Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T77494 |
TNF-α-IN-9
|
TNF | Apoptosis |
TNF-α-IN-9 是一种 NDM-1 inhibitor-3类似物,是一种 TNF-α 抑制剂。TNF-α-IN-9 显示低抑制活性。 | |||
T15017 |
CU-T12-9
|
TLR | Immunology/Inflammation |
CU-T12-9 是特异性 TLR1/2激动剂,可激活先天免疫系统和适应性免疫系统。它选择性激活 TLR1/2 异二聚体,可通过促进 TLR1 和 TLR2 二聚而激活 NF-κB 信号,引起下游 TNF-α、IL-10 和 iNOS 增加。 | |||
T61111 |
UCB-5307
|
TNF | Apoptosis |
UCB-5307 是一种小分子化合物,可在体外抑制 TNFR1 信号转导和下游功能。 人 TNFα 的 KD 为 9 nM。 TNF 直接通过缓慢的结合动力学结合,KD = 6 nM。 UCB-5307 可以通过预制的 hTNF/hTNFR1 复合物。 | |||
T4383 |
GSK-J4 Hydrochloride
GSK J4 HCl,GSK J4 HCl (1373423-53-0 free base) |
Histone Demethylase | Chromatin/Epigenetic |
GSK-J4 Hydrochloride (GSK J4 HCl) 是 H3K27me3/me2 去甲基化酶 JMJD3/KDM6B 和 UTX/KDM6A 双抑制剂,IC50分别为 8.6 和 6.6 μM。它是 GSK-J1 的乙酯衍生物,体外 IC50 值大于 50 μM。它抑制 LPS 诱导的人原代巨噬细胞产生 TNF-α,IC50值为 9 μM。 | |||
T3100 |
GSK-J4
GSK J4 HCl |
Apoptosis; Histone Demethylase | Apoptosis; Chromatin/Epigenetic |
GSK-J4 (GSK J4 HCl) 是 H3K27me3/me2 去甲基化酶JMJD3/KDM6B 和UTX/KDM6A 双抑制剂,IC50分别为 8.6 μM 和 6.6 μM。它是 GSK-J1 的细胞通透性前药,可诱导内质网应激相关的细胞凋亡。它抑制 LPS 诱导的人原代巨噬细胞产生 TNF-α,IC50值为 9 μM。 | |||
T37726 |
MMP-9 Inhibitor I
|
||
MMP-9 inhibitor I is an inhibitor of matrix metalloproteinase-9 (MMP-9) that is selective over MMP-1 and MMP-13 (IC50s = 5, 1,050, and 113 nM, respectively). It also decreases the activity of TNF-α converting enzyme (TACE) in a dose-dependent manner (IC50 = 0.54 μM). MMP-9 inhibitor I decreases TNF-α secretion stimulated by LPS in BV-2 microglial cells when used at concentrations of 50 and 100 μM. | |||
T78548 |
3-Hydroxyxanthone
3-Hydroxy-xanthen-9-one |
Integrin | Cytoskeletal Signaling |
3-Hydroxyxanthone (3-Hydroxy-xanthen-9-one) 是一种具有抗炎活性的氧杂蒽酮化合物。它能抑制人脐静脉内皮细胞(HUVEC)中NADPH催化的脂质过氧化,并且阻止TNF-α所诱导的ICAM-1表达。 | |||
T72102 | Glucocorticoid receptor modulator 1 | ||
Glucocorticoid receptor modulator1 是一种高效且具有口服活性的 NF-κB 和 AP-1抑制剂,IC50分别为 9 nM 和 130 nM。Glucocorticoid receptor modulator1 可有效降低炎症因子 IL-6、IL-1β、TNF-α 的表达,可缓解小鼠皮炎。 | |||
T35854 |
9(Z),11(E)-Conjugated Linoleic Acid (sodium salt)
|
||
9(Z),11(E)-Conjugated linoleic acid is an isomer of linoleic acid that has been found in beef and milk fat.1It binds to peroxisome proliferator-activated receptor α (PPARα; IC50= 140 nM) and activates the receptor in a reporter assay using COS-1 cells expressing mouse PPARα when used at a concentration of 100 μM.29(Z),11(E)-Conjugated linoleic acid inhibits TNF-α-inducedGLUT4expression and increases insulin-stimulated glucose transport in 3T3-L1 adipocytes.3Dietary administration of 9(Z)11(E)-co... |