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19

抑制剂 & 化合物

1

天然产物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
TP1924	ZIP
	Novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1
T22175L	ZIP (SCRAMBLED) Acetate ZIP (SCRAMBLED) Acetate(908012-18-0 Free Base)	Others	Others
	ZIP (SCRAMBLED) Acetate (ZIP (SCRAMBLED) Acetate (908012-18-0 Free Base)) 是一种乱序肽，可用作 zeta 抑制肽 (ZIP) 的阴性对照。
TP1924L1	ZIP acetate(863987-12-6 free base)	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	ZIP acetate(863987-12-6 free base) 是一种新型的细胞渗透性蛋白激酶 Mζ (PKMζ) 抑制剂，它是一种参与 LTP 维持的组成型活性非典型 PKC 同工酶。在体外选择性阻断 PKMζ 诱导的海马切片突触增强。逆转晚期 LTP (IC50 = 1 - 2.5 μM) 并在体内中央给药后导致 1 天前的空间记忆持续丧失。
TP2303	ZIP, Biotinylated	Others	Others
	ZIP with a biotin moiety covalently attached
T75884	ZIP TFA
	ZIP TFA为选择性PKMζ肽抑制剂，能够抑制因吗啡条件性位置偏好所诱导的神经损伤。
T0031	Ziprasidone hydrochloride monohydrate 齐拉西酮盐酸盐一水合物,盐酸齐拉西酮水合物,CP 88059	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; Norepinephrine; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Ziprasidone hydrochloride monohydrate (CP 88059) 是一种联合 5-HT（5-羟色胺）和多巴胺受体拮抗剂，具有抗精神病活性的强效作用。它也是去甲肾上腺素再摄取抑制剂。
T0031L	Ziprasidone hydrochloride 盐酸齐拉西酮,齐拉西酮盐酸盐,CP-88059 hydrochloride,CP-88059,Ziprasidone HCl	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; Norepinephrine; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Ziprasidone hydrochloride (CP-88059 hydrochloride) 是一种联合 5-HT（5-羟色胺）和多巴胺受体拮抗剂，具有抗精神病活性的强效作用。它也是去甲肾上腺素再摄取抑制剂。
T0031L2	Ziprasidone 齐拉西酮,Geodon,Zeldox,CP-88059	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; Norepinephrine; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Ziprasidone (Geodon) 是一种联合的 5-HT(5-羟色胺)和多巴胺受体拮抗剂，具有强大的抗精神病活性。它是去甲肾上腺素再摄取抑制剂，对大鼠和人的5-HT1A，5-HT2A 和多巴胺 D2 受体有很高的亲和力。
T11753	Keto Ziprasidone	Potassium Channel	Membrane transporter/Ion channel
	Ziprasidone, an antipsychotic agent, functions as a dual antagonist of 5-HT (serotonin) and dopamine receptors. Keto Ziprasidone represents an impurity found within Ziprasidone.
T63979	Ziprasidone mesylate trihydrate
	Ziprasidone (CP-88059) mesylate trihydrate 是一种具有口服具有活力的 5-HT 和多巴胺 (dopamine) 受体拮抗剂，对大鼠 D2、5-HT2A 和 5-HT1A 有亲和作用，他们的 Ki 值分别为 4.8 nM、0.42 nM 和 3.4 nM。
T30289	Balazipone UNII-GLI733V999
	Balazipone is a bio-active chemical.
T63504	Ziprasidone mesylate
	Ziprasidone (CP-88059) mesylate 是口服具有活力的5-HT 和多巴胺 (dopamine) 受体拮抗剂。Ziprasidone mesylate 对大鼠D2、5-HT2A 和5-HT1A 有亲和作用，他们的Ki 值分别为4.8 nM、0.42 nM、Ki=3.4 nM。
T13400	Ziprasidone D8 CP-88059 D8	Others	Others
	Ziprasidone D8 is deuterium labeled Ziprasidone, which is a antagonist of combined 5-HT (serotonin) and dopamine receptor and exhibits potent effects of antipsychotic activity.
T11586	Hydroxy ziprasidone	Others	Others
	Hydroxy ziprasidone is an impurity of Ziprasidone. Ziprasidone, an antipsychotic agent, is a 5-HT and dopamine receptor antagonist.
T124294	Norjuziphine
	Norjuziphine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124294。
T33218	Mazipredone Mazipredonum,Mazipredona
	Mazipredone is a water-soluble, long-acting prednisolone derivative used topically for skin conditions & parenterally as a glucocorticoid.
T73961	Ziprasidone amino acid
	Ziprasidone amino acid (Ziprasidone Impurity C) 是 Ziprasidone 的杂质。Ziprasidone 是5-HT 和多巴胺 (dopamine receptor) 受体拮抗剂，具有抗精神病活性。
T83740	Ziptide TFA
	Ziptide是多种丝氨酸/苏氨酸蛋白激酶的肽底物，包括MAPK激活蛋白激酶2（MAPKAPK2）、MAPKAPK3、MAPKAPK5、checkpoint kinase 1（Chk1）、AMP激活蛋白激酶（AMPK）和钙/钙调蛋白依赖型蛋白激酶II（CamKII）。它被用来评估CamKII活性以用于抑制剂的开发。
T70843	Orazipone
	Orazipone inhibits cytokine production and histamine release; an NSAID.

