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36

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T78515	Follicle-stimulating hormone	Others	Others
	卵泡刺激素(Follicle-stimulating hormone, FSH)为一种由垂体前叶分泌的异二聚体糖蛋白，其参与调控动物的生殖能力与繁殖效率。
T9625	Sandalore	Apoptosis	Apoptosis
	Sandalore 通过减少细胞凋亡和增加外根鞘中延长生长期的生长因子 IGF-1 的产生来延长人类头发的生长。 Sandalore 是嗅觉受体 OR2AT4 的选择性激动剂。
T8135	Minoxidil sulfate Minoxidil sulphate,U-58838,米诺地尔硫酸盐	Potassium Channel	Membrane transporter/Ion channel
	Minoxidil sulfate (U-58838) 是米诺地尔的硫酸代谢物，是ATP 敏感的 K+通道激动剂。它被认为是血管扩张试剂，在动物实验模型中，促进头发生长。
TP1342L	GnRH-I acetate GnRH-I acetate(33515-09-2 free base)	Others	Others
	GnRH-I acetate 在血液中释放具有生物活性的促卵泡激素 (FSH) 和促黄体激素 (LH)。
TP2373L	Biotinoyl tripeptide-1 Acetate Biotinoyl tripeptide-1 Acetate(299157-54-3 Free base)	Others	Others
	Biotinoyl tripeptide-1 Acetate 可通过促进头皮微循环产生毛囊，减少毛囊萎缩和衰老。
T5520L	Cetrorelix diacetate NS-75A,醋酸西曲瑞克,SB-075 acetate,SB-075 diacetate,Cetrorelix acetate,NS-75A diacetate	GNRH Receptor	GPCR/G Protein
	Cetrorelix diacetate (NS-75A) 是GnRH 受体的强效拮抗剂(IC50:1.21 nM)。
TP1700L	LGnRH-III, lamprey acetate(147859-97-0 free base)	GNRH Receptor	GPCR/G Protein
	LGnRH-III, lamprey acetate(147859-97-0 free base) 是 GnRH 家族进化上保守的成员，可刺激促性腺激素的分泌，同时刺激促黄体激素和促卵泡激素的分泌。
T2597	Norgestrel 甲基炔诺酮,SH-850,FH 122-A,炔诺孕酮,WY-3707,SH-70850	Estrogen/progestogen Receptor; Reactive Oxygen Species	Endocrinology/Hormones; Immunology/Inflammation; Metabolism; NF-κB
	Norgestrel (WY-3707) 是一种孕酮的合成类似物，是一种口服避孕药中常见的化合物，也是一种神经保护性强抗氧化剂，能够防止光诱导的感光细胞中的ROS 的生成以及细胞死亡。
T21309	Nafarelin acetate(76932-56-4 free base) RS-94991-298,醋酸萘法瑞林,Nafarelin acetate,Nafarelin acetate hydrate,Synarel	GNRH Receptor	GPCR/G Protein
	Nafarelin acetate(76932-56-4 free base) (RS-94991-298) 是一种 GnRH 激动剂，可作为 GnRH 的类似物。 Nafarelin acetate(76932-56-4 free base) 导致促性腺激素促黄体激素 (LH) 和促卵泡激素 (FSH) 的垂体分泌减少。它可用于治疗雌激素依赖性病症。
T21410	Triptorelin acetate(57773-63-4 free base) 醋酸曲普瑞林,Wy 42422,Triptorelin Acetate,CL 118532,AY 25650,CL 118,532,Wy 42462,BIM 21003	GNRH Receptor	GPCR/G Protein
	Triptorelin acetate(57773-63-4 free base) (CL 118,532) 用作 GnRH 激动剂。它通过引起垂体的持续刺激来减少垂体促性腺激素促黄体激素 (LH) 和促卵泡激素 (FSH) 的分泌。曲普瑞林可用于治疗激素反应性癌症，如乳腺癌或前列腺癌、性早熟、雌激素依赖性疾病和辅助生殖。
TP2107L	Histrelin acetate Histrelin acetate(76712-82-8 free base),醋酸组氨瑞林	GNRH Receptor	GPCR/G Protein
	Histrelin acetate 是促性腺激素释放激素 (GnRH) 的九肽类似物，具有增加的效力。当存在于血流中时，它作用于称为促性腺激素的垂体特定细胞。 Histrelin 刺激这些细胞释放促黄体激素和促卵泡激素。因此，它被认为是促性腺激素释放激素激动剂或 GnRH 激动剂。
T3630	Relugolix RVT-601,瑞卢戈利,TAK-385	GNRH Receptor	GPCR/G Protein
	Relugolix (RVT-601) 是口服有活性的非肽性促性腺激素释放激素的拮抗剂。同 TAK-013 相比，它对人和猴子的受体具有高亲和力和强拮抗活性，它们的 IC50值分别为0.33 nM 和0.32 nM。它可用于研究性激素依赖性疾病，如子宫肌瘤、子宫内膜异位症、前列腺癌等。
T5015L2	Gonadorelin HCl Factrel,AY-24,031,AY24,031,AY 24,031,LH-RH hydrochloride,Gonadorelin hydrochloride
	Gonadorelin HCl, as a decapeptide, can stimulate the synthesis and secretion of both pituitary gonadotropins, LUTEINIZING HORMONE, and FOLLICLE STIMULATING HORMONE.
