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GJ103 sodium salt

GJ103 sodium salt

产品编号 T4251   CAS 1459687-96-7

GJ103 sodium salt 是 GJ072 的活性类似物,它是一种通读化合物 (RTC)。它已被证明可以降低水溶液的表面张力,使分子更容易在溶液中移动。它还被证明可以降低水溶液的粘度,使分子更容易在溶液中移动。此外,它还被证明可以降低水溶液的pH 值,这会对生物体的生化和生理过程产生各种影响。

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GJ103 sodium salt Chemical Structure
GJ103 sodium salt, CAS 1459687-96-7
规格 价格/CNY 货期 数量
2 mg ¥ 415 现货
5 mg ¥ 848 现货
10 mg ¥ 1,342 现货
25 mg ¥ 2,652 现货
50 mg ¥ 3,220 现货
100 mg ¥ 4,700 现货
1 mL * 10 mM (in DMSO) ¥ 665 现货
其他形式的 GJ103 sodium salt:
产品目录号及名称: GJ103 sodium salt (T4251)
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选择批次  
纯度: 99.88%
纯度: 99.75%
纯度: 99.72%
纯度: 99.63%
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生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 GJ103 sodium salt is an active analog of GJ072, a read-through compound. It has been shown to reduce the surface tension of aqueous solutions, which makes it easier for molecules to move through the solution. It has also been shown to reduce the viscosity of aqueous solutions, which makes it easier for molecules to move through the solution. Additionally, it has been shown to reduce the pH of aqueous solutions, which can have a variety of effects on the biochemical and physiological processes of living organisms.
体外活性 GJ072 induces ATM kinase on both TGA and TAG stop codons and restored ATMpSer1981 autophosphorylation and SMC1pSer966 transphosphorylation as measured by FACS. GJ072 is active in A-T cells with a homozygous TAA mutation. GJ072 is able to induce detectable full-length ATM protein in treated A-T cells. Early structure-activity relationship studies generates eight active analogs of GJ072. Some GJ072 analogs (e.g., GJ103, GJ106, GJ109, and GJ111) consistently demonstrates their activities in all three PTCs by both FCATMpSer1981 and IRIF assays. GJ071 and GJ072 and some of their analogs (such as GJ103) have similar read-through activity as RTC13 or RTC14, but are more tolerable than RTC13 and RTC14 to A-T cells. GJ103 does not show obvious cytotoxicity in A-T cells at concentration as high as 300 μM.
体内活性 GJ103 sodium salt is water soluble, which will enable us to evaluate its in vivo activity by systematic administration.
细胞实验 Cell proliferation assay is used to measure cytotoxicity. Cells are seeded into a flat-bottom 96-well plate, including control wells containing complete growth medium alone as blank absorbance readings. After RTC treatment (GJ103), activated-XTT Solution is added into each well, and the cells are returned to the cell culture incubator for 12-14 hours. The absorbance is measured at 480 nM with relevant 630 nM to assess nonspecific readings.
分子量 364.36
分子式 C16H13N4NaO3S
CAS No. 1459687-96-7

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

H2O: Soluble

DMSO: 50 mg/mL (137.23 mM)

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7445 mL 13.7227 mL 27.4454 mL 68.6135 mL
5 mM 0.5489 mL 2.7445 mL 5.4891 mL 13.7227 mL
10 mM 0.2745 mL 1.3723 mL 2.7445 mL 6.8613 mL
20 mM 0.1372 mL 0.6861 mL 1.3723 mL 3.4307 mL
50 mM 0.0549 mL 0.2745 mL 0.5489 mL 1.3723 mL
100 mM 0.0274 mL 0.1372 mL 0.2745 mL 0.6861 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. Du L, et al. A new series of small molecular weight compounds induce read through of all three types of nonsense mutations in the ATM gene. Mol Ther. 2013 Sep;21(9):1653-60.
KU-55933 ETP-46464 Elimusertib hydrochloride(1876467-74-1 free base) (Z)-Mirin AZ32 ATM Inhibitor-1 KU-60019 Schisandrin B

相关化合物库

该产品包含在如下化合物库中:
NO PAINS 化合物库 抗抑郁症化合物库 DNA 损伤和修复分子库 抗胰腺癌化合物库 氧化还原化合物库 抗结直肠癌化合物库 糖酵解化合物库 抗肺癌化合物库 代谢化合物库 抗前列腺癌化合物库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
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% Tween 80
% ddH2O
计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

GJ103 sodium salt 1459687-96-7 DNA Damage/DNA Repair PI3K/Akt/mTOR signaling ATM/ATR Inhibitor inhibit GJ-103 sodium salt GJ103 sodium GJ 103 GJ-103 GJ103 inhibitor

 

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