8
2
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2123 |
LY2109761
|
Autophagy; TGF-beta/Smad | Autophagy; Stem Cells |
LY2109761 是一种新型选择性 TGF-β 受体 I/II 型 (TβRI/II) 双重抑制剂,Ki 分别为 38 nM 和 300 nM。 | |||
T3636 |
(E)-SIS3
SIS3,SIS3 盐酸盐,SIS3 HCl |
TGF-beta/Smad | Stem Cells |
(E)-SIS3 (SIS3) 是 Smad3 的选择性抑制剂,能够抑制 Smad3 磷酸化(IC50:3 μM)。它利用 TGF-β1 抑制成纤维细胞向肌成纤维细胞分化。 | |||
T80628 |
Myristoyl tetrapeptide-12
|
TGF-beta/Smad | Stem Cells |
Myristoyl tetrapeptide-12 直接激活SMAD2,并促使SMAD3与DNA结合。该化合物能有效促进毛发,特别是睫毛的生长。 | |||
T10426 | AZ12601011 | ALK | Angiogenesis; Tyrosine Kinase/Adaptors |
AZ12601011 is a highly potent and selective inhibitor of the TGFBR1 kinase, administered orally. It displays an IC50 of 18 nM and a Kd of 2.9 nM. By selectively targeting ALK4, TGFBR1, and ALK7, AZ12601011 effectively inhibits the phosphorylation of SMAD2. Additionally, it has been shown to hinder the growth and metastasis of mammary tumors [1]. | |||
T77076 |
Luspatercept
|
||
Luspatercept (ACE-536) 是一种重组修饰的 ActRIIB 融合蛋白,与转化生长因子β超家族配体结合,通过与GDF11结合抑制Smad2/3信号通路,从而增加红细胞数量并促进红细胞前体成熟,用于贫血的研究。 | |||
T61203 |
ALK5-IN-8
|
||
ALK5-IN-8 is a highly effective inhibitor of TGFβRI (ALK5). It hinders the phosphorylation of ALK5 on downstream signaling proteins (Smad2 or Smad3) by obstructing the interaction between TGFβRI and ligands. Consequently, it disrupts or prevents TGF-β signaling. ALK5-IN-8 shows promise in the study of diverse diseases associated with ALK5-mediated pathways[1]. | |||
T26925 |
Butaprost
Butaprostum,TR-4979,(R)-Butaprost |
||
Butaprost is a chemical compound that functions as a selective agonist for the prostaglandin E receptor (EP2). It exhibits an EC50 of 33 nM and a Ki of 2.4 μM when interacting with the murine EP2 receptor. However, Butaprost demonstrates lower activity against murine EP1, EP3, and EP4 receptors. Furthermore, it effectively attenuates fibrosis by inhibiting the TGF-β/Smad2 signaling pathway [1] [2] [3]. | |||
T61029 |
TP0427736 hydrochloride
|
||
TP0427736 hydrochloride 可用于雄激素性脱发 (AGA) 研究。TP0427736 hydrochloride 可抑制由 TGF-β1 诱导的 A549 细胞中 Smad2/3 的磷酸化,IC50值为 8.68 nM。它也是ALK5激酶的有效抑制剂,IC50值为 2.72 nM,比对 ALK3 836 nM 的抑制作用高 300 倍。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5247 |
Trimethylamine N-oxide dihydrate
二水氧化三甲胺,TMANO Dihydrate |
Others; Endogenous Metabolite | Metabolism; Others |
Trimethylamine N-oxide dihydrate (TMANO Dihydrate) 是内源性代谢产物的一种。 | |||
T3876 |
Loureirin B
龙血素B,龙血素 B |
PAI-1; ERK; Potassium Channel; JNK | MAPK; Membrane transporter/Ion channel; Metabolism |
Loureirin B 是从剑叶龙血树中分离到的一种黄酮,是 PAI-1抑制剂,IC50值为 26.10 μM。它抑制 KATP,以及 ERK 和 JNK 的磷酸化,具有抗糖尿病的功效。 |