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34

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T7545	6-Aminonicotinamide	Others	Others
	6-Aminonicotinamide 是一种竞争性 NADP+依赖性酶，是一种烟酰胺抗代谢药，葡萄糖 6-磷酸脱氢酶抑制剂 (Ki=0.46 μM)。它干扰糖酵解，导致 ATP 耗竭，并与 DNA 交联化学疗法药物，如Cisplatin，协同杀死癌细胞。
T35648	4-Thiouridine	Others	Others
	4-Thiouridine (4-TU) 是一种光活化核糖核苷类似物，广泛用于RNA 分析。
T19958	2-Iminothiolane HCl 2-Iminothiolane,2-亚氨基硫烷盐酸盐,Traut's reagent,Trauts reagent,2-IT	Others	Others
	2-Iminothiolane HCl (Trauts reagent) 可用于将巯基引入衍生自天冬酰胺连接聚糖的寡糖中。
T1616	Cefotiam hydrochloride 盐酸头孢替安,Pansporin,SCE-963 hydrochloride,Pansporine,头孢替安盐酸盐,Cefotiam dihydrochloride,Halospor	Antibacterial; Antibiotic	Microbiology/Virology
	Cefotiam hydrochloride (SCE-963 hydrochloride) 是一种肠外头孢菌素类广谱抗生素，对革兰氏阳性菌和革兰氏阴性菌有活性。
T14061	EMCS 6-Maleimidohexanoic acid N-hydroxysuccinimide ester	Others	Others
	EMCS (6-Maleimidohexanoic acid N-hydroxysuccinimide ester) 是一种异双官能团交联剂，是一种制备半抗原结合物和酶免疫偶联物的化合物，是抗体药物偶联物中一种有效的保护基团。
T4047	Bisantrene CL216942,比生群	Topoisomerase	DNA Damage/DNA Repair
	Bisantrene (CL216942) 是一种具有抗肿瘤活性的蒽基双腙，可靶向作用于真核生物的 II 型拓扑异构酶。它插入并破坏 DNA 的构型，导致 DNA 单链断裂、DNA-蛋白质交联和 DNA 复制的抑制。
T5024	Cefotiam Hexetil Hydrochloride 盐酸头孢替安酯,头孢替安海替酯盐酸盐	Antibacterial; Antibiotic	Microbiology/Virology
	Cefotiam hexetil hydrochloride 是一种可口服头孢菌素，是抗生素 cefotiam 的前药，但无抗菌作用。
T4657	WHI-P97 4-(3',5'-二溴-4-羟基苯基)氨基-6,7-二甲氧基喹唑啉	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	WHI-P97 是一种选择性 JAK-3抑制剂，可用于预防过敏性哮喘的研究。
T38951	Isatuximab SAR-650984,hu38SB19,Isatuximab-irfc	Apoptosis; CD38	Apoptosis; Immunology/Inflammation
	Isatuximab 是一种在血液系统恶性细胞中靶向跨膜受体和胞外酶 CD38 的单克隆抗体，是在多发性骨髓瘤中高度表达的蛋白。Isatuximab 具有抗肿瘤活性、抗体依赖性细胞介导的细胞毒性、补体依赖性细胞毒性、抗体依赖性细胞吞噬作用，可在无交联情况下直接诱导细胞凋亡 (apoptosis)。Isatuximab 对 CD38 胞外酶活性有抑制作用，这与许多细胞功能有关。
T38294	4-Deoxypyridoxine hydrochloride	S1P Receptor	GPCR/G Protein
	4-Deoxypyridoxine hydrochloride 通过抑制 S1P 裂解酶 (SPL) 活性来抑制细胞内 S1P 的降解，与 S1P 一样，减少化学诱导的胰岛素瘤细胞系的细胞凋亡。
T39757	EC2629 EC2629
	EC2629 is a highly potent folate- receptor-targeted DNA crosslinking agent.
T19560	SGD-1882 PBD dimer	Others	Others
	SGD-1882 is a agent of cytotoxic, DNA minor-groove crosslinking pyrrolobenzodiazepine (PBD) dimer, and acting as the payload for ADCs.
T19941	MBS Crosslinker MBS protein crosslinker
	MBS crosslinker is a non-cleavable, water-insoluble, heterobifunctional protein crosslinking reagent. The MBS protein crosslinker extended spacer arm analog is SMPB crosslinker SATA Protein Modifier can be used to add sulfhydryl groups to proteins or pept
T24841	Sulfo-MBS Crosslinker Sulfo-MBS Cross linker,Sulfo-MBS Cross-linker
	Sulfo-MBS Crosslinker is a non-cleavable, water-soluble, heterobifunctional protein crosslinking reagent. It is commonly used to crosslink haptens to carrier proteins and enzymes to antibodies.
T29964	Ametantrone Acetate CI-881
