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44

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T7460	α-Cyano-4-hydroxycinnamic acid α-Cyano-4-hydroxycinnamic acid(α-CHCA),2-氰基-4-羟基	Monocarboxylate transporter	Membrane transporter/Ion channel
	α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamic acid(α-CHCA)) 是非竞争性单羧酸盐转运蛋白 (MCTs) 抑制剂，可抑制线粒体丙酮酸转运蛋白，Ki 值为 6.3 μM。它可作为基质辅助激光解吸电离-飞行时间质谱 (MALDI-TOF) 分析的基质，可以促进肽离子化。
T0156	Rocuronium bromide ORG 9426,罗库溴铵,ORG 9426 (Bromide)	AChR	Neuroscience
	Rocuronium bromide (ORG 9426) 是一种氨基甾体类的、非去极化的神经肌肉受体抑制剂，也是一种肌肉松弛剂。
T60485	DIF-3
	DIF-3 is a chemical compound that acts by activating GSK-3β to facilitate the degradation of cyclin D1 and c-Myc, resulting in reduced expression levels of these proteins. In addition, DIF-3 inhibits Wnt/β-catenin signaling pathway-related proteins in DLD-1 cells. This compound exerts a potent antiproliferative effect on the HeLa human cervical cancer cell line by inducing cyclin D1 degradation and inhibiting cyclin D1 mRNA expression [1].
T17811	DBCO-SS-aldehyde	Others	Others
	DBCO-SS-aldehyde is an ADC linker employed for ADC synthesis[1]. This cleavable linker is designed to facilitate the conjugation of antibodies and drugs, resulting in antibody-drug conjugates (ADCs).
T25636	Laudexium Laudexium ion,Laudexium cation
	Laudexium is a neuromuscular blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs. It is used adjunctively in surgical anesthesia to facilitate endotracheal intubation and to provide skeletal muscle re
T17975	Fmoc-NH-pentanoic acid-NHS-SO3Na	Others	Others
	Fmoc-NH-pentanoic acid-NHS-SO3Na is a PROTAC linker molecule derived from an alkyl chain. It possesses the ability to facilitate the synthesis of PROTACs[1].
T77934	PhosTAC7	PROTACs	PROTAC
	PhosTAC7类似于PROTACs通过诱导三元复合物的作用机制，其主要作用是招募Ser/Thr磷酸酶至磷酸化底物，从而介导目标蛋白的去磷酸化。
T25637	Laudexium methylsulfate Laudexium,Laudolissin methosulphate
	Laudexium methylsulfate is a neuromuscular blocking drug or skeletal muscle relaxant. It is used adjunctively in surgical anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
T18446	N-Methyl-N'-(hydroxy-PEG2)-Cy5	Others	Others
	N-Methyl-N'-(hydroxy-PEG2)-Cy5 is a PEG-based linker utilized for the synthesis of PROTACs. It serves as a chemical compound with the ability to facilitate the formation of PROTACs[1].
T17943	FAK ligand-Linker Conjugate 1	Others	Others
	FAK ligand-Linker Conjugate 1 is a chemical compound designed to facilitate PROTAC-mediated protein degradation. This compound consists of a ligand specifically targeting FAK and a PROTAC linker module, which acts as a recruitment agent for E3 ligases including VHL, CRBN, MDM2, and IAP[1].
T31963	Glyco-lipid Glycolipid,Glyco lipid
	Glycolipids are lipids with a carbohydrate attached by a glycosidic (covalent) bond. Their role is to maintain the stability of the cell membrane and to facilitate cellular recognition, which is crucial to the immune response and in the connections that allow cells to connect to one another to form tissues.
T39642	Thalidomide-O-C3-acid Thalidomide-O-C3-acid
	Thalidomide-O-C3-acid is a chemically derived conjugate that combines a cereblon ligand based on Thalidomide and a linker commonly employed in PROTAC technology. This synthesized E3 ligase ligand-linker conjugate serves to facilitate targeted protein degradation.
T80972	TNH TMP-NVOC linker-Halo
	TNH为一种二聚体，能够渗透活细胞并招募蛋白质至细胞结构。
T68206	Arbortristoside A
	Arbortristoside A is an anti-inflammatory and antinociceptive. This activity may be due to the inhibiting effect of prostaglandin, histamine and serotonin. Arbortristoside A has also been shown to act on ulcerations and may facilitate healing of peptic ulcers.
T14101	Acid-PEG3-C2-Boc	Others	Others
	Acid-PEG3-C2-Boc is a compound used as a linker in the synthesis of PROTACs to facilitate the degradation of EGFR and the inhibition of mTOR[1][2]. It is classified as a PEG- and alkyl/ether-based PROTAC linker.
T17647	Boc-C1-PEG3-C4-OH	Others	Others
	Boc-C1-PEG3-C4-OH is an Alkyl/ether-based PROTAC linker utilized in the synthesis of PROTACs, which are characterized by their structure comprising two distinct ligands tethered by a linker. One ligand of PROTACs binds to an E3 ubiquitin ligase, while the other binds to the target protein. By leveraging the intracellular ubiquitin-proteasome system, PROTACs facilitate the targeted degradation of specific proteins[1].
