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Clusterin Protein, Human, Recombinant (sCLU, His)

产品编号 TMPY-06908

别名: KUB1, SP-40, TRPM-2, SGP2, CLI, TRPM2, APOJ, NA1/NA2, CLU1, AAG4, CLU2, APO-J, clusterin, SGP-2

Clusterin Protein, Human, Recombinant (sCLU, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51.51 kDa and the accession number is NP_001822.3.

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Clusterin Protein, Human, Recombinant (sCLU, His)

规格	价格/CNY		货期	数量
100 μg	￥ 2,790		5日内发货
1 mg	￥ 17,800		5日内发货

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生物活性	Testing in progress
产品描述	Clusterin Protein, Human, Recombinant (sCLU, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51.51 kDa and the accession number is NP_001822.3.

种属	Human
表达系统	HEK293 Cells
标签	C-His
蛋白编号	NP_001822.3
别名	KUB1, SP-40, TRPM-2, SGP2, CLI, TRPM2, APOJ, NA1/NA2, CLU1, AAG4, CLU2, APO-J, clusterin, SGP-2
蛋白构建	The Human CLU (NP_001822.3) (Met1-Glu449) was expressed with a polyhistidine tag at the C-terminus.
蛋白纯度	≥ 95 % as determined by SDS-PAGE.
分子量	51.51 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted protein which belongs to the clusterin family. Clusterin/Apolipoprotein J/Apo-J is an enigmatic glycoprotein with a nearly ubiquitous tissue distribution and an apparent involvement in biological processes ranging from mammary gland involution to neurodegeneration in Alzheimer's disease. Its major form, a heterodimer, is secreted and present in physiological fluids, but truncated forms targeted to the nucleus have also been identified. Clusterin/Apolipoprotein J/Apo-J is a widely distributed glycoprotein with a wide range of biologic properties. A prominent and defining feature of clusterin is its marked induction in such disease states as glomerulonephritis, cystic renal disease, renal tubular injury, neurodegenerative conditions, atherosclerosis, and myocardial infarction. Upregulation of clusterin mRNA and protein levels detected in diverse disease states and in in vitro systems have led to suggestions that it functions in membrane lipid recycling, in apoptotic cell death, and as a stress-induced secreted chaperone protein, amongst others.

参考文献

1. Silkensen JR,et al.(1994) The role of clusterin in tissue injury. Biochem Cell Biol. 72(11-12):483-8. 2. Naik RR,et al.(2002) Biomimetic synthesis and patterning of silver nanoparticles. Nat Mater. 1(3): 169-72. 3. Djeu JY,et al.(2009) Clusterin and chemoresistance. Adv Cancer Res. 105: 77-92.

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Keywords

Clusterin Protein, Human, Recombinant (sCLU, His) SGP 2 KUB1 SP 40 KUB 1 CLU 1 SP-40 TRPM-2 SGP2 CLU 2 AAG-4 KUB-1 CLI TRPM2 APOJ AAG 4 SP40 NA1/NA2 CLU1 AAG4 CLU2 TRPM 2 APO-J clusterin CLU-2 SGP-2 CLU-1 recombinant recombinant-proteins proteins protein

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