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34

抑制剂 & 化合物

7

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T20137	Dimethoate Rogor,Phosphamid,Lurgo,L395,乐果,L 395,L-395	Others	Others
	Dimethoate (L-395) 是一种系统性和接触性杀虫剂，用于控制牛蛴螬和农场动物的某些其他害虫。
T4966	Ufenamate 氟芬那酸丁酯,Flufenamic acid butyl ester,Butyl flufenamate,氟灭酸丁酯	Others	Others
	Ufenamate (Flufenamic acid butyl ester) 是一种基于邻氨基苯甲酸的抗炎药。它可用于皮肤疾病研究。
T39280	Nitrofen	Others	Others
	Nitrofen 是选择性接触除草剂，也是视原卟啉原氧化酶和网膜脱氢酶抑制剂。
T20444	Hexyl nicotinate AI3 15769,AI3-15769,烟酸己酯,AI315769	Others	Others
	Hexyl nicotinate (AI3 15769) 是一种皮肤血管扩张剂，可用于研究头皮、面部和背部的非免疫性接触性荨麻疹。
T37071	Pyrimethanil	Antifungal	Microbiology/Virology
	Pyrimethanil 是苯胺嘧啶类广谱接触杀菌剂，用于控制多种作物上的Botrytis spp.。它抑制灰霉病菌中氨基酸的生物合成，可用于霉菌感染的水果、蔬菜和观赏植物真菌病害防治的相关研究。
T20625	Prochloraz 咪鲜胺,Sporgon,Prelude	Estrogen Receptor/ERR; AhR; Androgen Receptor; Antifungal	Endocrinology/Hormones; Immunology/Inflammation; Metabolism; Microbiology/Virology
	Prochloraz (Prelude) 是咪唑类抗真菌剂。Prochloraz 抑制羊毛甾醇的细胞色素 P450 依赖性 14α-脱甲基作用，由此抑制麦角固醇的生物合成，从而导致真菌细胞膜破裂和细胞死亡。它也是雌激素受体和雄激素受体的拮抗剂，IC50分别为25 μM 和4 μM，并激活芳烃受体，EC50为1μM。
T16240	N,N'-Diacetyl-L-cystine (Ac-Cys-OH)2,DiNAC	Others	Others
	N,N'-Diacetyl-L-cystine (DiNAC) 是一种具有免疫调节特性的 N-乙酰基半胱氨酸的二硫二聚体。它在高脂血症兔中也具有抗动脉粥样硬化的作用。它是啮齿类动物中接触敏感/迟发型超敏反应的有效口服活性调节剂。
T16582	Propanil	Others	Others
	Propanil is a widely used contact herbicide. It is mainly used in rice production.
T30476L	Bisoxatin acetate WY 8138,WY-8138,WY8138,Exodol,Kritel Tropfen
	Bisoxatin acetate is a contact laxative in pearl form.
T24442	Mecrylate
	Mecrylate polymerizes in contact with moisture. It is used as a tissue adhesive. It also has higher homologs have hemostatic and antibacterial properties.
T68493	Umifenovir hydrochloride monohydrate
	Umifenovir hydrochloride monohydrate is an antiviral that inhibits membrane fusion by preventing contact between a virus and target host cells.
T20559	Tetradifon Roztoczol,Roztoczol extra,Roztozol,三氯杀螨砜
	Tetradifon is a contact acaricide.
T20150	C.I. 37505 3-Hydroxy-2-naphthanilide,2-Naphthanilide, 3-hydroxy- (8CI)
	C.I. 37505 is an azo dye coupling component.It implicated in occupational pigmented contact dermatitis.
T71938	MNF
	MNF, also known as 3,4-MNF, is an antagonist of the aryl hydrocarbon receptor (AhR). MNF reduces UVR-mediated immunosuppression and induces Tregs in murine contact hypersensitivity (CHS).
T40833	ω-Hydroxy-DEET
	ω-Hydroxy-DEET, a significant metabolite of the insect repellent N-N-diethyl-meta-toluamide (DEET), exhibits anti-proliferative properties. DEET, renowned for being a spatial repellent and irritant, is frequently employed to deter mosquito contact.
TP1794	p53 (17-26) p53 17-26
	This peptide is amino acids 17 to 26 fragment of p53, the Mdm-2 binding domain of p53 known also as p53N. This sequence contains all of the residues that contact the binding domain of Mdm-2.
T69950	Delgocitinib EtOH
	Delgocitinib, also known as LEO-124249 and JTE052, is a potent and selective JAK inhibitor. JTE-052 reduces skin inflammation and ameliorates chronic dermatitis in rodent models: Comparison with conventional therapeutic agents. JTE-052 regulates contact hypersensitivity by downmodulating T cell activation and differentiation.
T70974	Cipamfylline
	Cipamfylline is a xanthine, a theophylline analogue, and is a potent and selective inhibitor of phosphodiesterase type 4 (PDE-4). Cipamfylline was tested in patients with a diagnosis of atopic dermatitis and in two human models of acute and chronic irritant contact dermatitis. The outcome of the study revealed that cipamfylline was more effective than vehicle in treating atopic dermatitis, but less effective than a group II steroid, hydrocortisone-17-butyrate both in the treatment of atopic derm...
T31671	Erythrityl Tetranitrate Eritrityli tetranitras,Tetranitrato de eritritilo,CHEBI:60072,Tetranitrate d'eritrityle
	Erythrityl Tetranitrate is a vasodilator with general properties similar to nitroglycerin. Like many nitrate esters, ETN acts as a vasodilator, and was the active ingredient in the original "sustained release" tablets, made in the early 50s. Ingesting ETN or prolonged skin contact can lead to absorption and what is known as a "nitro headache".
T31126	CX-659S CX659S,UNII-YG2F04AVMQ,CX 659S
	CX-659S is a novel diaminuracil derivative that indirectly inhibits Langerhans cell function by blocking the MEK1/2 -- ERK1/2 pathway in keratinocytes. CX-659S can inhibit the contact hypersensitivity induced by haptens in mice.
T72391	Clocortolone pivalate
	Clocortolone pivalate是一种合成糖皮质激素和皮质类固醇酯，适用于治疗脂溢性皮炎、接触性皮炎、特应性皮炎及银屑病。
T26827	Bisnorcymserine N1 N8 Bisnorcymserine,N1N8Bisnorcymserine,N1-N8-Bisnorcymserine
	Bisnorcymserine is a reversible inhibitor of butyrylcholinesterase. The leaving group, bisnoreseroline, interacts in a non-covalent way with Ser(200) and His(440), disrupting the existing interactions within the catalytic triad, and it stacks with Trp(84)
T36127	TNF-α Antagonist
	TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor. By blocking the TNF receptor ligand contact site, this peptide interferes with both activating receptor activator of NF-κB (RANK) and TNF-α's recruitment and activation of osteoclasts. TNF-α antagonist has been used to block bone resorption in the study of systemic bone loss in rheumatoid arthritis and inflammatory bone destr...
