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Cat. No.	Product Name	Target	Signaling Pathways
T9912	Trastuzumab	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Trastuzumab 是人源化单克隆抗体，以高亲和力与HER2选择性结合，可用于 HER2 阳性转移性乳腺癌和 HER2 阳性胃癌的研究。
T36646	Trastuzumab deruxtecan DS-8201a,VRN-101099,DS 8201,T-DXd	Others	Others
	Trastuzumab deruxtecan (T-DXd) 是一种具有抗癌抗肿瘤活性的抗体-活性分子偶联物 (ADC)。Trastuzumab deruxtecan 对 HER2 阳性乳腺癌和胃癌有改善作用。
T80955	Trastuzumab duocarmazine (vic)-Trastuzumab duocarmazine
	Trastuzumab duocarmazine ((vic)-Trastuzumab duocarmazine) 是一款HER2靶向ADC，它通过组织蛋白酶B的识别和裂解作用，选择性地作用于肿瘤细胞。此化合物在子宫和卵巢癌肉瘤等癌症的研究中显示出抗肿瘤活性。
T36647	Trastuzumab emtansine	Others	Others
	Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that combines the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of DM1, a microtubule-inhibitory derivative of maytansine. This compound is utilized in the investigation of advanced breast cancer[1][2].
T76971	Trastuzumab beta
	Trastuzumab beta (ABP 980)是Trastuzumab的生物仿制药，靶向人表皮生长因子受体2 (HER2) 的单克隆抗体 (McAb)。该药物适用于研究HER2阳性转移性乳腺癌、早期乳腺癌 (EBC) 和转移性胃癌。
T38889	Thailanstatin A
	Thailanstatin A 是真核 RNA 剪接抑制剂，IC50为650 nM，通过非共价结合到剪接体的 U2 snRNA 亚复合物的 SF3b 亚单位发挥作用。Thailanstatin A 对多种癌细胞系的抑制显示 nM 级别的 IC50。它与 Trastuzumab 上的赖氨酸结合，可产生“无连接子” ADC。
T9996	NCT-58 NCT58	HSP	Cytoskeletal Signaling; Metabolism
	NCT-58是一种有效的C 端HSP90抑制剂。NCT-58不会引起热休克反应（HSR）。NCT-58通过同时下调HER 家族成员以及抑制Akt 磷酸化来激发抗肿瘤活性。NCT-58杀死对曲妥珠单抗耐药的乳腺癌干细胞样细胞。NCT-58诱导HER2阳性乳腺癌细胞凋亡。
T36669	IYPTNGYTR acetate
	IYPTNGYTR acetate, a deamidation-sensitive peptide derived from Trastuzumab, is a suitable tool for monitoring the metabolism of Trastuzumab in vivo [1].
T38906	IYPTNGYTR
	IYPTNGYTR, a deamidation-sensitive peptide, is a deamidation derivative of Trastuzumab. This compound, IYPTNGYTR, can be utilized for monitoring Trastuzumab metabolism in vivo.
T81288	Rezetecán
	Rezetecán 是 Trastuzumab rezetecan 合成的原料，后者为抗肿瘤药物。
T74940	Anticancer agent 81	Apoptosis	Apoptosis
	Anticanceragent 81（Compound 37b3）是用于诱导肿瘤细胞发生周期阻滞和凋亡（apoptosis）的化合物。当Anticanceragent 81作为有效载荷与Trastuzumab结合时，可生成抗体药物偶联物（ADC）T-PBA，此ADC保留了Trastuzumab的靶向特性和内化功能。
T11936	Macropa-NCS	Others	Others
	Macropa-NCS is conjugated to trastuzumab as well as to the prostate-specific membrane antigen-targeting compound RPS-070.
T81084	STING agonist-18
	STINGagonist-18（compound 1a）适用于ADCs的合成，例如与Trastuzumab偶联。
T38023	FTISADTSK acetate
	FTISADTSK acetate is a stable endogenous signature peptide sourced from Trastuzumab, which can be monitored using selected reaction monitoring (SRM)[1].
T38907	FTISADTSK
	FTISADTSK is an endogenous stable signature peptide derived from Trastuzumab, which can be accurately assessed using selected reaction monitoring (SRM).
T15872	m-PEG4-Br	Others	Others
	m-PEG4-Br is a cleavable ADC linker used in the synthesis of antibody-drug conjugate (ADC) for Trastuzumab. m-PEG4-Br is placed distally from the monomethyl auristatin E (MMAE) payload to yield an ADC with altered hydrophilicity, antigen binding, and in v
T16008	Maleimido-tri(ethylene glycol)-propionic acid Mal-PEG3-acid	Others	Others
	Maleimido-tri(ethylene glycol)-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Maleimido-tri(ethylene glycol)-propionic acid is used for the preparation of neolymphostin-based ADC precursors for site-spec
T77885	(Aminooxy)acetamide-Val-Cit-PAB-MMAE
	'(Aminooxy)acetamide-Val-Cit-PAB-MMAE (MMAE 5) 是用于ADC药物-接头偶联物合成的中间体。该化合物通过与聚酰胺形成肟键，得到MMAE聚酰胺偶联物，进一步与Trastuzumab偶联，制备成ADC。'
T36648	Tucatinib hemiethanolate
	Tucatinib (Irbinitinib) hemiethanolate is a potent, orally active and selective HER2 inhibitor with an IC50 of 8 nM. Tucatinib hemiethanolate has nanomolar activity against purified HER2 enzyme and is approximately 500-fold selective for HER2 versus EGFR in cell-based assays. Tucatinib selectively inhibits the receptor tyrosine kinase HER2 relative to EGFR[1].Tucatinib blocks proliferation and the phosphorylation of HER2 and its downstream effector, Akt in HER2 overexpressing cell lines. In the ...

化合物

Cat.No: T9912

Target: EGFR

Trastuzumab deruxtecan

Cat.No: T36646

Synonym: DS-8201a,VRN-101099,DS 8201,T-DXd

Target: Others

Trastuzumab duocarmazine

Cat.No: T80955

Synonym: (vic)-Trastuzumab duocarmazine

Trastuzumab emtansine

Cat.No: T36647

Target: Others

Trastuzumab beta

Cat.No: T76971

Thailanstatin A

Cat.No: T38889

Cat.No: T9996

Synonym: NCT58

Target: HSP

IYPTNGYTR acetate

Cat.No: T36669

Cat.No: T38906

Cat.No: T81288

Anticancer agent 81

Cat.No: T74940

Target: Apoptosis

Cat.No: T11936

Target: Others

STING agonist-18

Cat.No: T81084

FTISADTSK acetate

Cat.No: T38023

Cat.No: T38907

Cat.No: T15872

Target: Others

Maleimido-tri(ethylene glycol)-propionic acid

Cat.No: T16008

Synonym: Mal-PEG3-acid

Target: Others

(Aminooxy)acetamide-Val-Cit-PAB-MMAE

Cat.No: T77885

Tucatinib hemiethanolate

Cat.No: T36648

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