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41

抑制剂 & 化合物

9

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T6023	Nutlin-3a (-)-Nutlin-3,Nutlin-3a chiral,(−)-Nutlin-3	Apoptosis; E1/E2/E3 Enzyme; Autophagy	Apoptosis; Autophagy; Ubiquitination
	Nutlin-3a ((−)-Nutlin-3) 是 Nutlin-3 的活性对映体，是一种 MDM2抑制剂，可抑制 MDM2-p53相互作用，稳定 p53 蛋白，从而诱导细胞自噬和凋亡，有潜力研究 TP53野生型卵巢癌。
T40247	Ethofumesate	Others	Others
	Ethofumesate 是一种手性除草剂。Ethofumesate 通过抑制有丝分裂减少光合作用和植物呼吸。
T19891	Metolachlor	Others	Others
	Metolachlor 是出苗前的选择性的，氯乙酰苯胺除草剂，由四种立体异构体组成的手性除草剂。它可用于控制玉米和其他农作物中的各种一年生草和阔叶杂草。
T2275	YK-4-279 4,7-二氯-1,3-二氢-3-羟基-3-[2-(4-甲氧基苯基)-2-氧代乙基]-2H-吲哚-2-酮	Apoptosis; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	YK 4-279是一种RNA 解旋酶A 与致癌转录因子EWS-FLI1结合抑制剂，能抑制ESFT 细胞增长，诱导凋亡。
T19758	D-alpha-Methylbenzyl isothiocyanate	Others	Others
	D-alpha-Methylbenzyl isothiocyanate 是一种抗氧化剂和手性试剂，可诱导 II 期酶活性。
T20058	Prothioconazole HSDB7893,HSDB-7893,Proline 480 SC Fungicide,JAU 6476,丙硫菌唑,HSDB 7893	Antifungal	Microbiology/Virology
	Prothioconazole (Proline 480 SC Fungicide) 是一种手性三唑类杀菌剂，用于植物病原控制。
T20224	L-Dithiothreitol L-Dtt,L-1,4-二硫代苏糖醇	Others	Others
	L-Dithiothreitol (L-Dtt) 是一种具有两个立体中心的手性二齿二硫醇。它可用于手性响应研究。
T0028	Gamibetal 3-Hydroxy-GABA,4-氨基-3-羟基丁酸,4-Amino-3-hydroxybutyric Acid	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Gamibetal (4-Amino-3-hydroxybutyric Acid) 是 γ-氨基-β-羟基丁酸，对癫痫具有潜在的研究价值。
T50096	1,3,3,5,5-pentamethylcyclohexan-1-amine hydrochloride	Others	Others
	1,3,3,5,5-pentamethylcyclohexan-1-amine hydrochloride，又称PAC，是一种环胺，通常用作不对称合成中的手性助剂，包括Diels-Alder 反应、羟醛反应和Michael 加成。
T0763	Hexylene glycol 2-Methyl-2,4-pentanediol,Diolane,MPD,己二醇,已二醇	Others	Others
	Hexylene glycol (Diolane) 是一种活性剂，分子量小，被广泛用作工业涂料溶剂，对健康或环境无不良影响。
T72050	4-N-Dodecyloxyphenol 4-dodecoxyphenol,p-Dodecyloxyphenol
	4-N-Dodecyloxyphenol (p-Dodecyloxyphenol) 是一种可作为铁电液晶或铁电液晶的添加剂或显示SmC 相且无手性基团的化合物。
T50100	3-hydroxy-3-phenylpentanamide	Others	Others
	3-hydroxy-3-phenylpentanamide 是一种手性化合物，属于β-羟基酰胺类。在神经病学中，它已被证明对缺血性脑损伤和脑出血具有神经保护作用。在精神病学中，它被研究为焦虑、抑郁和成瘾的潜在治疗方法。在肿瘤学中，它已被证明通过诱导细胞凋亡和抑制肿瘤生长而具有抗肿瘤活性。
T20269	Dibutyl tartrate AI3 00396,AI3-00396,AI300396
	Dibutyl tartrate is an agent of chiral surfactant.
T19745	Furalaxyl A 5430,A5430,A-5430
	Furalaxyl is an fungicide of acyl amino chiral.
T25714	L-Hamamelose Hamamelose L-form,L-Ribose, 2-C-(hydroxymethyl)-
	L-Hamamelose plays a significant role as a chiral building block in synthesizing a wide variety of enantiopure compounds.
T26150	RU 35929 RU-35929,RU35929
	RU 35929 is a chiral antiamnesic agent.
T26033	RAC 109 RAC-109,RAC109
	RAC 109 is a chiral antiarrhythmic agent.
T30146	Arverapamil (R)-Norverapamil,Agi-003,UNII-3J8P56R04P,Rezular
	Arverapamil is a chiral metabolite of Verapamil.
T33603	Nb-enantride
	Nb-enantride is a novel chiral trialkylborohydride for the asymmetric reduction of ketones.
T34324	Ribulose, L- L-Adonose,L-Ribulose,L-Erythro-pentulose,L-erythro-2-Pentulose
	Ribulose is an important metabolite in pentose interconversions. Ribulose is useful for analyzing L-ribose isomerase, engineering yeast for xylose metabolism, interesting chiral pool compound.
T36053	D-Lysine lactam
	D-Lysine lactam is a chiral building block.1,2It has been used in the synthesis of a chiral antibiotic synthetic intermediate, as well as in the stereoselective synthesis of neurokinin (NK) receptor antagonists. 1.Kumar, A., Bhashkar, B., Bhavsar, J., et al.Catalytic reduction: Efficient synthesis of chiral key intermediate of besifloxacin hydrochlorideDer Pharma Chemica7(9)297-3000(2015) 2.Gerspacher, M., Lewis, C., Ball, H.A., et al.Stereoselective preparation of N-[(R,R)-(E)-1-(3,4-dichlorobe...
