首页工具

登录

搜索结果

Search Results for " dimeric "

19

抑制剂 & 化合物

12

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T3146	BMS-202 PD1-PDL1 inhibitor 2,PD-1/PD-L1 inhibitor 2	Apoptosis; PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	BMS-202 (PD1-PDL1 inhibitor 2) 是一种非肽类 PD-1/PD-L 复合物抑制剂，其 IC50为 18 nM，KD 为 8 μM。它与 PD-L1 直接结合并阻断人类 PD-1/PD-L 的相互作用，具有抗肿瘤活性。
T37445	Etanercept	TNF	Apoptosis
	Etanercept is a dimeric fusion protein that serves as a competitive TNF inhibitor by binding to TNF. It effectively inhibits the binding of both TNF-α and TNF-β to the TNF receptors on cell surfaces, thereby rendering TNF biologically inactive. Etanercept has demonstrated efficacy in treating rheumatoid arthritis, juvenile idiopathic arthritis, and plaque psoriasis.
T3437	Lys05 Lys01 trihydrochloride	lysosomal autophagy; Autophagy	Autophagy
	Lys05 是一种有效的水溶性溶酶体自噬抑制剂，具有抗肿瘤活性。在 MTT 试验中，对1205Lu、c8161、LN229 和 HT-29细胞系的IC50值分别为3.6、3.8、6 和7.9 μM。
T32413	Kopsoffine
	Kopsoffine is a new dimeric indole alkaloid of pleiomutine type from kopsia offcinalis.
T70688	S 0960
	S 0960 is a dimeric bile acid analogue that acts as a specific inhibitor of the apical sodium-dependent bile salt transporter (ASBT) in the ileum.
T32177	Ioforminol GE-145,GE145,AN 113111,AN113111,AN-113111,GE 145
	Ioforminol, also known as GE-145 and AN-113111, is a new low-osmolar dimeric radiographic contrast agent. GE-145 exhibits similar preclinical properties to other dimeric radiographic contrast media. In addition, the low osmolality enables an iso-osmolar f
T68322	IMP-321
	IMP-321 is a soluble dimeric recombinant form of LAG-3 and first-in-class antigen presenting cell activator.
T61305	LasR-IN-3
	LasR-IN-3, a chemical compound, acts as an inhibitor of LasR in Pseudomonas aeruginosa. It induces structural instability in LasR and causes complete dissociation of its functioning dimeric form [1].
T37817	Terazosin dimer impurity dihydrochloride
	Terazosin dimer impurity dihydrochloride, a dimeric form of Terazosin, is a chemical impurity found in Terazosin. Terazosin itself is a derivative of quinazoline and acts as a competitive and orally active α1-adrenoceptor antagonist[1].
T80972	TNH TMP-NVOC linker-Halo
	TNH为一种二聚体，能够渗透活细胞并招募蛋白质至细胞结构。
T74169	Fluticasone dimer impurity
	Fluticasone dimer impurity，Fluticasone Propionate的一种二聚体杂质，为具有较高受体亲和力和局部活性的皮质类固醇。
T70418	TLN-232
	TLN-232, also known as CAP-232, is a synthetic cyclic heptapeptide with potential antineoplastic activity. Pyruvate kinase (PK) inhibitor TLN-232 targets pyruvate kinase M2 (M2PK), which may disrupt tumor cell anaerobic glycolysis. M2PK is a dimeric isoform of PK and the predominant PK isoform found in tumor cells.
T36201	AZD5582 dihydrochloride AZD 5582 dihydrochloride
	Dimeric Smac mimetic; potent inhibitor of X-linked (XIAP) and cellular (cIAP) inhibitor of apoptosis protein (IC50 values are 15, 15 and 21 nM for XIAP, cIAP1 and cIAP2 respectively). Binds to the BIR3 domain of XIAP to prevent interaction with caspase-9. Causes degradation of cIAP1 and cIAP2 and induces apoptosis in MDA-MB-231 breast cancer cells. Causes tumor regression in MDA-MB-231 xenograft-bearing mice. Hennessy et al (2013) Discovery of a novel class of dimeric Smac mimetics as potent IAP...
T76099	Alcohol dehydrogenase
	Alcohol dehydrogenase 是细胞内的一种二聚蛋白。Alcohol dehydrogenase 是体内消耗酒精的关键酶，在肝脏中表达高，参与环境酒精的解毒机制。
T78328	Efbemalenograstim alfa F 627,Bineuta,Benegrastim
	Efbemalenograstim alfa（F 627）为重组长效二聚体G-CSF，融合了两个人源G-CSF与人免疫球蛋白G2（hIgG2）-Fc片段，并能有效促进白细胞生成。
T76152	Glucose 6-phosphate isomerase
	Glucose 6-phosphate isomeras (GPI) 葡萄糖 6-磷酸异构酶，即磷酸葡萄糖异构酶/磷酸葡萄糖异构酶 (PGI) 或磷酸己糖异构酶 (PHI)，常用于生化研究。Glucose 6-phosphate isomeras 是一种高度保守的糖酵解酶和二聚酶。Glucose 6-phosphate isomeras 催化葡萄糖-6-磷酸异构成果糖-6-磷酸。
T22048	bis(7)-Tacrine
	Bis(7)-tacrine dihydrochloride 衍生自 tacrine ，是一种二聚体乙酰胆碱酯酶 (AChE) 抑制剂，具有治疗阿尔茨海默病的潜力。Bis(7)-tacrine dihydrochloride 通过阻断 NMDA 受体防止谷氨酸诱导的神经元凋亡。Bis(7)-tacrine dihydrochloride 是一种有效的 GABAA 受体拮抗剂。
T82574	DFAME
	DFAME为一种帶有红色荧光的基团（Ex=508 nm，Em=641 nm）。它能与二聚体荧光RNA适体Beetroot及Corn结合，分别形成Beetroot-DFAME复合体（Kd=460 nM）和Corn-DFAME复合体（Kd=3600 nM）。这两种复合体可应用于细胞内RNA组装体的形成，利用RNA结构的自组装特性研究RNA纳米结构。
T37288	Remisporine B
	Remisporine B is a polyketide and derivative of remisporine A that has been found inPenicilliumand has immunosuppressant activity.1,2It inhibits LPS- or concanavalin A-induced proliferation of isolated mouse splenic lymphocytes (IC50s = 30.1 and 32.4 μg/ml, respectively).1 1.Liu, H., Chen, S., Liu, W., et al.Polyketides with immunosuppressive activities from mangrove endophytic fungus Penicillium sp. ZJ-SY2Mar. Drugs14(12)217(2016) 2.Kong, F., and Carter, G.T.Remisporine B, a novel dimeric chrom...