TP2373	Biotinoyl tripeptide-1 Biotin GHK,BiotinGHK,Biotin-GHK
	Biotinoyl tripeptide-1 can produce hair follicles by promoting scalp micro-circulation and reduce follicle atrophy and aging.
TP2010	Kisspeptin 10 (dog)
	Endogenous ligand for the canine KISS1 receptor (Kisspeptin receptor or GPR54). Stimulates section of luteinizing hormone, follicle stimulating hormone and estradiol in vivo.
T81270	Ripafollitropin alfa (bovine)
	Ripafollitropin alfa (bovine)为一种结合了重组促卵泡激素(FSH)与绒毛膜促性腺激素(HCG)的融合蛋白。
T83489	[Lys8] LH-RH
	"[Lys8] LH-RH"为LH-RH的类似物, 能够有效促进LH与FSH的释放。
TP1700	LGnRH-III, lamprey
	GnRH III, an evolutionarily conserved member of the GnRH family, can stimulate the secretion of gonadotropins, it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
T75991	Ganirelix
	Ganirelix为一种竞争性且选择性的促性腺激素释放激素(GnRH)拮抗剂，其主要作用机制为抑制内源性GnRH，从而抑制黄体生成素(LH)及促卵泡激素的释放。
T64270	Lutropin
	Lutropin 是一种异二聚体糖蛋白，是一种由垂体前叶促性腺细胞产生的激素，对卵泡的发育具有刺激作用。Lutropin 能够用于研究不孕症。
T73680	Urofollitropin
	Urofollitropin是从更年期人类尿液中提取的蛋白质，具有促进卵泡发育和成熟的作用，但其含有的尿蛋白量极少。
T76620	(D-Tyr5,D-Ser(tBu)6,Azagly10)-LHRH
	(D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH 是黄体生成素释放激素 (LHRH) 的类似物。LHRH 通过刺激垂体黄体生成素 (LH) 和促卵泡激素 (FSH) 的释放，在控制生殖中发挥核心作用。
T76615	(D-Ser(tBu)6,D-Leu7,Azagly10)-LHRH
	(D-Ser(tBu)6,D-Leu7,Azagly10)-LHRH是一种LHRH(黄体生成素释放激素)的类似物，主要通过激活垂体分泌黄体生成素(LH)和促卵泡激素(FSH)来在生殖调控中发挥核心作用。
T82162	Human follicular gonadotropin releasing peptide hF-GRP
	Human follicular gonadotropin releasing peptide (hF-GRP)是一种刺激垂体分泌促黄体激素(LH)及促卵泡激素(FSH)的激素类多肽，其作用可在体外实现。
T70309	Dicetrorelix pamoate
	Dicetrorelix pamoate is a synthetic decapeptide with gonadotropin-releasing hormone (GnRH) antagonistic activity. GnRH induces the production and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the gonadotrophic cells of the anterior pituitary. Due to a positive estradiol (E2) feedback at midcycle, GnRH liberation is enhanced resulting in an LH-surge. This LH-surge induces the ovulation of the dominant follicle, resumption of oocyte meiosis and subsequently lutein...
T82307	Glp-His-Pro-Gly-NH2 pGlu-His-Pro-Gly-NH2
	pGlu-His-Pro-Gly-NH2（Glp-His-Pro-Gly-NH2）为含四氨基酸肽类化合物，可激发促性腺激素、黄体生成素（LH）与促卵泡激素（FSH）释放。
T72835	FSHR agonist 1
	FSHR agonist 1是一种对卵泡刺激素(FSH)受体(FSHR)具有高亲和力并能引起变构的激动剂，具有pEC50值为7.72。它通过与TMD广泛相互作用直接激活FSHR。
T76616	(D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH
	(D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH 是一种黄体生成素释放激素 (LHRH) 的类似物，主要通过促进垂体分泌黄体生成素 (LH) 和促卵泡激素 (FSH) 来在生殖调控中发挥关键作用。
T76222	hFSH-β-(33-53) (TFA)
	hFSH-β-(33-53) TFA 是一种含有硫醇的肽，对应于第二个 FSH 受体结合域，是 FSHR(卵泡刺激素受体) 拮抗剂。hFSH-β-(33-53) TFA 抑制 FSH 与受体的结合，是 Sertoli 细胞中雌二醇合成的部分激动剂。
T71149	Triptorelin pamoate
	Triptorelin, a decapeptide (pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2), is a gonadotropin-releasing hormone agonist (GnRH agonist) used as the acetate or pamoate salts. By causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Like other GnRH agonists, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, es...
