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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10247 |
Adenosine 5'-diphosphoribose sodium
Adenosine 5'-diphosphoribose sodium,ADP ribose sodium |
Endogenous Metabolite; TRP/TRPV Channel; Autophagy | Autophagy; Membrane transporter/Ion channel; Metabolism |
Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) 是一种烟酰胺腺嘌呤核苷酸 (NAD+) 的代谢产物,广泛存在于生物体内。Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) 是一种高效的细胞内 Ca2+ 渗透性阳离子 TRPM2 通道激活剂,还可以诱导自噬 (autophagy)。 | |||
T16532 |
Pico145
HC-608 |
TRP/TRPV Channel | Membrane transporter/Ion channel |
Pico145 (HC-608) 是有效的瞬时受体电位通道蛋白 1/4/5 (TRPC1/TRPC4/TRPC5) 抑制剂,在细胞中,抑制 (-)-englerin A 活化TRPC4/TRPC5 通道的IC50分别为 0.349 和 1.3 nM。 | |||
T2007 |
RQ-00203078
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
RQ00203078是一种口服有效的TRPM8高选择性拮抗剂,对大鼠和人类TRPM8通道的IC50分别为 5.3 nM 和 8.3 nM。它对 TRPV1,TRPA1,TRPV4 或 TRPM2 通道基本没有抑制作用。 | |||
T1622 |
Rosiglitazone maleate
BRL 49653C,BRL 49653,马来酸罗格列酮 |
Ferroptosis; TRP/TRPV Channel; PPAR; Autophagy | Apoptosis; Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism |
Rosiglitazone maleate (BRL 49653) 是一种选择性PPARγ激活剂,具有抗糖尿病特性和潜在抗肿瘤活性。它也是TRP 通道调节剂,可抑制 TRPM2、TRPM3 的活性,激活 TRPC5。 | |||
T9263 |
cim0216
N-(5-methyl-1,2-oxazol-3-yl)-2-phenyl-2-(1,2,3,4-tetrahydroquinolin-1-yl)acetamide |
TRP/TRPV Channel | Membrane transporter/Ion channel |
CIM0216 是选择性的TRPM3激动剂,对 TRPM3 的选择性高于 TRPM1、TRPM2 和 TRPM4-8。它以TRPM3依赖性的方式引起疼痛并唤起感觉神经末梢的神经肽释放,可用于神经源性炎症的相关研究。 | |||
T80506 |
TAT-M2NX
tatM2NX |
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TAT-M2NX (tatM2NX) 是一种特异性针对雄性小鼠神经保护的TRPM2抑制剂,适用于缺血性神经元损伤研究。 | |||
T78081 |
Farnesyl Pyrophosphate ammonium
Farnesyl diphosphate ammonium |
||
Farnesyl pyrophosphate ammonium salt为15碳类异戊二烯代谢中间体,源自MVA途径,兼具TRPM2激动剂功能,能够触发TRPM2通道开放并促进离子流入细胞。它亦是胆固醇合成、泛醌合成、蛋白质法尼基化修饰以及GGPP合成的关键底物。 | |||
T73755 |
Farnesyl pyrophosphate
|
||
Farnesyl pyrophosphate (Farnesyl diphosphate) 是一种由15个碳原子组成的异戊二烯类化合物,作为甲羟戊酸 (MVA) 途径的关键代谢中间体。它充当TRPM2 (TRP Channel) 的激动剂,通过激活并打开TRPM2通道,促使离子流入细胞。此外,Farnesyl pyrophosphate 在胆固醇合成、泛醌合成、蛋白质法尼基化修饰以及香叶基-香叶基焦磷酸 (GGPP) 合成过程中扮演着至关重要的底物角色。 | |||
T74779 | JNJ-28583113 | ||
JNJ-28583113 是一种具有脑透性的 TRPM2拮抗剂。JNJ-28583113 抑制 TRPM2 阻断 GSK3α和β亚基的磷酸化。JNJ-28583113 保护细胞免受氧化应激诱导的细胞死亡。JNJ-28583113 还抑制小胶质细胞响应促炎刺激而释放细胞因子。 | |||
T83730 |
Tat-M2NX TFA
|
||
Tat-M2NX是一种瞬时受体电位麦拉斯汀2(TRPM2)的肽类拮抗剂。在25到100µM的浓度范围内,能够抑制表达人类TRPM2的HEK293细胞中氢过氧化物诱导的钙离子流入。在体内,Tat-M2NX(20 mg/kg)通过在中大脑动脉阻塞(MCAO)诱导的中风模型中,如果在阻塞前或阻塞后3小时内给药,能减少雄性小鼠的脑梗塞体积,但对雌性小鼠无效。 | |||
T37475 |
Cyclic ADP-Ribose (ammonium salt)
cADP-Ribose,cADPR,Cyclic ADP-Ribose (ammonium salt) |
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Cyclic ADP-ribose (cADP-ribose) is an endogenous metabolite of NAD+ that mobilizes the release of stored Ca2+ in the endoplasmic reticulum via ryanodine receptors in various cell types.[1],[2],[3],[4],[5] This second messenger is generated via the cADP-ribose synthases CD38 and CD157.[6],[5],[7] cADP-Ribose may also trigger the cell surface Ca2+ influx channel TRPM2 in a temperature-dependent manner.[8] In vitro, cADP-ribose modulates Ca2+ signaling in rat and mouse cardiomyocytes treated with i... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T37687 | Cyclic ADP-ribose ammonium | ||
Cyclic ADP-ribose ammonium (cADPR ammonium) is a powerful calcium mobilization second messenger synthesized from NAD+ by an ADP-ribosyl cyclase. It primarily raises cytosolic calcium levels through Ryanodine receptor-mediated release from the endoplasmic reticulum, while also facilitating extracellular influx through the opening of TRPM2 channels [1][2][3]. | |||
T19253 |
Cyclic ADP-ribose
cADPR |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Cyclic ADP-ribose (cADPR) is an effective calcium mobilization second messenger, which is synthesized from NAD + by ADP-ribosyl cyclase. Cyclic ADP-ribose mainly increases cytosolic calcium through Ryanodine receptor-mediated endoplasmic reticulum release |
Cat. No. | Product Name | Species | Expression System |
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TMPY-01691 |
Clusterin Protein, Human, Recombinant (CLU34, His)
SGP-2,AAG4,KUB1,CLI,CLU2,TRPM... |
Human | HEK293 Cells |
Clusterin Protein, Human, Recombinant (CLU34, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51.5 kDa and the accession number is P10909-2. | |||
TMPY-06908 |
Clusterin Protein, Human, Recombinant (sCLU, His)
KUB1,SP-40,TRPM-2,SGP2,CLI,TR... |
Human | HEK293 Cells |
Clusterin Protein, Human, Recombinant (sCLU, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51.51 kDa and the accession number is NP_001822.3. | |||
TMPJ-00278 |
Clusterin Protein, Human, Recombinant (hFc & His)
CLU,NA1/NA2,TRPM-2,40,Apo-J,Clust... |
Human | HEK293 Cells |
Clusterin Protein, Human, Recombinant (hFc & His) is expressed in HEK293 mammalian cells with C-Fc-6xHis tag. The predicted molecular weight is (33-45) and (60-85) KDa and the accession number is P10909. | |||
TMPJ-00279 |
Clusterin Protein, Human, Recombinant (His)
Clusterin,Ku70-Binding Protein 1,Apo-J,Testosterone-Represse... |
Human | HEK293 Cells |
Clusterin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 28-40 KDa and the accession number is P10909. |