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Search Results for " desaturase "

36

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T81471	Phytoene desaturase-IN-2
	PDS-IN-1为Oryza sativa中八氢番茄红素去饱和酶（OsPDS）的抑制剂，具备除草效能。
T74929	Phytoene desaturase-IN-1
	Phytoene desaturase-IN-1 是高效的PDS抑制剂（Kd: 65.9 μM），通过与Phe301残基形成π-π堆叠效应。该化合物显示出广谱的芽后除草活性，并能在白化病叶片中诱导PDS mRNA水平下降及八氢番茄红素与ROS累积，适用于农业生产。
T2650	MK-8245	Dehydrogenase; Stearoyl-CoA Desaturase (SCD)	Metabolism
	MK8245 是肝靶向的硬脂酰 -CoA 去饱和酶(SCD)抑制剂，对人 SCD1 和鼠 SCD1 的IC50值分别为 1 nM 和 3 nM，具有抗糖尿病和抗血脂异常的作用。
T10525	SCD1 inhibitor-4	Dehydrogenase; Stearoyl-CoA Desaturase (SCD)	Metabolism
	SCD1 inhibitor-4 是一种具有口服活性的 stearoylCoA desaturase-1 抑制剂，可用于研究糖尿病。
T16068	MF-438	Dehydrogenase; Stearoyl-CoA Desaturase (SCD)	Metabolism
	MF-438 是一种口服具有活力的 stearoyl-CoA desaturase 1 抑制剂，其对 rSCD1 的 EC50值为 2.3 nM。
T13356	XEN723	Dehydrogenase; Stearoyl-CoA Desaturase (SCD)	Metabolism
	XEN723 是新型的硬脂酰辅酶 A 去饱和酶的噻唑基咪唑烷酮抑制剂，能够抑制小鼠和 HepG2 细胞的活性，它们的 IC50值分别为 45 和 524 nM。
T6412	CVT-12012	Stearoyl-CoA Desaturase (SCD)	Metabolism
	CVT-12012 是口服具有活性的硬脂酰-CoA 去饱和酶抑制剂，能够抑制大鼠微粒体和人 HEPG2 的活性，它们的IC50值分别为 38 nM，6.1 nM。
T4515	A939572	Dehydrogenase; Stearoyl-CoA Desaturase (SCD)	Metabolism
	A939572 是口服具有活性的硬脂酰 CoA 去饱和酶 1SCD1抑制剂，对mSCD1和hSCD1的IC50分别为 <4 nM 和 37 nM。
T14878	CAY10566	Dehydrogenase; Stearoyl-CoA Desaturase (SCD)	Metabolism
	CAY10566 是选择性的、口服具有活性的硬脂酰辅酶 A 去饱和酶 1 抑制剂，在小鼠和人酶测定中IC50分别为 4.5 和 26 nM。它具有显著的细胞活性，可阻断 HepG2 细胞中饱和长链脂肪酸-CoAs (LCFA-CoAs) 向单不饱和 LCFA-CoAs 的转化。
T9722	YTX-465	Stearoyl-CoA Desaturase (SCD)	Metabolism
	YTX-465 是有效的硬脂酰辅酶 A 去饱和酶 (Ole1/SCD) 抑制剂，抑制 Ole1 和 SCD1的IC50=分别为 0.039 μM 和 30.4 μM。YTX-465在帕金森病和其他突触核蛋白病领域有研究的价值。
T5427	GSK1940029 SCD inhibitor 1	Dehydrogenase; Stearoyl-CoA Desaturase (SCD)	Metabolism
	GSK1940029 (SCD inhibitor 1) 是酰基-辅酶A 去饱和酶 (SCD) 抑制剂。
T12856	SC-26196 ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈	Others	Others
	SC-26196 是一种 Delta6 去饱和酶 (D6D, FADS2) 抑制剂 (在大鼠肝微粒体中，IC50=0.2 µM)，具有口服活性，具有抗炎作用。
T27061	CP-24879 hydrochloride CP-24879 HCl	Others	Others
	CP-24879 hydrochloride (CP-24879 HCl) 是选择性的 delta5D/delta6D 联合抑制剂。它能显著降低肝细胞内脂质积聚和炎症损伤。它在脂肪-1 和 ω-3 处理的肝细胞中表现出优越的抗脂肪变性和抗炎作用，可用于非酒精性脂肪性肝炎的研究。
T1869	PluriSIn 1 4-吡啶羧酸 2-苯基酰肼,NSC 14613,PluriSIn #1,PluriSln 1	Apoptosis; Dehydrogenase; Stearoyl-CoA Desaturase (SCD)	Apoptosis; Metabolism
	PluriSIn 1 (NSC 14613) 是一种酰基-辅酶 A 去饱和酶抑制剂，是一种多能细胞特异性的抑制剂。
T9003	CVT-11127 N-[2-[6-[[(3,4-二氯苯基)甲基]氨基]-2-(4-甲氧基苯基)-3-氧代-3,4-二氢吡啶并[2,3-B]吡嗪-4-基]乙基]乙酰胺	Dehydrogenase	Metabolism
	CVT-11127 是 SCD 抑制剂。它将细胞周期阻滞在 G1/S 期，诱导细胞凋亡。它可用于肺癌的研究。
T21012	Diflufenican M&B 38544,吡氟草胺	Others	Others
