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Search Results for " cytostatic "

17

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9626	Cycloleucine	NMDAR	Neuroscience
	Cycloleucine 是 NMDA 受体相关甘氨酸受体的拮抗剂，Ki 为 600 μM。Cycloleucine 也是 S-腺苷甲硫氨酸介导的甲基化的竞争性抑制剂，具有抗焦虑和细胞抑制作用。
T27112	Cytembena	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Cytembena 是一种细胞抑制剂，是一种致癌化合物，可之间纤维腺瘤发生的几率。Cytembena 广泛地抑制 DNA 的生物合成。
T13569	Benin Butocine,Butocin	Others	Others
	Benin (Butocine) 是细胞生长抑制剂，可用于研究广义的乳腺癌。
T14871	Carboxyamidotriazole Orotate L-651582 Orotate,CAI Orotate	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Carboxyamidotriazole Orotate (L-651582 Orotate) 是一种可口服的信号转导抑制剂，是Carboxyamidotriazole (CAI) 的乳清酸盐形式。它是一种非电压性钙通道和钙通道介导的信号通路的细胞抑制剂，具有抗癌、抗炎活性和抗血管生成作用。
T35057	Vinformide NS269419,Formyl-leurosine,NSC 269419,NSC-269419
	Vinformide is a potent cytostatic agent.
T14872	Carboxyamidotriazole CAI,L-651582	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Carboxyamidotriazole is a cytostatic inhibitor of non-voltage-operated calcium channels and calcium channel-mediated signaling pathways. It shows anti-inflammatory, anti-tumor, and antiangiogenic effects.
T23697	AL-8417 J1.090.276B,AL8417,(2R)-AL-5898
	AL-8417 is an enzyme inhibitor. It acting as an antioxidant, anti-inflammatory, and cytostatic agent. It also has the ability to suppress vitrectomy-induced posterior lens fiber changes.
T40603	Dihydrochlamydocin
	Dihydrochlamydocin, an inhibitor of histone deacetylases (HDAC), exhibits potent cytostatic activity against mastocytoma cells.
T25043	Alestramustine
	Alestramustine is a cytostatic antineoplastic agent. The drug, via its active metabolites, binds to microtubule-associated proteins and β-tubulin and interferes with microtubule function, thereby suppressing cell division. Due to its estrogen moiety, Ales
T68666	Benfluron Hydrochloride
	Benfluron Hydrochloride is an inhibitor of HIV-1 Rev function which also acts as a cytostatic agent with substantial antiretroviral activity.
T13889	SLLN-15	Others	Others
	SLLN-15 是一个具有口服活性的、选择性的、有效的自噬 (autophagy) 增强剂。SLLN-15 可激活三阴乳腺癌细胞的自噬。
T71063	Tolytoxin
	Tolytoxin is a cytostatic, antifungal macrolide produced by blue-green algae of the genus Scytonema, is a potent, reversible inhibitor of cytokinesis in cultured mammalian cells
T24258	KCG 1 KCG-1,KCG1
	KCG 1 is a keto-C-glycoside drug with antiproliferative and cytotoxic properties on tumor cells. KCG1 was 25-125 times more cytostatic on epithelial cells than on lymphoma.
T69117	Pinafide
	Pinafide is a rodenticide and anti-protozoal agent. Pinafide shows strong cytostatic activity against both HeLa and KB cells and is moderately toxic to both mice and rats. It has been proved active against experimental tumors and shown to be inhibitor of two DNA viruses. Pinafide blocks cell growth by inhibiting DNA and RNA synthesis. It has been shown to bind to double-helical DNA by intercalation. Pinafide inhibited the activity of M. tuberculosis NAD⁺-dependent DNA ligase A at concentrations ...
T36107	YW3-56 YW3-56
	YW3-56 is a potent peptidylarginine deiminase (PAD) inhibitor, with an IC50 of 1-5 μM for PAD4. Compared with Cl-amidine, YW3-56 shows >60-fold increase in cell growth inhibition efficacy (IC50 about 2.5 μM) but only 5-fold increase in PAD4 inhibition (IC sub>50 about 1-5 μM). At 2-4 μM concentrations, YW3-56 displays mainly cytostatic effects by slowing cell division, whereas at higher concentrations, it exerts cytotoxic effects by altering cell morphology and killing cells[1]. [1]. Wang Y, et ...
T75142	Acid Ceramidase-IN-2
	Acid Ceramidase-IN-2（compound 1）是一款针对酸性神经酰胺酶（ceramidase）的抑制剂，显示出抗增殖及细胞活性抑制的潜力。有研究表明，该化合物在前列腺癌细胞中可阻止人酸性神经酰胺酶的过度表达，从而揭示了其潜在的抗肿瘤能力。此外，Acid Ceramidase-IN-2被三种α-酮酰胺：GT85、GT98和GT99在体外有效抑制其水解作用。
T60401	Tezacitabine
	Tezacitabine 是一种抑制细胞生长和细胞毒性的抗代谢物。 Tezacitabine 是一种核苷类似物，具有双重作用机制。 Tezacitabine 不可逆地抑制核糖核苷酸还原酶，并可在复制或修复过程中掺入 DNA，导致 DNA 链终止。 Tezacitabine 在细胞周期的 G1 期和 S 期阻断肿瘤细胞并诱导凋亡细胞死亡。 Tezacitabine 具有治疗白血病和实体瘤的潜力[1][2]。