T75379	Biotin-16-UTP
	Biotin-16-UTP作为RNA聚合酶的活性底物，在体外转录反应中可取代UTP进行RNA标记。
T17903	Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH E3 ligase Ligand-Linker Conjugates 49,Cereblon Ligand-Linker Conjugates 14	Others	Others
	Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH is a chemically synthesized compound, designed as an E3 ligase ligand-linker conjugate, integrating the cereblon ligand derived from Pomalidomide and a linker employed in PROTAC technology. This compound serves to facilitate targeted protein degradation through the modulation of E3 ligase activity, enabling the selective elimination of specific proteins of interest.
T18350	Methyltetrazine-PEG4-oxyamine	Others	Others
	Methyltetrazine-PEG4-oxyamine is a 4-unit polyethylene glycol (PEG) linker employed in the synthesis of antibody-drug conjugates (ADCs), which are extensively used for targeted drug delivery [1]. This cleavable linker offers a means to efficiently attach drugs to antibodies and facilitate their controlled release at the target site.
TP1676	C-Reactive Protein (CRP) (201-206) C-Reactive Protein (CRP) 201-206	Others	Others
	C-Reactive Protein (CRP) (201-206) 是 C-反应蛋白的 201-206 片段。其中C-反应蛋白 (CRP) 是炎症的原型标志物，是心血管风险标志物，可能促进动脉粥样硬化形成。
T83834	Sp-Guanosine-5'-O-(1-thiotriphosphate) sodium Sp-GTP-α-S,GTPαS(Sp),GTPαS(A)
	Sp-Guanosine-5'-O-(1-thiotriphosphate) (Sp-GTP-α-S) 是一种含硫核苷酸衍生物GTP-α-S的异构体。它能结合到微管蛋白上，在20 mM的浓度下用于无细胞实验时可诱导微管组装。
T61090	CD73-IN-8
	CD73-IN-8, a potent CD73 inhibitor, prevents the catalytic activity of CD73, an enzyme responsible for converting extracellular 5'-phosphate adenosine (5'-AMP) to adenosine. Adenosine, once produced, can induce immunosuppressive effects and facilitate tumor proliferation and/or metastasis. Therefore, CD73-IN-8 holds promise in the development of therapeutic interventions for tumor-related diseases[1].
T77935	Tri-GalNAc(OAc)3-Perfluorophenyl	LYTACs	PROTAC
	Tri-GalNAc(OAc)3-Perfluorophenyl 为五氟苯基修饰的 Tri-GalNAc(OAc)3，属 tri-GalNAc 配体类，用于 GalNAc-LYTAC 合成。该 GalNAc-LYTAC 通过去唾液酸糖蛋白受体实现靶向蛋白降解。
T81576	PA22-2 IKVAV sequence,Laminin A-chain fragment
	PA22-2（IKVAV序列；层粘连蛋白A链片段）为一生物活性肽，源于小鼠层粘连蛋白a1氨基酸2110至2127残基。构成的细胞外基质能够促进神经突生长。
T22036	Arylquin 1
	Arylquin 1 是一种前列腺-凋亡-反应-4(Par-4)促分泌剂，靶向波形蛋白诱导 Par-4 分泌。Arylquin 1 通过诱导溶酶体膜通透性 (LMP) 诱导癌细胞非凋亡性细胞死亡。
T83343	3x DYKDDDDK Tag
	3x DYKDDDDK Tag 作为研究Abs时无法使用的蛋白质功能与定位的工具而得到应用。它经常以3x标志形式（3x DYKDDDDK Tag TFA）用于纯化低丰度蛋白。
T63004	NUCC-390 dihydrochloride
	NUCC-390 dihydrochloride 是新型的选择性小分子CXCR4receptor 受体激动剂。NUCC-390 dihydrochloride 可以诱导CXCR4受体的内化，作用方式与 AMD3100 相反。NUCC-390 dihydrochloride 在动物模型中，有助于神经退行性变后神经功能恢复。
T36523	Extracellular Death Factor
	Programmed cell death in bacteria is dependent on a system of cell-to-cell communication termed quorum sensing. Extracellular death factor (EDF) is a linear pentapeptide that communicating cells produce and release, which upon reaching a sufficient concentration activates the cell death pathway in a subset of cells. It is sensitive to extreme pH, high temperatures, and other stressful conditions. At 2.5 ng/ml, EDF has been shown to facilitate mazEF-mediated cell death, significantly reducing pop...
T38093	NT1-O12B NT1-O12B
	NT1-O12B, an endogenous neurotransmitter-derived lipidoid (NT-lipidoid), serves as a highly efficient carrier for enhancing the transportation of various blood-brain barrier (BBB)-impermeable cargos to the brain. Incorporating NT1-O12B into BBB-impermeable lipid nanoparticles (LNPs) enables these LNPs to effectively traverse the BBB. In addition to enabling cargo passage through the BBB, NT-lipidoid formulations facilitate efficient delivery of the cargo into neuronal cells for purposes such as ...
T40340	SARS-CoV-2-IN-10
	SARS-CoV-2-IN-10 is a powerful and non-toxic inhibitor of SARS-CoV-2 3CL protease, with IC50 and EC50 values of 0.13 nM and 1.03 nM, respectively. The SARS-CoV-2 3C-like protease (3CLpro) is a critical enzyme for viral replication and serves as an ideal target for intervention. By targeting the SARS-CoV-2 3CL protease, SARS-CoV-2-IN-10 has the potential to facilitate the development of effective antiviral drugs specific to SARS-CoV-2.
