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Cat. No. | Product Name | Target | Signaling Pathways |
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T125567 |
AAL Toxin TC1
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AAL Toxin TC1 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T125567。 | |||
T23423 | TC 1 | Others | Others |
σ1 receptor ligand | |||
T9083 |
TC11
CLT-003,1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11 |
BCL; Caspase; CDK | Apoptosis; Cell Cycle/Checkpoint; Proteases/Proteasome |
TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) 是一种有效的肿瘤细胞增殖抑制剂,并通过激活 caspase-3、8 和 9 诱导细胞凋亡。在长时间有丝分裂阻滞期间,它诱导 MCL1降解导致凋亡。它作为苯酞酰亚胺衍生物在结构上与免疫调节药物相关。 | |||
TP2112L |
TC14012 acetate
TC14012 acetate(368874-34-4 free base) |
CXCR; Arrestin | Autophagy; GPCR/G Protein; Immunology/Inflammation |
TC14012 acetate 是 T140 的血清稳定衍生物,是一种选择性的肽模拟 CXCR4 拮抗剂,IC50 为 19.3 nM。 TC14012 还是一种有效的 CXCR7 激动剂,EC50 为 350 nM,可将 β-arrestin 2 募集到 CXCR7。 TC14012 具有抗癌活性和抗 HIV 活性。 | |||
T61531 |
NFATc1-IN-1
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RANKL/RANK | NF-κB |
NFATc1-IN-1 (also known as compound A04) is a highly effective inhibitor of osteoclast formation induced by RANKL, with an IC50 of 1.57 μM. It exerts its anti-osteoclastogenic effects by attenuating the RANKL-induced nuclear translocation of NFATc1. Due to its remarkable properties, NFATc1-IN-1 holds significant potential for advancing research related to osteoclastic diseases [1]. | |||
T34425 |
RTC13
Read-through compound 13,RTC 13,RTC-13 |
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RTC13, as a premature termination codon (PTC) readthrough inducer, can act by restoring dystrophin expression and improving muscle function in the mdx mouse model for Duchenne muscular dystrophy. | |||
T74400 | TC113 | ||
TC113是一种与c(RGDyK)偶联的Gemcitabine。它通过整合素αvβ3可被A549细胞内化。此外,TC113对WM266.4和A549细胞表现出显著的抗增殖效果。 | |||
TP2112 |
TC14012
TC 14012 |
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CXCR4 antagonist and ACKR3 (CXCR7) agonist (EC50 = 350 nM for CXCR7). | |||
T75801 |
TC14012 TFA
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TC14012 TFA 是 T140 的血清稳定衍生物,是一种选择性的 CXCR4拮抗剂,IC50为 19.3 nM。TC14012 TFA 是有效的 CXCR7激动剂,可将 β-arrestin2 募集到 CXCR7,EC50为 350 nM。TC14012 TFA 具有抗 HIV 活性和抗癌活性。 | |||
T34426 |
RTC14
Read-through compound-14,RTC 14,RTC-14,Read-through compound 14 |
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RTC14, as a premature termination codon (PTC) readthrough inducer, can act by restoring dystrophin expression and improving muscle function in the mdx mouse model for Duchenne muscular dystrophy. | |||
T17010 |
TC13172
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Others | Others |
TC13172 is an inhibitor of mixed lineage kinase domain-like protein (EC50: 2 nM for HT-29 cells). |
Cat. No. | Product Name | Species | Expression System |
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TMPY-00469 |
CXCL7 Protein, Human, Recombinant (His)
LA-PF4,TC1,LDGF,NAP-2,TGB,CTAP-III,PBP,Bet... |
Human | E. coli |
CXCL7 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 9.9 kDa and the accession number is P02775. | |||
TMPY-00371 |
STC1 Protein, Human, Recombinant (His)
stanniocalcin 1,STC |
Human | HEK293 Cells |
Stanniocalcin-1 (STC1) is a paracrine factor associated with inflammation and carcinogenesis. STC1 is a secreted glycoprotein hormone and involved in various types of human malignancies. Stanniocalcin-1 (STC1), which has myriad functions, including the maintenance of calcium homeostasis, the promotion of early wound healing, uncoupling respiration (aerobic glycolysis), reepithelialization in damaged tissues, the inhibition of vascular leakage, and the regulation of macrophage functions to keep e... | |||
TMPY-03986 |
PIST Protein, Human, Recombinant (His)
CAL,dJ94G16.2,golgi-associated PDZ and coiled-coil ... |
Human | E. coli |
GOPC, also known as PIST, interacts specifically with TC1 (a Rho-family small GTPase)] as a binding partner for Rhotekin. Rhotekin associates with PIST in vitro and both polarized and non-polarized MDCK (Madin-Darby canine kidney) cells. The C-terminal SPV (Ser-Pro-Val) motif of Rhotekin binds to the PDZ domain of PIST. The co-localization of PIST and Rhotekin at the Golgi apparatus can be detected in non-polarized fibroblast-like MDCK cells and AJs (adherens junctions) in the fully polarized ce... |