6
2
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1960 |
YL-109
|
AhR; Aryl Hydrocarbon Receptor | Immunology/Inflammation; Metabolism |
YL-109是一种抗肿瘤剂,可以通过芳烃受体 AhR 信号传导诱导 Hsp70 相互作用蛋白 (CHIP) 表达,具有抑制乳腺癌细胞生长和侵袭性的能力。 | |||
T4657L |
WHI-P97 HCl 211555-05-4(free base)
|
JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
WHI-P97 HCl 211555-05-4(free base) 是一种有效的选择性 JAK-3 抑制剂。 WHI-P97 在模型研究中估计 Ki 值为 0.09 microM,在 EGFR 激酶抑制试验中测得的 IC50 值为 2.5 microM。 WHI-P97以浓度依赖性方式有效抑制EGFR 阳性人癌细胞的体外侵袭性。 | |||
T10767 | Cerivastatin sodium | HMG-CoA Reductase | Metabolism |
Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent and orally active HMG-CoA reductase inhibitor (Ki: 1.3 nM). It also inhibits the proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition. | |||
T14931 | Cerivastatin | Others | Others |
Cerivastatin is a highly potent, well-tolerated, and orally active HMG-CoA reductase inhibitor (Ki: 1.3 nM/L). Cerivastatin also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition with anti-cancer effect. Cerivastatin r | |||
T78202 | IV-255 | Epigenetic Reader Domain | Chromatin/Epigenetic |
IV-255为BRG1溴域的选择性小分子抑制剂,能增强Temozolomide及Bleomycin诱导的DNA损伤。此外,IV-255抑制GBM细胞侵袭,并强化Temozolomide诱导的细胞死亡与细胞凋亡活性。 | |||
T79642 |
IV-275
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
IV-275为BRG1与BRM溴域的抑制剂,能够增强Temozolomide和Bleomycin所诱导的DNA损害。此外,IV-275可抑制GBM(Glioblastoma multiforme)细胞的侵袭性,并增强Temozolomide所诱导的细胞凋亡。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3860 |
Isoliquiritin apioside
|
MMP; p38 MAPK; NF-κB | MAPK; NF-κB; Proteases/Proteasome |
Isoliquiritin apioside 可抑制癌细胞和内皮细胞的侵袭和血管生成,显著降低 PMA 诱导的MMP9活性增加,并抑制 PMA 诱导的MAPK 和NF-κB 活化。 | |||
T3330 |
trans-Trimethoxyresveratrol
trans-trismethoxy Resveratrol,E-Resveratrol Trimethyl Ether,MR-3,Tri-O-methylresveratrol,白藜芦醇三甲醚,3,4',5-Trimethoxy-trans-stilbene,Trimethoxystilbene |
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
trans-Trimethoxyresveratrol (MR-3) 是一种 Resveratrol(RSV) 的衍生物,与Resveratrol(RSV)相比,它可能是一个更有效的抗炎、抗血管新生的化合物。 |