T35456	(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane
	(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane (BMC) is a cyclohexane with two mercaptoacetamido groups. It is used, both in vitro and in vivo, to promote the correct folding of proteins that require disulfide bonds for functionality. For in vitro applications, BMC may be used to facilitate protein refolding of solubilized proteins from inclusion bodies. Reducing agents, like dithiothreitol, may interfere with refolding. BMC may also be added to the growth medium of cells, including yeast cel...
T81106	SRC-1 (686-700)
	SRC-1 (686-700) 是一种含有第二个 LXXLL 基序的生物活性肽，构成自类固醇受体共激活剂 (SRC1) NR 盒 II 的氨基酸 686 至 700 片段。这种共激活蛋白能够以配体依赖的方式与核受体发生相互作用，并增强转录活性。
T78305	Briquilimab JSP-191
	Briquilimab (JSP-191) 是针对 CD117 (c-Kit) 的无毒人源化单克隆抗体，用于消耗造血干细胞 (HSC)。它被应用于重度联合免疫缺陷 (SCID) 治疗中，以清空宿主骨髓生态位，为供体造血干细胞移植及免疫重建创造条件。
T38153	NF-κB Inhibitor (trifluoroacetate salt)
	NF-κB inhibitor is a synthetic peptide corresponding to the nuclear localization sequence of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells.1It blocks the nuclear import of p105 in cells treated with activators of NF-κB signaling, including LPS and TNF-α.1In this way, NF-κB inhibitor blocks gene expression that is regulated by NF-κB.2,3This peptide is commonly used to evaluate the role of NF-κB signaling in cellular responses.4,5
T76007	RGD peptide (GRGDNP) (TFA)
	RGD peptide (GRGDNP) TFA 作为整合素-配体之间相互作用的竞争性抑制剂，阻碍α5β1与细胞外基质(ECM)的结合，并通过激活增强pro-caspase-3的自我加工和构象变化来促进细胞凋亡。该化合物在细胞粘附、迁移、生长和分化等过程中扮演着关键角色。
T37559	NF-κB Control
	NF-κB inhibitor is a synthetic peptide corresponding to the nuclear localization sequence (NLS) of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells. It blocks the nuclear import of p105 in cells treated with activators of NF-κB signaling, including LPS and TNF-α. NF-κB control is a peptide that is identical in sequence to NF-κB inhibitor, except two essential, basic residues of the p105 NLS are substituted with non-basic amino acids...
T76123	Carboxylesterase
	Carboxylesterase (CESs), 即羧酸酯水解酶，广泛分布于自然界，常见于哺乳动物肝脏，常用于生化研究。Carboxylesterase 催化多种内源和外源底物的水解，包括酯、硫酯、氨基甲酸酯和酰胺，使羧酸酯水解成相应的醇和羧酸。
T35567	BIX01294 (hydrochloride hydrate)
	The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development. BIX01294 (hydrochloride hydrate) is a selective inhibitor of G9a HMTase (IC50 = 1.7 μM). It less effectively inhibits the HMTase G9a-like protein (GLP; IC50 = 38 μM) and has no effect on other ...
T36368	2H-Cho-Arg (trifluoroacetate salt)
	2H-Cho-Arg is a steroid-based cationic lipid that contains a 2H-cholesterol skeleton coupled to an L-arginine head group and can be used to facilitate gene transfection. It forms a complex with plasmid DNA (pDNA) and decreases pDNA migration in an electrophoretic mobility shift assay at +/- charge ratios of 4 or higher. 2H-Cho-Arg facilitates transfection of a luciferase gene into H1299 cells, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin and t...
T73809	UDP-GalNAc disodium
	UDP-GalNAc (UDP-N-acetyl-D-galactosamine) disodium 是一种糖核苷酸，同时为EpsC115底物，其中EpsC115为exopolymeric substance (EPS) N端残基1-115缺失的突变体。此化合物充当多种N-乙酰半乳糖胺基转移酶的供体底物，这些酶专门负责将GalNAc从核苷酸糖转移至特定的糖或肽受体上。
T78024	Selcopintide acetate Cpne7-DP acetate
	Selcopintide acetate (Cpne7-DP) 是一种合成肽，其结构基于hCPNE7蛋白的10个氨基酸残基344-353片段。该化合物通过上调成牙本质细胞标记基因DSPP和巢蛋白，高度复现了CPNE7在体外的作用。Selcopintide acetate能够促进牙本质再生，对不同程度的牙本质缺损有治疗效果，再生的硬组织具有真牙本质的特性。
T83813	8-Azidoadenosine-5'-O-diphosphate sodium 8-azido-ADP,Click Tag™ 8-Azidoadenosine-5'-O-diphosphate
	8-Azidoadenosine-5'-O-diphosphate（8-azido-ADP）是ATP前体和嘌呤受体配体ADP的可点击形式。8-azido-ADP的放射性标记形式已被用作各种蛋白质的光亲和标签，包括从牛脑中分离的谷氨酸脱氢酶（GDH）同工酶，以及从兔网织红细胞中分离的真核翻译起始因子2（eIF2）和鸟苷核苷酸交换因子（GEF）。
T82574	DFAME
	DFAME为一种帶有红色荧光的基团（Ex=508 nm，Em=641 nm）。它能与二聚体荧光RNA适体Beetroot及Corn结合，分别形成Beetroot-DFAME复合体（Kd=460 nM）和Corn-DFAME复合体（Kd=3600 nM）。这两种复合体可应用于细胞内RNA组装体的形成，利用RNA结构的自组装特性研究RNA纳米结构。
T74120	Cy5 maleimide
	Cy5 maleimide 是一种 CY 染料。CY 为花菁 (Cyanine) 的缩写，是由奇数个甲基单位连接的两个氮原子组成的化合物。菁类化合物具有波长长、吸收和发射可调、消光系数高、水溶性好、合成相对简单等特点。CY 系类染料常被用于蛋白，抗体以及小分子化合物的标记，对于蛋白抗体的标记，可以通过简单的混合反应来完成结合，以下我们介绍了蛋白抗体标记的标记方法，具有一定的参考意义。储存方式：避光。