T37857	9(Z)-Pentacosene
	9(Z)-Pentacosene is a cuticular hydrocarbon and insect sex hormone.1,2,3 It is found in the cuticle of female F. canicularis flies and is an attractant to males in a trap assay.1 9(Z)-Pentacosene is a contact sex hormone in scarab beetles and locust borers that is more abundant in females than males.2,3 It elicits arrestment, alignment, and mounting by males of both species in mating assays but only elicits copulation by the locust borer. 9(Z)-Pentacosene is also produced by the orchid O. exalta...
T31194	Dalapon Basfapon B,Dowpon M,Dawpon-Rae
	Dalapon is a selective herbicide used to control perennial grasses. The major use of dalapon is on food crops including sugarcane and sugar beets. Its use is no longer authorized in France. The National Institute for Occupational Safety and Health in the
T37923	7(Z)-Pentacosene
	7(Z)-Pentacosene is an unsaturated cuticular hydrocarbon that acts as a contact sex pheromone in fruit flies. In different species and genotypes of Drosophila, it can be found on both males and females. Pentacosene may stimulate copulation either by itself at high concentrations or when combined with other alkenes. Interestingly, the absolute level of pentacosene increases in Drosophila females immediately after copulation.
T33914	Pentaerythrityl tetracaprate Pentaerythritol tetradecanoate,Pentaerythritol tetracaprate
	Pentaerythrityl tetracaprate is an ester found in cosmetics and beauty products because of its binding and moisturizing properties; it is also used as a viscosity increasing agent. It is a synthetic compound derived from fatty acids, according to research
T37963	Methylchloroisothiazolinone/Methylisothiazolinone Mixture
	Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) is a mixture of isothiazolinone-derived biocides.1,2It is effective against Gram-positive and Gram-negative bacteria with MIC values of 0.0002, 0.0002, 0.00005, and 0.00005% (w/w) forS. aureus,P. aeruginosa,A. niger, andC. albicans, respectively.2MCIT/MIT can elicit contact sensitization.3Formulations containing MCIT/MIT have been used for controlling microbial growth in industrial and household products. 1.Frenzel, E., Schmidt...
T70287	BMS-186511
	BMS-186511 is a Farnesyltransferase (FT) inhibitor with potential anticancer activity. BMS-186511 is a bisubstrate analogue inhibitor of FT, would inhibit the malignant growth properties of a cell line established from malignant schwannoma of an NF1 patient. Following treatment with BMS-186511 , ST88-14 cells became flat, nonrefractile, were contact-inhibited, and lost their ability to grow in soft agar. BMS-186511 was found to specifically inhibit FT, but not geranylgeranyltransferase I, a clos...
T20104	C.I. 37545 NSC 37618,Brenthol FO,Naphtanilide BG,Acna Naphthol BG,Azoic dyes
	C.I. 37545 is also known as Azoic dyes. C.I. 37545 is impregnated cotton with an alkaline solution of β-naphthol, then treated it with a diazo solution obtained from aniline, a toluidine, xylidine, naphthylamine, aminoazobenzene or aminoazotoluene, so tha
T37831	CAY10641
	Cytosolic phospholipase A2α (cPLA2α) specifically catalyzes the hydrolysis of arachidonic acid from thesn-2-ester position of membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes, both important mediators of the inflammatory process.1CAY10641 is an inactive alcohol derivative of a highly potent (IC50= 12 nM) cPLA2α inhibitor.2The parent compound demonstrates strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in...
T68581	AP23464
	AP23464 is a potent adenosine 5'-triphosphate (ATP)-based inhibitor of Src and Abl kinases, displays antiproliferative activity against a human CML cell line and Bcr-Abl-transduced Ba/F3 cells (IC(50) = 14 nM. AP23464 ablates Bcr-Abl tyrosine phosphorylation, blocks cell cycle progression, and promotes apoptosis of Bcr-Abl-expressing cells. Biochemical assays with purified glutathione S transferase (GST)-Abl kinase domain confirmed that AP23464 directly inhibits Abl activity. Importantly, the lo...
T37837	2-Methylhexacosane
	2-Methylhexacosane is a saturated hydrocarbon and an insect pheromone.1,2It has been found in the cuticle ofM. dasystomusfemales, but not males, where it contributes to the mating behavior of males, as well as inD. melanogasterfemales where it modulates aggression of males towards females. 2-methylhexacosane has also been found in yellow jacket (V. vulgaris) trail extracts.3 1.Spikes, A.E., Pashen, M.A., Millar, J.G., et al.First contact pheromone identified for a longhorned beetle (Coleoptera: ...
T35419	τ-Fluvalinate
	τ-Fluvalinate is a pyrethroid acaricide.1It induces tail currents in Western honeybee (A. mellifera) voltage-gated sodium channels (AmNav1) expressed inXenopusoocytes (EC50= 60 nM). It also induces tail currents in honeybee parasitic Varroa mite (V. destructor) Nav1 channels (VdNav1) expressed inXenopusoocytes (EC50= 160 nM) with a faster tail current decay than that of AmNav1 channels. Topical application of τ-fluvalinate (2 μl) in combination with coumaphos , atrazine , 2,4-DMPF, chlorpyrifos ...