	Diflufenican (M&B 38544) 是一种选择性除草剂，用于专门防治某些阔叶杂草。
T20950	MK-8245 analog MK-8245-analog,MK 8245 analog	Others	Others
	MK-8245 analog 是 MK-8245 的类似物，MK-8245 是一种肝脏靶向的硬脂酰辅酶 A 去饱和酶 (SCD) 抑制剂。它可用于治疗血脂异常和糖尿病。
T9859	SW209049	Dehydrogenase	Metabolism
	SW209049 是一种硬脂酰辅酶A 9-去饱和酶抑制剂。 SW209049 对H2122细胞表现出有效的活性，IC50为0.13uM。
T28903	T-3364366 T 3364366,T3364366	Others	Others
	T-3364366 是一种噻吩并嘧啶酮 delta-5 去饱和酶 (Δ5D) 抑制剂，在 HepG2 和 RLN-10 细胞中的 IC50 分别为 1.9 nM 和 2.1 nM。
T60952	Fluridone EL-171	Others	Others
	Fluridone (EL-171) 是一种有效的合成脱落酸 (ABA) 的抑制剂，抑制 AchnFAR 和 TF 基因的表达，减少伯醇的形成。Fluridone 常作为水生除草剂用于控制入侵植物，也被用来控制水螅和欧亚水螅等物种。
T28892	SW208108 SW 208108,SW-208108
	SW208108 is a tumor-specific irreversible inhibitor of stearoyl CoA desaturase (SCD).
T19796	Beflubutamid
	Beflubutamid is an herbicide. It works by inhibiting phytoene-desaturase.
T13054	T-3764518	Dehydrogenase	Metabolism
	T-3764518 is a novel and potent inhibitor of stearoyl coenzyme A desaturase (SCD)(IC50 of 4.7 nM).
T68939	GT11
	GT-11 is an inhibitor of dihydroceramides (DHCer) desaturase activity.
T12863	SCD1 inhibitor-1	Others	Others
	SCD1 inhibitor-1 is a potent and liver-selective inhibitor of stearoyl-CoA desaturase-1 (SCD1).
T71745	XEN103
	XEN103 is a potent and selective Stearoyl-CoA Desaturase-1 inhibitor.
T60308	N'-(2-Fluorophenyl)pyrazine-2-carbohydrazide
	N'-(2-Fluorophenyl)pyrazine-2-carbohydrazide 是Ole1p 去饱和酶抑制剂，也是一种抗真菌剂。
T10167	5-Dehydroepisterol	Others	Others
	5-Dehydroepisterol is an episterol derivative with anti-fungal activities. It can be formed by C-5 sterol desaturase and converted into 24-methylenecholesterol by 7-dehydrocholesterol reductase.
T79262	SSI-4	Stearoyl-CoA Desaturase (SCD)	Metabolism
	SSI-4为SCD1 (硬脂酰辅酶A去饱和酶1) 抑制剂，能够通过11C标记，用于SCD1体内小动物PET/CT成像的配体。
T15043	D5D-IN-326	Others	Others
	D5D-IN-326 is an orally active delta-5 desaturase (D5D) inhibitor (IC50s: 72 and 22 nM for rat and human D5D in enzymic and cell-based assays). It has no effect on D6D or D9D activity. D5D-IN-326 reduces insulin resistance and decreases body weight in die
T35675	SW203668 (trifluoroacetate salt)
	SW203668 is an irreversible inhibitor of stearoyl-CoA desaturase (IC50 = 54 nM). It is selectively cytotoxic to H2122, H460, HCC44, and HCC95 cell lines that express cytochrome P450 (CYP) isoform CYP4F11 over eight other cancer cell lines that lack CYP4F11 in vitro (IC50s = 22-116 and >10,000 nM, respectively) and ectopic expression of CYP4F11 in SW203668-insensitive H1155 cells results in sensitization to SW203668. In vivo, SW203668 reduces tumor growth rate without reducing sebocyte production...