化合物

α-Cyano-4-hydroxycinnamic acid

Cat.No: T7460

Synonym: α-Cyano-4-hydroxycinnamic acid(α-CHCA),2-氰基-4-羟基

Target: Monocarboxylate transporter

Rocuronium bromide

Cat.No: T0156

Synonym: ORG 9426,罗库溴铵,ORG 9426 (Bromide)

Target: AChR

Cat.No: T60485

DBCO-SS-aldehyde

Cat.No: T17811

Target: Others

Cat.No: T25636

Synonym: Laudexium ion,Laudexium cation

Fmoc-NH-pentanoic acid-NHS-SO3Na

Cat.No: T17975

Target: Others

Cat.No: T77934

Target: PROTACs

Laudexium methylsulfate

Cat.No: T25637

Synonym: Laudexium,Laudolissin methosulphate

N-Methyl-N'-(hydroxy-PEG2)-Cy5

Cat.No: T18446

Target: Others

FAK ligand-Linker Conjugate 1

Cat.No: T17943

Target: Others

Cat.No: T31963

Synonym: Glycolipid,Glyco lipid

Thalidomide-O-C3-acid

Cat.No: T39642

Synonym: Thalidomide-O-C3-acid

Cat.No: T80972

Synonym: TMP-NVOC linker-Halo

Arbortristoside A

Cat.No: T68206

Acid-PEG3-C2-Boc

Cat.No: T14101

Target: Others

Boc-C1-PEG3-C4-OH

Cat.No: T17647

Target: Others

Cat.No: T75379

Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH

Cat.No: T17903

Synonym: E3 ligase Ligand-Linker Conjugates 49,Cereblon Ligand-Linker Conjugates 14