	Ametantrone Acetate is a topoisomerase II inhibitor of anthrapyrazole family, which can lead to DNA covalent crosslinking.
T31584	DST Crosslinker DST Cross linker,DST Cross-linker
	DST crosslinker(disuccinimide tartarate) is an isotype bifunctional, cleavable crosslinker (cleavable by an oxidizer) for applications that require crosslinking cleavability and that do not interfere with protein disulfide bonds with reducing agents.
T19193	Amotosalen hydrochloride S-59	Others	Others
	Amotosalen hydrochloride (S-59) is a light-activated, RNA-, DNA-crosslinking psoralen compound and is used to neutralize pathogens.
T30598	BS2G-d4 Deuterated Crosslinker D4-BS2G,BS2G-d4
	BS2G-d4 or Bis(Sulfosuccinimidyl) 2,2,4,4-glutarate-d4, is a water-soluble and membrane impermeable protein crosslinking agent.
T19942	SBA Crosslinker SBA Cross-linker,SBA Cross linker
	SBA crosslinker is a sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent. SBA protein crosslinker is non-cleavable and is among the shortest amine and sulfhydryl reactive crosslinking reagents known with a spacer arm length of on
T24453	Metamelfalan NSC-67781,Metamelfalanum,NSC67781,NSC 67781,m-L-Sarcolysin
	Metamelfalan is an alkylating nitrogen mustard with potential antineoplastic activity. It causes crosslinking of DNA, thereby preventing DNA replication and eventually cellular proliferation.
T19944	DSSeb Crosslinker DSSeb Cross linker,DSSeb Cross-linker
	DSSeb Crosslinker is a homobifunctional cross-linking reagent. It is useful in protein crosslinking and making antibody-drug conjugates.
T30599	BS3-d4 Deuterated Crosslinker Deuterated Crosslinker BS3-d4,BS3-d4,D4-BS3
	BS3-d4 Deuterated Crosslinker or Bis(Sulfosuccinimidyl) 2,2,7,7-suberate-d4, is a water-soluble and membrane impermeable protein crosslinking agent.
T19943	SMPB Crosslinker SMPB Cross linker,SMPB Cross-linker
	SMPB crosslinker is a heterobifunctional protein crosslinking reagent that is reactive toward sulfhydryl and amino groups. The SMPB protein crosslinker is an extended chain length analog of MBS crosslinker. SMPB crosslinker's spacer arm is non-cleavable.
T61870	(rel)-Oxaliplatin
	(rel)-Oxaliplatin is a DNA synthesis inhibitor that induces DNA crosslinking damage, inhibits DNA replication and transcription, and stimulates apoptosis. This compound has applications in cancer research [1] [2] [3].
T33490	m-PEG12-aldehyde
	m-PEG12-aldehyde is a PEG derivative containing an aldehyde group. Aldehyde is reactive to hydrazide and aminooxy groups which are commonly used in biomolecular probes for labeling and crosslinking carbonyls (oxidized carbohydrates). The hydrophilic PEG s
T16025	SGD-1910 MC-Val-Ala-PBD	Others	Others
	MC-Val-Ala-PBD is a drug-linker conjugate for ADC by using the antitumor antibiotic, pyrrolobenzodiazepine (PBD, a cytotoxic DNA crosslinking), linked via the cleavable linker MC-Val-Ala[1].