T38278	9(Z),12(Z),15(Z),18(Z),21(Z)-Tetracosapentaenoic Acid
	9(Z),12(Z),15(Z),18(Z),21(Z)-Tetracosapentaenoic acid is an ω-3 very long-chain polyunsaturated fatty acid. It has been used to study the desaturation and elongation of ω-3 polyunsaturated fatty acids. It is elongated to form C26:5 or acted on by δ6 desaturase to form C24:6. 9(Z),12(Z),15(Z),18(Z),21(Z)-Tetracosapentaenoic acid is found at low levels in mouse brain and spleen and levels decrease in the brain and spleen of old and exceptionally old mice.
T35810	C24 dihydro Ceramide (d18:0/24:0) Cer(d18:0/24:0)
	C24 dihydro Ceramide is a sphingolipid that has been found in the stratum corneum of human skin.[1] It is found in higher concentrations in female sebum compared to male sebum.[2] C24 dihydro Ceramide levels positively correlate with cytotoxicity in CCRF-CEM, MOLT-4, COG-LL-317h, and COG-LL-332h T cell acute lymphoblastic leukemia (ALL) cell lines.[4] Levels of C24 dihydro ceramide are increased by 149.49-fold in dihydroceramide desaturase 1 (DEGS1) knockdown UM-SCC-22A human head and neck squam...
T36099	Jacaric Acid
	Jacaric acid is a conjugated polyunsaturated fatty acid first isolated from seeds of Jacaranda plants. Structurally, it is an 18-carbon ω-6 triene isomer of γ-linolenic acid . Jacaric acid induces cell cycle arrest and apoptosis in a variety of cancer cell lines (GI50 = 1-5 μM). It increases the production of reactive oxygen species, and cytotoxicity is abolished by the antioxidant α-tocopherol, suggesting that apoptosis results from oxidative stress. Jacaric acid is metabolized in vivo to conju...
T38844	MK-8245 Trifluoroacetate
	MK-8245 trifluoroacetate is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. IC50 value: 1 nM (hSCD1) Target: SCD1 in vitro: MK-8245, a phenoxy piperidine isoxazole derivative, has been identified as a potent and liver-specific SCD inhibitor. It contains a tetrazole acetic acid moiety, which is the key molecule for OATPs recognition and liver-targeting. MK...
T36887	8(E),10(E),12(Z)-Octadecatrienoic Acid
	8(E),10(E),12(Z)-Octadecatrienoic acid is a conjugated polyunsaturated fatty acid (PUFA) that has been found inC. officinalisseed oil and has anticancer activity.1,2,3It inhibits the growth of Caco-2 cells when used at concentrations ranging from 10 to 50 μM.28(E),10(E),12(Z)-Octadecatrienoic acid (10 μM) induces formation of thiobarbituric acid reactive substances (TBARS) and apoptosis in DLD-1 colorectal adenocarcinoma cells.3It also inhibits prostaglandin biosynthesis in sheep vesicular gland...