T20120	Acetylmandelic acid, (+)- S-Acetylmandelic acid,Mandelic acid, acetate, L-
	Acetylmandelic acid, (+)- is a chiral derivatizing agent,and used for NMR determination of enantiomeric purity of α-deuterated carboxylic acids, alcohols, and amines.
T27793	L-alpha-Methylbenzyl isothiocyanate
	L-alpha-Methylbenzyl isothiocyanate is an antioxidant. It induces phase II enzyme activity and is also used as a chiral agent.
T37812	6-O-Sulfo-β-cyclodextrin (sodium salt)
	6-O-Sulfo-β-cyclodextrin is a sulfated cyclodextrin.1It has been used for the chiral separation of nadolol racemates by capillary electrophoresis. 1.Wang, F., Dowling, T., Bicker, G., et al.Electrophoretic chiral separation of pharmaceutical compounds with multiple stereogenic centers in charged cyclodextrin mediaJ. Sep. Sci.24(5)378-384(2001)
T37155	8(R)-HETE
	8(R)-HETE is biosynthesized by lipoxygenation of arachidonic acid in marine invertebrates such as gorgonian corals and starfish. Stereochemical assignment of the (R) enantiomer is based on comparison of chiral HPLC retention times to published results.
T35843	9(R)-HODE cholesteryl ester
	9(R)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions. It remains uncertain whether the oxidized fatty acid portion of the molecule results from enzymatic lipoxygenation or from random lipid peroxidation. 9(R)-HODE cholesteryl ester can be used as a standard for analysis of chiral HODE cholesteryl esters.
T35462	(±)11-HETE
	(±)11-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid . The individual R and S isomers of racemic HETEs have been separated and identified using chiral phase HPLC. The racemic HETEs have been quantified as an index of lipid peroxidation using GC/MS.
T36558	(±)9-HETE
	(±)9-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. The individual R and S isomers of racemic HETEs have been separated and identified using chiral phase HPLC. The racemic HETEs have been quantified as an index of lipid peroxidation using GC/MS.
T35846	13(R)-HODE cholesteryl ester
	13(R)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions. It remains uncertain whether the oxidized fatty acid portion of the molecule results from enzymatic lipoxygenation or from random lipid peroxidation. 13(R)-HODE cholesteryl ester can be used as a standard for analysis of chiral HODE cholesteryl esters.
T37410	9(R)-HETE
	9(R)-HETE is an enantiomer which makes up 50% of (±)9-HETE . At a concentration of 300 nM, 9(R)-HETE activates RXRγ-dependent transcription 1.5 fold relative to a control. Stereochemical assignment of the (R) enantiomer is based on comparison of chiral HPLC retention times to published results.
T35853	9(S)-HODE cholesteryl ester
	9(S)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions. It remains uncertain whether the oxidized fatty acid portion of the molecule results from enzymatic lipoxygenation or from random lipid peroxidation. 9(S)-HODE cholesteryl ester can be used as a standard for analysis of chiral HODE cholesteryl esters.
T37411	9(S)-HETE
	9(S)-HETE is an enantiomer which makes up 50% of (±)9-HETE . There are no reports of 9(S)-HETE occurring as an enzymatic lipoxygenation product. Whereas 12(S)-HETE promotes adhesion of several cell lines to endothelial cell monolayes, 9(S)-HETE and other positional HETEs are without effect. Stereochemical assignment of the (S) enantiomer is based on comparison of chiral HPLC retention times to published results.
T37158	8(S)-HETE
