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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T9043	AS1810722	P450; STAT	JAK/STAT signaling; Metabolism; Stem Cells
	AS1810722 是口服有效的STAT6抑制剂，IC50为 1.9 nM。它是一种稠合双环嘧啶衍生物，对有良好的CYP3A4抑制作用，具有用于过敏性疾病，如哮喘和特应性疾病的研究潜力。
T9962	Mepolizumab 美泊利单抗,SB 240563	IL Receptor	Immunology/Inflammation
	Mepolizumab (SB 240563) 是一种中和 IL-5 的人源化单克隆抗体。美泊利单抗可用于严重嗜酸性哮喘和嗜酸性肉芽肿伴多血管炎的研究。
T4657	WHI-P97 4-(3',5'-二溴-4-羟基苯基)氨基-6,7-二甲氧基喹唑啉	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	WHI-P97 是一种选择性 JAK-3抑制剂，可用于预防过敏性哮喘的研究。
T25465	GS143 GS-143,GS 143	IκB/IKK; E1/E2/E3 Enzyme; NF-κB	NF-κB; Ubiquitination
	GS-143 是选择性的IκBα泛素化抑制剂，抑制 SCFβTrCP1介导的IκBα泛素化作用，IC50=5.2 μM。GS143 抑制NF-κB 的活化和靶基因的转录，并且不抑制蛋白酶体的特性，并具有抗哮喘作用。
T9239	RS-25344	PDE	Metabolism
	RS-25344 是一种有效的选择性磷酸二酯酶 (PDE) 4 抑制剂。它在体外抑制嗜酸性粒细胞趋化性并增加精子的进行性运动。
T9416	Dansylglycine	Others	Others
	Dansylglycine 是一种荧光探针，用于特异性测定髓过氧化物酶和嗜酸性粒细胞过氧化物酶的卤化活性。
T9084	Cetirizine Impurity B dihydrochloride De(carboxymethoxy) Cetirizine Acetic Acid Dihydrochloride,西替利嗪杂质B二盐酸盐,西替利嗪杂质04	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Cetirizine Impurity B dihydrochloride (De(carboxymethoxy) Cetirizine Acetic Acid Dihydrochloride) 是 Cetirizine dihydrochloride 的杂质。Cetirizine 是一种抗组胺剂，是口服有活力的、特异性 H1受体拮抗剂。它能够抑制过敏反应期间嗜酸性粒细胞趋化，可以标记抗过敏特性。
T20752	Biebrich scarlet NSC-79710,NSC79710,NSC 79710
	Biebrich scarlet is a scarlet dye, it has been used in Masson’s trichrome stain for the staining of collagen. It has also been used for the staining of eosinophil.
T28221	NVP-QAV-680 NVP-QAV680,QAV690 free acid,NVP,QAV-690 free acid,NVPQAV680,QAV 690 free acid
	NVP-QAV-680 is a potent and selective antagonist of CRTh2 receptor. NVP-QAV-680 has nM functional potency for inhibition of CRTh2 driven human eosinophil and Th2 lymphocyte activation in vitro.
T27638	Israpafant Y-24180,Y 24180,Y24180
	Israpafant is a selective antagonist for the platelet-activating factor receptor ( IC50 = 0.84nM). Israpafant inhibits PAF-induced human platelet aggregation. Israpafant inhibits the activation of eosinophil cells and consequently delays the development o
T40430	Cetirizine Impurity D
	Cetirizine Impurity D is an impurity of Cetirizine. Cetirizine is a second-generation antihistamine that acts as a specific, orally active, and long-acting antagonist of the histamine H1-receptor. Cetirizine exhibits antiallergic properties and inhibits eosinophil chemotaxis in response to allergies.
T37156	8(S),15(S)-DiHETE
	8(S),15(S)-DiHETE is formed when 15(S)-HETE is subjected to further oxidation by 15-LO. It causes eosinophil chemotaxis with an ED50 value of 1.5 μM but is not chemotactic for neutrophils. 8(S),15(S)-DiHETE antagonizes the hyperalgesic activity of 8(R),15(S)-DiHETE and LTB4 in the rat hind paw pain model.
TP2008	Lyn peptide inhibitor
	Cell-permeable inhibitor of Lyn-dependent effects of the IL-5 receptor. Blocks binding of Lyn tyrosine kinase to βc subunit of IL-3/GM-CSF/IL-5 receptors, blocking Lyn activation. Inhibits IL-5 receptor-mediated eosinophil differentiation and survival in
T79185	STAT6-IN-2	STAT	JAK/STAT signaling; Stem Cells
	STAT6-IN-2 (Comp R-84) 是STAT6的一种抑制剂，能够抑制嗜酸粒细胞趋化因子-3的分泌，常用于免疫疾病研究。
T71329	Theophylline-d6
	Theophylline-d6 is intended for use as an internal standard for the quantification of theophylline by GC- or LC-MS. Theophylline is an inhibitor of phosphodiesterase. It is also an adenosine A1 and A2 receptor antagonist. Theophylline induces relaxation of isolated cat bronchial smooth muscle segments precontracted with acetylcholine. It inhibits ovalbumin-induced increases in bronchoalveolar lavage fluid (BALF) eosinophil infiltration in an ovalbumin-sensitized mouse model of allergic asthma. F...