化合物

Phytoene desaturase-IN-2

Cat.No: T81471

Phytoene desaturase-IN-1

Cat.No: T74929

Cat.No: T2650

Target: Dehydrogenase, Stearoyl-CoA Desaturase (SCD)

SCD1 inhibitor-4

Cat.No: T10525

Target: Dehydrogenase, Stearoyl-CoA Desaturase (SCD)

Cat.No: T16068

Target: Dehydrogenase, Stearoyl-CoA Desaturase (SCD)

Cat.No: T13356

Target: Dehydrogenase, Stearoyl-CoA Desaturase (SCD)

Cat.No: T6412

Target: Stearoyl-CoA Desaturase (SCD)

Cat.No: T4515

Target: Dehydrogenase, Stearoyl-CoA Desaturase (SCD)

Cat.No: T14878

Target: Dehydrogenase, Stearoyl-CoA Desaturase (SCD)

Cat.No: T9722

Target: Stearoyl-CoA Desaturase (SCD)

Cat.No: T5427

Synonym: SCD inhibitor 1

Target: Dehydrogenase, Stearoyl-CoA Desaturase (SCD)

Cat.No: T12856

Synonym: ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈

Target: Others

CP-24879 hydrochloride

Cat.No: T27061

Synonym: CP-24879 HCl

Target: Others

Cat.No: T1869

Synonym: 4-吡啶羧酸 2-苯基酰肼,NSC 14613,PluriSIn #1,PluriSln 1

Target: Apoptosis, Dehydrogenase, Stearoyl-CoA Desaturase (SCD)

Cat.No: T9003

Synonym: N-[2-[6-[[(3,4-二氯苯基)甲基]氨基]-2-(4-甲氧基苯基)-3-氧代-3,4-二氢吡啶并[2,3-B]吡嗪-4-基]乙基]乙酰胺

Target: Dehydrogenase

Cat.No: T21012

Synonym: M&B 38544,吡氟草胺

Target: Others

Cat.No: T20950

Synonym: MK-8245-analog,MK 8245 analog

Target: Others

Cat.No: T9859

Target: Dehydrogenase

Cat.No: T28903

Synonym: T 3364366,T3364366

Target: Others

Cat.No: T60952

Synonym: EL-171

Target: Others

Cat.No: T28892

Synonym: SW 208108,SW-208108

Cat.No: T19796

Cat.No: T13054

Target: Dehydrogenase

Cat.No: T68939

SCD1 inhibitor-1

Cat.No: T12863

Target: Others

Cat.No: T71745

N'-(2-Fluorophenyl)pyrazine-2-carbohydrazide

Cat.No: T60308

5-Dehydroepisterol

Cat.No: T10167

Target: Others

Cat.No: T79262

Target: Stearoyl-CoA Desaturase (SCD)

Cat.No: T15043

Target: Others

SW203668 (trifluoroacetate salt)

Cat.No: T35675

9(Z),12(Z),15(Z),18(Z),21(Z)-Tetracosapentaenoic Acid

Cat.No: T38278

C24 dihydro Ceramide (d18:0/24:0)

Cat.No: T35810

Synonym: Cer(d18:0/24:0)

Cat.No: T36099

MK-8245 Trifluoroacetate

Cat.No: T38844

8(E),10(E),12(Z)-Octadecatrienoic Acid

Cat.No: T36887

Cat. No.	Product Name	Target	Signaling Pathways
T3341	Elemicin Elemicine,3,4,5-trimethoxyallylbenzene,榄香素	Influenza Virus; 5-HT Receptor; Stearoyl-CoA Desaturase (SCD)	GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience
	Elemicin (Elemicine) 是广泛分布于许多草药和香料中的一种烯基苯。它是芳香族食品中的主要成分之一，具有抗微生物，抗氧化剂和抗病毒活性，有遗传毒性和致癌性。它通过代谢激活抑制硬脂酰辅酶 A 去饱和酶 1。
T2919	Sesamin Fagarol,Fsesamin,芝麻素	Others	Others
	Sesamin (Fsesamin) 是多不饱和脂肪酸生物合成中的选择性delta 5 去饱和酶抑制剂，是在芝麻油中存在丰富的木脂素。它对脑缺血具有有效的神经保护作用。
T4868	gamma-Linolenic acid gamolenic acid,γ-Linolenic acid,γ-亚麻酸	Endogenous Metabolite	Metabolism
	gamma-Linolenic acid (gamolenic acid) 是一种 omega-6 (n-6)，18 碳 (18C-) 多不饱和脂肪酸 (PUFA)，可以从人乳和植物种子油中提取。
T41253	Sterculic acid
	Sterculic acid 是一种硬脂酰辅酶 A 去饱和酶 1 (SCD1) 抑制剂。Sterculic acid 剂量依赖性抑制 delta-9 去饱和酶 (Δ9D) 活性，IC50值为 0.9 μM。

天然产物

Cat.No: T3341

Synonym: Elemicine,3,4,5-trimethoxyallylbenzene,榄香素

Target: Influenza Virus, 5-HT Receptor, Stearoyl-CoA Desaturase (SCD)

Cat.No: T2919

Synonym: Fagarol,Fsesamin,芝麻素

Target: Others

gamma-Linolenic acid

Cat.No: T4868

Synonym: gamolenic acid,γ-Linolenic acid,γ-亚麻酸

Target: Endogenous Metabolite

Cat.No: T41253

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