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Cat. No.	Product Name	Target	Signaling Pathways
T27837	Linzagolix	GNRH Receptor	GPCR/G Protein
	Linzagolix 是一种口服有活性的非多肽GnRH 拮抗剂。可用于研究子宫肌瘤、子宫腺肌症、子宫内膜异位症。
T2577	Dienogest 地诺孕素,STS 557	Apoptosis; Estrogen/progestogen Receptor; Progesterone Receptor; Autophagy	Apoptosis; Autophagy; Endocrinology/Hormones; Others
	Dienogest (STS 557) 是一种孕酮受体激动剂，作用于子宫内膜异位，有口服的子宫内膜活性。
T3630	Relugolix RVT-601,瑞卢戈利,TAK-385	GNRH Receptor	GPCR/G Protein
	Relugolix (RVT-601) 是口服有活性的非肽性促性腺激素释放激素的拮抗剂。同 TAK-013 相比，它对人和猴子的受体具有高亲和力和强拮抗活性，它们的 IC50值分别为0.33 nM 和0.32 nM。它可用于研究性激素依赖性疾病，如子宫肌瘤、子宫内膜异位症、前列腺癌等。
T21308	Histrelin Supprelin LA,组氨瑞林,Histrelin Acetate	Others	Others
	Histrelin (Supprelin LA) 是促性腺激素释放激素 (GnRH) 的九肽类似物，具有增加的效力。它被认为是 GnRH 激动剂。 Histrelin 用于治疗对激素敏感的男性前列腺癌和女性子宫肌瘤。
T27267	ENMD-1068 HCl ENMD-1068 HCl,ENMD 1068,ENMD-1068,ENMD1068,ENMD-1068 hydrochloride	Protease-activated Receptor	GPCR/G Protein
	ENMD-1068 HCl (ENMD 1068) 是一种选择性蛋白酶激活受体（PAR-2）拮抗剂，具有抗血管生成和抗炎活性。
T28362	PF-02413873 PF02413873	Progesterone Receptor	Others
	PF-02413873 是一种非甾体孕酮受体的竞争性拮抗剂，Ki 为 2.6 nM。 PF-02413873 可用于治疗子宫内膜异位症等妇科疾病的研究。
T25742	Linzagolix choline	GNRH Receptor	GPCR/G Protein
	Linzagolix choline 是一种可口服的非肽类的促性腺激素释放激素（GnRH）拮抗剂。可用于研究子宫肌瘤和子宫内膜异位症相关疼痛。
T1514	Norethindrone Norethisterone,炔诺酮	Estrogen/progestogen Receptor; Progesterone Receptor	Endocrinology/Hormones; Others
	Norethindrone (Norethisterone) 是孕激素，能够用于子宫内膜异位症、由激素水平异常引起的子宫出血和继发性闭经的研究。
T40598	Norethindrone acetate 19-Norethindroneacetate	Estrogen Receptor/ERR; Progesterone Receptor	Endocrinology/Hormones; Others
	Norethindrone acetate (19-Norethindroneacetate) 是一种雌性激素，对青少年月经和肝腺瘤有抑制作用，常与孕激素联合使用，可用于研究子宫内膜异位症。
T32684	Leuprolide (1-3) Leuprorelin
	Leuprolide (1-3) is a manufactured version of a hormone used to treat prostate cancer, breast cancer, endometriosis, uterine fibroids, and early puberty.
T37003	GnRH antagonist 2
	GnRH antagonist 2 (formula I) is a potent GnRH receptor antagonist with valuable applications in endometriosis research[1].
T62237	Steroid sulfatase-IN-4
	Steroid sulfatase-IN-4 (Compound 16) 是一种类固醇硫酸酯酶 (STS) 的不可逆抑制剂，能够作用于人 STS (IC50: 25 nM)。Steroid sulfatase-IN-4 能够用于研究子宫内膜异位。
T0171	Norethynodrel Lynestrol,异炔诺酮	Estrogen/progestogen Receptor	Endocrinology/Hormones
	Norethynodrel (Lynestrol) 是一种合成的孕激素，其作用和用途类似于孕酮。它已被用于治疗功能性子宫出血和子宫内膜异位症。它作为避孕药，通常与 MESTRANOL 联合使用。
T69492	Ozarelix
	Ozarelix is a fourth generation GnRH antagonist, induces apoptosis in hormone refractory androgen receptor negative prostate cancer cells modulating expression and activity of death receptors. Mechanistically, LHRH antagonists exert rapid inhibition of luteinizing hormone and follicle stimulating hormone with an accompanying rapid decrease in sex hormones and would therefore be expected to be effective in a variety of hormonally dependent disease states including ovarian cancer, prostate cancer,...
T81092	Steroid sulfatase/17β-HSD1-IN-5
	Steroid sulfatase/17β-HSD1-IN-5 是一种不可逆抑制剂，针对类固醇硫酸酯酶(STS)，同时也是17β-羟甾类固醇脱氢酶1型(17β-HSD1)的可逆且选择性抑制剂，表现出对17β-HSD1的IC50为43 nM，对17β-HDS1为6.2 μM。该化合物主要用于研究代谢性疾病，特别是子宫内膜异位症。
T71149	Triptorelin pamoate
	Triptorelin, a decapeptide (pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2), is a gonadotropin-releasing hormone agonist (GnRH agonist) used as the acetate or pamoate salts. By causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Like other GnRH agonists, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, es...
T62236	Steroid sulfatase/17β-HSD1-IN-3
	Steroid sulfatase/17β-HSD1-IN-3 (compound 19) 是一种双重的类固醇硫酸酯酶 (STS) 和 17β-羟基类固醇脱氢酶 1 型 (17β HSD1) 抑制剂。Steroid sulfatase/17β-HSD1-IN-3 对 hSTS 的活性具有不可逆的抑制作用 (IC50: 27 nM)。Steroid sulfatase/17β-HSD1-IN-3 能够用于研究子宫内膜异位症及其他雌激素依赖性疾病。
T61979	Steroid sulfatase/17β-HSD1-IN-4
	Steroid sulfatase/17β-HSD1-IN-4 (compound 37) 是一种类固醇硫酸酯酶 (STS) 和 17β-羟基类固醇脱氢酶 1 型 (17β HSD1) 双重抑制剂。Steroid sulfatase/17β-HSD1-IN-4 对 hSTS 的活性抑制作用不可逆，IC50为 63 nM。Steroid sulfatase/17β-HSD1-IN-4 在子宫内膜异位症及其他雌激素依赖性疾病方面有研究价值。
T60854	ENMD-1068 hydrochloride
	ENMD-1068 hydrochloride 是一种选择性的蛋白酶激活受体 2 (PAR2) 拮抗剂。ENMD-1068 hydrochloride 可通过抑制TGF-β1/Smad 信号转导而减少肝星状细胞的活化和胶原蛋白的表达。ENMD-1068 hydrochloride 还能抑制子宫内膜细胞的增殖，并诱导病灶中上皮细胞的凋亡。ENMD-1068 hydrochloride 可用于子宫内膜异位症、肝纤维化的研究。
T68525	Nafarelin acetate hydrate
	Nafarelin is a gonadotropin-releasing hormone agonist (GnRH agonist) which acts as an analog of GnRH. Nafarelin increases the release of FSH and LH by the anterior pituitary, which in turn leads to an increase of estrogen/progesterone. When administered, Nafarelin has the purpose of causing increase estrogen that will negatively feed back upon hypothalamus to decrease GnRH ( negative feedback loop ) Through negative feedback, Nafarelin causes a decrease in pituitary secretion of gonadotropins lu...

