11
4
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9272 |
Xaliproden hydrochloride
|
Dopamine Receptor; 5-HT Receptor | GPCR/G Protein; Neuroscience |
Xaliproden hydrochloride 是选择性和具有口服活性的5-HT1A 受体激动剂,对大鼠海马中的 5-HT1A 特异性结合位点表现出高亲和力。它也是选择性的多巴胺D2受体拮抗剂,具有抗抑郁和抗焦虑作用,有用于神经退行性疾病的研究潜力。 | |||
T2371 |
Emapunil
AC-5216,XBD-173 |
Others | Others |
Emapunil (XBD-173) 是一种选择性的、口服有效的TSPO(一种线粒体苯二氮受体) 的配体。在多种动物模型中,它显示出抗焦虑和抗抑郁特性。 | |||
T21233 |
Dihydrolipoic acid
Reduced thioctic acid,Reduced lipoic acid,DHLA,USAF XR-12,6,8-Dihydrothioctic acid,二氢硫辛酸 |
Antioxidant | oxidation-reduction |
Dihydrolipoic acid (USAF XR-12) 是高效的抗氧化剂,对所有以氧为中心的自由基都有很强的清除能力。它在多种疾病中表现出抗炎特性。在 LPS 诱导的疾病行为大鼠中,它通过 ERK/Nrf2/HO-1/ROS/NLRP3 通路发挥预防作用。它还可以可用于抑郁症的研究。 | |||
T67937 |
Ampreloxetine hydrochloride
TD-9855 HCl |
||
Ampreloxetine hydrochloride (TD-9855 HCl) 具有抗炎活性,是治疗抑郁症和阿尔茨海默病的潜在化合物。 | |||
T10201 |
PDE IV-IN-1
|
PDE | Metabolism |
PDE IV-IN-1 是一种有效的磷酸二酯酶4 (PDE4)抑制剂,具有抗炎活性,可用于治疗哮喘,慢性阻塞性肺病和其他炎症性疾病,是研究抑郁症的潜在化合物。 | |||
T50003 |
Debrisoquin hydriodide
1,2,3,4-tetrahydroisoquinoline-2-carboximidamide hydroiodide |
Others | Others |
Debrisoquin hydriodide (1,2,3,4-tetrahydroisoquinoline-2-carboximidamide hydroiodide) 具有抗氧化、抗炎和神经保护特性,也被发现可以调节某些神经递质的活性,包括多巴胺和血清素,使其成为治疗帕金森病和抑郁症等神经疾病的有前途的候选药物。 | |||
T32535 |
Ladostigil
TV-3326,Ladostigil,TV 3326,TV3326,Ladostigil free base |
Antioxidant; MAO; AChE | Metabolism; Neuroscience; oxidation-reduction |
Ladostigil (Ladostigil free base) 是一种具有口服活性的胆碱酯酶和脑选择性单胺氧化酶(MAO)双重抑制剂,对 MAO-B 和 AChE 具有抑制作用,IC50值分别为37.1和31.8μM。Ladostigil 具有抗炎、抗氧化和神经保护活性,可用于研究抑郁症和阿尔茨海默病。 | |||
T61625 | GABAA receptor agonist 2 | ||
GABAA receptor agonist 2 (compound 4c) is a highly potent GABAA receptor agonist which exhibits anti-depressive properties in classical mouse models of depression, such as the FST and TST. By binding to the GABA binding site on the GABAA receptor, GABAA receptor agonist 2 produces GABAergic effects. Notably, Compound 4c holds promise for depression research [1]. | |||
T60842 | GABAA receptor agonist 1 | ||
GABAA receptor agonist 1 (compound 3e) 是有效的 GABAA 受体激动剂,它结合在GABAA 受体的 GABAA 结合位点结合以产生 GABA 能效应。GABAA receptor agonist 1 在 FST 和 TST 抑郁症的经典小鼠模型中具有抗抑郁活性,在抑郁症研究中具有潜力。 | |||
T39513 |
Ladostigil hemitartrate
TV-3326 hemitartrate,Ladostigil hemitartrate |
||
Ladostigil hemitartrate (TV-3326) is a compound that acts as a dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO). It has IC50 values of 37.1 μM for MAO-B and 31.8 μM for AChE. In addition, Ladostigil hemitartrate possesses neuroprotective, antioxidant, and anti-inflammatory properties. It is commonly used in research relating to depression and Alzheimer's disease. | |||
T72247 |
Ladostigil hydrochloride
TV-3326 hydrochloride |
||
Ladostigil (TV-3326) hydrochloride 是一种口服有效的胆碱酯酶(cholinesterase)和脑选择性单胺氧化酶(MAO)的双重抑制剂,抑制MAO-B 和AChE 的IC50值分别为 37.1 和 31.8 μM。Ladostigil hydrochloride 具有神经保护,抗氧化和抗炎的作用,可用于抑郁症和阿尔茨海默症的研究。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN6490 |
Regaloside C
|
Others | Others |
Regaloside C 是一种从百合属的中分离出来的甘油葡糖苷,具有抗炎作用。 | |||
TN1015 |
Meranzin
|
Adrenergic Receptor; Immunology/Inflammation related | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Meranzin 是从传统中药 Chaihu-Shugan-San (CSS) 中的生物活性化合物,是从紫茉莉叶中分离出的,能够调节共有的 α2-肾上腺素受体,并参与 AMPA-ERK1/2-BDNF 信号传导。它有潜在的预防动脉粥样硬化和抑郁症合并症。 | |||
TN4519 |
Mesuaxanthone A
胡桐,海棠木 |
Others | Others |
Mesuaxanthone A and mesuaxanthone B are two yellow pigments.They produce varying degrees of C.N.S. depression characterised by ptosis, sedation, decreased spontaneous motor activity, loss of muscle tone, potentiation of pentobarbitone sleeping time and et | |||
TN1194 | 16beta,17-Dihydroxy-ent-kaurane-19-oic acid | HIV Protease | Microbiology/Virology; Proteases/Proteasome |
16beta,17-Dihydroxy-ent-kaurane-19-oic acid as an anti-HIV principle, it showed significant activity against HIV replication in H9 lymphocyte cells with an EC50 value of 0.8 microgram/mL. It also possesses the activities of decompression and blood viscosi |