化合物

Cat.No: T20137

Synonym: Rogor,Phosphamid,Lurgo,L395,乐果,L 395,L-395

Target: Others

Cat.No: T4966

Synonym: 氟芬那酸丁酯,Flufenamic acid butyl ester,Butyl flufenamate,氟灭酸丁酯

Target: Others

Cat.No: T39280

Target: Others

Hexyl nicotinate

Cat.No: T20444

Synonym: AI3 15769,AI3-15769,烟酸己酯,AI315769

Target: Others

Cat.No: T37071

Target: Antifungal

Cat.No: T20625

Synonym: 咪鲜胺,Sporgon,Prelude

Target: Estrogen Receptor/ERR, AhR, Androgen Receptor, Antifungal

N,N'-Diacetyl-L-cystine

Cat.No: T16240

Synonym: (Ac-Cys-OH)2,DiNAC

Target: Others

Cat.No: T16582

Target: Others

Bisoxatin acetate

Cat.No: T30476L

Synonym: WY 8138,WY-8138,WY8138,Exodol,Kritel Tropfen

Cat.No: T24442

Umifenovir hydrochloride monohydrate

Cat.No: T68493

Cat.No: T20559

Synonym: Roztoczol,Roztoczol extra,Roztozol,三氯杀螨砜

Cat.No: T20150

Synonym: 3-Hydroxy-2-naphthanilide,2-Naphthanilide, 3-hydroxy- (8CI)

