Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T18893 |
5(6)-Carboxyfluorescein
5(6)-羧基荧光素,5-(and-6)-Carboxyfluorescein mixed isomers,5(6)-FAM |
Others | Others |
5(6)-Carboxyfluorescein (5-(and-6)-Carboxyfluorescein mixed isomers) 是一种胺反应性 pH 敏感的绿色荧光标记物,能够标记蛋白质、多肽和氨基酸,可用于体内实验检测肿瘤位置。 | |||
T77456 |
Lumiliximab
IDEC-152,ST-152 |
||
Lumiliximab (IDEC-152) 是一种灵长类化的靶向 CD23 猕猴/人嵌合抗体,对 IgE 抗体的产生有抑制作用,用于研究过敏性疾病。 | |||
T76844 |
Abciximab
C7E3 |
Integrin | Cytoskeletal Signaling |
Abciximab (C7E3) 是一种小鼠/人嵌合单克隆抗体,是一种有效的糖蛋白 IIb/IIIa (glycoprotein IIb/IIIa) 抑制剂。 Abciximab 具有抗血小板聚集和白细胞粘附的作用,通过与糖蛋白 IIb/IIIa、vitronectin 和 Mac-1 受体结合发挥作用。 | |||
T9910 |
Rituximab
|
Others | Others |
Rituximab 是抗 CD20 嵌合单克隆抗体,用于研究某些自身免疫疾病和癌症。 | |||
T22889 |
KF38789
KF 38789 |
Others | Others |
KF38789 特异性的抑制P-selectin 与PSGL-1结合。它对 U937 细胞与 P-selectin 免疫球蛋白 G 嵌合蛋白 (P-selectin-Ig) 的结合具有抑制作用 (IC50:1.97 μM) 。 | |||
T76671 |
Amatuximab
MORab-009 |
Others | Others |
Amatuximab (MORab-009) 是一种人源化针对细胞表面间皮素 (MSLN) 的嵌合 IgG1/k 单抗,具有抗肿瘤活性,可用于治疗实体肿瘤。 | |||
T73698 |
Basiliximab
CHI 621 |
Interleukin | Immunology/Inflammation |
Basiliximab (CHI 621) 是一种嵌合鼠/人 IgG1 单克隆抗白细胞介素 2 受体 (interleukin-2 receptor) 重组抗体。Basiliximab 具有良好的免疫抑制活性,可用于研究肾移植。 | |||
T76718 |
Brentuximab
|
TNF | Apoptosis |
Brentuximab 是靶向 CD30 的嵌合抗体,是 Brentuximab vedotin 的裸抗。Brentuximab 具有抗肿瘤活性,可用于研究复发或难治性霍奇金淋巴瘤。 | |||
T76773 |
Rolinsatamab
|
IL Receptor | Immunology/Inflammation |
Rolinsatamab 是一种完全人源化的选择性单克隆抗体,是一种有效的 IL-4 和 IL-13 双重抑制剂。Rolinsatamab 嵌合抗原受体序列 T 细胞。Rolinsatamab 可用于预防和治疗免疫疾病。 | |||
T76830 |
Teneliximab
Chi220,Anti-Human CD40 Recombinant Antibody,BMS 224819 |
TNF | Apoptosis |
Teneliximab (Chi220) 是一种嵌合的单克隆抗体,也是一种肿瘤坏死因子受体超家族成员5(CD40)抑制剂,可阻断CD40-CD40L 的相互作用。Teneliximab 通过CD40 和外周B细胞损耗发挥部分激动剂活性,可用于研究器官移植排斥和类风湿关节炎。 | |||
TP1991L |
M 1145 acetate
|
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
M1145 acetate 是一种嵌合肽,是一种选择性甘丙肽受体 2 (GAL2) 激动剂,Ki 为 6.55 nM。它对 GAL2 的亲和力比 GAL1 高 90 倍以上(Ki=587 nM),比 GalR3 的亲和力高 76 倍(Ki=497 nM)。 它对甘丙肽的信号转导具有累加作用。 | |||
T77484 |
Atibuclimab
|
TNF | Apoptosis |
Atibuclimab 是一种靶向 CD14 的嵌合单克隆抗体,由小鼠可变区和人类 IgG4 Fc 区构成。Atibuclimab 可用于治疗肌萎缩侧索硬化症。Atibuclimab 可减少 LPS 诱导的病症,并对 LPS 诱导的促炎细胞因子释放有抑制作用,可延迟抗炎细胞因子可溶性 TNF 受体 I 型的释放, | |||
T39954 |
AU-15330
|
Epigenetic Reader Domain; PROTACs | Chromatin/Epigenetic; PROTAC |
AU-15330是SWI/SNF ATPase亚基SMARCA2和SMARCA4的蛋白水解靶向嵌合体(PROTAC)降解剂。AU-15330 能有效抑制肿瘤在前列腺癌异种移植模型中的生长,并与 AR 拮抗剂恩杂鲁胺具有协同作用。AU-15330在去势抵抗性前列腺癌(CRPC)模型中显示出部分治疗效果和AU-15330具有无毒性的特点。 | |||
T15517 | Hydroxy-PEG2-C2-PFP ester | Others | Others |
Hydroxy-PEG2-C2-PFP ester, a PEG/Alkyl/ether-based PROteolysis TArgeting Chimeric (PROTAC) linker, is suitable for the synthesis of PROTACs. | |||
T31949 |
Glutathione amide
GASH cpd,L-gamma-Glutamyl-L-cysteinylglycinamide |
||
Glutathione amide is a enzyme of a chimeric protein. | |||
T78339 |
Human IgG4 (S228P) kappa, Isotype Control
|
||
