88
16
Cat. No. | Product Name | Target | Signaling Pathways |
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T3978 |
Linerixibat
GSK2330672,Iinerixibat |
HBV | Microbiology/Virology |
Linerixibat (GSK2330672) 是高效的、不可吸收的、具有口服活性的顶端钠依赖性胆汁酸转运蛋白 (ASBT) 抑制剂,对人ASBT 的IC50为 42 nM。它是一种降脂剂,具有用于 2 型糖尿病和原发性胆源性胆管炎的研究潜力。 | |||
T4251 |
GJ103 sodium salt
|
ATM/ATR | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
GJ103 sodium salt 是 GJ072 的活性类似物,它是一种通读化合物 (RTC)。它已被证明可以降低水溶液的表面张力,使分子更容易在溶液中移动。它还被证明可以降低水溶液的粘度,使分子更容易在溶液中移动。此外,它还被证明可以降低水溶液的pH 值,这会对生物体的生化和生理过程产生各种影响。 | |||
T18919 |
Bathophenanthroline
|
Others | Others |
Bathophenanthroline 是一种能够通过染色法测量水,血清和尿液样中铁浓度的试剂。 | |||
T27527 |
HBF-0259
HBF 0259 |
Antiviral | Immunology/Inflammation |
HBF-0259 是有效的乙型肝炎病毒 表面抗原分泌选择性抑制剂,在 HepG2.2.15 细胞中的 EC50为 1.5 μM。 | |||
T18890 |
5-ROX
5-羧基-X-罗丹明,5-Carboxy-X-rhodamine |
Others | Others |
5-ROX (5-Carboxy-X-rhodamine) 是罗丹明染料的一种,λexit 为 580 nm (ε=3.6×104M-1cm-1),λemit 为 604 nm (ϕ=0.94)。 | |||
T21240 |
Sodium caprate
Caprinic acid sodium salt,Sodium caprinate,癸酸钠,Decanoic acid, sodium salt,Sodium decanoate,Capric acid, sodium salt,Sodium decanoic acid |
Others | Others |
Sodium caprate (Sodium decanoate) 是己酸的钠盐,己酸是一种 10 个碳的饱和脂肪酸。它具有两亲性,可在水溶液中形成液晶相和胶束。 | |||
T2016 |
MLN9708
Ixazomib Citrate |
Proteasome | Proteases/Proteasome; Ubiquitination |
MLN9708 (Ixazomib Citrate) 抑制 20S 蛋白酶体的糜蛋白酶样蛋白水解 (β5) 位点 (Ki50=0.93 nM, IC50=3.4 nM/)。 MLN9708 的生物活性形式是水溶液或血浆中的 MLN2238。 | |||
T19051 |
Reactive Blue 4
活性艳蓝X-ARL,活性蓝4 |
Others | Others |
Reactive Blue 4 是蒽醌类染料,具有植物毒性、细胞毒性和基因毒性。它可作为单一的比色化学传感器,用于在水介质中连续测定具有不同光学响应的多种分析物。 | |||
T77284 |
DSPE-NHS
|
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DSPE-NHS 是一种具有两个疏水性脂质尾巴的生物共轭磷脂分子。DSPE-NHS 是一种在水溶液中形成脂质双分子层的自组装试剂。DSPE-NHS 可用于制备脂质体作为活性分子纳米载体。 | |||
T60924 |
Verosudil
AR-12286 |
ROCK | Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells |
Verosudil (AR-12286) 是一种高效的 Rho 激酶 (ROCK) 抑制剂,对 ROCK1 和 ROCK2 的 Ki 分别为 2 和 2 nM。AR-12286 可逆转类固醇诱导的小鼠眼内压,可通过增加眼房水通过小梁网流出来减缓眼压。 | |||
T8947 |
dasiglucagon acetate
dasiglucagon acetate(1544300-84-6 free base) |
Others | Others |
dasiglucagon acetate 是一种用于糖尿病低血糖治疗的新型胰高血糖素类似物。 它已证明在水性制剂中的溶解度和稳定性。药代动力学研究表明,与传统的重组胰高血糖素相比,它的胰高血糖素具有更高的吸收率和更长的血浆消除半衰期。 | |||
T23409 |
FM4-64
SynaptoRedTM C2 |
Others | Others |
FM4-64 (SynaptoRedTM C2) 是一种苯乙烯类染料,染色效果稳定,但在在水溶液中基本不发荧光。FM4-64与质膜双层结合后不能被动扩散进入细胞内部,必须通过主动运输的方式进行跨膜运输。FM4-64 可用于研究胞吞胞吐和囊泡运输。 | |||
T2130 |
Propidium Iodide
PI,碘化丙啶,碘化丙啶(PI) |
Others | Others |
Propidium Iodide (PI) 是一种可用于细胞染色的红色荧光染料,适用于荧光显微镜、共聚焦显微镜、流式细胞仪以及荧光计分析。在水溶液中,Propidium Iodide 的Ex/Em 为493/636 nm;与核酸结合后,PI-核酸的Ex/Em 变为535/617 nm,同时荧光信号增强20-30倍。 | |||
T2403 |
Bromfenac sodium hydrate
Bromfenac sodium,Bromfenac monosodium salt sesquihydrate,溴芬酸钠 |
COX | Immunology/Inflammation; Neuroscience |
Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) 是一种可口服的 COX 抑制剂,抑制 COX-1和COX-2的IC50值分别为 5.56 和 7.45 nM。它是一种溴化非甾体类抗炎药,有用于白内障的术后炎症和疼痛以及假晶状体囊状黄斑水肿的研究。 | |||
T20190 |
Polyoxyl 10 oleyl ether
Genapol O 020,Genapol O,Genapol O 050 |
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Polyoxyl 10 oleyl ether is an emulsifying agent. It is used as vehicle for organic compunds in aqueous solutions. | |||
T40984 |
(S)-Pro-xylane
(S)-Pro-xylane,(S)-Hydroxypropyl tetrahydropyrantriol |
