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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0712 |
Suloctidil
|
ATPase; Platelet aggregation | Membrane transporter/Ion channel; Others |
Suloctidil 是一种外周血管扩张剂,作用于大鼠脑突触, 影响Na+/ K+ ATP 酶活性和膜流动性,可治疗痴呆和血栓形成病症。 | |||
T32579 |
Lasiocarpine HCl
Lasiocarpine hydrochloride |
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Lasiocarpine HCl is a hepatotoxic and carcinogenic food contaminant. | |||
T32982 |
Luteoskyrin
Flavomycelin |
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Luteoskyrin is a hepatotoxic and hepatocarcinogenic bisdihydroanthraquinone produced by Penicillium islandicum Sopp. | |||
T61515 | 5-HT7 receptor ligand 1 | ||
5-HT7 receptor ligand 1 (Compound 5c) is a potent ligand for the 5-HT7 receptor, with a K i value of 8 nM. The compound demonstrates non-hepatotoxic properties and displays moderate potential for drug-drug interactions with substrates of CYP3A4 or CYP2D6 enzymes [1]. | |||
T40688 |
Fulvine
|
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Fulvine, a pyrrolizidine alkaloid extracted from Crotalaria fulva seeds, exhibits hepatotoxic properties and can be employed for inducing hypertensive pulmonary vascular disease in vivo. | |||
T63337 | CYP2C19-IN-1 | ||
CYP2C19-IN-1 是强效的,无遗传毒性的、无肝脏毒性的 CYP2C19 抑制剂。 CYP2C19-IN-1 能够抑制 RNA 依赖的 RNA 聚合酶 (RdRP) (Ki: 6.16 μM),能够用于研究寨卡病毒 (ZIKV) 感染。 | |||
T69106 |
Avarol
|
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Avarol induces apoptosis in pancreatic ductal adenocarcinoma cells by activating PERK-eIF2α-CHOP signaling. Avarl also acts as a competitive AChE inhibitor which are non-hepatotoxic and neuroprotective agents for Alzheimer's disease. | |||
T35777 |
Nodularin
|
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The cyanobacterium Nodularia spumigena often contaminates the drinking water of rural communities in developing countries and accumulates in mussels, flounder, and cod from the northern Baltic Sea. Nodularin is a hepatotoxic monocylic pentapeptide produced by the N. spumigena. It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC50 values of 1.8 and 0.026 nM, respectively. PP2B is inhibited to a lesser extent with an IC50 of 1.8 μM. No apparent inhibitory eff... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN2147 |
Retrorsine
|
P450; OCT | Membrane transporter/Ion channel; Metabolism |
Retrorsine 特异性地抑制肝细胞增殖,并在肝损伤后唤起小肝细胞样祖细胞。逆转录酶可用于肝细胞损伤的研究。 | |||
TQ0192 |
Senecionine
Aureine,Senecionan-11,16-dione, 12-hydroxy-,千里光宁,Senecionin |
Others | Others |
Senecionine (Senecionin) 是一种吡咯里西啶生物碱,从Senecio vulgaris 中分离得到,它对动物和人类有毒性。 | |||
T3409 |
Plantamajoside
Y0160,C10485,大车前苷,车前子甙 |
Others | Others |
Plantamajoside (Y0160) 是一种苯丙烷类糖苷,从车前Plantago asiaticaL.中分离出来得到。它对 LPS 诱导的急性肺损伤小鼠模型具有保护作用。它对肺部炎症具有潜在的研究价值。 | |||