HumanIgG4(S228P) kappa, Isotype Control为人-鼠嵌合型单克隆抗体,作为humanIgG4(S228P)κ抗体的同型对照使用。 | |||
T82159 |
Human IgG1 (K214R) kappa, Isotype Control
|
||
HumanIgG1(K214R) kappa, Isotype Control为HumanIgG1(K214R)κ 抗体的人源化同型对照,属于人-鼠嵌合型抗体。 | |||
T39364 |
Desthiobiotin-PEG4-propargyl
Desthiobiotin-PEG4-propargyl |
||
Desthiobiotin-PEG4-propargyl is a PEG-coupled PROteolysis TArgeting Chimeric (PROTAC) linker, employed for PROTAC synthesis. | |||
T34858 |
THIQ-20c
THIQ 20c |
||
THIQ-20c is a steroidomimetic and chimeric microtubule disruptor. | |||
T15512 |
Hydroxy-PEG1-(CH2)2-Boc
|
Others | Others |
Hydroxy-PEG1-(CH2)2-Boc is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis-targeting chimeric molecules (PROTACs)[1]. | |||
T76689 | Margetuximab | ||
Margetuximab (MGAH22)为优化Fc结构域的嵌合抗HER2单克隆抗体,EC50值为39.33 ng/mL,适用于转移性HER2阳性乳腺癌研究。 | |||
T81247 |
Runimotamab
|
||
Runimotamab为针对CD3E和HER2的IgG1-κ型人源化嵌合单克隆抗体。 | |||
T18857 |
Tri(Amino-PEG3-amide)-amine
|
Others | Others |
Tri(Amino-PEG3-amide)-amine is a polyethylene glycol (PEG)-derived linker employed for the synthesis of proteolysis-targeting chimeric molecules (PROTACs)[1]. | |||
T80564 |
Vamikibart
|
||
Vamikibart为针对IL-6的人源化嵌合IgG2κ抗体。 | |||
T40886 |
Onzigolide
BIM-23A760,TBR-760,Onzigolide |
||
Onzigolide (BIM-23A760), a chimeric compound combining properties of both dopamine and somatostatin, exhibits strong agonistic activity towards the D2 subtype of dopamine receptors (D2R) as well as type 2 somatostatin receptors (SSTR2). | |||
T39191 |
DSTYSLSSTLTLSK
|
||
DSTYSLSSTLTLSK is a generic human peptide and can be used for infliximab quantitative detection. Infliximab (Avakine) is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α. | |||
T27461 |
GSK2336805
GSK 2336805,GSK-2336805,JNJ-56914845,GSK-805,GSK805 |
||
GSK-2336805 is a HCV NS5A inhibitor. GSK2336805 retained activity on chimeric replicons containing NS5A patient sequences from genotype 1 and patient and consensus sequences for genotypes 4 and 5 and part of genotype 6. | |||
T17363 |
β-Naphthoflavone-CH2-OH
β-NF-CH2-OH |
Others | Others |
β-Naphthoflavone-CH2-OH (β-NF-CH2-OH) serves as an AhR E3 ligase ligand, forming chimeric molecules when connected to a protein ligand through a linker, resulting in PROTACs or SNIPERs (e.g., β-naphthoflavone-JQ1). These chimeric molecules recruit the AhR E3 ligase complex by incorporating AhR ligands. By inducing ubiquitination-mediated degradation, PROTACs effectively target and degrade cancer-promoting proteins [1]. | |||
T77496L |
AZD 1775 Linker Conjugate 1 TFA
AZD 1775 Linker Conjugate 1 TFA( 2101954-45-2 Free base) |
||
AZD 1775 Linker Conjugate 1 TFA 是一种参与泛素酶靶向嵌合体实验的化合物。 | |||
T16190 | N-(Azido-PEG3)-N-Boc-PEG4-Boc | Others | Others |
N-(Azido-PEG3)-N-Boc-PEG4-Boc is a polyethylene glycol (PEG)-based proteolysis targeting chimeric (PROTAC) linker employed in PROTAC synthesis[1]. | |||
T39521 |
LEESGGGLVQPGGSMK
|
||