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(S)-Pro-xylane, also known as (S)-Hydroxypropyl tetrahydropyrantriol, is the S-enantiomer of Pro-xylane. Pro-xylane is a biologically active C-glycoside that functions as an activator of glycosaminoglycans (GAGs) biosynthesis in aqueous media. | |||
T30477 |
Bis-PEG5-thiol
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Bis-PEG5-thiol is a PEG derivative containing two thiol groups. The thiol groups react with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc. The hydrophilic PEG spacer increases solubility in aqueous media. | |||
T19785 |
Isocyclosporin A
IsocyclosporinA,Isocyclosporin-A |
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Isocyclosporin A is a rearranged degradation product. It is formed by acid treatment of cyclosporin A under aqueous and non-aqueous conditions. | |||
T19024 |
MCLA hydrochloride
|
Others | Others |
MCLA hydrochloride, a chemiluminescent compound, can be used to quantify aqueous concentrations of superoxide. | |||
T68337 |
PLX647(OMe)
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PLX647(OMe) is a slightly less potent inhibitor of FMS than PLX647 but has better aqueous solubility. | |||
T24668 | Propargyl-PEG4-CH2CO2-NHS | ||
Propargyl-PEG4-CH2CO2-NHS is a PEG derivative containing a propargyl group and an NHS group. The hydrophilic PEG spacer increases solubility in aqueous media. | |||
T31835 |
Fmoc-PEG3-Ala-Ala-Asn(Trt)-PAB-PNP
|
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Fmoc-PEG3-Ala-Ala-Asn(Trt)-PAB-PNP is a peptide reagent for ADC conjugation that possesses a cleavable peptide sequence. The hydrophilic PEG spacer increases solubility in aqueous media. | |||
T20978 |
S-acetyl-PEG6
S-acetyl-PEG6-alcohol |
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S-acetyl-PEG6-alcohol is a PEG Linker, which is used to synthesize compounds and increases solubility in aqueous media. | |||
T71953 |
Thiol-PEG2-acid
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Thiol-PEG2-acid is a PEG derivative containing a thiol group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. | |||
T40536 |
[Glu4]-Oxytocin
[Glu4]-Oxytocin |
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[Glu4]-Oxytocin is a suitable derivative of oxytocin for conducting a thorough investigation, utilizing various methods, into the conformation of "oxytocin-like" molecules in aqueous solution. | |||
T61216 |
Dichlorphenamide disodium
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Dichlorphenamide disodium is a specific, orally active carbonic anhydrase inhibitor. It effectively reduces intraocular pressure by impeding the secretion of aqueous humor. Notably, dichlorphenamide disodium holds potential for glaucoma research [1]. | |||
T36751 |
Dihydroxy Melphalan
|
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Dihydroxy melphalan is an inactive degradation product of melphalan . It is formed by the hydrolysis of melphalan via the intermediate monohydroxy melphalan in aqueous solutions, including cell culture medium and human plasma. | |||
T20904 |
m-PEG11-Tos
|
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M-PEG11-Tos is a PEG derivative containing a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. For nucleophilic substitution reactions, the tosyl group is a good leaving group. | |||