T68292	GTX-758
	GTX-758, also known as Capesaris, is a n orally available, nonsteroidal selective estrogen receptor (ER) alpha agonist with potential antineoplastic activity. Upon administration of GTx-758, this agent suppresses the secretion of the gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the pituitary gland through feedback inhibition. In males, the inhibition of LH secretion prevents the synthesis of androgens, including testosterone, by the testes. This may result in ...
T69492	Ozarelix
	Ozarelix is a fourth generation GnRH antagonist, induces apoptosis in hormone refractory androgen receptor negative prostate cancer cells modulating expression and activity of death receptors. Mechanistically, LHRH antagonists exert rapid inhibition of luteinizing hormone and follicle stimulating hormone with an accompanying rapid decrease in sex hormones and would therefore be expected to be effective in a variety of hormonally dependent disease states including ovarian cancer, prostate cancer,...
T68525	Nafarelin acetate hydrate
	Nafarelin is a gonadotropin-releasing hormone agonist (GnRH agonist) which acts as an analog of GnRH. Nafarelin increases the release of FSH and LH by the anterior pituitary, which in turn leads to an increase of estrogen/progesterone. When administered, Nafarelin has the purpose of causing increase estrogen that will negatively feed back upon hypothalamus to decrease GnRH ( negative feedback loop ) Through negative feedback, Nafarelin causes a decrease in pituitary secretion of gonadotropins lu...
T76566	Fsh receptor-binding inhibitor fragment(bi-10)
	FSHreceptor-binding inhibitor fragment(bi-10) 是一种有效的 FSH 拮抗剂。FSHreceptor-binding inhibitor fragment(bi-10) 阻断 FSH 与 FSHR 的结合，并在受体水平上改变 FSH 的作用。FSHreceptor-binding inhibitor fragment(bi-10) 导致小鼠排卵抑制和卵泡闭锁。FSHreceptor-binding inhibitor fragment(bi-10) 通过下调卵巢中 FSHR 和 ERβ的过度表达来抑制卵巢癌发生。
T36912	17α,20β-Dihydroxy-4-pregnen-3-one 17α,20β-dihydroxy Progesterone,17α,20β-DHP,17α,20β-Dihydroxy-4-pregnen-3-one
	17α,20β-Dihydroxy-4-pregnen-3-one (17α,20β-DHP) is an endogenous, maturation-inducing steroid that stimulates oocyte maturation in females of several teleost species. For example, 1 μg/ml of 17α,20β-DHP applied to Persian sturgeon oocytes has been shown to effectively induce germinal vesicle breakdown, an essential step during oocyte maturation.1 Gonadotropin-releasing hormone and the gonadotropins, follicle-stimulating hormone and luteinizing hormone, have been shown to stimulate the production...
T76047	TAK-683 TFA
	TAK-683 TFA是一种高效的全KISS1R激动剂(IC50=170 pM)，拥有较好的代谢稳定性，是九肽metastin的类似物，对KISS1R有激动效应，其对人和大鼠EC50值分别为0.96 nM和1.6 nM。TAK-683 TFA能够降低下丘脑GnRH水平，进而减少血浆FSH、LH、睾酮的浓度，显示出对激素依赖性前列腺癌研究的可能性。

