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Search Results for " glycosylation "

20

抑制剂 & 化合物

11

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T12282	Benzyl-α-GalNAc O-glycosylation-IN-1	Others	Others
	Benzyl-α-GalNAc (O-glycosylation-IN-1) 是 O-糖基化的有效抑制剂，用于减少细胞表面粘蛋白的含量。它抑制人胰腺癌细胞模型黏蛋白 O-糖基化的合成。
T9720	T3Inh-1	Others	Others
	T3Inh-1 是一种有效的选择性 ppGalNAc-T3 抑制剂，IC50 为 7 µM。 T3Inh-1 可预防乳腺癌细胞。 T3Inh-1 降低组织细胞和小鼠中的 FGF23 激素水平，而不会引起任何毒副作用。
T3161L	BACE-IN-1 acetate BACE-IN-1 acetate (350228-37-4，Free base)	BACE	Neuroscience
	BACE-IN-1 acetate (BACE-IN-1 acetate (350228-37-4，Free base)) 已被用作 BACE1 抑制剂测定中的 β 位淀粉样前体蛋白 (APP) 裂解酶-1 (BACE1) 抑制剂。 β-位点淀粉样前体蛋白 (APP) 切割酶-1 (BACE1)是一种天冬氨酸蛋白酶，属于蛋白酶家族，由六个腔内半胱氨酸残基组成。这些残基有助于形成三个分子间二硫键和 N-连接的糖基化位点。
T71844	Methyl potassium malonate
	Methyl potassium malonate is a protein advanced glycosylation inhibitor.
TNU1108	(R)-1,4-Anhydro-2-O-(2,4-dimethoxybenzoyl)-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-4-sulfinyl-D-ribitol
	Carbohydrate Derivatives; Ready for glycosylation
T36134	3,4,6-Tri-O-benzyl-β-D-Mannopyranose 1,2-(methyl orthoacetate)
	3,4,6-Tri-O-benzyl-β-D-mannopyranose 1,2-(methyl orthoacetate) is a synthetic intermediate used in glycosylation reactions. Typically, the methyl orthoester protecting group is first removed by mild acid hydrolysis, producing a glycosyl donor. Removal of the O-benzyl protecting groups is performed late in the synthesis.
T38976	MUC1, mucin core MUC1, mucin core
	MUC1, mucin core is a type I transmembrane glycoprotein that is characterized by its overexpression and abnormal glycosylation in carcinoma cells. It specifically binds to domain 1 of ICAM-1.
T12148L	N-Desmethyltamoxifen	Others	Others
	N-Desmethyltamoxifen, the principal metabolite of tamoxifen in humans, serves as an efficacious modulator of ceramide metabolism within human AML cells by inhibiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation. Although it demonstrates weak antiestrogenic properties, it acts as a protein kinase C (PKC) inhibitor with a potency ten times greater than that of tamoxifen.
T80089	HCV-1 e2 Protein (554-569) (TFA)
	HCV-1 e2 Protein (554-569) TFA 为丙型肝炎病毒（HCV）e2 蛋白关键抗原区段，含一个假定 N-糖基化位点，该位点早先推测会影响 e2 蛋白的免疫识别。
T36474	TunR1
	TunR1 is an antibiotic and derivative of tunicamycin .1It is active againstB. subtilis(MIC = 0.3 μg/ml) and increases the efficacy of the β-lactam antibiotics oxacillin , methicillin , and penicillin G againstB. subtiliswhen used at a concentration of 0.4 μg/ml. TunR1 (5 μg/ml) is cytotoxic to MDA-MB-231 breast cancer cells and non-cancerous CHO cells. Unlike tunicamycin, TunR1 does not inhibit glycosylation in a protein N-glycosylation assay. 1.Price, N.P., Hartman, T.M., Li, J., et al.Modified...
T36475	TunR2
	TunR2 is an antibiotic and derivative of tunicamycin .1It is active againstB. subtilis(MIC = 0.3 μg/ml) and increases the efficacy of the β-lactam antibiotics oxacillin , methicillin , and penicillin G againstB. subtiliswhen used at a concentration of 0.4 μg/ml. Unlike tunicamycin, TunR2 is non-toxic toS. cerevisiae(MIC = >10 μg/ml) and does not inhibit glycosylation in a protein N-glycosylation assay. TunR2 also has reduced antiproliferative activity against MDA-MB-231 and CHO cells compared wi...
T83602	(+)-Chloroquine
	(+)-Chloroquine是一种影响血管紧张素转换酶2（ACE-2）末端糖基化的氨基喹啉药物，其作用表现在体外。
TNU1050	3-Deoxy-1,2;5,6-di-O-isopropylidene-D-glucofuranose
	3-Deoxy-1,2;5,6-di-O-isopropylidene-D-glucofuranose 是一种多糖类的低聚糖。它用于糖基化的合成，可以定制合成用作药物中的碳水化合物。它通过抑制病毒蛋白合成而对Epstein-Barr 病毒具有抗病毒活性。
T79928	Phosphomannose isomerase
	Phosphomannose isomerase 是 GDP-Man 生物合成途径中关键的首要酶，负责催化 Fru6P 与 Man6P 之间的互转。该酶对于细胞壁合成及蛋白质糖基化过程至关重要。同时，作为一种潜在的抗真菌靶点，Phosphomannose isomerase 可以有效抑制 A. flavus。
T73770	Galactosylhydroxylysine hydrochloride
	Galactosylhydroxylysine hydrochloride, 一种羟基赖氨酸经糖基化转换后生成的骨胶原蛋白成分，该化合物在骨吸收过程中释放，其浓度在代谢性骨丢失疾病中会上升。
T76514	HCV-1 e2 Protein (554-569)
	HCV-1 e2 Protein (554-569) 是一段重要的丙型肝炎病毒(HCV) e2 蛋白的抗原区域，具有一个推定的 N-糖基化位点，这个位点被认为之前影响了e2蛋白的免疫识别。
T74092	Cyanine5 alkyne
	Cyanine5 alkyne (Alkyne-Cy5) 是一种荧光染料，用于标记叠氮蛋白，可用于分析蛋白质的翻译后修饰，糖基化等。Cyanine5 alkyne 也可以作为线粒体OXPHOS 抑制剂，抑制癌症干细胞 (CSC) 的生长。储存方式：避光。
T72917	D-threo-PDMP
	D-threo-PDMP 为一有效的葡萄糖神经酰胺合成酶 (GCS) 抑制剂, 通过抑制糖基化作用减少细胞表面糖鞘脂，进而减少轴突丛总长度与轴突分支点数量，抑制神经突生长。
T64475	FMOC-L-THR
	FMOC-L-THR (AZP-531) is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight. The O-glycosidic linkage and the O-acetyl protection in this building block is stable to both piperidine and TFA, making it completely compatible with standard protocols in Fmoc solid phase peptide synthesis. The Tn antigen is a tumor-associated carbohydrate antigen that is not normally expressed in peripheral tissues or blood cells. Expression of this antigen, which is found in a m...
T35890	Pentosidine
	Advanced glycation end products (AGEs) are compounds formed by non-enzymatic chemical reactions following the bonding of sugars to proteins or lipids during diabetes, uremia, aging, rheumatic arthritis, and other conditions. A receptor for the AGEs (RAGE) binds certain members of this class to initiate cell signaling.[1][2] Pentosidine is a well-characterized natural AGE that is often used as a biomarker for the production of all AGEs. While pentosidine can be measured in urine, the majority of ...