T21134	Decane, 1,10-diiodo- Decamethylene diiodide,1,10-Diiododecane
	Decane, 1,10-diiodo- is used as a crosslinking reagent for tetrabutylammonium polygalacturonic acid and as an alkylating agent in the synthesis of symmetrical and unsymmetrical bis-cryptophanes. It is also used to produce decane at temperature of 20°C.
T79196	4-Thiouridine 5′-triphosphate tetralithium 4-Thio-UTP tetralithium	P2Y Receptor	GPCR/G Protein; Neuroscience
	4-Thiouridine 5’-triphosphate (4-Thio-UTP) tetralithium 作为P2Y2和P2Y4受体的高效激动剂，其对hP2Y2的EC50为35 nM，对hP2Y4的EC50为350 nM。该化合物广泛应用于交联实验以及转录复合物标记研究。
T70229	Laromustine
	Laromustine is a sulfonyl hydrazine prodrug with antineoplastic activity. Laromustine releases the DNA chloroethylating agent 90CE after entering the blood stream; 90CE chloroethylates alkylates the 06 position of guanine, resulting in DNA crosslinking, strand breaks, chromosomal aberrations, and disruption of DNA synthesis. Intracellular metabolism of this agent also releases methyl isocyanate which inhibits 06-alkyl-guanine transferase, an enzyme involved with DNA repair.
T79197	4-Thiouridine 5′-triphosphate tetrasodium 4-Thio-UTP tetrasodium	P2Y Receptor	GPCR/G Protein; Neuroscience
	4-Thiouridine 5′-triphosphate (4-Thio-UTP) tetrasodium 作为P2Y2和P2Y4受体的有效激动剂，显示出对hP2Y2的EC50为35 nM，以及对hP2Y4的EC50为350 nM。该化合物适用于交联实验和转录复合物标记研究。
T77238	Fmoc-L-photo-proline
	Fmoc-L-photo-proline为可通过Fmoc固相法纳入合成肽中的光交联氨基酸。该化合物在环状拟肽抗生素合成及肽基光亲和探针研究制备中应用广泛。
T36745	cDPCP
	cDPCP is a platinum-containing DNA-crosslinking agent.1Unlike cisplatin or oxaliplatin , cDPCP forms monofunctional DNA adducts. It is transported into cells by organic cation transporter 1 (OCT1) and OCT2, inhibiting proliferation of MDCK cells expressing the human transporters with IC50values of 8.1 and 1.5 μM, respectively. cDPCP inhibits RNA polymerase II-mediated transcription in a reporter assay using HeLa cells. It increases survival in murine S180 sarcoma and P388 leukemia models when ad...
T12585L	PXS-5153A monohydrochloride PXS-5153A monohydrochloride (2125956-82-1 free base)	Others	Others
	PXS-5153A monohydrochloride 是一种有效的、选择性的、具有口服活性和快速起效的赖氨酰氧化酶 2/3(LOXL2/LOXL3)的双抑制剂，对几乎所有哺乳动物物种 LOXL2的 IC50均< 40 nM，对人类 LOXL3 的 IC50为63 nM。PXS-5153A monohydrochloride 可减少交联并改善纤维化。
T71401	Oxaliplatin-d10
	Oxaliplatin-d10 is intended for use as an internal standard for the quantification of oxaliplatin by GC- or LC-MS. Oxaliplatin is a platinum-containing DNA-crosslinking agent. It induces the formation of DNA inter- and intrastrand crosslinks and DNA-protein adducts, inhibits DNA and RNA synthesis, and induces apoptosis in cancer cells. Oxaliplatin is cytotoxic to cisplatin-sensitive A2780(1A9) and KB-3-1 cells and cisplatin-resistant A2780-E(80) and KB-CP20 cells (IC50s = 0.12, 0.39, 4.7, and 2....

