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19

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T5469	K-Ras-IN-1	Raf; Ras	GPCR/G Protein; MAPK
	K-Ras-IN-1 是K-Ras 抑制剂。K-Ras-IN-1 能与 K-Ras (WT)、K-Ras (G12D)、K-Ras (G12V) 和 H-Ras 结合。它对胰腺癌、结肠癌和肺癌的具潜在的研究价值。
T6023	Nutlin-3a (-)-Nutlin-3,Nutlin-3a chiral,(−)-Nutlin-3	Apoptosis; E1/E2/E3 Enzyme; Autophagy	Apoptosis; Autophagy; Ubiquitination
	Nutlin-3a ((−)-Nutlin-3) 是 Nutlin-3 的活性对映体，是一种 MDM2抑制剂，可抑制 MDM2-p53相互作用，稳定 p53 蛋白，从而诱导细胞自噬和凋亡，有潜力研究 TP53野生型卵巢癌。
TP1554L	HPV16 E7 (86-93) acetate HPV16 E7 (86-93) acetate(160212-93-1 Free base)	Others	Others
	HPV16 E7 (86-93) acetate 是人源白细胞抗原 A2.1 限制性 HPV16 E7 的衍生肽，在宫颈癌中具有免疫原性。
T9007	Germinone A 3-Methyl-5-((3-nitro-[1,1'-biphenyl]-4-yl)oxy)furan-2(5H)-one	Others	Others
	Germinone A (3-Methyl-5-((3-nitro-[1,1'-biphenyl]-4-yl)oxy)furan-2(5H)-one) 是一种新型强效 HTL/KAI2 激动剂，可刺激拟南芥种子萌发，在多种癌症中具有抗肿瘤活性。
T33411	Mitopodozide SP-I 77,SPI 77,SPI-77
	Mitopodozide, as an ethylhydrazide derivative of podophyllic acid, acts as a mitotic poison in carcinomas of the ovary.
T36415	N-Nitroso-N-methyl-4-Aminobutyric Acid
	N-Nitroso-N-methyl-4-aminobutyric acid (NMBA) is a tobacco-specific nitrosamine carcinogen.1It is oxidized to the reactive metabolite methyl-2-oxopropylnitrosamine (MOPN) in isolated rat liver mitochondria.2NMBA induces bladder transitional cell carcinomas in rats when administered in the drinking water at a concentration of 300 mg/L per day.3
T72355	KRAS G12D inhibitor 16
	KRAS G12D inhibitor 16 是一种 KRAS G12D 抑制剂。KRAS G12D inhibitor 16 对 KRAS G12D 和 KRAS G12D 突变具有抑制活性，IC50值分别为 0.7 nM 和 0.35 μM。KRAS G12D inhibitor 16 可用于多种恶性肿瘤的研究，如胰腺导管腺癌（PDAC）、结肠直肠癌（CRC）、非小细胞肺癌（NSCLC）。
TP1427	ReACp53
	ReACp53 is a cell-penetrating peptide, designed to inhibit p53 amyloid formation, resues p53 function in cancer cell lines and in organoids derived from high-grade serous ovarian carcinomas (HGSOC).
T76015	HPV16 E7 (86-93) (TFA)
	HPV16 E7 (86-93) TFA，一种HLA-A2.1限制的HPV16 E7衍生肽，在宫颈癌中显示出免疫原性。
T78284	Edrecolomab CO17-1A,Panorex
	Edrecolomab (Panorex) 是靶向细胞表面糖蛋白17-1A的小鼠单克隆抗体，该蛋白在上皮组织和肿瘤中表达。Edrecolomab 表现出抗肿瘤活性，并可用于结直肠癌研究。
T72319	Lewis y tetrasaccharide Lewis y
	Lewis Y tetrasaccharide (Lewis Y, LeY) 是Lewis X trisaccharide 的四糖衍生物。Lewis Y tetrasaccharide 是一种与恶性卵巢癌转移和预后不良相关的抗原。
T63199	Dalpiciclib hydrochloride
	Dalpiciclib (SHR-6390) hydrochloride 是高度选择性的、口服具有活力的CDK4/6抑制剂，他们的IC50值分别为 12.4 nM 和 9.9 nM，能够作用于乳腺癌和食道鳞状细胞癌，具有出抗肿瘤作用。
T20016	Diuron HW 920,Dirurol,Karmex,Lucenit,Marmer,Seduron
	Diuron is a Phenylurea herbicide that inhibits photosynthesis by preventing the formation of ATP and NADH. Diuron (25 nM/ml) decreases total respiration in roots of wheat by 50% and ground respiration by 100%. Diuron (2,500 ppm, dietary) increases the inc
TP2005	Kisspeptin-54(human) Metastin (human)
	Potent endogenous ligand of the kisspeptin receptor (KISS1, GPR54). Binds with high affinity to rat and human KISS1 receptors with Ki values of 1.80 and 1.45 nM respectively. Inhibits chemotaxis, invasion and metastasis of human melanomas and breast carci
T64475	FMOC-L-THR
	FMOC-L-THR (AZP-531) is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight. The O-glycosidic linkage and the O-acetyl protection in this building block is stable to both piperidine and TFA, making it completely compatible with standard protocols in Fmoc solid phase peptide synthesis. The Tn antigen is a tumor-associated carbohydrate antigen that is not normally expressed in peripheral tissues or blood cells. Expression of this antigen, which is found in a m...
T79226	AMPK activator 11	Mitochondrial Metabolism	Metabolism
	AMPK activator11 是一种抗肿瘤活性纳米级化合物，有效针对多种CRC。通过激活AMPK及上调OXPHOS（mitochondrial metabolism），该化合物能选择性抑制RKO异种移植物生长，应用于肿瘤和代谢性疾病研究领域。
T76723	Tilvestamab
	Tilvestamab (BGB149) 是一种人源化抗AXL 抗体，阻断AXL 介导的细胞信号传导。Tilvestamab 在体外能显著抑制Gas6刺激诱导的AXL 激活，并抑制 786-0-Luc RCC 细胞中下游AXL 的磷酸化。Tilvestamab 可用于癌症，尤其是AXL 过度表达肾细胞癌的研究。
T36414	N-Nitroso Sarcosine
	N-Nitroso sarcosine is a carcinogen and nitrosation product of sarcosine that has been found in cured meat products.1,2In vivo, N-nitroso sarcosine (225 mg/kg) induces the formation of metastatic liver carcinomas in mice.2 1.Janzowski, C., Eisenbrand, G., and Preussmann, R.Occurrence of N-nitrosamino acids in cured meat products and their efffect on formation of N-nitrosamines during heatingFood Cosmet. Toxicol.16(4)343-348(1978) 2.Wogan, G.N., Paglialunga, S., Archer, M.C., et al.Carcinogenicit...
T36862	Ganglioside GT1b Mixture (sodium salt) Ganglioside GT1b Mixture (sodium salt),Ganglioside G1 Mixture
	Ganglioside GT1b is a trisialoganglioside that is characterized by having two sialic residues linked to the inner galactose unit. It binds to the neurotoxins botulinum toxin serotype A (BTxA), BTxA heavy chain, and tetanus toxin with IC50 values of 11, 0.74, and 7.2 μM, respectively.[1] Ganglioside GT1b-containing liposomes bind to the major coat protein VP1 from Merkel cell polyomavirus (MCPyV), which has been identified in Merkel cell carcinomas, identifying ganglioside GT1b as a putative MCP...