T25826 |
MMV024101
MMV-024101,TCMDC 134293,TCMDC134293,TCMDC-134293,MMV 024101 |
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MMV024101 is a PI4K inhibitor. MMV024101 exhibits submicromolar potency against P. falciparum NF54 (IC50 =543 nM), low aqueous solubility (<5 μM), and rapid clearance by mouse liver microsomes with only 2% of parent compound remaining after 30 min of incu | |||
TP1030 |
Thymus factor X
TFX-Jelfa,胸腺因子X |
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Thymic factor X (TFX-Jelfa) is an aqueous extract from the thymus of a juvenile calf and is a natural stimulator of lymphocyte function. | |||
T20903 |
m-PEG12-Mal
|
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M-PEG12-Mal is a PEG derivative containing a maleimide group. The hydrophilic PEG spacer increases solubility in aqueous media. The maleimide group could form a covalent bond with a thiol group , enabling the further connection of biomolecule with a thiol | |||
T20850 |
Hydroxy-PEG14-acid
|
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Hydroxy-PEG14-acid is a PEG derivative containing a hydroxyl group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive funct | |||
T30273 |
Azido-PEG4-acrylate
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Azido-PEG4-acrylate is a crosslinker containing an azide group and an acrylate group. The azide group enables Click Chemistry and the acrylate group enables Michael addition. The hydrophilic PEG spacer increases solubility in aqueous media. | |||
T20328 |
Biotin-PEG7-amine
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Biotin-PEG7-amine is a PEG derivative containing a biotin group and a terminal primary amine group. The hydrophilic PEG spacer increases solubility in aqueous media and increases membrane impermeability of the molecules conjugated to the biotin compound. | |||
T82543 |
diSulfo-Cy3 alkyne
|
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diSulfo-Cy3 alkyne 是一款炔基的点击化学试剂,且为水溶性染料,其吸光度和发射特性与Cy3荧光团一致。该染料适用于蛋白质标记,以及水相环境中完整生物体的标记。 | |||
T20901 | m-PEG12-NHS ester | ||
M-PEG12-NHS ester is a PEG derivative containing an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label amine-modified oligonucleotides, the primary amines (-NH2) of proteins, and other amine-con | |||
T20915 |
Azido-PEG2-t-butyl ester
|
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Azido-PEG2-t-butyl ester is a PEG derivative containing a t-butyl ester and an azide group. The hydrophilic PEG spacer increases solubility in aqueous media. Under acidic conditions, the t-butyl protected carboxyl group can be deprotected. | |||
T30274 |
Azido-PEG4-Ala-Ala-Asn(Trt)-PAB
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Azido-PEG4-Ala-Ala-Asn(Trt)-PAB is a PEG derivative conjugated with a peptide via an amide bond. The azide group on the PEG end enables Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media. | |||
T20849 |
Hydroxy-PEG3-acid
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Hydroxy-PEG3-acid is a PEG derivative containing a hydroxyl group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functi | |||
T20973 |
Thiol-C2-PEG2-OH
Thiol-PEG3-alcohol,HS-PEG3-OH |
