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Search Results for " antidote "

15

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T39477	Calcium trinatrium diethylenetriaminepentaacetic acid hydrate Ca-DTPA trisodium salt hydrate	Others	Others
	Calcium trinatrium diethylenetriaminepentaacetic acid hydrate (Ca-DTPA trisodium salt hydrate) 是螯合剂和有用的解毒剂，如急性镉中毒。它是一种无毒的 CMV 复制抑制剂。
T0765	Fomepizole Antizol-Vet,4-甲基吡唑,甲吡唑,4-Methylpyrazole,Antizol	P450; CAT; AChR	Metabolism; Neuroscience; oxidation-reduction
	Fomepizole (4-Methylpyrazole) 是细胞色素 P450 (CYP2E1) 抑制剂。它是乙醇脱氢酶 (alcohol dehydrogenase) 竞争性抑制剂。它能够阻断甲醇和乙二醇进一步转化为有毒代谢产物。它具有成为乙二醇或甲醇中毒的解毒剂的潜力。
T20608	3-Benzoylpyridine 3 Benzoylpyridine,Phenyl 3-pyridyl ketone,3-苯甲酰基吡啶,Pyridine, 3-benzoyl-	Others	Others
	3-Benzoylpyridine (Phenyl 3-pyridyl ketone) 是人体解毒剂 HGG-12的分解产物。
T21447	Tolazoline Priscol,妥拉苏林,Priscoline,Pridazole,Divascol,Vasimid,Benzalolin	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Tolazoline (Benzalolin) 是一种竞争性的α-肾上腺素受体拮抗剂。
T9948	NecroX-7 LC-280126,LC28-0126,LC28 0126	NADPH-oxidase	Immunology/Inflammation
	NecroX-7 (LC-280126) 是一种有效的自由基清除剂和 HMGB1(高迁移率族蛋白 1) 抑制剂。NecroX-7 可以作为对乙酰氨基酚毒性的解毒剂。NecroX-7 通过抑制缺血/再灌注损伤中 HMGB1 的释放发挥保护作用。NecroX-7 抑制 HMGB1 诱导的 TNF 和 IL-6的释放，以及TLR-4和晚期糖基化终产物受体的表达，用于移植物抗宿主病 (GVHD) 研究。
T24538	N-Monoacetylcystine Parvolex,N-Acetylcystine
	N-Monoacetylcystine is a paracetamol poisoning antidote. It is used in the treatment of influenza A virus pandemic.
T22404	Pralidoxime Iodide 2-PAM,碘解磷定	Others	Others
	Pralidoxime Iodide, also named 2-PAM, is an antidote approved for reactivation of inhibited acetylcholinesterase (AChE) in organophosphate poisoning.
T69079	Trimedoxime bromide
	Trimedoxime bromide is a cholinesterase reactivator used as an antidote in alkyl phosphate poisoning.
T16372	Obidoxime dichloride	Others	Others
	Obidoxime dichloride, a selective oxime agent, effectively reactivates sarin-inhibited acetylcholinesterase (AChE) and mitigates the acute toxicity associated with sarin exposure. It is also utilized as an antidote for organophosphate nerve agent poisoning.
T31370	Delparantag PMX60056,PMX-60056,PMX 60056
	Delparantag( PMX-60056) is a heparins antidote designed to restore coagulation.
T69472	Edrophonium
	Edrophonium is a rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.
T62857	K203
	K203 是一种有效的 tabun 抑制的 AChE 再激活剂，是一种重要的有机磷中毒解毒剂。
T61187	BRD4 Inhibitor-17
	BRD4 Inhibitor-17 (Compound 5i) is a highly potent inhibitor of BRD4, exhibiting an impressive IC50 value of 0.33 μM. It fulfills a crucial regulatory function in transcription by effectively modulating the expression of inflammatory, proliferation, and cell cycle genes. Moreover, BRD4 Inhibitor-17 shows promise as a potential remedy for arsenical-induced toxicity, thus highlighting its potential as an antidote in such cases [1].
T72245	Fomepizole hydrochloride 4-Methylpyrazole hydrochloride
	Fomepizole hydrochloride（4-Methylpyrazole）是一种高效、具口服活性的细胞色素P450（CYP2E1）和竞争性乙醇脱氢酶（alcohol dehydrogenase）抑制剂，阻止甲醇和乙二醇转化为有毒代谢产物，具有用于乙二醇或甲醇中毒解毒的潜力。
T73060	Pralidoxime
	Pralidoxime 是一种有效的乙酰胆碱酯酶 (AChE) 的再激活剂。Pralidoxime 通过肟部分对结合神经毒剂磷中心的亲核攻击，重新激活受神经毒剂抑制的 AChE。Pralidoxime 是一种有机磷中毒的解毒剂。