化合物

Cat.No: TP1924

ZIP (SCRAMBLED) Acetate

Cat.No: T22175L

Synonym: ZIP (SCRAMBLED) Acetate(908012-18-0 Free Base)

Target: Others

ZIP acetate(863987-12-6 free base)

Cat.No: TP1924L1

Target: PKC

ZIP, Biotinylated

Cat.No: TP2303

Target: Others

Cat.No: T75884

Ziprasidone hydrochloride monohydrate

Cat.No: T0031

Synonym: 齐拉西酮盐酸盐一水合物,盐酸齐拉西酮水合物,CP 88059

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, Norepinephrine, Histamine Receptor

Ziprasidone hydrochloride

Cat.No: T0031L

Synonym: 盐酸齐拉西酮,齐拉西酮盐酸盐,CP-88059 hydrochloride,CP-88059,Ziprasidone HCl

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, Norepinephrine, Histamine Receptor

Cat.No: T0031L2

Synonym: 齐拉西酮,Geodon,Zeldox,CP-88059

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, Norepinephrine, Histamine Receptor

Keto Ziprasidone

Cat.No: T11753

Target: Potassium Channel

Ziprasidone mesylate trihydrate

Cat.No: T63979

Cat.No: T30289

Synonym: UNII-GLI733V999

Ziprasidone mesylate

Cat.No: T63504

Ziprasidone D8

Cat.No: T13400

Synonym: CP-88059 D8

Target: Others

Hydroxy ziprasidone

Cat.No: T11586

Target: Others

Cat.No: T124294

Cat.No: T33218

Synonym: Mazipredonum,Mazipredona

Ziprasidone amino acid

Cat.No: T73961

Cat.No: T83740

Cat.No: T70843

Cat. No.	Product Name	Target	Signaling Pathways
T73069	Kurzipene D
	Kurzipene D是一种有效的抗癌剂(anticanceragent)，通过诱导HepG2细胞凋亡(apoptosis)并使其在S期阻滞，显示出明显的抗肿瘤作用。通过体内斑马鱼模型，Kurzipene D展现了其抑制肿瘤增殖和迁移的特性。

天然产物

Cat.No: T73069

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04385	ZIP Kinase/DAPK3 Protein, Human, Recombinant (GST) death-associated protein kinase 3,DLK,ZIP,ZIP	Human	Baculovirus Insect Cells
	Death-associated protein kinase 3, also known as DAP kinase 3, ZIP-kinase, DAPK3 and ZIPK, is a nucleus and cytoplasm protein which belongs to theprotein kinase superfamily, CAMK Ser/Thr protein kinase family and DAP kinase subfamily. DAPK3 / ZIPK contains oneprotein kinase domain. It is a serine/threonine kinase which acts as a positive regulator of apoptosis. It phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. DAPK3 / ZIPK is a homodimer or forms heterodimers with AT...
TMPH-03648	Cruzipain Protein, Trypanosoma cruzi, Recombinant (His & Myc) Cruzaine,Cruzipain,Major cysteine proteinase	Trypanosoma cruzi	E. coli
	Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group.; The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle. Cruzipain Protein, Trypanosoma cruzi, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weig...

重组蛋白

ZIP Kinase/DAPK3 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04385

Species: Human

Expression System: Baculovirus Insect Cells

Cruzipain Protein, Trypanosoma cruzi, Recombinant (His & Myc)

Cat.No: TMPH-03648

Species: Trypanosoma cruzi

Expression System: E. coli

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