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Search Results for " toxoplasma "

12

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1172	Diclazuril 地克珠利,R-64433	Antibiotic; Parasite	Microbiology/Virology
	Diclazuril (R-64433) 是一种具有口服活性的抗球虫剂，是苯乙腈衍生物。它可用于某些传染病和寄生虫病的相关研究。
T25549	JCP174 JCP 174,JCP-174	Serine Protease	Proteases/Proteasome
	JCP174是一种去棕榈酰化酶抑制剂，可通过靶向 TgPPT1增强弓形虫的宿主细胞侵袭。
T78605	CpCDPK1/TgCDPK1-IN-1	Bcr-Abl; Src	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	CpCDPK1/TgCDPK1-IN-1 是一种高效的 CpCDPK1 和 TgCDPK1 双重抑制剂，抑制 Abl 和 Src，具有抗寄生虫活性，适用于研究弓形虫感染和隐孢子虫病。
T72081	CpCDPK1/TgCDPK1-IN-2	Parasite	Microbiology/Virology
	CpCDPK1/TgCDPK1-IN-2 是 CpCDPK1 和 TgCDPK1 双重抑制剂，对 CpCDPK1 和 TgCDPK1 有抑制这样，IC50 值分别为 12 和 5 nM。CpCDPK1/TgCDPK1-IN-2 可用于研究弓形虫 (T. gondii)、细小隐孢子虫 (C. parvum) 和隐孢子虫 (C. hominus) 等顶复门原生动物感染相关疾病。
T36692	Fanotaprim	DHFR	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Fanotaprim 是二氢叶酸还原酶的有效抑制剂，抑制 tgDHFR (Toxoplasma gondiiDHFR) 和 hDHFR (human DHFR)的 IC50分别为 1.57 和 308 nM。Fanotaprim 在研究弓形虫病方面具有价值。
T72033	pCDPK1/TgCDPK1-IN-3	Parasite	Microbiology/Virology
	CpCDPK1/TgCDPK1-IN-3 是一种 CpCDPK1 和 TgCDPK1双重抑制剂，对 CpCDPK1 的IC50 为 0.003µM ，对TgCDPK1 的IC50 为 0.0036 µM。CpCDPK1/TgCDPK1-IN-3 可用于研究像弓形虫、细小隐孢子虫和隐孢子虫等顶复门原生动物相关疾病感染。
T69311	GW300657X
	GW300657X is a small molecule inhibitor that blocks toxoplasma gondii rhoptry kinase 18 and maintains moderate CDK2-cyclin A inhibitory activity.
T29003	TRC-19
	TRC-19 is a potent and selective inhibitor of Toxoplasma gondii dihydrofolate reductase. TRC-19 shows an IC50 of 9 nM and 89-fold selectivity in favor of Toxoplasma gondii dihydrofolate reductase.
T61671	MMV687807
	MMV687807 is a potent anthelmintic compound exhibiting strong efficacy against Toxoplasma gondii (T. gondii). It demonstrates an IC50 value of 0.15 μM and a CC50 value of 1.69 μM [1].
T76121	Phosphoglucomutase	Endogenous Metabolite	Metabolism
	Phosphoglucomutase可促进弓形虫的囊肿发育。缺乏 Phosphoglucomutase 会引发代谢疾病。
T62333	Anti-Trypanosoma cruzi agent-1
	Anti-Trypanosoma cruzi agent-1 (Compd E5) 具有有效的抗弓形虫效果。
T38269	Purfalcamine
	Purfalcamine is an orally active, selective Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) inhibitor with an IC50 of 17 nM and an EC50 of 230 nM. Purfalcamine has antimalarial activity and causes malaria parasites developmental arrest at the schizont stage[1][2]. Purfalcamine has low activity against Toxoplasma gondii calcium-dependent protein kinase 3 (TgCDPK3)[1]. Purfalcamine (225, 450 nM) has no effect on the parasitemia in the first 32 hours. After about 40 hours, paras...

化合物

Cat.No: T1172

Synonym: 地克珠利,R-64433

Target: Antibiotic, Parasite

Cat.No: T25549

Synonym: JCP 174,JCP-174

Target: Serine Protease

CpCDPK1/TgCDPK1-IN-1

Cat.No: T78605

Target: Bcr-Abl, Src

CpCDPK1/TgCDPK1-IN-2

Cat.No: T72081

Target: Parasite

Cat.No: T36692

Target: DHFR

pCDPK1/TgCDPK1-IN-3

Cat.No: T72033

Target: Parasite

Cat.No: T69311

Cat.No: T29003

Cat.No: T61671

Phosphoglucomutase

Cat.No: T76121

Target: Endogenous Metabolite

Anti-Trypanosoma cruzi agent-1

Cat.No: T62333

Cat.No: T38269

Cat. No.	Product Name	Target	Signaling Pathways
TN7103	13,21-Dihydroeurycomanone Pasakbumin C	Anti-infection; Parasite	Microbiology/Virology
	13,21-Dihydroeurycomanone (Pasakbumin C) 是从 Eurycoma longifolia 根部分离得到的一种天然产物，有抗寄生虫活性。
T0819	Spiramycin Espiramicin,螺旋霉素,Sequamycin,Rovamycin,Provamycin,Formacidine	Antibacterial; Antibiotic; Parasite	Microbiology/Virology
	Spiramycin (Rovamycin) 是一种由安博链霉菌产生的大环内酯类抗生素，具有抗细菌和弓形虫活性，并具有抗寄生虫作用。它由 16 个内酯环组成，其上附着 mycaminose，forosamine 和 mycarose 三种糖。
T35750	Trypacidin
	Trypacidin is a fungal metabolite originally isolated fromA. fumigatus.1It is active againstB. subtilisandM. bovis(MICs = 12.5 and 1.25 μg/ml, respectively), as well asT. cruziandT. gondii(MICs = 5-10 and 10-20 μg/ml, respectively).1,2It reduces viability and induces lysis of A549 human lung cancer cells (IC50s = 7.4 μM for both).3Trypacidin increases survival in a mouse model ofT. gondiiinfection when administered in six doses of 12.5 mg/kg each.1 1.Balan, J., Ebringer, L., Nemec, P., et al.Ant...

天然产物

13,21-Dihydroeurycomanone

Cat.No: TN7103

Synonym: Pasakbumin C

Target: Anti-infection, Parasite

Cat.No: T0819

Synonym: Espiramicin,螺旋霉素,Sequamycin,Rovamycin,Provamycin,Formacidine

Target: Antibacterial, Antibiotic, Parasite

Cat.No: T35750

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