化合物

Cat.No: T9626

Target: NMDAR

Cat.No: T27112

Target: DNA/RNA Synthesis

Cat.No: T13569

Synonym: Butocine,Butocin

Target: Others

Carboxyamidotriazole Orotate

Cat.No: T14871

Synonym: L-651582 Orotate,CAI Orotate

Target: Calcium Channel

Cat.No: T35057

Synonym: NS269419,Formyl-leurosine,NSC 269419,NSC-269419

Carboxyamidotriazole

Cat.No: T14872

Synonym: CAI,L-651582

Target: Calcium Channel

Cat.No: T23697

Synonym: J1.090.276B,AL8417,(2R)-AL-5898

Dihydrochlamydocin

Cat.No: T40603

Cat.No: T25043

Benfluron Hydrochloride

Cat.No: T68666

Cat.No: T13889

Target: Others

Cat.No: T71063

Cat.No: T24258

Synonym: KCG-1,KCG1

Cat.No: T69117

Cat.No: T36107

Synonym: YW3-56

Acid Ceramidase-IN-2

Cat.No: T75142

Cat.No: T60401

Cat. No.	Product Name	Target	Signaling Pathways
T7032	Eupatorin	Others; P450	Metabolism; Others
	Eupatorin 是天然存在的黄酮，可捕获 G2-M 细胞周期，激活多个 caspase、细胞色素 C 的释放、多聚 (ADP-核糖) 聚合酶的裂解，促使凋亡细胞死亡。
T5S0018	Betulonic acid 路路通酸,(+)-Betulonic acid,Betunolic acid,Liquidambaric acid	Parasite; HSV	Microbiology/Virology
	Betulonic acid (Liquidambaric acid) 是一种在许多植物中存在的三萜类天然产物，具有抗肿瘤，抗炎，抗寄生虫和抗病毒的活性。
TN4944	Santamarine	Caspase	Apoptosis; Proteases/Proteasome
	Santamarine has significant anticancer activity, can inhibit L1210 cells because of its cytotoxic,cytostatic and blocking mitosis and reducing uptake of thymidine. Santamarine and reynosin show bactericidal activity against clinical strains of Mycobacterium tuberculosis.
TMA0478	Loliolid	Others	Others
	Loliolid is a germination inhibitor, and a repellent for ants (Atta cephalotes).It has cytostatic activity against carcnoma and leukaemia cells.
T82636	Cyclosporin U
	Cyclosporin U (SMP0V32C6L)为一种细胞免疫抑制剂，关键用于防止移植器官的排斥反应。
T36430	Pheophorbide a
	Pheophorbide a is a product of chlorophyll breakdown that has been used as a photosensitizer in photodynamic therapy for the treatment of cancer. It has been reported to inhibit U87MG cells with an IC50 value of 2.8 μg/ml and demonstrates cytostatic activity specifically against glioblastoma cells without affecting normal cells. It also displays antiproliferative activity against melanoma, breast, and lung cancer cells in vitro at 100 μg/ml.
T73925	α-D-Glucose-1-phosphate disodium hydrate
	α-D-Glucose-1-phosphate disodium hydrate 为合成葡萄糖醛酸的初始原料之一，同时，在心脏病研究领域，亦被广泛应用作为细胞抑制剂、抗生素、免疫抑制剂与循环系统研究的关键材料。
T36749	Herboxidiene
	Herboxidiene is a polyketide originally isolated from S. chromofuscus that has diverse biological activities.[1],[2,][3],[4],[5] It inhibits growth of HeLa S3, SK-MEL-2, PC3, A549, and EBC-1 cells with GI50 values ranging from 7.4 to 62 nM.3 Herboxidiene is cytostatic against human umbilical vein endothelial cells (HUVECs; (IC50 = 26 nM)) and inhibits VEGF-induced invasion and tube formation of serum-starved HUVECs in a concentration-dependent manner, indicating antiangiogenic activity.[4] Herbo...

天然产物

Cat.No: T7032

Target: Others, P450

Cat.No: T5S0018

Synonym: 路路通酸,(+)-Betulonic acid,Betunolic acid,Liquidambaric acid

Target: Parasite, HSV

Cat.No: TN4944

Target: Caspase

Cat.No: TMA0478

Target: Others

Cat.No: T82636

Cat.No: T36430

α-D-Glucose-1-phosphate disodium hydrate

Cat.No: T73925

Cat.No: T36749

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