	8(S)-HETE is a major lipoxygenase product in PMA-treated murine epidermis. It activates mouse keratinocyte protein kinase C with an IC50 of 100 μM. 8(S)-HETE also activates PPARα selectively at concentrations as low as 0.3 μM. Stereochemical assignment of the (S) enantiomer is based on comparison of chiral HPLC retention times to published results.
T2579	Reboxetine 瑞波西汀,Norebox	Norepinephrine	Neuroscience
	Reboxetine (Norebox) 是一种抗抑郁药，用于治疗临床抑郁症、恐慌症和 ADD/ADHD。它有两个手性中心，但它仅作为两种对映体存在，(R, R)-(-)- 和 (S, S)-(+)-Reboxetine。
T69740	AMG-315
	AMG-315 is a Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes. AMG-315 is a chiral arachidonoyl ethanolamide (AEA) analogue or (13S,1′R)-dimethylanandamide. AMG-315 is a high affinity ligand for the CB1 receptor (Ki of 7.8 ± 1.4 nM) that behaves as a potent CB1 agonist in vitro (EC50 = 0.6 ± 0.2 nM). AMG-315 is the first potent AEA analogue with significant stability for all endocannabinoid hydrolyzing enzymes as well as the oxidative enzymes COX-2. AMG-315 will serve as a ...
T37490	11(R)-HETE
	11(R)-HETE is biosynthesized by 11(R)-LOs of the sea urchin, S. purpuratus, and the fresh water hydra, H. vulgaris. The biological activity of 11(R)-HETE relates to oocyte maturation and tentacle regeneration, respectively, in these two species. 11(R)-HETE is also produced when aspirin-treated recombinant COX-2 is incubated with arachidonic acid. Stereochemical assignment of the (R) enantiomer is based on comparison of chiral HPLC retention times to published results.
T60832	(S)-Bromoenol lactone
	(S)-Bromoenol lactone ((S)-BEL) 以 2 μM 的IC50值抑制大鼠主动脉平滑肌（A10）细胞中血管加压素诱导的花生四烯酸的释放。(S)-Bromoenol lactone 是一种不可逆的、手性的、基于机制的钙非依赖性磷脂酶A2β (iPLA2β) 抑制剂。
T36838	(R)-Bromoenol lactone
	The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components. The calcium-independent phospholipases (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase γ (iPLA2γ). Unlike (S)-BEL, (R)-BEL does not inhibit iPLA2β exce...
T36015	PDMP (hydrochloride)
	PDMP is a ceramide analog first prepared in a search for inhibitors of glucosylceramide synthase. PDMP has two adjacent chiral centers (C1 and C2) allowing for the formation of four possible isomers. PDMP contains all four of these stereoisomers. PDMP inhibits glucosylceramide synthase by 90% when used at a concentration of 0.8 μM in MDCK cell homogenates, however, the ability to inhibit glucosylceramide synthase has been found to reside in the D-threo (1R,2R) enantiomer. The D-threo PDMP enanti...
T36564	(S)-Acenocoumarol
	Acenocoumarol is a short-lived oral anti-coagulant, which, like warfarin, functions by inhibiting vitamin K epoxide reductase. It has higher intrinsic anticoagulant potency than warfarin and phenprocoumon, when evaluated in vitro. Acenocoumarol has a single chiral center that gives rise to two different enantiomeric forms. (S)-Acenocoumarol has a shorter plasma elimination half-life (1.8 hours) and faster plasma clearance (28.5 L/hour), compared to the (R)-enantiomer (6.6 hours, 1.9 L/hour). The...
T36241	Arecaidine propargyl ester (hydrobromide)
	Arecaidine propargyl ester is an agonist of M2muscarinic acetylcholine receptors (mAChRs).1It selectively binds to M2over M1, M3, M4, and M5mAChRs in CHO cells expressing the human receptors (Kis = 0.0871, 1.23, 0.851, 0.977, and 0.933 μM, respectively). Arecaidine propargyl ester induces contractions in isolated guinea pig atrium (pD2= 8.67). It induces apoptosis and the production of reactive oxygen species (ROS) in U87 and U251 glioblastoma cells when used at a concentration of 100 μM.2Arecai...