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Thiol-PEG3-alcohol is a PEG derivative containing a hydroxyl group and a thiol group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. | |||
T39852 |
Triton X-45(n=4)
|
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Triton X-45, a nonionic surfactant with a low Hydrophile-Lypophile Balance (HLB) value, is a dispersible compound in the aqueous solution at room temperature. With a Krafft point above room temperature, Triton X-45 shows promise for research on the Hepatitis C Virus (HCV). | |||
T20899 | m-PEG1-acid | ||
M-PEG1-acid is a PEG derivative containing a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. In the presence of activators (e.g. EDC, DCC), the terminal carboxylic acid can be reacted with primary amine groups t | |||
T20837 |
Fmoc-N-amido-PEG12-acid
|
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Fmoc-N-amido-PEG12-acid is a PEG derivative, it contains a Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. Under the basic conditions, the Fmoc group can be deprotected to obtain the f | |||
T70908 |
EST64454 free base
|
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EST64454 is a σ1 receptor (σ1R) antagonist clinical candidate for the treatment of pain. EST64454 shows an outstanding aqueous solubility, which together with its high permeability in Caco-2 cells will allow its classification as a BCS class I compound. It also shows high metabolic stability. | |||
T81699 |
NBD-amine
|
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NBD-amine是荧光性质变化的胺类化合物,其在水介质中的荧光较弱,而在有机溶剂、膜结构以及疏水条件下则显著增强。 | |||
T30272 |
Azido-PEG12-t-butyl ester
|
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Azido-PEG12-t-butyl ester is a PEG derivative containing an azide group and a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole | |||
T32120 |
Hydroxy-PEG1-methylamine
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Hydroxy-PEG1-methylamine is a PEG derivative containing a hydroxyl group with a methylamine group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive funct | |||
T32121 |
Hydroxy-PEG3-NHS
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Hydroxy-PEG3-NHS is a PEG derivative containing a hydroxyl group with an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. T | |||
T36708 | Monohydroxy Melphalan (hydrochloride) | ||
Monohydroxy melphalan is a DNA alkylating agent and a degradation product of melphalan . Monohydroxy melphalan is formed by the hydrolysis of melphalan in aqueous solutions, including cell culture medium and human plasma. It increases the level of DNA adducts in ML-1 myeloblastic leukemia cells in a concentration-dependent manner and induces cytotoxicity with an IC50 value of 28.1 μg/ml. | |||
T69900 |
GUN 00775
|
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GUN 00775, also known as N-(m-PEG4)-3,3-Dimethyl-3H-indole-N'-(acid-PEG3)-Benzothiazole Cy5, is a PEG derivative containing a cyanine dye with excitation/emission maximum 649/667 nm and a free terminal carboxyl acid. Terminal carboxylic acid can react with primary amine groups in the presence of of activators (e.g. EDC, or DCC) to form a stable amide bond. The hydophilic PEG spacer increases solubility in aqueous media. This product has no formal name at the moment. For the convenience of commu... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN7083 |
