958

Synonym: CAY 10583,CAY-10583

Cat.No: T62055

Cat.No: T81330

(1S)-Calcitriol

Cat.No: T35524

Casein Kinase II Inhibitor IV Hydrochloride

Cat.No: T10687L

Synonym: Casein Kinase II Inhibitor IV Hydrochloride (863598-09-8 free base)

Target: Others

Cat.No: T37158

Antiproliferative agent-6

Cat.No: T61996

trans-Urocanic Acid

Cat.No: T37547

PAR2 (1-6) (mouse, rat)

Cat.No: T36531

Synonym: PAR2 (1-6) (mouse, rat)

Cat.No: T35671

β-Defensin-2 (human) (trifluoroacetate salt)

Cat.No: T35451

Cat. No.	Product Name	Target	Signaling Pathways
T3855	Tracheloside	Estrogen Receptor/ERR; Phosphorylase	Endocrinology/Hormones; Metabolism
	Tracheloside 是抗雌激素木质素，利用 ERK1/2 刺激促进角质形成细胞增殖，是一种良好的促进伤口愈合的药物。
T37753	Aureusimine B	Cysteine Protease; Antibacterial	Microbiology/Virology; Proteases/Proteasome
	Aureusimine B 是一种钙蛋白酶抑制剂，由金黄色葡萄球菌生物膜产生，可能是金黄色葡萄球菌生物膜感染的潜在生物标志物。

天然产物

Cat.No: T3855

Target: Estrogen Receptor/ERR, Phosphorylase

Cat.No: T37753

Target: Cysteine Protease, Antibacterial

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