化合物

Cat.No: T6023

Synonym: (-)-Nutlin-3,Nutlin-3a chiral,(−)-Nutlin-3

Target: Apoptosis, E1/E2/E3 Enzyme, Autophagy

Cat.No: T40247

Target: Others

Cat.No: T19891

Target: Others

Cat.No: T2275

Synonym: 4,7-二氯-1,3-二氢-3-羟基-3-[2-(4-甲氧基苯基)-2-氧代乙基]-2H-吲哚-2-酮

Target: Apoptosis, DNA/RNA Synthesis

D-alpha-Methylbenzyl isothiocyanate

Cat.No: T19758

Target: Others

Prothioconazole

Cat.No: T20058

Synonym: HSDB7893,HSDB-7893,Proline 480 SC Fungicide,JAU 6476,丙硫菌唑,HSDB 7893

Target: Antifungal

L-Dithiothreitol

Cat.No: T20224

Synonym: L-Dtt,L-1,4-二硫代苏糖醇

Target: Others

Cat.No: T0028

Synonym: 3-Hydroxy-GABA,4-氨基-3-羟基丁酸,4-Amino-3-hydroxybutyric Acid

Target: HIV Protease

1,3,3,5,5-pentamethylcyclohexan-1-amine hydrochloride

Cat.No: T50096

Target: Others

Hexylene glycol

Cat.No: T0763

Synonym: 2-Methyl-2,4-pentanediol,Diolane,MPD,己二醇,已二醇

Target: Others

4-N-Dodecyloxyphenol

Cat.No: T72050

Synonym: 4-dodecoxyphenol,p-Dodecyloxyphenol

3-hydroxy-3-phenylpentanamide

Cat.No: T50100

Target: Others

Dibutyl tartrate

Cat.No: T20269

Synonym: AI3 00396,AI3-00396,AI300396

Cat.No: T19745

Synonym: A 5430,A5430,A-5430

Cat.No: T25714

Synonym: Hamamelose L-form,L-Ribose, 2-C-(hydroxymethyl)-

Cat.No: T26150

Synonym: RU-35929,RU35929

Cat.No: T26033

Synonym: RAC-109,RAC109

Cat.No: T30146

Synonym: (R)-Norverapamil,Agi-003,UNII-3J8P56R04P,Rezular

Cat.No: T33603

Cat.No: T34324

Synonym: L-Adonose,L-Ribulose,L-Erythro-pentulose,L-erythro-2-Pentulose

D-Lysine lactam

Cat.No: T36053

Acetylmandelic acid, (+)-

Cat.No: T20120

Synonym: S-Acetylmandelic acid,Mandelic acid, acetate, L-

L-alpha-Methylbenzyl isothiocyanate

Cat.No: T27793

6-O-Sulfo-β-cyclodextrin (sodium salt)

Cat.No: T37812

Cat.No: T37155

9(R)-HODE cholesteryl ester

Cat.No: T35843

Cat.No: T35462

Cat.No: T36558

13(R)-HODE cholesteryl ester

Cat.No: T35846

Cat.No: T37410

9(S)-HODE cholesteryl ester

Cat.No: T35853

Cat.No: T37411

Cat.No: T37158

Cat.No: T2579

Synonym: 瑞波西汀,Norebox

Target: Norepinephrine

Cat.No: T69740

Cat.No: T37490

(S)-Bromoenol lactone

Cat.No: T60832

(R)-Bromoenol lactone

Cat.No: T36838

PDMP (hydrochloride)

Cat.No: T36015

(S)-Acenocoumarol

Cat.No: T36564

Arecaidine propargyl ester (hydrobromide)