化合物

Benzyl-α-GalNAc

Cat.No: T12282

Synonym: O-glycosylation-IN-1

Target: Others

Cat.No: T9720

Target: Others

BACE-IN-1 acetate

Cat.No: T3161L

Synonym: BACE-IN-1 acetate (350228-37-4，Free base)

Target: BACE

Methyl potassium malonate

Cat.No: T71844

(R)-1,4-Anhydro-2-O-(2,4-dimethoxybenzoyl)-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-4-sulfinyl-D-ribitol

Cat.No: TNU1108

3,4,6-Tri-O-benzyl-β-D-Mannopyranose 1,2-(methyl orthoacetate)

Cat.No: T36134

MUC1, mucin core

Cat.No: T38976

Synonym: MUC1, mucin core

N-Desmethyltamoxifen

Cat.No: T12148L

Target: Others

HCV-1 e2 Protein (554-569) (TFA)

Cat.No: T80089

Cat.No: T36474

Cat.No: T36475

(+)-Chloroquine

Cat.No: T83602

3-Deoxy-1,2;5,6-di-O-isopropylidene-D-glucofuranose

Cat.No: TNU1050

Phosphomannose isomerase

Cat.No: T79928

Galactosylhydroxylysine hydrochloride

Cat.No: T73770

HCV-1 e2 Protein (554-569)

