首页工具

Germinone A

产品编号 T9007 CAS T9007

别名: 3-Methyl-5-((3-nitro-[1,1'-biphenyl]-4-yl)oxy)furan-2(5H)-one

Germinone A (3-Methyl-5-((3-nitro-[1,1'-biphenyl]-4-yl)oxy)furan-2(5H)-one) 是一种新型强效 HTL/KAI2 激动剂，可刺激拟南芥种子萌发，在多种癌症中具有抗肿瘤活性。

TargetMol的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Germinone A, CAS T9007

规格	价格/CNY	货期
1 mg	￥ 1,300	现货
5 mg	￥ 2,920	现货
10 mg	￥ 4,320	现货
25 mg	￥ 6,890	现货
50 mg	￥ 9,330	现货
100 mg	￥ 12,500	现货
500 mg	￥ 25,200	现货
1 mL * 10 mM (in DMSO)	￥ 2,760	现货

大包装超大折扣，点击咨询

选择批次

纯度: 99.97%

更多批次查询请联系客服

生物活性

化学信息

存储 & 溶解度

参考文献

产品描述

Germinone A (3-Methyl-5-((3-nitro-[1,1'-biphenyl]-4-yl)oxy)furan-2(5H)-one) is a novel potent agonist of HTL/KAI2, stimulating activity for Arabidopsis seed germination, has antitumor activity in multiple types of carcinomas.

体外活性

CRT0066101 suppressed the proliferation and migration of four bladder cancer cell lines in vitro.?CRT0066101 blocked tumor growth in a mouse flank xenograft model of bladder cancer.?To further assess the role of PKD in bladder carcinoma, examined the three PKD isoforms and found that PKD2 was highly expressed in eight bladder cancer cell lines and in urothelial carcinoma tissues from the TCGA database,?and that short hairpin RNA (shRNA)-mediated knockdown of PKD2 dramatically reduced bladder cancer growth and invasion in vitro and in vivo, suggesting that the effect of the compound in bladder cancer is mediated through inhibition of PKD2.?This notion was corroborated by demonstrating that the levels of phospho-PKD2 were markedly decreased in CRT0066101-treated bladder tumor explants.?CRT0066101 treatment or PKD2 silencing arrested bladder cancer cells at the G2/M phase, the arrest being accompanied by decreases in the levels of cyclin B1, CDK1 and phospho-CDK1 (Thr161) and increases in the levels of p27Kip1 and phospho-CDK1 (Thr14/Tyr15).?Moreover, CRT0066101 downregulated the expression of Cdc25C, which dephosphorylates/activates CDK1, but enhanced the activity of the checkpoint kinase Chk1, which inhibits CDK1 by phosphorylating/inactivating Cdc25C.?CRT0066101 was found to elevate the levels of Myt1, Wee1, phospho-Cdc25C (Ser216), Gadd45α, and 14-3-3 proteins, all of which reduce the CDK1-cyclin B1 complex activity.?CRT0066101 suppresses bladder cancer growth by inhibiting PKD2 through induction of G2/M cell cycle arrest, leading to the blockade of cell cycle progression[1].

别名	3-Methyl-5-((3-nitro-[1,1'-biphenyl]-4-yl)oxy)furan-2(5H)-one
分子量	311.29
分子式	C17H13NO5
CAS No.	T9007

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 22.5 mg/mL (72.28 mM)

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.2124 mL	16.0622 mL	32.1244 mL	80.311 mL
	5 mM	0.6425 mL	3.2124 mL	6.4249 mL	16.0622 mL
	10 mM	0.3212 mL	1.6062 mL	3.2124 mL	8.0311 mL
	20 mM	0.1606 mL	0.8031 mL	1.6062 mL	4.0155 mL
	50 mM	0.0642 mL	0.3212 mL	0.6425 mL	1.6062 mL

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

质量

浓度

容积

分子量

浓度 (起始)

容积 (起始)

浓度 (终)

容积 (终)

溶液体积

质量

配液浓度

参考文献

1. Li Q Q , Hsu I , Sanford T , et al. Protein kinase D inhibitor CRT0066101 suppresses bladder cancer growth in vitro and xenografts via blockade of the cell cycle at G2/M[J]. Cellular & Molecular Life Sciences, 2017. 2. Borges S , EA Perez, EA Thompson, et al. Effective Targeting of Estrogen Receptor-Negative Breast Cancers with the Protein Kinase D Inhibitor CRT0066101.[J]. Molecular Cancer Therapeutics, 2015, 14(6).

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

剂量

mg/kg

每只动物体重

给药体积

μL

动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

% DMSO+

% +