Cat.No: T36241

Cat. No.	Product Name	Target	Signaling Pathways
T2S0461	D-Arabinose	Others; Endogenous Metabolite	Metabolism; Others
	D-arabinose 是内源性代谢产物的一种。
T4896	D-Lyxose 来苏糖,D-(-)-Lyxose	Others; Endogenous Metabolite	Metabolism; Others
	D-Lyxose (D-(-)-Lyxose) 是内源性代谢产物的一种。
T2956	Cedryl acetate 乙酸柏木酯,Cedrol acetate,Cedranyl acetate	Antifungal	Microbiology/Virology
	Cedryl acetate (Cedranyl acetate) 是一种三环倍半萜烯，分离自草莓番石榴植物，能够表现出 α-葡萄糖苷酶的抑制活性。
T8042	2-Acetylthiazole 2-Acetylthiazole;2 Acetylthiazole,2-Acetylthiazole,2-Thiazolyl methyl ketone,2 Acetylthiazole,1-(2-Thiazolyl)ethanone	Others	Others
	2-Acetylthiazole (2-Acetylthiazole;2 Acetylthiazole) 用于制备手性醇、三唑并噻唑，也用于羟醛缩合反应。
TMS2262	(-)-CAMPHOR L-Camphor,左旋樟脑	Others	Others
	(-)-CAMPHOR (L-Camphor) 是樟脑的手性中间体，在食品中用作风味添加剂和甜味剂。
T2A2476	L-Hydroxyproline 羟脯氨酸,trans-4-Hydroxy-L-proline,L-Hydroxyprolin,Trans-4-Hydroxyproline	Endogenous Metabolite	Metabolism
	L-Hydroxyproline (L-Hydroxyprolin) 是羟脯氨酸的异构体之一，是药物生产中有用的手性结构单元。
T5220	D-(-)-Lactic acid sodium Sodium D-lactate,D-乳酸钠	Others; Endogenous Metabolite	Metabolism; Others
	D-(-)-Lactic acid sodium (Sodium D-lactate) 是一种有机酸。它是一种手性分子，由 L-乳酸和 D-乳酸两种光学异构体组成，其中 L-异构体在生物体中最常见。D-(-)-Lactic acid sodium 也是一种微生物代谢产物。
T5290	(S)-2-Hydroxy-3-phenylpropanoic acid L-(−)-3-Phenyllactic acid,L-3-苯乳酸	Others; Endogenous Metabolite	Metabolism; Others
	(S)-2-Hydroxy-3-phenylpropanoic acid (L-(−)-3-Phenyllactic acid) 是苯丙氨酸的代谢产物。苯丙酮尿症患者体液中苯丙氨酸的水平升高。
T5250	Levoglucosan 1,6-anhydro-b-D-Glucose,1,6-脱水-β-D-葡萄糖	Others; Endogenous Metabolite	Metabolism; Others
	Levoglucosan (1,6-anhydro-b-D-Glucose) 是一种无水己糖，是 β -D-葡萄糖的 1,6-无水衍生物。它是由碳水化合物，如淀粉和纤维素的热解形成的。左旋葡聚糖还可用于手性聚合物如不可水解葡萄糖聚合物的合成。左旋葡聚糖也可以通过糖的焦糖化产生。食用焦糖或含焦糖的甜食可导致尿中左旋葡聚糖水平短期增加5倍(从20 μm /mM肌酐增加到100 μm /mM肌酐)。

天然产物

Cat.No: T2S0461

Target: Others, Endogenous Metabolite

Cat.No: T4896

Synonym: 来苏糖,D-(-)-Lyxose

Target: Others, Endogenous Metabolite

Cat.No: T2956

Synonym: 乙酸柏木酯,Cedrol acetate,Cedranyl acetate

Target: Antifungal

2-Acetylthiazole

Cat.No: T8042

Synonym: 2-Acetylthiazole;2 Acetylthiazole,2-Acetylthiazole,2-Thiazolyl methyl ketone,2 Acetylthiazole,1-(2-Thiazolyl)ethanone

Target: Others

Cat.No: TMS2262

Synonym: L-Camphor,左旋樟脑

Target: Others

L-Hydroxyproline

Cat.No: T2A2476

Synonym: 羟脯氨酸,trans-4-Hydroxy-L-proline,L-Hydroxyprolin,Trans-4-Hydroxyproline

Target: Endogenous Metabolite

D-(-)-Lactic acid sodium

Cat.No: T5220

Synonym: Sodium D-lactate,D-乳酸钠

Target: Others, Endogenous Metabolite

(S)-2-Hydroxy-3-phenylpropanoic acid

Cat.No: T5290

Synonym: L-(−)-3-Phenyllactic acid,L-3-苯乳酸

Target: Others, Endogenous Metabolite

Cat.No: T5250

Synonym: 1,6-anhydro-b-D-Glucose,1,6-脱水-β-D-葡萄糖

Target: Others, Endogenous Metabolite

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