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13

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T7318	Elimusertib BAY-1895344	ATM/ATR	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	Elimusertib (BAY-1895344) 是一种可口服的选择性ATR 抑制剂，IC50值为 7 nM。它具有抗肿瘤活性，可研究实体瘤和淋巴瘤。
T60026	KIF18A-IN-2	Microtubule Associated	Cytoskeletal Signaling
	KIF18A-IN-2 是有丝分裂驱动蛋白 Kif18A 的抑制剂，IC50 为 28 nM，可用于染色体不稳定性相关漏洞的研究。
T8856	Ascorbyl Propyl Hyaluronate	Others	Others
	Ascorbyl Propyl Hyaluronate 是透明质酸和维生素 C 的完美结合，克服了维生素 C 的不稳定性，是改善皱纹、滋润、镇静肌肤、美白的优质原料。
T3353	Niraparib hydrochloride 尼拉帕利盐酸盐,MK-4827 hydrochloride,MK-4827 (hydrochloride)	Apoptosis; Others; PARP	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Others
	Niraparib hydrochloride (MK-4827 hydrochloride) 是一种具有口服活性的PARP1和PARP2抑制剂，IC50值分别为 3.8 nM 和 2.1 nM。它抑制 DNA 损伤修复，诱导凋亡并具有抗肿瘤活性。
T13884	Shield-1	Others	Others
	Shield-1 是 FK506 结合蛋白 12 (FKBP) 的特异性、高亲和力和细胞渗透性配体，通过与突变的 FKBP (mtFKBP) 结合来逆转不稳定性，允许 mtFKBP 融合蛋白的条件表达。它可以稳定整个融合蛋白。
T9497	Niraparib tosylate monohyrate	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Niraparib tosylate monohyrate 也称为 MK-4827，是一种聚 (ADP-核糖) 聚合酶 (PARP) 抑制剂，具有潜在的抗肿瘤活性。 MK4827 抑制 PARP 活性，增强 DNA 链断裂的积累，促进基因组不稳定性和细胞凋亡。 PARP 蛋白家族通过碱基切除修复 (BER) 途径检测和修复单链 DNA 断裂。
T61305	LasR-IN-3
	LasR-IN-3, a chemical compound, acts as an inhibitor of LasR in Pseudomonas aeruginosa. It induces structural instability in LasR and causes complete dissociation of its functioning dimeric form [1].
T71483	Streptonigrin (racemate)
	Streptonigrin is an aminoquinone antitumor and antibacterial antibiotic produced by Streptomyces flocculus. Streptonigrin inhibits β-Catenin/Tcf signaling and shows cytotoxicity in β-catenin-activated cells. Streptonigrin induces delayed chromosomal instability involving interstitial telomeric sequences in Chinese hamster ovary cells. Note: Streptonigrin from natural resource is (-)-rotation, has CAS#3930-19-6 and is a R-isomer.
T68344	AGG-523
	AGG-523 is an aggrecanase specific inhibitor that has been shown to attenuate increases in synovial fluid ARG-aggrecan levels following surgically-induced joint instability in the rat MT model. Pharmacologic inhibition of aggrecanase activity in humans using AGG-523 may be an effective treatment for slowing cartilage degradation following joint injury.
T9126	PIP-199
	PIP-199 是一种 RecQ 介导的基因组不稳定蛋白 RMI 核心复合物/MM2 相互作用 (RMI core complex/MM2 interaction) 的选择性抑制剂，其 IC50值为 36 μM。PIP-199 可用于研究 DNA 交联修复的潜在机制，并可用作增敏化疗耐药肿瘤。
T61471	Antitubercular agent-13
	Antitubercular agent-13 (Compound 3d) 是一种抗结核剂，对 MTB H37Rv 和 MDR-MTB 16833 的 MIC 值分别为 0.007 μg/mL 和 1.851 μg/mL。Antitubercular agent-13 表现出代谢不稳定性。
T70115	Pamiparib hydrate
	Pamiparib, also known as BGB-290, is a highly potent and selective PARP inhibitor with favorable drug metabolism and pharmacokinetic properties. BGB-290 selectively binds to PARP and prevents PARP-mediated repair of single-strand DNA breaks via the base-excision repair (BER) pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability, and eventually leads to apoptosis. BGB-290 may both potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo...
T28293	Pamiparib maleate BGB290,BGB 290,BGB-29 maleat 0
	Pamiparib is a highly potent and selective PARP inhibitor. BGB-290 selectively binds to PARP and prevents PARP-mediated repair of single-strand DNA breaks via the base-excision repair (BER) pathway. This enhances the accumulation of DNA strand breaks, pro

化合物

Cat.No: T7318

Synonym: BAY-1895344

Target: ATM/ATR

Cat.No: T60026

Target: Microtubule Associated

Ascorbyl Propyl Hyaluronate

Cat.No: T8856

Target: Others

Niraparib hydrochloride

Cat.No: T3353

Synonym: 尼拉帕利盐酸盐,MK-4827 hydrochloride,MK-4827 (hydrochloride)

Target: Apoptosis, Others, PARP

Cat.No: T13884

Target: Others

Niraparib tosylate monohyrate

Cat.No: T9497

Target: PARP

Cat.No: T61305

Streptonigrin (racemate)

Cat.No: T71483

Cat.No: T68344

Cat.No: T9126

Antitubercular agent-13

Cat.No: T61471

Pamiparib hydrate

Cat.No: T70115

Pamiparib maleate

Cat.No: T28293

Synonym: BGB290,BGB 290,BGB-29 maleat 0

Cat. No.	Product Name	Target	Signaling Pathways
T40834	5-Hydroxymethyl-2'-deoxycytidine 5hmdC,2'-脱氧-5-(羟甲基)胞啶	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	5-Hydroxymethyl-2'-deoxycytidine 是 DNA 中 5-methyl-2'-deoxycytidine (5-mdC) 的氧化衍生物，引起DNA损伤反应，染色体畸变，复制叉损伤和细胞活力丧失。5-Hydroxymethyl-2’-deoxycytidine 复制叉不稳定性与染色质上聚（ADP-核糖）聚合酶1（PARP1）的存在有关。
T4110	Perivine Perivin,派利文碱	Others	Others
	Perivine (Perivin) 以视网膜母细胞瘤相关蛋白 (RbAp48) 为靶点，能够解决 RbAp48-FOG-1 复合物的不稳定性。Perivine 可用于研究阿尔茨海默病。

天然产物

5-Hydroxymethyl-2'-deoxycytidine

Cat.No: T40834

Synonym: 5hmdC,2'-脱氧-5-(羟甲基)胞啶

Target: PARP

Cat.No: T4110

Synonym: Perivin,派利文碱

Target: Others

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