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Search Results for " tetrandrine "

3

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T26911	Bromotetrandrine 5-Bromotetrandrine,W-198,BrTet,W 198,W198
	Bromotetrandrine is an P-glycoprotein inhibitor, which were developed and coadministered with chemotherapeutic drugs to overcome the effect of efflux pumps thus enhancing the chemosensitivity of therapeutics.
T67948	OY-101
	OY-101为口服生效的特异性P-glycoprotein(P-gp)抑制剂。该化合物可增强耐药性肿瘤的敏感性，并有效逆转多药耐药现象。相较于Tetrandrine，OY-101在水溶性、细胞毒性以及逆转活性方面均表现出改进。
T36805	TPC2-A1-N TPC2-A1-N
	TPC2-A1-N is a novel, lipophilic, membrane permeable isoform-selective small molecule agonist of two-pore channel 2 (TPC2). TPC2-A1-N plays its role by mimicking the physiological actions of NAADP and PI(3,5)P2 through independent binding sites. TPC2-A1-N has inverse effects on key lysosomal activities and increases the pH in the lysosomal lumen in a TPC2-dependent manner[1].

化合物

Bromotetrandrine

Cat.No: T26911

Synonym: 5-Bromotetrandrine,W-198,BrTet,W 198,W198

Cat.No: T67948

Cat.No: T36805

Synonym: TPC2-A1-N

Cat. No.	Product Name	Target	Signaling Pathways
T2996	Tetrandrine NSC-77037,d-Tetrandrine,Hanfangchin A,粉防己碱,Fanchinine,Sinomenine A,汉防己甲素	Potassium Channel; Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Tetrandrine (Sinomenine A) 是来自粉防己的一种双苯基异喹啉生物碱，可抑制电压门控钙离子通道 (ICa) 和 Ca2+激活的钾离子通道。
T2809	(R)-Fangchinoline 防己醇灵,Thaligine,(+)-Thalrugosine,Demethyl tetrandrine	FAK; Antibacterial; Antibiotic	Angiogenesis; Cytoskeletal Signaling; Microbiology/Virology; Tyrosine Kinase/Adaptors
	(R)-Fangchinoline ((+)-Thalrugosine) 是一种来自Stephania 属的生物碱，具有抗菌和降血压活性。它可用作中药，可用于发烧，腹泻，消化不良和泌尿疾病的研究。
T3122	Fangchinoline Tetrandrine B,防己诺林碱,(+)-Limacine,Hanfangichin B,防己醇灵,(+)-Fangchinoline	Apoptosis; FAK; HIV Protease; Autophagy	Angiogenesis; Apoptosis; Autophagy; Cytoskeletal Signaling; Microbiology/Virology; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	Fangchinoline (Tetrandrine B) 是从Stephaniatetrandra 中分离出来的，一种具有广泛生物学活性的天然产物。它是新型HIV-1抑制剂，通过损害 gp160 蛋白水解过程来抑制 HIV-1 复制。它靶向Focal adhesion kinase (FAK)并抑制肿瘤细胞中 FAK 介导的的信号传导途径。
TN4335	Isotetrandrine N-2'-oxide	Others	Others
	Isotetrandrine N-2'-oxide 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN4335，CAS号为 70191-83-2。
TN1806	Isotetrandrine	IL Receptor; NF-κB; MAPK	Immunology/Inflammation; MAPK; NF-κB
	Isotetrandrine is a small molecule inhibitor, on various aspects of LPS-induced inflammation in vitro and in vivo. It dose-dependently suppresses the severity of LPS-induced ALI by inactivation of MAPK and NF-κB, which may involve the inhibition of tissue

天然产物

Cat.No: T2996

Synonym: NSC-77037,d-Tetrandrine,Hanfangchin A,粉防己碱,Fanchinine,Sinomenine A,汉防己甲素

Target: Potassium Channel, Calcium Channel

(R)-Fangchinoline

Cat.No: T2809

Synonym: 防己醇灵,Thaligine,(+)-Thalrugosine,Demethyl tetrandrine

Target: FAK, Antibacterial, Antibiotic

Cat.No: T3122

Synonym: Tetrandrine B,防己诺林碱,(+)-Limacine,Hanfangichin B,防己醇灵,(+)-Fangchinoline

Target: Apoptosis, FAK, HIV Protease, Autophagy

Isotetrandrine N-2'-oxide

Cat.No: TN4335

Target: Others

Cat.No: TN1806

Target: IL Receptor, NF-κB, MAPK

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