Cat.No: T71938

ω-Hydroxy-DEET

Cat.No: T40833

Cat.No: TP1794

Synonym: p53 17-26

Delgocitinib EtOH

Cat.No: T69950

Cat.No: T70974

Erythrityl Tetranitrate

Cat.No: T31671

Synonym: Eritrityli tetranitras,Tetranitrato de eritritilo,CHEBI:60072,Tetranitrate d'eritrityle

Cat.No: T31126

Synonym: CX659S,UNII-YG2F04AVMQ,CX 659S

Clocortolone pivalate

Cat.No: T72391

Bisnorcymserine

Cat.No: T26827

Synonym: N1 N8 Bisnorcymserine,N1N8Bisnorcymserine,N1-N8-Bisnorcymserine

TNF-α Antagonist

Cat.No: T36127

9(Z)-Pentacosene

Cat.No: T37857

Cat.No: T31194

Synonym: Basfapon B,Dowpon M,Dawpon-Rae

7(Z)-Pentacosene

Cat.No: T37923

Pentaerythrityl tetracaprate

Cat.No: T33914

Synonym: Pentaerythritol tetradecanoate,Pentaerythritol tetracaprate

Methylchloroisothiazolinone/Methylisothiazolinone Mixture

Cat.No: T37963

Cat.No: T70287

Cat.No: T20104

Synonym: NSC 37618,Brenthol FO,Naphtanilide BG,Acna Naphthol BG,Azoic dyes

Cat.No: T37831

Cat.No: T68581

2-Methylhexacosane

Cat.No: T37837

Cat.No: T35419

Cat. No.	Product Name	Target	Signaling Pathways
T4S0398	Rosin 松香树脂	p38 MAPK	MAPK
	Rosin 分离自松木或松树桩中，是一种频繁接触的过敏原，能够导致过敏性接触性皮炎。
T5320	Tulipalin A α-methylene-γ-butyrolactone,2-Methylenebutyrolactone,2-甲烯基丁内酯	Others; Drug Metabolite	Metabolism; Others
	Tulipalin A (α-methylene-γ-butyrolactone) 是来源于郁金香鳞茎的有毒糖苷。Tulipalin A 是引起过敏性接触皮炎的致敏性致敏物 (causative allergen)，在低剂量影响免疫细胞的功能，例如 Jurkat T 细胞。
TN7022	Cymen-ar-ol	Antibacterial	Microbiology/Virology
	Cymen-ar-ol 是一种广谱高效的杀菌剂，可接触黏膜。
T40712	Diethyl fumarate	Others	Others
	Diethyl fumarate 是农药马拉硫磷的分解产物。 Diethyl fumarate 会在皮肤上引起非免疫性接触性荨麻疹。
T5112	DI-N-OCTYL PHTHALATE	Others	Others
	DI-N-OCTYL PHTHALATE 用作增塑剂和添加剂。用于毒理学研究以及通过邻苯二甲酸盐从食品接触材料 (FCM) 迁移到食品中而发生的食品污染风险评估研究。
T5074	Cholesteryl palmitate	Others; Endogenous Metabolite	Metabolism; Others
	Cholesteryl palmitate 是一种慢性间质性肺炎的有用预后生物标志物。
TL0012	Shyobunone	Others	Others
	Shyobunone and isoshyobunone have insecticidal and repellant activity, they exhibit strong contact toxicity against Lasioderma serricorne (LS adults with LD50 values of 20.24 and 24.19 ug/adult, respectively; they are strongly repellent against Tribolium

天然产物

Cat.No: T4S0398

Synonym: 松香树脂

Target: p38 MAPK

Cat.No: T5320

Synonym: α-methylene-γ-butyrolactone,2-Methylenebutyrolactone,2-甲烯基丁内酯

Target: Others, Drug Metabolite

Cat.No: TN7022

Target: Antibacterial

Diethyl fumarate

Cat.No: T40712

Target: Others

DI-N-OCTYL PHTHALATE

Cat.No: T5112

Target: Others

Cholesteryl palmitate

Cat.No: T5074

Target: Others, Endogenous Metabolite

Cat.No: TL0012

Target: Others

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