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抑制剂 & 化合物

2

天然产物

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Cat. No. Product Name Target Signaling Pathways
T1785 Palbociclib

PD 0332991,帕博西尼,帕布昔利布

CDK Cell Cycle/Checkpoint
Palbociclib (PD 0332991) 是一种 CDK 抑制剂,抑制 CDK4 和 CDK6 (IC50=11/16 nM),具有口服活性。Palbociclib 具有抗肿瘤活性,有用于 ER 阳性和 HER2 阴性乳腺癌的研究潜力。
T68389 LY2457546

LY2457546 is a potent and orally bioavailable inhibitor of multiple receptor tyrosine kinases involved in angiogenic and tumorigenic signalling. LY2457546 demonstrates potent activity against targets that include VEGFR2 (KDR), PDGFRβ, FLT-3, Tie-2 and members of the Eph family of receptors. In vivo, LY2457546 inhibited VEGF-driven autophosphorylation of lung KDR in the mouse and rat in a dose and concentration dependent manner. LY2457546 was well tolerated and exhibited efficacy in a 13762 synge...

化合物

Palbociclib
Cat.No: T1785
Synonym: PD 0332991,帕博西尼,帕布昔利布
Target: CDK
LY2457546
Cat.No: T68389
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T4S1849 Tubeimoside III

Others Others
Tubeimoside III 是一种具有抗炎和抗肿瘤活性的三萜皂苷,在体内具急性毒性。
TN5050 Sprengerinin C

NADPH-oxidase; VEGFR; p38 MAPK; ROS; Akt; PI3K; mTOR; p53 Angiogenesis; Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can strongly suppress tumor angiogenesis in human umbilical vein endothelial cells, it blocks vascul

天然产物

Tubeimoside III
Cat.No: T4S1849
Synonym:
Target: Others
Sprengerinin C
Cat.No: TN5050
Synonym:
Target: NADPH-oxidase, VEGFR, p38 MAPK, ROS, Akt, PI3K, mTOR, p53
TargetMol Loading
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