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19

抑制剂 & 化合物

9

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T13507	4,4'-Iminodiphenol 4-(4-羟基苯胺)苯酚,Leucoindophenol	Estrogen/progestogen Receptor	Endocrinology/Hormones
	4,4'-Iminodiphenol (Leucoindophenol) 是基于二苯胺骨架的无活性雌激素受体配体。
T77504	JAK1/2/3 Inhibitor 1	PKA	Tyrosine Kinase/Adaptors
	JAK1/2/3 Inhibitor 1 是一种有效的蛋白激酶抑制剂。2,4-dichlorothieno[3,2-d]pyrimidine 具有抗肿瘤活性可抑制多种癌细胞株的生长。它通过与癌细胞的骨架结合，抑制新蛋白质的生成，从而抑制癌细胞的生长。
T15993	Mal-PEG4-PFP ester	Others	Others
	Mal-PEG4-PFP ester is a non-cleavable antibody-drug conjugate (ADC) linker that incorporates a Maleimide moiety, a 4-unit Polyethylene Glycol (PEG) backbone, and a Pentafluorophenyl (PFP) ester.
T38896	VPM peptide
	VPM peptide functions as a protease-cleavable dithiol cross-linker. It is capable of integration into the PEG-diacrylate (PEG-DA) macromer backbone, resulting in the formation of PEG hydrogel.
T76708	Penpulimab
	Penpulimab 是一种IgG1抗PD-1单克隆抗体，具有抗肿瘤活性。
T18488	NH2-MPAA-NODA	Others	Others
	NH2-MPAA-NODA, a nitroveratryl-based photocleavable linker featuring a NODA motif and a methyl phenyl acetic acid (MPAA) backbone, serves as a radiolabel when labeled with 18F-fluoride.
T16591	Propargyl-PEG1-SS-PEG1-PFP ester	Others	Others
	Propargyl-PEG1-SS-PEG1-PFP ester is a cleavable linker consisting of a 1-unit polyethylene glycol (PEG) backbone, designed for use in the synthesis of antibody-drug conjugates (ADCs)[1].
T34180	Psilostachyin C NSC 106392
	Psilostachyin c is a member of the class of compounds known as ambrosanolides and secoambrosanolides. Ambrosanolides and secoambrosanolides are sesquiterpene lactones from the Ambrosia family, with a backbone derivative of azuleno[6,5-b]furan-2-one (ambro
T34686	Sonoflora 1 SF 1,SF-1,Sonoflora1,Sonoflora-1,SF1
	Sonoflora 1, also known as SF1, a PDT photosensitivizer. Chemically, SF1 is an analog of chlorophyll in that its macrocycle backbone is porphyrin-based and the center of the porphyrin ring consists of a metal ion. Preclinical studies showed that SF1 had v
T14448	Azido-PEG4-CH2-Boc	Others	Others
	Azido-PEG4-CH2-Boc is a four-unit cleavable polyethylene glycol (PEG) linker compound employed in the synthesis of antibody-drug conjugates (ADCs)[1] and PROTACs[2]. This linker is characterized by its azide functional group and PEG backbone, facilitating the conjugation of drugs to antibodies in ADC development and enabling the synthesis of PROTACs utilizing PEG and alkyl/ether moieties.
T37123	1,2-Dioctanoyl PC
	Phosphatidylcholine (PC) species are a common class of phospholipids that comprise the mammalian cell membrane. 1,2-Dioctanoyl PC is a synthetic analog of natural phosphatidylcholine species containing saturated C8:O fatty acids in the sn-1 and sn-2 positions of the glycerol backbone. It exhibits a critical micelle concentration (CMC) value of 0.25 mM at 27°C. 1,2-Dioctanoyl PC serves as an efficient substrate for phospholipase D (PLD) as well as sPLA2 isozymes from bovine pancreas and bee venom...
T76098	Glycerol-3-phosphate oxidase
	Glycerol-3-phosphate oxidase，即磷酸甘油氧化酶，是甘油代谢的关键中间体。Glycerol-3-phosphate oxidase 能够从大肠杆菌中提取得到。Glycerol-3-phosphate oxidase 是膜脂质的磷脂的骨架，也是呼吸链的底物。Glycerol-3-phosphate oxidase 通过氧化产生电子。
T38180	C16 Phytoceramide (t18:0/16:0)