化合物

Follicle-stimulating hormone

Cat.No: T78515

Target: Others

Cat.No: T9625

Target: Apoptosis

Minoxidil sulfate

Cat.No: T8135

Synonym: Minoxidil sulphate,U-58838,米诺地尔硫酸盐

Target: Potassium Channel

Cat.No: TP1342L

Synonym: GnRH-I acetate(33515-09-2 free base)

Target: Others

Biotinoyl tripeptide-1 Acetate

Cat.No: TP2373L

Synonym: Biotinoyl tripeptide-1 Acetate(299157-54-3 Free base)

Target: Others

Cetrorelix diacetate

Cat.No: T5520L

Synonym: NS-75A,醋酸西曲瑞克,SB-075 acetate,SB-075 diacetate,Cetrorelix acetate,NS-75A diacetate

Target: GNRH Receptor

LGnRH-III, lamprey acetate(147859-97-0 free base)

Cat.No: TP1700L

Target: GNRH Receptor

Cat.No: T2597

Synonym: 甲基炔诺酮,SH-850,FH 122-A,炔诺孕酮,WY-3707,SH-70850

Target: Estrogen/progestogen Receptor, Reactive Oxygen Species

Nafarelin acetate(76932-56-4 free base)

Cat.No: T21309

Synonym: RS-94991-298,醋酸萘法瑞林,Nafarelin acetate,Nafarelin acetate hydrate,Synarel

Target: GNRH Receptor

Triptorelin acetate(57773-63-4 free base)

Cat.No: T21410

Synonym: 醋酸曲普瑞林,Wy 42422,Triptorelin Acetate,CL 118532,AY 25650,CL 118,532,Wy 42462,BIM 21003

Target: GNRH Receptor

Histrelin acetate

Cat.No: TP2107L

Synonym: Histrelin acetate(76712-82-8 free base),醋酸组氨瑞林

Target: GNRH Receptor

Cat.No: T3630

Synonym: RVT-601,瑞卢戈利,TAK-385

Target: GNRH Receptor

Gonadorelin HCl

Cat.No: T5015L2

Synonym: Factrel,AY-24,031,AY24,031,AY 24,031,LH-RH hydrochloride,Gonadorelin hydrochloride

Biotinoyl tripeptide-1

Cat.No: TP2373

Synonym: Biotin GHK,BiotinGHK,Biotin-GHK

Kisspeptin 10 (dog)

Cat.No: TP2010

Ripafollitropin alfa (bovine)

Cat.No: T81270

Cat.No: T83489

LGnRH-III, lamprey

Cat.No: TP1700

Cat.No: T75991

Cat.No: T64270

Cat.No: T73680

(D-Tyr5,D-Ser(tBu)6,Azagly10)-LHRH

Cat.No: T76620

(D-Ser(tBu)6,D-Leu7,Azagly10)-LHRH

Cat.No: T76615

Human follicular gonadotropin releasing peptide

Cat.No: T82162

Synonym: hF-GRP

Dicetrorelix pamoate

Cat.No: T70309

Glp-His-Pro-Gly-NH2

Cat.No: T82307

Synonym: pGlu-His-Pro-Gly-NH2

Cat.No: T72835

(D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH

Cat.No: T76616

hFSH-β-(33-53) (TFA)

Cat.No: T76222

Triptorelin pamoate

Cat.No: T71149

Cat.No: T68292

Cat.No: T69492

Nafarelin acetate hydrate

Cat.No: T68525

Fsh receptor-binding inhibitor fragment(bi-10)

Cat.No: T76566

17α,20β-Dihydroxy-4-pregnen-3-one

Cat.No: T36912

Synonym: 17α,20β-dihydroxy Progesterone,17α,20β-DHP,17α,20β-Dihydroxy-4-pregnen-3-one

Cat.No: T76047

Cat. No.	Product Name	Target	Signaling Pathways
T5S0896	Loureirin A 龙血素 A,龙血素A	Akt; PI3K	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Loureirin A 是一种黄酮类物质，从龙血树中分离得到，能够降低Akt 的磷酸化，具有抗血小板聚集作用。
T40442	Propylparaben sodium Propyl4-hydroxybenzoatesodium,羟苯丙酯钠,Propylparahydroxybenzoatesodium
	Propylparaben sodium (propyl parahydroxybenzoate) is a naturally occurring antimicrobial preservative found in plants and bacteria. Widely utilized in cosmetics, pharmaceuticals, and foods, this compound impairs antral follicle growth and steroidogenic function by modifying the cell-cycle, apoptosis, and steroidogenesis pathways. Additionally, propylparaben sodium reduces sperm count and motility in rats.

天然产物

Cat.No: T5S0896

Synonym: 龙血素 A,龙血素A

Target: Akt, PI3K

Propylparaben sodium

Cat.No: T40442

Synonym: Propyl4-hydroxybenzoatesodium,羟苯丙酯钠,Propylparahydroxybenzoatesodium

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