T37264	15(R)-15-methyl Prostaglandin D2 15(R)15methyl PGD2	GPR	Endocrinology/Hormones; GPCR/G Protein
	15(R)-15-methyl Prostaglandin D2 (15(R)15methyl PGD2) 是一种 PGD2 合成类似物，也是一种具有选择性和强效性的 CRTH2/DP2 受体激动剂，可调节嗜酸性粒细胞 CD11b 表达、肌动蛋白聚合和趋化。
T79618	M3/PDE4 modulator-1
	M3/PDE4 modulator-1 (10f) 为多功能化合物，具备M3mAChR拮抗和PDE4抑制作用。于OVA大鼠模型中，M3/PDE4 modulator-1 (10-1000 nM/kg；iv) 能降低半胱氨酸嗜酸性粒细胞内流。
T80599	Dectrekumab QAX576
	Dectrekumab (QAX576) 是针对IL-13的人源化单克隆抗体。它能显著降低嗜酸性粒细胞性食管炎 (EoE) 患者上皮内的嗜酸性粒细胞数量，并改善食管疾病相关的转录失调情况，适用于免疫炎症研究。
T23154	Piclamilast RPR 73401,RP 73401,吡拉米司特	PDE	Metabolism
	Piclamilast (RP 73401) 是一种有效的磷酸二酯酶 4(PDE4)的抑制剂，对猪主动脉和可溶性嗜酸性粒细胞中的 IC50值分别为 16 nM 和 2 nM。
T36764	PAF C-18:1
	PAF C-18:1 is a naturally occurring phospholipid produced by cells upon stimulation and plays a role in the establishment and maintenance of the inflammatory response. It is less potent than PAF C-16 and PAF C-18 in the induction of neutrophil chemotaxis, but is equipotent to PAF C-16 and PAF C-18 in promoting eosinophil migration. PAF C-18:1 activates the PAF receptor and has been used in antibody binding experiments to determine the importance of an acyl linkage at the sn-2 position for recogn...
T38350	TAS 205
	TAS 205 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS; IC50= 55.8 nM).1It is selective for H-PGDS over lipocalin-type PGDS (L-PGDS) at 100 μM, as well as over enzyme and receptor panels at 10 μM. TAS 205 inhibits production of prostaglandin D2induced by A23187 in KU812 human and RBL-2H3 rat basophils with IC50values of 78.3 and 181.3 nM, respectively. It inhibits ovalbumin-induced nasal lavage fluid eosinophil infiltration and late-phase nasal obstruction in an ovalbumin-sens...
T80959	Trabikibart CSL311
	Trabikibart（CSL311）为βc特异性的全人源单克隆抗体，专一性结合人βc受体的细胞因子结合位点表位，并展现高皮摩尔级别的结合亲和力。此抗体能有效抑制IL-3、GM-CSF和IL-5在嗜酸性粒细胞存活中的协同作用，显示出治疗慢性炎症性疾病的应用潜力。
T72145	Montelukast dicyclohexylamine MK0476 dicyclohexylamine
	Montelukast (MK0476) dicyclohexylamine 是一种有效、选择性且具口服活性的半胱氨酸白三烯受体1 (CysLT1) 拮抗剂，用于哮喘和肝损伤预防研究。它在肠缺血-再灌注损伤中展现抗氧化作用，减轻心脏损伤，并降低嗜酸性粒细胞对哮喘气道的浸润。此外，亦被用于COVID-19的研究。
T69262	ABE171
	ABE171, also known as NVP-ABE171, is a potent and novel phosphodiesterase 4 inhibitor with anti-inflammatory activities. NVP-ABE171 inhibited the activity of phosphodiesterase 4A, 4B, 4C, and 4D with respective IC(50) values of 602, 34, 1230, and 1.5 nM. In human cells, NVP-ABE171 inhibited the eosinophil and neutrophil oxidative burst, the release of cytokines by T cells, and the tumor necrosis factor-alpha release from monocytes, in the nanomolar range. NVP-ABE171 inhibited the airway neutrop...
T38365	CAY10597
	The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. In humans, CRTH2/DP2 is expressed on Th2 cells, eosinophils, and basophils where it mediates the chemotactic activity of PGD2. CAY10597, as a racemic mixture, is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki value of 37 nM. The R enantiomer is slightly more potent exhibiting Ki values of 23 and 22 nM at the...
T38100	Betamethasone 21-phosphate (sodium salt hydrate)
	Betamethasone 21-phosphate is a synthetic glucocorticoid.1It prevents increases in macrophage and eosinophil numbers in bronchoalveolar lavage fluid (BALF) and decreases in blood leukocyte numbers in a guinea pig model of parainfluenza-3 viral infection when administered at a dose of 8 mg/kg but does not prevent airway hyperresponsiveness after infection.2Betamethasone 21-phosphate inhibits cell infiltration into the aqueous humor in a rat model of endotoxin-induced uveitis when administered top...