化合物

6-Aminonicotinamide

Cat.No: T7545

Target: Others

Cat.No: T35648

Target: Others

2-Iminothiolane HCl

Cat.No: T19958

Synonym: 2-Iminothiolane,2-亚氨基硫烷盐酸盐,Traut's reagent,Trauts reagent,2-IT

Target: Others

Cefotiam hydrochloride

Cat.No: T1616

Synonym: 盐酸头孢替安,Pansporin,SCE-963 hydrochloride,Pansporine,头孢替安盐酸盐,Cefotiam dihydrochloride,Halospor

Target: Antibacterial, Antibiotic

Cat.No: T14061

Synonym: 6-Maleimidohexanoic acid N-hydroxysuccinimide ester

Target: Others

Cat.No: T4047

Synonym: CL216942,比生群

Target: Topoisomerase

Cefotiam Hexetil Hydrochloride

Cat.No: T5024

Synonym: 盐酸头孢替安酯,头孢替安海替酯盐酸盐

Target: Antibacterial, Antibiotic

Cat.No: T4657

Synonym: 4-(3',5'-二溴-4-羟基苯基)氨基-6,7-二甲氧基喹唑啉

Target: JAK

Cat.No: T38951

Synonym: SAR-650984,hu38SB19,Isatuximab-irfc

Target: Apoptosis, CD38

4-Deoxypyridoxine hydrochloride

Cat.No: T38294

Target: S1P Receptor

Cat.No: T39757

Synonym: EC2629

Cat.No: T19560

Synonym: PBD dimer

Target: Others

MBS Crosslinker

Cat.No: T19941

Synonym: MBS protein crosslinker

Sulfo-MBS Crosslinker

Cat.No: T24841

Synonym: Sulfo-MBS Cross linker,Sulfo-MBS Cross-linker

Ametantrone Acetate

Cat.No: T29964

Synonym: CI-881

DST Crosslinker

Cat.No: T31584

Synonym: DST Cross linker,DST Cross-linker

Amotosalen hydrochloride

Cat.No: T19193

Synonym: S-59

Target: Others

BS2G-d4 Deuterated Crosslinker

Cat.No: T30598

Synonym: D4-BS2G,BS2G-d4

SBA Crosslinker

Cat.No: T19942

Synonym: SBA Cross-linker,SBA Cross linker

Cat.No: T24453

Synonym: NSC-67781,Metamelfalanum,NSC67781,NSC 67781,m-L-Sarcolysin

DSSeb Crosslinker

Cat.No: T19944

Synonym: DSSeb Cross linker,DSSeb Cross-linker

BS3-d4 Deuterated Crosslinker

Cat.No: T30599

Synonym: Deuterated Crosslinker BS3-d4,BS3-d4,D4-BS3

SMPB Crosslinker

Cat.No: T19943

Synonym: SMPB Cross linker,SMPB Cross-linker

(rel)-Oxaliplatin

Cat.No: T61870

m-PEG12-aldehyde

Cat.No: T33490

Cat.No: T16025

Synonym: MC-Val-Ala-PBD

Target: Others

Decane, 1,10-diiodo-

Cat.No: T21134

Synonym: Decamethylene diiodide,1,10-Diiododecane

4-Thiouridine 5′-triphosphate tetralithium

Cat.No: T79196

Synonym: 4-Thio-UTP tetralithium

Target: P2Y Receptor

Cat.No: T70229

4-Thiouridine 5′-triphosphate tetrasodium

Cat.No: T79197

Synonym: 4-Thio-UTP tetrasodium

Target: P2Y Receptor

Fmoc-L-photo-proline

Cat.No: T77238

Cat.No: T36745

PXS-5153A monohydrochloride

Cat.No: T12585L

Synonym: PXS-5153A monohydrochloride (2125956-82-1 free base)

Target: Others

Oxaliplatin-d10

Cat.No: T71401

Cat. No.	Product Name	Target	Signaling Pathways
T2210	Genipin 京尼平,(+)-Genipin	Others; Autophagy	Autophagy; Others
	Genipin ((+)-Genipin) 是衍生自黄栀果实的天然交联剂，可抑制细胞中的 UCP2 (解偶联蛋白 2)。它有蛋白质调节、抗肿瘤、抗炎症、免疫抑制、抗血栓形成和对海马神经元保护的多种生物活性，可研究 2 型糖尿病。
T4704	L-Anserine nitrate L-鹅肌肽硝酸盐,L-Anserine nitrate salt	Others; Endogenous Metabolite	Metabolism; Others
	L-Anserine nitrate (L-Anserine nitrate salt) 是一种存在于大多数动物组织中的二肽。在模型系统中，它是一种有效的抗氧化剂和羟基自由基清除剂。该化合物抑制醛糖和酮糖还原糖诱导的非酶蛋白糖基化。

天然产物

Cat.No: T2210

Synonym: 京尼平,(+)-Genipin

Target: Others, Autophagy

L-Anserine nitrate

Cat.No: T4704

Synonym: L-鹅肌肽硝酸盐,L-Anserine nitrate salt

Target: Others, Endogenous Metabolite

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