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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T17316	α-Lipoic acid-NHS DL-α-Lipoic acid-NHS	Others	Others
	α-Lipoic acid-NHS is an alkyl/ether-based PROTAC linker utilized in the synthesis of PROTACs [1].
T26599	Alpha-Lipoic Acid Choline Ester EV-06,EV 06,alphaLACE,alpha-LACE,EV06,alpha LACE
	Alpha-Lipoic Acid Choline Ester is used potentially to treat presbyopia.
T6157	Devimistat CPI-613,辛酸,CPI613,CPI 613,6,8-Bis(benzylthio)octanoic acid	Apoptosis; Dehydrogenase; Mitochondrial Metabolism	Apoptosis; Metabolism
	Devimistat (6,8-Bis(benzylthio)octanoic acid) 是一种线粒体代谢抑制剂，还是一种lipoic acid 拮抗剂，能阻断线粒体能量代谢，诱导多种癌细胞凋亡。
T35628	AN-7
	α-Lipoic acid is a cyclic disulfide antioxidant that interconverts with its reduced dithiol form. It is an essential cofactor for decarboxylation reactions of the citric acid cycle and acts as a general antioxidant. AN-7 is a more lipophilic analog of α-lipoic acid with enhanced potency and 1.5-fold increased maximal capacity to stimulate glucose transport into myocytes. This identifies the analogs of lipoic acid as potential new treatments for diabetes.
T37827	CAY10506 CAY10506
	Anti-diabetic drugs of the thiazolidinedione (TZD) structural class as well as α-lipoic acid activate peroxisome proliferator-activated receptor γ (PPARγ), a nuclear transcription factor that controls glucose metabolism and lipid homeostasis. CAY10506 is a hybrid lipoic acid-TZD derivative that transactivates human PPARγ with an EC50 value of 10 μM.
T21234	(R)-Dihydrolipoic acid
	(R)-Dihydrolipoic acid is a R-isomer of Dihydrolipoic acid. It is optically active, but only the R-enantiomer is biochemically significant. The lipoic acid/dihydrolipoic acid pair participate in a variety of biochemical transformations.
T73547	CPUL1
	CPUL1 是一种TrxR 抑制剂，对 A549 细胞显示出增殖抑制和抗转移活性。CPUL1 通过抑制TrxR1酶活性来诱导 ROS 介导的ERK/JNK 信号传导从而影响上皮-间质转化 (EMT)。CPUL1 与α-Lipoic Acid 或Dithiodipropionic acid 联合使用效果更好。
T74496	LA-Bac8c
	LA-Bac8c为经硫辛酸修饰的抗菌肽，展现出增强的抗菌效能。针对金黄色葡萄球菌、MRSA、表皮葡萄球菌、大肠杆菌及铜绿假单胞菌的MIC值分别为1、4、8、8和8μg/mL，显示其对上述菌株具有强效的抑制作用。

化合物

α-Lipoic acid-NHS

Cat.No: T17316

Synonym: DL-α-Lipoic acid-NHS

Target: Others

Alpha-Lipoic Acid Choline Ester

Cat.No: T26599

Synonym: EV-06,EV 06,alphaLACE,alpha-LACE,EV06,alpha LACE

Target:

Devimistat

Cat.No: T6157

Synonym: CPI-613,辛酸,CPI613,CPI 613,6,8-Bis(benzylthio)octanoic acid

Target: Apoptosis, Dehydrogenase, Mitochondrial Metabolism

Synonym: CAY10506

Target:

(R)-Dihydrolipoic acid

Cat. No.	Product Name	Target	Signaling Pathways
T2930	α-Lipoic Acid Lipoic acid,Alphalipoic acid,硫辛酸	NF-κB; HIV Protease; Mitochondrial Metabolism; Endogenous Metabolite	Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
	α-Lipoic Acid (Alphalipoic acid) 抑制 NF-κB 依赖性 HIV-1 LTR 活化。 α-硫辛酸诱导内质网 (ER) 应激介导的肝癌细胞凋亡。α-硫辛酸是一种抗氧化剂，是线粒体酶复合物的重要辅助因子。
T0200	α-Lipoic Acid Thioctic acid,DL-α-Lipoic acid,(±)-α-Lipoic acid,α-硫辛酸,硫辛酸	Apoptosis; NF-κB; HIV Protease; Mitochondrial Metabolism; Endogenous Metabolite	Apoptosis; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
	α-Lipoic Acid (DL-α-Lipoic acid) 是线粒体酶复合物的重要辅助因子，是一种抗氧化剂，可抑制NF-κB 依赖性的HIV-1LTR 活化。它还可诱导内质网应激介导的肝癌细胞凋亡。
T22235	Lipoic acid R-(+)-硫辛酸,硫辛酸,R-(+)-Thioctic acid,(R)-(+)-1,2-Dithiolane-3-pentanoic acid,(R)-(+)-α-Lipoic acid	Reactive Oxygen Species; Mitochondrial Metabolism; Endogenous Metabolite	Immunology/Inflammation; Metabolism; NF-κB
	Lipoic acid (R-(+)-Thioctic acid) ((R)-(+)-α-Lipoic acid) 是一种抗氧化剂，是线粒体酶复合物的重要辅助因子。与外消旋 Lipoic acid 相比，Lipoic acid ((R)-(+)-α-Lipoic acid)更有效。
T72429	α-Lipoic Acid sodium Thioctic acid sodium,DL-α-Lipoic acid sodium,Thioctic acid sodium ; (±)-α-Lipoic acid sodium ; DL-α-Lipoic acid sodium,(±)-α-Lipoic acid sodium
	α-Lipoic Acid (Thioctic acid) sodium 是一种抗氧化剂，是线粒体酶复合物的重要辅助因子。α-Lipoic Acid sodium 可抑制NF-κB 依赖性的HIV-1LTR 活化。α-Lipoic Acid sodium 诱导内质网应激 (ERS) 介导的肝癌细胞凋亡 (apoptosis)。α-Lipoic Acid sodium 可与CPUL1 合成自组装的纳米聚合体 CPUL1-LA NA，其抗肿瘤效果优于 CPUL1。