化合物

Cat.No: T5469

Target: Raf, Ras

Cat.No: T6023

Synonym: (-)-Nutlin-3,Nutlin-3a chiral,(−)-Nutlin-3

Target: Apoptosis, E1/E2/E3 Enzyme, Autophagy

HPV16 E7 (86-93) acetate

Cat.No: TP1554L

Synonym: HPV16 E7 (86-93) acetate(160212-93-1 Free base)

Target: Others

Cat.No: T9007

Synonym: 3-Methyl-5-((3-nitro-[1,1'-biphenyl]-4-yl)oxy)furan-2(5H)-one

Target: Others

Cat.No: T33411

Synonym: SP-I 77,SPI 77,SPI-77

N-Nitroso-N-methyl-4-Aminobutyric Acid

Cat.No: T36415

KRAS G12D inhibitor 16

Cat.No: T72355

Cat.No: TP1427

HPV16 E7 (86-93) (TFA)

Cat.No: T76015

Cat.No: T78284

Synonym: CO17-1A,Panorex

Lewis y tetrasaccharide

Cat.No: T72319

Synonym: Lewis y

Dalpiciclib hydrochloride

Cat.No: T63199

Cat.No: T20016

Synonym: HW 920,Dirurol,Karmex,Lucenit,Marmer,Seduron

Kisspeptin-54(human)

Cat.No: TP2005

Synonym: Metastin (human)

Cat.No: T64475

AMPK activator 11

Cat.No: T79226

Target: Mitochondrial Metabolism

Cat.No: T76723

N-Nitroso Sarcosine

Cat.No: T36414

Ganglioside GT1b Mixture (sodium salt)

Cat.No: T36862

Synonym: Ganglioside GT1b Mixture (sodium salt),Ganglioside G1 Mixture

Cat. No.	Product Name	Target	Signaling Pathways
T4903	Heptadecanoic acid	Others; Endogenous Metabolite	Metabolism; Others
	Heptadecanoic acid 是奇链饱和脂肪酸，与一些疾病（如冠心病、糖尿病前期和 2 型糖尿病以及多发性硬化症）有关。
TN4113	Garcinone E	Antifection	Microbiology/Virology
	Garcinone E is active constituents in the anticomplement assay used. Garcinone E exhibits potent activity in vitro against Plasmodium falciparum chloroquine-resistant strain W2, with IC50 values below 3 µM. It has potent cytotoxic effect on all hepatocellular carcinomas cell lines as well as on the other gastric and lung cancer cell lines included in the screen, may be potentially useful for the treatment of certain types of cancer.
T3425	Polyphyllin G 重楼皂苷VII,Polyphyllin VII,Polyphyllin VII,Y-0166,重楼皂苷G	Others	Others
	Polyphyllin G (Polyphyllin VII) 是从Paris yunnanensis 的根茎中分离出来的，具有抗菌活性，抑制革兰氏阳性和革兰氏阴性细菌的生长。它是polyphyllin 家族的主要成员，对肺癌、乳腺癌、结直肠癌、宫颈癌、肝细胞癌和骨肉瘤等多种癌症具有很强的抗癌活性。

天然产物

Heptadecanoic acid

Cat.No: T4903

Target: Others, Endogenous Metabolite

Cat.No: TN4113

Target: Antifection

Cat.No: T3425

Synonym: 重楼皂苷VII,Polyphyllin VII,Polyphyllin VII,Y-0166,重楼皂苷G

Target: Others

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