化合物

Cat.No: T3146

Synonym: PD1-PDL1 inhibitor 2,PD-1/PD-L1 inhibitor 2

Target: Apoptosis, PD-1/PD-L1

Cat.No: T37445

Target: TNF

Cat.No: T3437

Synonym: Lys01 trihydrochloride

Target: lysosomal autophagy, Autophagy

Cat.No: T32413

Cat.No: T70688

Cat.No: T32177

Synonym: GE-145,GE145,AN 113111,AN113111,AN-113111,GE 145

Cat.No: T68322

Cat.No: T61305

Terazosin dimer impurity dihydrochloride

Cat.No: T37817

Cat.No: T80972

Synonym: TMP-NVOC linker-Halo

Fluticasone dimer impurity

Cat.No: T74169

Cat.No: T70418

AZD5582 dihydrochloride

Cat.No: T36201

Synonym: AZD 5582 dihydrochloride

Alcohol dehydrogenase

Cat.No: T76099

Efbemalenograstim alfa

Cat.No: T78328

Synonym: F 627,Bineuta,Benegrastim

Glucose 6-phosphate isomerase

Cat.No: T76152

Cat.No: T22048

Cat.No: T82574

Cat.No: T37288

Cat. No.	Product Name	Target	Signaling Pathways
TN3869	Dimeric coniferyl acetate	Others	Others
	Dimeric coniferyl acetate has anti-inflammary activity, it shows strong NO inhibition with IC50 values of 27.1 uM in lipopolysacchalide (LPS)-activated murine macrophage-like J774.1 cells. It exhibits significant inhibitory effects on the nitric oxide pro
T0978	Pantethine LBF disulfide,Pantosin,Pantetina,Bis-pantethine,泛硫乙胺(维生素B5),泛硫乙胺,Pantomin,D-Pantethine	Endogenous Metabolite	Metabolism
	D-Pantethine (Pantomin) 是泛酸的二聚体形式, 是生产辅酶 A 的中间体。D-Pantethine 能够作为膳食补充剂，用于改善血液胆固醇和研究痤疮。
T33162	Maesol
	Maesol is a novel dimeric phenol isolated from seeds of Maesa montana and Maesa indica.
T28415	Picrasidine N Picrasidine-N,PicrasidineN
	Picrasidine N is a naturally occurring dimeric alkaloid and a PPARβ/δ agonist.
T81166	Shizukaol G
	Shizukaol G为一种从Chloranthus japonicus根部分离得到的二聚倍半萜烯。
T82962	Arundanine
	Arundanine是从Arundo donax中分离得到的二聚体生物碱。
T38395	Pyrrole-2-carboxaldehyde
	Pyrrole-2-carboxaldehyde exhibits distinctive vibrational and electronic properties which serve to validate its dimeric state in the solid phase and monomeric state in the solution phase.
T80856	Volucrin
	Volucrin，一种可自兰花lusia volucris中提取的二聚菲衍生物。
T81767	Monbarbatain A
	Monbarbatain A, 一种二聚菲类化合物，可从兰科植物Monomeria barbata中提取。
T83475	1,3,5,6-Tetrahydroxy-8-methylxanthone
	1,3,5,6-四羟基-8-甲基黄酮 (compound 8) 是从海洋真菌青霉属中分离的一种二聚1,4-苯醌衍生物。
T82273	Gochnatiolide A
	Gochnatiolide A是从Ainsliaea henryi中提取的一种二聚倍半萜烯，对肾脏、黑色素瘤、卵巢抵抗和神经胶质瘤细胞系显示出抗增殖活性。
T75638	Himastatin
	Himastatin 是一种具有抗肿瘤活性的抗生素，由S. hygroscopicus sp 菌株产生。Himastatin 是一种二聚环六肽，含有哌嗪酸和一个独特的芳香族中心。

天然产物

Dimeric coniferyl acetate

Cat.No: TN3869

Target: Others

Cat.No: T0978

Synonym: LBF disulfide,Pantosin,Pantetina,Bis-pantethine,泛硫乙胺(维生素B5),泛硫乙胺,Pantomin,D-Pantethine

Target: Endogenous Metabolite

Cat.No: T33162

Cat.No: T28415

Synonym: Picrasidine-N,PicrasidineN

Cat.No: T81166

Cat.No: T82962

Pyrrole-2-carboxaldehyde

Cat.No: T38395

Cat.No: T80856

Cat.No: T81767

1,3,5,6-Tetrahydroxy-8-methylxanthone

Cat.No: T83475

Gochnatiolide A

Cat.No: T82273

Cat.No: T75638

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