T2S1158 |
4,5-Dicaffeoylquinic acid
3,4-Dicaffeoylquinic acid,异绿原酸C(4,5),Isochlorogenic acid C |
Others; HBV; Endogenous Metabolite | Metabolism; Microbiology/Virology; Others |
4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) 是一种天然产物,有抗病毒、抗肝毒性活性。 | |||
T4S1718 |
Punicalin
|
HBV; HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Punicalin 是从Punica granatumL. 或Terminalia catappaL. 的叶子中分离的,一种可水解的单宁,具有抗炎活性。它是一种抗乙型肝炎病毒药物。 | |||
T3879 |
Silychristin
水飞蓟亭,水飞蓟汀,Silicristin |
Lipoxygenase | Metabolism |
Silychristin (Silicristin) 是甲状腺激素转运体MCT8的有效抑制剂,能强烈抑制 T3 的摄取(IC50:110 nM)。它是一种水飞蓟果实中富含的黄酮类化合物,具有抗氧化作用。 | |||
TN1078 |
Seneciphylline
千里光菲灵碱,千里光非灵 |
P450; GST | Metabolism; oxidation-reduction |
Seneciphylline 是一种有毒的吡咯烷核生物碱,存在于千里光植物中。它显著增加了环氧水合酶和谷胱甘肽-S-转移酶的特性,但导致细胞色素 P-450 和相关单加氧酶特性的抑制。 | |||
T6S1784 |
Brazilin
Natural Red 24,巴西苏木素;苏枋精,Braziletto,Brasilin,Superbresiline,巴西苏木素 |
Apoptosis; Others; AMPK; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling |
Brazilin (Braziletto) 是来自几种热带硬木的心材的一种红色染料前体,有软骨保护和抗炎活性。它抑制细胞增殖,促进细胞凋亡并通过 AMPK/mTOR 途径诱导自噬。 | |||
T6S0735 |
Flavokawain B
黄卡瓦胡椒素B,Flavokavain B,Flavokawin B,2'-Hydroxy-4',6'-Dimethoxychalcone |
Apoptosis; Others | Apoptosis; Others |
Flavokawain B (Flavokavain B) 是从卡瓦醉椒的根提取物中,分离出的查尔酮。它是一种凋亡诱导剂,可抑制各种癌细胞株生长。它以极低的无毒浓度抑制人脑内皮细胞的迁移和血管形成,具有抗血管生成活性。 | |||
TN3835 |
Desacetyldoronine
|
Others | Others |
Desacetyldoronine is a hepatotoxic pyrrolizidine alkaloid. | |||
TL0011 |
Adonifoline
|
Others | Others |
Adonifoline is a hepatotoxic pyrrolizidine alkaloid. | |||
TN3180 | 6-O-(3'',4''-Dimethoxycinnamoyl)catalpol | Others | Others |
6-O-(3'',4''-Dimethoxycinnamoyl)catalpol has anti-hepatotoxic activity. | |||
T40627 | Trichodesmine | ||
Trichodesmine, a dehydropyrrolizidine alkaloid, exhibits hepatotoxic, pneumotoxic, and neurotoxic effects in vivo. | |||
T25724 |
Ligularine
|
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Ligularine is a hepatotoxic otonecine-type pyrrolizidine alkaloid isolated from Ligularia hodgsonii, a Chinese traditional antitussive medicine. | |||
T40856 |
7-Acetylintermedine
|
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7-Acetylintermedine is a hepatotoxic botanical pyrrolizidine alkaloid. | |||
T81795 | Microcystin-WR | ||
Microcystin-WR为蓝藻代谢产物中的一种微囊藻毒素,对小鼠表现出肝脏毒性。 | |||
TN3913 | Echimidine | Antifection | Microbiology/Virology |
Echimidine, a major hepatotoxic dehydropyrrolizidine alkaloid produced by E. plantagineum, in the honey (780 ng/g) and in the subsequent mead samples (236-540 ng/mL). Echimidine-N-Oxide has antifungal activity. | |||
TN4346 |
Jaconine
|
Others | Others |
Jaconine, jacoline,jacobine, and jacozine, the hepatotoxic alkaloids, are potentially carcinogenic, mutagenic, and teratogenic and may pose health hazards to the human consumer. |