Ternatumoside II
|
Others | Others |
Ternatumoside II 是紫荆叶的水提取物,可抑制 GIA。 | |||
T10023 |
1-Naphthol
NSC 9586,Nako TRB,1-萘酚,Furro ER |
Endogenous Metabolite | Metabolism |
1-Naphthol (Furro ER) 是激发态质子转移荧光分子探针。 | |||
T40607 |
2,4,6-Trimethylphenol
Mesitol |
Others | Others |
2,4,6-Trimethylphenol (Mesitol) 是一种与有机物 (3DOM*) 反应的探针化合物,可在水溶液中被单线态氧快速氧化。 | |||
T2P2898 |
Neodiosmin
新地奥斯明,Diosmetin-7-neohesperidoside,新地奥司明,Diosmetin-7-O-neohesperidoside |
Antioxidant | oxidation-reduction |
Neodiosmin (Diosmetin-7-O-neohesperidoside) 是一种黄酮苷,分离自柑桔叶中。 | |||
T2723 |
Ketoisophorone
茶香酮,4-Oxoisophorone,2,6,6-Trimethyl-2-cyclohexene-1,4-dione |
Others | Others |
Ketoisophorone (2,6,6-Trimethyl-2-cyclohexene-1,4-dione) 是工业上重要的环状内酯,是合成类胡萝卜素和调味剂的关键中间体。 | |||
T3821 |
Deapioplatycodin D
Deapi-platycodin D,去芹糖桔梗皂苷 D,去芹糖桔梗皂苷D,DesapioplatycodinD |
Others; HCV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
Deapioplatycodin D 是从桔梗中分离出的一种三萜皂苷,具有抗丙型肝炎病毒活性。 | |||
T16579 |
Pro-xylane
玻色因,Hydroxypropyl tetrahydropyrantriol |
Others | Others |
Pro-xylane (Hydroxypropyl tetrahydropyrantriol) 是一种在水介质中具有生物活性的 c- 糖苷 (C-glycoside),是粘多糖 (GAGs) 的生物合成活化剂,也是第一种应用于化妆品的“绿色”化学物质。 | |||
TJS0315 |
4-Methyldaphnetin
7,8-Dihydroxy-4-methylcoumarin,4-甲基瑞香素,DHMC,7,8-二羟基-4-甲基香豆素 |
Apoptosis; Lipoxygenase | Apoptosis; Metabolism |
4-Methyldaphnetin (DHMC) 是一种合成 4-甲基香豆素衍生物的前体。它对几种肿瘤细胞株具有选择性的抗增殖和诱导凋亡的作用。它能够清除自由基,显著抑制膜脂过氧化。 | |||
TN1003 |
DL-Alanine
DL-2-Aminopropionic acid |
Endogenous Metabolite | Metabolism |
DL-Alanine (DL-2-Aminopropionic acid) 是一种氨基酸,是L-和D-丙氨酸的外消旋化合物。DL-Alanine 与硝酸银水溶液一起用于纳米颗粒生成时常作为还原剂和封端剂。DL-Alanine 是一种甜味剂,可把它位与甘氨酸和糖精钠归为一类。DL-Alanine 在组织和肝脏之间的葡萄糖-丙氨酸循环中起重要作用。DL-Alanine 可用于研究 Cu、Zn、Cd 等过渡金属螯合。 | |||
T39393 |
Samwirin A
|
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Samwirin A is a promising radical scavenger in aqueous media at physiological pH. | |||
T38537 |
Neopuerarin B
|
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Neopuerarin B, an isoflavone derived from the aqueous extract of dried Pueraria lobata (Willd.) roots, exhibits notable hepatoprotective properties. | |||
T20217 |
Grandiflorenic acid
|
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Grandiflorenic acid can reproduce the uterine responses induced by aqueous extract of zoapatle leaves. It is suggested that grandiflorenic acid may have an antifertility effect. | |||
TN6584 |
Pallidol
|
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Pallidol is a potent and selective singlet oxygen quencher in aqueous systems, it may be used in singlet oxygen-mediated diseases as a pharmacological agent. | |||
T38536 |
Neopuerarin A
|
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Neopuerarin A, an isoflavone derived from the aqueous extraction of dried roots of Pueraria lobata (Willd.), displays notable hepatoprotective activity. | |||
T75696 | Ilexoside XLVIII | ||
Ilexoside XLVIII为一种三萜皂苷,自苦冬青叶片水提物分离而得,功能为抑制酰基辅酶A胆固醇酰基转移酶(ACAT)。 | |||
TN4185 |
Hautriwaic acid
|
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Hautriwaic acid shows anti-inflammatory activity in 12-O-tetradecanoylphorbol 13-acetate (TPA) mice ear edema models, it diminishes the joint edema induced by this mixture of polysaccharides (carrageenan), possibly by acting as immunomodulator of the infl |