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Search Results for " silymarin "

4

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T15886	m-PEG4-Tos	Others	Others
	m-PEG4-Tos, a PEG-based PROTAC linker derived from silybin ethers, finds application in the synthesis of Silymarin[1].
T15939	m-PEG8-Tos	Others	Others
	Tos-PEG8-m, a PEG-based PROTAC linker, is a derivative of silybin ethers. It is utilized in the synthesis of Silymarin[1].
T15903	m-PEG5-Tos	Others	Others
	m-PEG5-Tos is a PEG-based PROTAC linker derived from silybin ethers. This compound serves as an essential component in the synthesis of Silymarin[1].
T15866	m-PEG3-Tos	Others	Others
	m-PEG3-Tos is a PEG-based PROTAC linker can be used in the synthesis of Silymarin[1].

化合物

Cat.No: T15886

Target: Others

Cat.No: T15939

Target: Others

Cat.No: T15903

Target: Others

Cat.No: T15866

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T6670	Silymarin Silybin B,水飞蓟素	SARS-CoV	Microbiology/Virology
	Silymarin (Silybin B) 是一种多酚类黄酮，是从水飞蓟或水飞蓟的种子中提取的一种 SARS-CoV-2 主蛋白酶抑制剂。它可降低肿瘤细胞的增殖，血管生成以及胰岛素抵抗，用于预防和治疗肝脏疾病，有潜力研究 COVID-19 。
T3797	Isosilybin Isosilybinin,Isosilibinin,异水飞蓟宾,Silymarin,Silybin B,Q-100795	P450	Metabolism
	Isosilybin (Isosilibinin) 是一种类黄酮，来源于乳蓟；能够抑制CYP3A4诱导(IC50:74 μM)。
T1660	Silibinin 水飞蓟宾 A,水飞蓟宾,Silibinin A,Silybin,Silymarin I	Reactive Oxygen Species; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Silibinin (Silybin) 是水飞蓟的主要活性成分，具有抗癌和化疗预防作用，能抑制细胞增殖和迁移。
TN1805	Isosilybin B	Apoptosis; Androgen Receptor	Apoptosis; Endocrinology/Hormones
	Isosilybin B 是一种从水飞蓟中提取的黄酮木脂素，具有抗前列腺癌 (PCA) 活性，对癌细胞增殖有抑制作用，促使 G1 期阻滞和凋亡。Isosilybin B 诱导雄激素受体降解。
T40080	(±)-Taxifolin (±)-Dihydroquercetin	Antioxidant; Tyrosinase	oxidation-reduction; Proteases/Proteasome
	(±)-Taxifolin ((±)-Dihydroquercetin) 是 Taxifolin 的外消旋体。Taxifolin 是一种常见于洋葱，水飞蓟，法国海洋松树皮和道格拉斯冷杉树皮中的类黄酮，具有抗酪氨酸酶和抗纤维化活性。Taxifolin 对胶原酶具有抑制作用，IC 50 值为 193.3 μM。Taxifolin是一种具有抗氧化能力的自由基清除剂。
TN2211	Silybin B Silibinin B	Apoptosis; Beta Amyloid; Bcr-Abl	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Neuroscience; Tyrosine Kinase/Adaptors
	Silybin B (Silibinin B) 是雷洛昔芬4′-和6-葡萄糖醛酸化的有效抑制剂，是水飞蓟素有效的抗纤维原性和抗低聚物成分，具有清除1,1-二苯基-2-吡啶酰肼(DPPH)自由基的活性，可通过减轻 DNA 损伤和细胞凋亡对顺铂诱导的神经毒性具有保护作用。Silybin B 对人慢性髓系白血病 K562细胞的生长抑制和诱导凋亡有较强的作用。
TN1366	Alcesefoliside	Others	Others
	Alcesefoliside has statistically significant cytoprotective activity similar to that of silymarin, tested at 60 ug/mL.
TN2936	3-Hydroxy-11-ursen-28,13-olide	Others	Others
	3β-Hydroxy-urs-11-en-28,13β-olide shows a potent concentration-independent cytoprotective effect against CCl4-induced injury on human hepatoma cell line relative to silymarin as a reference standard. It exhibits weak-moderate antiproliferative activity ag

天然产物

Cat.No: T6670

Synonym: Silybin B,水飞蓟素

Target: SARS-CoV

Cat.No: T3797

Synonym: Isosilybinin,Isosilibinin,异水飞蓟宾,Silymarin,Silybin B,Q-100795

Target: P450

Cat.No: T1660

Synonym: 水飞蓟宾 A,水飞蓟宾,Silibinin A,Silybin,Silymarin I

Target: Reactive Oxygen Species, Autophagy

Cat.No: TN1805

Target: Apoptosis, Androgen Receptor

Cat.No: T40080

Synonym: (±)-Dihydroquercetin

Target: Antioxidant, Tyrosinase

Cat.No: TN2211

Synonym: Silibinin B

Target: Apoptosis, Beta Amyloid, Bcr-Abl

Cat.No: TN1366

Target: Others

3-Hydroxy-11-ursen-28,13-olide

Cat.No: TN2936

Target: Others

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