Cat.No: T76514

Cyanine5 alkyne

Cat.No: T74092

Cat.No: T72917

Cat.No: T64475

Cat.No: T35890

Cat. No.	Product Name	Target	Signaling Pathways
TN2158	Robinetin 3,3',4',5',7-Pentahydroxyflavone,洋槐黄素	Anti-infection; HIV Protease; Antibacterial	Microbiology/Virology; Proteases/Proteasome
	Robinetin (3,3',4',5',7-Pentahydroxyflavone) 是一种天然黄酮，具有显著的“两种颜色”固有荧光特性。它具有抗真菌、抗病毒、抗菌、抗突变、抗氧化和抗自由基活性，高效抑制 EYPC 膜脂质过氧化和 HbA 糖基化。
T22468	1-Deoxymannojirimycin hydrochloride	Others; Influenza Virus; HIV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	1-Deoxymannojirimycin hydrochloride 是一种选择性的 α1,2-甘露糖苷酶抑制剂，IC50值为 20 μM。它还抑制 HIV-1 毒株，抗病毒活性较差。
T3S2156	Chrysin 7-O-beta-gentiobioside Chrysin 7-O-β-gentiobioside,白杨素-7-O-龙胆二糖	Others	Others
	Chrysin 7-O-beta-gentiobioside (Chrysin 7-O-β-gentiobioside) 是 Chrysin 的糖基化产物，来自 Spartium junceum。
T4812	D-Mannose D-(+)-Mannose,D-甘露糖	Endogenous Metabolite	Metabolism
	D-Mannose (D-(+)-Mannose) 是糖类，在人体代谢过程，尤其在特定蛋白的糖基化过程中具有重要作用。
T3881	Vaccarin	Integrin; Akt; PERK; AMPK	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Vaccarin 是从王不留行中提取的一种黄酮糖苷，可显著促进伤口愈合以及伤口部位的内皮和成纤维细胞增殖。它通过激活 AMPK 信号通路改善胰岛素抵抗和脂肪变性。
TN2122	Quercetin 3-gentiobioside Quercetin-3-gentiobioside	Reductase	Endocrinology/Hormones; Metabolism
	Quercetin 3-gentiobioside (Quercetin-3-gentiobioside) 是一种AR 和 AGE 形成的抑制剂，可从 A. iwayomogi 中提取。Quercetin 3-gentiobioside 对醛糖还原酶 (AR) 的生物活性和晚期糖基化终产物 (AGEs) 的形成具有抑制作用。
T13229	Tunicamycin	Influenza Virus; Antibacterial; Antibiotic; Antifungal	Microbiology/Virology
	Tunicamycin 是一种抗生素的混合物，通过阻断 GlcNAc 磷酸转移酶 (GPT)，抑制 N-连接糖基化。Tunicamycin 具有抗肿瘤活性，还具有抗细菌、抗真菌和抗病毒活性。
TN2331	Eleutheroside B1 刺五加苷B1	Influenza Virus	Microbiology/Virology
	Eleutheroside B1是具有广谱抗人流感病毒的一种香豆素。它抑制多种趋化因子基因和流感病毒核蛋白基因的 mRNA 表达。它具有抗病毒、抗流感和抗炎活性，且细胞毒性小。
T4843	2,2-Dihydroxyacetic acid Formylformic acid,Glyoxylic acid monohydrate,乙醛酸水合物	Others; Endogenous Metabolite	Metabolism; Others
	2,2-Dihydroxyacetic acid (Formylformic acid) 是乙醛酸循环的中间体，使某些生物体能够将脂肪酸转化为碳水化合物。2,2-Dihydroxyacetic acid 被发现与原发性高草酸尿有关，这是一种先天性代谢错误。作为一种醛，乙醛酸酯也具有高活性，可以修饰蛋白质形成晚期糖基化产物(AGEs)。
T4809	Pyrimidine 嘧啶,Metadiazine	Others; Endogenous Metabolite	Metabolism; Others
	Pyrimidine (Metadiazine) 是内源性代谢产物的一种。
T4825	D-(+)-Xylose D(+)-Xylose,木糖,(+)-Xylose,Wood sugar	Endogenous Metabolite	Metabolism
	D-(+)-Xylose (Wood sugar) 是一种是一种戊醛糖，其化学式为C5H10O5，甜度为蔗糖的40%。木糖也存在于结缔组织的粘多糖中，有时也存在于尿液中。

天然产物

Cat.No: TN2158

Synonym: 3,3',4',5',7-Pentahydroxyflavone,洋槐黄素

Target: Anti-infection, HIV Protease, Antibacterial

1-Deoxymannojirimycin hydrochloride

Cat.No: T22468

Target: Others, Influenza Virus, HIV Protease

Chrysin 7-O-beta-gentiobioside

Cat.No: T3S2156

Synonym: Chrysin 7-O-β-gentiobioside,白杨素-7-O-龙胆二糖

Target: Others

Cat.No: T4812

Synonym: D-(+)-Mannose,D-甘露糖

Target: Endogenous Metabolite

Cat.No: T3881

Target: Integrin, Akt, PERK, AMPK

Quercetin 3-gentiobioside

Cat.No: TN2122

Synonym: Quercetin-3-gentiobioside

Target: Reductase

Cat.No: T13229

Target: Influenza Virus, Antibacterial, Antibiotic, Antifungal

Eleutheroside B1

Cat.No: TN2331

Synonym: 刺五加苷B1

Target: Influenza Virus

2,2-Dihydroxyacetic acid

Cat.No: T4843

Synonym: Formylformic acid,Glyoxylic acid monohydrate,乙醛酸水合物

Target: Others, Endogenous Metabolite

Cat.No: T4809

Synonym: 嘧啶,Metadiazine

Target: Others, Endogenous Metabolite

Cat.No: T4825

Synonym: D(+)-Xylose,木糖,(+)-Xylose,Wood sugar

Target: Endogenous Metabolite

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