化合物

Cat.No: T9043

Target: P450, STAT

Cat.No: T9962

Synonym: 美泊利单抗,SB 240563

Target: IL Receptor

Cat.No: T4657

Synonym: 4-(3',5'-二溴-4-羟基苯基)氨基-6,7-二甲氧基喹唑啉

Target: JAK

Cat.No: T25465

Synonym: GS-143,GS 143

Target: IκB/IKK, E1/E2/E3 Enzyme, NF-κB

Cat.No: T9239

Target: PDE

Cat.No: T9416

Target: Others

Cetirizine Impurity B dihydrochloride

Cat.No: T9084

Synonym: De(carboxymethoxy) Cetirizine Acetic Acid Dihydrochloride,西替利嗪杂质B二盐酸盐,西替利嗪杂质04

Target: Histamine Receptor

Biebrich scarlet

Cat.No: T20752

Synonym: NSC-79710,NSC79710,NSC 79710

Cat.No: T28221

Synonym: NVP-QAV680,QAV690 free acid,NVP,QAV-690 free acid,NVPQAV680,QAV 690 free acid

Cat.No: T27638

Synonym: Y-24180,Y 24180,Y24180

Cetirizine Impurity D

Cat.No: T40430

8(S),15(S)-DiHETE

Cat.No: T37156

Lyn peptide inhibitor

Cat.No: TP2008

Cat.No: T79185

Target: STAT

Theophylline-d6

Cat.No: T71329

15(R)-15-methyl Prostaglandin D2

Cat.No: T37264

Synonym: 15(R)15methyl PGD2

Target: GPR

M3/PDE4 modulator-1

Cat.No: T79618

Cat.No: T80599

Synonym: QAX576

Cat.No: T23154

Synonym: RPR 73401,RP 73401,吡拉米司特

Target: PDE

Cat.No: T36764

Cat.No: T38350

Cat.No: T80959

Synonym: CSL311

Montelukast dicyclohexylamine

Cat.No: T72145

Synonym: MK0476 dicyclohexylamine

Cat.No: T69262

Cat.No: T38365

Betamethasone 21-phosphate (sodium salt hydrate)

Cat.No: T38100

Cat. No.	Product Name	Target	Signaling Pathways
TN5079	Sulochrin	HCV Protease; Antifection	Microbiology/Virology; Proteases/Proteasome
	Sulochrin shows antifungal and antibacterial activities, it can inhibit hepatitis C virus (HCV) infection in a dose-dependent manner without any apparent cytotoxicity up to 50 uM. Sulochrin has an inhibitory activity to eosinophil degranulation.

天然产物

Cat.No: TN5079

Target: HCV Protease, Antifection

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