	C16 Phytoceramide (t18:0/16:0) is a phytoceramide, which is a family of sphingolipids found in the intestine, kidney, and extracellular spaces of the stratum corneum of the mammalian epidermis. C16 Phytoceramide (t18:0/16:0) is composed of a phytosphingosine backbone amine-linked to a C16 fatty acid chain. The levels of C16 phytoceramide (t18:0/16:0) increase following heat stress in S. cerevisiae. It has been used with other ceramides to create stratum corneum substitutes to study percutaneous ...
T73753	Neuraminic acid
	Neuraminic acid是由9个碳原子的主链构成的酸性氨基糖，也是丙酮酸与D-甘露胺(2-氨基-2-脱氧甘露糖)醛酸经缩合反应生成的产物。它作为具有生物活性的黏液蛋白的官能团。
T37244	Palmitoyl thio-PC
	Thioester analogs of glycerophospholipids, in combination with Ellman's reagent, are convenient colorimetric substrates for the measurement of phospholipase (PL) activity. Palmitoyl thio-PC is a chromogenic PLA2 substrate that contains a palmitoyl thioester at the sn-2 position of the glycerol backbone. Hydrolysis of the thioester by PLA2 yields a free thiol that reacts readily with DTNB (Ellman's reagent) giving a bright yellow product with an absorbance maximum at 412 nm. Palmitoyl thio-PC has...
T38291	C24 Phytosphingosine (t18:0/24:0)
	C24 Phytosphingosine (t18:0/24:0) is a phytoceramide, which is a family of sphingolipids found in the intestine, kidney, and extracellular spaces of the stratum corneum of the mammalian epidermis. C24 Phytosphingosine (t18:0/24:0) is composed of a phytosphingosine backbone amine-linked to a C24 fatty acid chain. It has been used with other ceramides to create stratum corneum substitutes to study percutaneous penetration and psoriasis in vitro. In a stratum corneum model of healthy skin, the inco...
T38284	C24 dihydro 1-Deoxyceramide (m18:0/24:0) C24 dihydro 1-Deoxyceramide (m18:0/24:0)
	C24 dihydro 1-Deoxyceramide (m18:0/24:0) is a very long-chain atypical ceramide containing a 1-deoxysphinganine backbone. 1-Deoxysphingolipids are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis.1,2 C24 dihydro 1-Deoxyceramide (m18:0/24:0) has been found in mouse embryonic fibroblasts (MEFs) following application of 1-deoxysphinganine alkyne or 1-deoxysphinganine-d3.3 It has also been found in mouse brain, spinal cord, ...
T38280	C22 dihydro 1-Deoxyceramide (m18:0/22:0) C22 dihydro 1-Deoxyceramide (m18:0/22:0)
	C22 dihydro 1-Deoxyceramide (m18:0/22:0) is a very long-chain atypical ceramide containing a 1-deoxysphinganine backbone. 1-Deoxysphingolipids are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis.1,2 C22 dihydro 1-Deoxyceramide (m18:0/22:0) has been found in mouse embryonic fibroblasts (MEFs) following application of 1-deoxysphinganine alkyne or 1-deoxysphinganine-d3.3 It has also been found as the most prevalent dihydro...
T37458	C18 Phytoceramide (t18:0/18:0)
	C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid found in S. cerevisiae, wheat grains, and the stratum corneum layer of mammalian epidermis. Cer(t18:0/18:0) is composed of a phytosphingosine backbone amine-linked to a C18 fatty acid chain. Cer(t18:0/18:0) has a role in regulation of apoptosis, cell differentiation, proliferation of smooth muscle cells, and inhibition of the mitochondrial respiratory chain. It also inhibits expression of the allergic cytokines IL-4, TN...