LEESGGGLVQPGGSMK, a proteolysis peptide, is a constituent of Infliximab, a chimeric monoclonal IgG1 antibody that selectively binds to TNF-α. It can be employed for quantitative assessment of Infliximab. | |||
T17458 | Azide-PEG-amine (MW 3500) | Others | Others |
Azide-PEG-amine (MW 3500) is a polyethylene glycol (PEG) derived linker compound, specifically designed for the synthesis of proteolysis targeting chimeric molecules (PROTACs)[1]. | |||
T80606 |
Duvortuxizumab
MGD 011 |
||
Duvortuxizumab (MGD 011) 是一种嵌合人源化IG抗体,特异性靶向CD19和CD3E。 | |||
T16310 |
NH2-PEG1-CH2CH2-Boc
|
Others | Others |
NH2-PEG1-CH2CH2-Boc is a polyethylene glycol (PEG) and alkyl/ether-based proteolysis targeting chimeric (PROTAC) linker, commonly employed in the synthesis of PROTACs[1]. | |||
T77051 | Larcaviximab | ||
Larcaviximab (c4G7-N) 是一种IgG1kappa 抗Ebola virus 糖蛋白嵌合单克隆抗体。 | |||
T18603 | PROTAC BRD4 degrader for PAC-1 | Others | Others |
PROTAC BRD4 degrader for PAC-1 (compound 5) is a chimeric BET degrader GNE-987 conjugated with a disulfide-containing linker[1]. This PROTAC-linker conjugate specifically targets and degrades BRD4, enabling selective proteolysis of PAC-1. | |||
T82575 |
Devextinetug
IXT-M200 |
||
Devextinetug (IXT-M200) 是一种小鼠源IgG2κ抗体,其特异性针对嵌合抗甲基苯丙胺 (Methamphetamine)。 | |||
T80610 |
Romilkimab
SAR156597 |
||
Romilkimab (SAR156597),一种特异性结合IL-4与IL-13的嵌合人源化IG抗体。 | |||
T82157 |
Human IgG1 lambda1, Isotype Control
|
||
HumanIgG1lambda1, Isotype Control为人-鼠嵌合型单克隆抗体,作为human IgG1λ1抗体的同型对照物。 | |||
T75103 | CD19 CAR mRNA | ||
CD19CAR mRNA 能够编码CD19car蛋白,适用于CAR-T细胞免疫治疗(CAR-CD19)。CD19car作为嵌合抗原受体,针对B细胞表面的CD19,一种关键参与B细胞增殖、分化、活化及产生抗体的CD分子(即白细胞分化抗原),进而增强BCR信号传递。 | |||
T77150 | Cosfroviximab | ||
Cosfroviximab(c13C6-FR1)是一种抗埃博拉病毒糖蛋白(EBOV-GP)的鼠/人嵌合单克隆抗体。 | |||
T77015 | Futuximab | ||
Futuximab 是一种嵌合单克隆抗体,靶向 EGFR 上的非重叠表位。Futuximab 具有抗肿瘤活性。 | |||
T82961 |
ASB20123
|
||
ASB20123 是一款融合了CNP/ghrelin序列的嵌合肽,具有促进骨骼生长的效能,适用于研究生长障碍和侏儒症。 | |||
T81174 |
Setoxaximab
|
||
Setoxaximab是一种IgG1-κ型的人源化嵌合单克隆抗体,专门针对shiga toxin 1。 | |||
T36091 |
LEESGGGLVQPGGSMK acetate
|
||
LEESGGGLVQPGGSMK acetate is a proteolysis peptide found in Infliximab, a chimeric monoclonal IgG1 antibody. It serves as a component of Infliximab and can be employed for the quantitative analysis of this antibody. Infliximab is specifically designed to bind to TNF-α[1]. | |||
T76209 |
DSTYSLSSTLTLSK TFA
|
||
DSTYSLSSTLTLSK TFA 是用于 Infliximab (Avakine) 定量检测的通用肽。Infliximab (Avakine) 是一种嵌合单克隆IgG1抗体,能特异性地结合到 TNF-α。 | |||
T82161 |
Human IgG1 (D265A) kappa, Isotype Control
|
||
HumanIgG1(D265A) kappa, Isotype Control是一种人鼠嵌合型抗体,用作HumanIgG1(D265A)κ抗体的同型对照。 | |||
T80871 |
Veligrotug
|
IGF-1R | Tyrosine Kinase/Adaptors |
Veligrotug为IgG1-kappa型抗IGF1R(胰岛素样生长因子1受体,CD221)嵌合单克隆抗体。 | |||
T80567 |
Boserolimab
MK-5890 |
||
Boserolimab (MK-5890)为一款嵌合人源化IgG1κ抗体,其特异性靶向小鼠CD27信号调节蛋白。 | |||
T82155 |
Human IgG4 (S228P) lambda1, Isotype Control
|
||
HumanIgG4(S228P) lambda1, Isotype Control,为人-鼠嵌合型抗体,作为humanIgG4(S228P) λ1抗体同型对照使用。 |