Target: Others

Methyltetrazine-PEG4-oxyamine

Cat.No: T18350

Target: Others

C-Reactive Protein (CRP) (201-206)

Cat.No: TP1676

Synonym: C-Reactive Protein (CRP) 201-206

Target: Others

Sp-Guanosine-5'-O-(1-thiotriphosphate) sodium

Cat.No: T83834

Synonym: Sp-GTP-α-S,GTPαS(Sp),GTPαS(A)

Cat.No: T61090

Tri-GalNAc(OAc)3-Perfluorophenyl

Cat.No: T77935

Target: LYTACs

Cat.No: T81576

Synonym: IKVAV sequence,Laminin A-chain fragment

Cat.No: T22036

3x DYKDDDDK Tag

Cat.No: T83343

NUCC-390 dihydrochloride

Cat.No: T63004

Extracellular Death Factor

Cat.No: T36523

Cat.No: T38093

Synonym: NT1-O12B

SARS-CoV-2-IN-10

Cat.No: T40340

(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane

Cat.No: T35456

SRC-1 (686-700)

Cat.No: T81106

Cat.No: T78305

Synonym: JSP-191

NF-κB Inhibitor (trifluoroacetate salt)

Cat.No: T38153

RGD peptide (GRGDNP) (TFA)

Cat.No: T76007

Cat.No: T37559

Carboxylesterase

Cat.No: T76123

BIX01294 (hydrochloride hydrate)

Cat.No: T35567

2H-Cho-Arg (trifluoroacetate salt)

Cat.No: T36368

UDP-GalNAc disodium

Cat.No: T73809

Selcopintide acetate

Cat.No: T78024

Synonym: Cpne7-DP acetate

8-Azidoadenosine-5'-O-diphosphate sodium

Cat.No: T83813

Synonym: 8-azido-ADP,Click Tag™ 8-Azidoadenosine-5'-O-diphosphate

Cat.No: T82574

Cat.No: T74120

Cat. No.	Product Name	Target	Signaling Pathways
TN1529	Coumarin 6 Coumarin VI,香豆素 6	Others	Others
	Coumarin 6 (Coumarin VI) 是一种荧光染料，可作为微粒给药系统中的荧光探针，研究药物给药系统的体内跟踪、细胞摄取和转运机制。
T3931	Isobavachin	Others	Others
	Isobavachin 是一种分离自Psoralea morisiana 中的抗氧化剂，在A 环的8号位置有一个prenyl 基团，具有潜在的促进神经元的分化和其蛋白异戊烯化作用。
T19529	Proteinase	Others	Others
	Proteinase 是一种催化蛋白质分解的酶。它们通过水解作用来裂解蛋白质内的肽键，将蛋白质分解成更小的多肽或单个氨基酸。Proteinase 参与许多生物功能，包括消化进食的蛋白质、旧蛋白质的分解，以及细胞信号传递。它们同时促进新的蛋白质产物的形成
T6S0525	Farrerol	ERK; p38 MAPK; Akt	Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
	Farrerol 是一种杜鹃花的生物活性成分，具有抗氧化、抗肿瘤、抗炎、神经保护和肝保护等多种功能。
T81961	Lacto-N-difucohexaose I LDFH I
	LNDFH I是一种连接子，它能够将含Lewis b糖链的寡糖有效结合形成水不溶性多糖。
T71471	Chrysotobibenzyl
	Chrysotobibenzyl, a bibenzyl found in the stem of Dendrobium pulchellum, may facilitate anoikis--a form of programmed cell death that occurs in anchorage-dependent cells when they detach from the surrounding extracellular matrix (ECM)-- and inhibit the growth of lung cancer cells in anchorage-independent condition. Preliminary data obtained discloses the inhibitory effect on cancer cell metastasis of the isolated compounds and may provide a new approach for cancer drug development.

天然产物

Cat.No: TN1529

Synonym: Coumarin VI,香豆素 6

Target: Others

Cat.No: T3931

Target: Others

Cat.No: T19529

Target: Others

Cat.No: T6S0525

Target: ERK, p38 MAPK, Akt

Lacto-N-difucohexaose I

Cat.No: T81961

Synonym: LDFH I

Chrysotobibenzyl

Cat.No: T71471

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