化合物

4,4'-Iminodiphenol

Cat.No: T13507

Synonym: 4-(4-羟基苯胺)苯酚,Leucoindophenol

Target: Estrogen/progestogen Receptor

JAK1/2/3 Inhibitor 1

Cat.No: T77504

Target: PKA

Mal-PEG4-PFP ester

Cat.No: T15993

Target: Others

Cat.No: T38896

Cat.No: T76708

Cat.No: T18488

Target: Others

Propargyl-PEG1-SS-PEG1-PFP ester

Cat.No: T16591

Target: Others

Psilostachyin C

Cat.No: T34180

Synonym: NSC 106392

Cat.No: T34686

Synonym: SF 1,SF-1,Sonoflora1,Sonoflora-1,SF1

Azido-PEG4-CH2-Boc

Cat.No: T14448

Target: Others

1,2-Dioctanoyl PC

Cat.No: T37123

Glycerol-3-phosphate oxidase

Cat.No: T76098

C16 Phytoceramide (t18:0/16:0)

Cat.No: T38180

Neuraminic acid

Cat.No: T73753

Palmitoyl thio-PC

Cat.No: T37244

C24 Phytosphingosine (t18:0/24:0)

Cat.No: T38291

C24 dihydro 1-Deoxyceramide (m18:0/24:0)

Cat.No: T38284

Synonym: C24 dihydro 1-Deoxyceramide (m18:0/24:0)

C22 dihydro 1-Deoxyceramide (m18:0/22:0)

Cat.No: T38280

Synonym: C22 dihydro 1-Deoxyceramide (m18:0/22:0)

C18 Phytoceramide (t18:0/18:0)

Cat.No: T37458

Cat. No.	Product Name	Target	Signaling Pathways
T17155	Trabectedin Ecteinascidin 743,曲贝替定,ET-743	Apoptosis; Reactive Oxygen Species	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB
	Trabectedin (Ecteinascidin 743) 是一种四氢异喹啉生物碱，有抗肿瘤的活性，通过与 DNA 的小沟结合，阻断应激诱导的蛋白质的转录，诱导 DNA 骨架裂解和癌细胞凋亡，并增加 MCF-7 和 MDA-MB-453 细胞中 ROS 的生成。Trabectedin 在软组织肉瘤和卵巢癌中具有的研究价值。
T8240	Cis-5-Dodecenoic Acid	Others	Others
	Cis-5-Dodecenoic Acid 是一种单不饱和脂肪酸，具有 C12 链作为主链，C5 位具有顺式双键。
T5658	Adamantane	Others	Others
	Adamantane 是许多化合物的结构骨架，也是有机多面体化合物的物理化学和生物学特性，在制药工业中有实际应用。
T6873	Lauric Acid 月桂酸,Dodecylic acid,dodecanoic acid,Vulvic acid,N-Dodecanoic acid	Others; Endogenous Metabolite; Antibacterial	Metabolism; Microbiology/Virology; Others
	Lauric Acid (Dodecylic acid) 是一种有抗菌活性的中链脂肪酸，对P. acnes，S.aureus 和S. epidermidis 的 EC50值分别为 2，6，4 μg/mL。
T2910	Flavonol 3-羟基黄酮,3-Hydroxyflavone,3-HF,Flavon-3-ol,3-Hydroxy-2-phenylchromone	Others; Endogenous Metabolite	Metabolism; Others
	Flavonol (3-Hydroxyflavone) 是内源性代谢产物的一种。
T4776	Glycerol Glycerin,甘油	Endogenous Metabolite	Metabolism
	Glycerol 是甘油三酯（即脂肪和油）和磷脂的重要成分。它在食品工业中被广泛用作甜味剂和保湿剂以及药物制剂。
T13729	Hydrolyzed Fumonisin B1 Aminopentol	Others	Others
	Hydrolyzed Fumonisin B1 is the backbone and the main hydrolysis product of the mycotoxin fumonisin B1 (FB1), can weakly inhibit ceramide synthase.
T40589	6-O-β-D-Galactopyranosyl-D-galactose
	6-O-beta-D-Galactopyranosyl-D-galactose, a disaccharide, is a constituent of the polysaccharide backbone characterized by beta-(1→6) glycoside linkages, with a side chain attached to the primary chain through a beta-(1→3) bond.
TN4592	Murrangatin	IL Receptor; TNF; COX; Prostaglandin Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the high viability of Raji cells, it also exhibits cytotoxicity against cholangiocarcinoma cell line,

天然产物

Cat.No: T17155

Synonym: Ecteinascidin 743,曲贝替定,ET-743

Target: Apoptosis, Reactive Oxygen Species

Cis-5-Dodecenoic Acid

Cat.No: T8240

Target: Others

Cat.No: T5658

Target: Others

Cat.No: T6873

Synonym: 月桂酸,Dodecylic acid,dodecanoic acid,Vulvic acid,N-Dodecanoic acid

Target: Others, Endogenous Metabolite, Antibacterial

Cat.No: T2910

Synonym: 3-羟基黄酮,3-Hydroxyflavone,3-HF,Flavon-3-ol,3-Hydroxy-2-phenylchromone

Target: Others, Endogenous Metabolite

Cat.No: T4776

Synonym: Glycerin,甘油

Target: Endogenous Metabolite

Hydrolyzed Fumonisin B1

Cat.No: T13729

Synonym: Aminopentol

Target: Others

6-O-β-D-Galactopyranosyl-D-galactose

Cat.No: T40589

Cat.No: TN4592

Target: IL Receptor, TNF, COX, Prostaglandin Receptor

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