化合物

Cat.No: T27837

Target: GNRH Receptor

Cat.No: T2577

Synonym: 地诺孕素,STS 557

Target: Apoptosis, Estrogen/progestogen Receptor, Progesterone Receptor, Autophagy

Cat.No: T3630

Synonym: RVT-601,瑞卢戈利,TAK-385

Target: GNRH Receptor

Cat.No: T21308

Synonym: Supprelin LA,组氨瑞林,Histrelin Acetate

Target: Others

Cat.No: T27267

Synonym: ENMD-1068 HCl,ENMD 1068,ENMD-1068,ENMD1068,ENMD-1068 hydrochloride

Target: Protease-activated Receptor

Cat.No: T28362

Synonym: PF02413873

Target: Progesterone Receptor

Linzagolix choline

Cat.No: T25742

Target: GNRH Receptor

Cat.No: T1514

Synonym: Norethisterone,炔诺酮

Target: Estrogen/progestogen Receptor, Progesterone Receptor

Norethindrone acetate

Cat.No: T40598

Synonym: 19-Norethindroneacetate

Target: Estrogen Receptor/ERR, Progesterone Receptor

Leuprolide (1-3)

Cat.No: T32684

Synonym: Leuprorelin

GnRH antagonist 2

Cat.No: T37003

Steroid sulfatase-IN-4

Cat.No: T62237

Cat.No: T0171

Synonym: Lynestrol,异炔诺酮

Target: Estrogen/progestogen Receptor

Cat.No: T69492

Steroid sulfatase/17β-HSD1-IN-5

Cat.No: T81092

Triptorelin pamoate

Cat.No: T71149

Steroid sulfatase/17β-HSD1-IN-3

Cat.No: T62236

Steroid sulfatase/17β-HSD1-IN-4

Cat.No: T61979

ENMD-1068 hydrochloride

Cat.No: T60854

Nafarelin acetate hydrate

Cat.No: T68525

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