化合物

Calcium trinatrium diethylenetriaminepentaacetic acid hydrate

Cat.No: T39477

Synonym: Ca-DTPA trisodium salt hydrate

Target: Others

Cat.No: T0765

Synonym: Antizol-Vet,4-甲基吡唑,甲吡唑,4-Methylpyrazole,Antizol

Target: P450, CAT, AChR

3-Benzoylpyridine

Cat.No: T20608

Synonym: 3 Benzoylpyridine,Phenyl 3-pyridyl ketone,3-苯甲酰基吡啶,Pyridine, 3-benzoyl-

Target: Others

Cat.No: T21447

Synonym: Priscol,妥拉苏林,Priscoline,Pridazole,Divascol,Vasimid,Benzalolin

Target: Adrenergic Receptor

Cat.No: T9948

Synonym: LC-280126,LC28-0126,LC28 0126

Target: NADPH-oxidase

N-Monoacetylcystine

Cat.No: T24538

Synonym: Parvolex,N-Acetylcystine

Pralidoxime Iodide

Cat.No: T22404

Synonym: 2-PAM,碘解磷定

Target: Others

Trimedoxime bromide

Cat.No: T69079

Obidoxime dichloride

Cat.No: T16372

Target: Others

Cat.No: T31370

Synonym: PMX60056,PMX-60056,PMX 60056

Cat.No: T69472

Cat.No: T62857

BRD4 Inhibitor-17

Cat.No: T61187

Fomepizole hydrochloride

Cat.No: T72245

Synonym: 4-Methylpyrazole hydrochloride

Cat.No: T73060

Cat. No.	Product Name	Target	Signaling Pathways
T0130	Physostigmine Salicylate 水杨酸依色林,水杨酸毒扁豆碱	AChR; AChE	Neuroscience
	Physostigmine salicylate 是一种可逆的乙酰胆碱酯酶抑制剂，也一种是抗胆碱能中毒的解毒剂。它可透过血脑屏障并刺激中枢胆碱能神经传递。它能逆转阿尔茨海默病转基因小鼠的记忆缺陷。
T1396	Bemegride 贝美格,Bemegrid,3-Ethyl-3-methylglutarimide,Agipnon	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Bemegride (3-Ethyl-3-methylglutarimide) 是一种中枢神经系统兴奋剂和巴比妥类中毒的解毒剂。
T8034	Dimethyl Trisulfide	Others; Endogenous Metabolite	Metabolism; Others
	Dimethyl trisulfide 是存在于大蒜，洋葱，西兰花和类似植物中的有机三硫化物。它是一种氰化物解毒剂。
T0148	Folinic acid calcium 亚叶酸钙,Wellcovorin,Calcium folinate,Leucovorin Calcium,Folinic acid calcium salt	DNA/RNA Synthesis; Endogenous Metabolite; Antifolate	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Folinic acid calcium (Leucovorin Calcium) 是叶酸的活性代谢物，是一种解毒剂，通常与甲氨蝶呤 (MTX) 联用，以降低 MTX 诱导的毒性。

天然产物

Physostigmine Salicylate

Cat.No: T0130

Synonym: 水杨酸依色林,水杨酸毒扁豆碱

Target: AChR, AChE

Cat.No: T1396

Synonym: 贝美格,Bemegrid,3-Ethyl-3-methylglutarimide,Agipnon

Target: GABA Receptor

Dimethyl Trisulfide

Cat.No: T8034

Target: Others, Endogenous Metabolite

Folinic acid calcium

Cat.No: T0148

Synonym: 亚叶酸钙,Wellcovorin,Calcium folinate,Leucovorin Calcium,Folinic acid calcium salt

Target: DNA/RNA Synthesis, Endogenous Metabolite, Antifolate

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