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30

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1638	OV-1, sheep
	This alpha-helical antimicrobial OV-1 ovispirin peptide derived from SMAP29 peptide.It was found to inhibit several antibiotic-resistant bacterial strains including mucoid and nonmucoid Pseudomonas aeruginosa.
TP1035L	Cyclic somatostatin Acetate(38916-34-6(free base)) Somatostatin (sheep), monoacetate (salt),Somatostatin-14,SRIF-14,monoacetate (salt)	Others	Others
	Cyclic somatostatin Acetate(38916-34-6(free base)) (Somatostatin-14) 是一种环状十四肽，可调节许多内分泌和神经系统功能。
T83738	SMAP 29 (ovine) TFA Sheep Myeloid Antimicrobial Peptide 29
	SMAP 29是一种抗微生物肽，同时也是绵羊防御素前体肽的C末端切割产物。在低盐和高盐条件下，对P. aeruginosa菌株PAO1具有杀菌作用，该作用在能量依赖的发光测定中表现出来（EC50s分别为0.05和0.06 µM）。它还能够以浓度依赖的方式引起绵羊红细胞的溶血。
TP1035	Cyclic somatostatin SRIF-14,合成生长抑素,环状生长激素抑制素,Somatostatin-14	Others	Others
	Cyclic somatostatin (SRIF-14) 是生长激素释放抑制因子，可用于研究胃十二指肠溃疡出血。
T14953	Chloroquinoxaline sulfonamide NSC-339004,Chloroquinoxaline	Topoisomerase	DNA Damage/DNA Repair
	Chloroquinoxaline sulfonamide is a topoisomerase II alpha/beta poison. It is used to control coccidiosis in poultry, rabbit, sheep, and cattle.
T30596	Brotianide BAY-VA 4059,Dirian,BAY-VA-4059,BAY-VA4059	Parasite	Microbiology/Virology
	Brotianide (BAY-VA4059) 具有驱虫活性，对肝吸虫和胃吸虫侵染具有很高的效力，可用于治疗绵羊的急性、亚急性和慢性肝脏法氏囊病感染。
T3361	Cambendazole 坎苯达唑,Bonlam,MK-905,Novazole	Others	Others
	Cambendazole (Novazole) 是治疗人类圆线虫病最有效的一种药物。
T15272	Febantel	Parasite	Microbiology/Virology
	Febantel 是一种用于家禽和家畜的蛔虫、绦虫感染的驱虫剂。
T35258	YM 16638 YM 638,YM-16638,YM16638	LTR	Immunology/Inflammation
	YM 16638 是一种具有口服活性的白三烯（LT）拮抗剂，具有降低甘油三酯和增加过氧化物酶体的作用，可用于研究抗原诱导过敏性绵羊早期和晚期气道反应。
T1137	Clorsulon 克洛索隆,L631529,MK401,氯舒隆	ATPase; Antibiotic; Parasite	Membrane transporter/Ion channel; Microbiology/Virology
	Clorsulon (L631529) 是一种具有口服活性的灭虫试剂，用于犊牛和羊的肝吸虫感染。它也是 3-磷酸甘酸酯和 ATP 的竞争性抑制剂，可抑制成熟肝片吸虫对葡萄糖的利用以及乙酸和丙酸的形成。
T7724	Tepoxalin RWJ-20485,RWJ20485,ORF20485,替泊沙林,ORF-20485,RWJ 20485,ORF 20485	Lipoxygenase; COX	Immunology/Inflammation; Metabolism; Neuroscience
	Tepoxalin (RWJ 20485) 是有效的5-脂氧合酶和环氧合酶抑制剂，表现出强大的抗炎活性和较小的胃肠道刺激性。
T22415	Resorantel	Parasite	Microbiology/Virology
	Resorantel 是一种驱虫剂，用于研究牛和羊的寄生虫病，也被用于研究G. aegypticus。
T67959	Pirodomast	Thrombin; Serine Protease	Proteases/Proteasome
	Pirodomast 是血栓素 A（TXA2）合成酶抑制剂。Pirodomast 能抑制白三烯（LT）D4、C4、E4 的形成和血栓素 B2（TXB2）的活性，但对组胺、甲氧胆碱、血清素、LTC4 或血小板活化因子诱导的豚鼠支气管痉挛的拮抗作用较弱或无效。Pirodomast 在体外对豚鼠气管只有微弱的松弛活性。Pirodomast 是一种潜在的抗过敏化合物，在体外可抑制胰蛋白酶的蛋白水解活性，在体内可阻止抗原诱发过敏绵羊的即时和晚期哮喘反应，抑制抗原诱导的过敏绵羊对组胺和卡巴胆碱的气道高反应性。
T20826	Dioxabenzofos Salithion
	Dioxabenzofos, a pesticide, could cause reversible ataxia in mice, chicken, and sheep.
TP2378	Diamfenetide NSC-291838,NSC291838,NSC 291838
	Diamfenetide is used in sheep and cattle for the treatment of liver fluxobacteria infections.
T60083	MMP-12 Inhibitor MMP12,MMP408	MMP	Proteases/Proteasome
	MMP-12 Inhibitor 是一种选择性的 MMP-12 抑制剂，对人、小鼠、大鼠和绵羊 MMP-12 的 IC50 分别为 2、160、320 和 22.3 nM。
T2214	Flumethrin	Others	Others
	Flumethrin 是一种拟除虫菊酯类杀虫剂。外用在兽药中，用于防治牛、绵羊、山羊、马和狗身上的寄生虫和蜱，以及治疗蜜蜂群中的寄生虫。
T83484	[Tyr0] Corticotropin Releasing Factor, ovine
	[Tyr0] Corticotropin Releasing Factor, ovine 是从绵羊分离的促肾上腺皮质激素释放因子/激素。该因子（CRF）为下丘脑激素，能激发促肾上腺皮质激素（ACTH）及β-内啡肽的释放。
T80882	Val-Gly-Ser-Glu NSC 350591
	Val-Gly-Ser-Glu (NSC 350591) 是一种ECF-A四肽。该化合物能剂量依赖性地提升人类嗜酸性粒细胞的数量，而不影响中性粒细胞的数量，并可与补体包被的绵羊红细胞(EAC3b)形成玫瑰花结。
T22189	APC 366
	APC 366 是肥大细胞类胰蛋白酶 (tryptase) 的选择性抑制剂，Ki 值为7.1 μM。在羊过敏性哮喘模型中，APC 366 抑制抗原诱导的早期哮喘反应 (EAR)、晚期哮喘反应 (LAR) 和支气管高反应性 (BHR)。
T36045	1a,1b-dihomo Prostaglandin E2 1a,1b-dihomo Prostaglandin E2
	1a,1b-dihomo Prostaglandin E2 (PGE2) is a rare polyunsaturated fatty acid first identified in extracts of sheep vesicular gland microsomes, known to contain COX, incubated with adrenic acid . 1a,1b-dihomo PGE2 has also been identified in conditioned media of RAW 264.7 macrophages stimulated with endotoxin and arachidonic acid . This product is thought to be produced by elongation of AA to adrenic acid, which is then metabolized sequentially by COX and PGE synthase.
T26751	BBR 2160 BBR-2160,BBR2160
	BBR 2160 is a dihydropyridine derivative belonging to the group of the so-called tiampidine. BBR 2160 has calcium-antagonistic properties in cardiac tissue. Intracellular microelectrodes have been used to characterize the electrophysiological properties o
T36887	8(E),10(E),12(Z)-Octadecatrienoic Acid
	8(E),10(E),12(Z)-Octadecatrienoic acid is a conjugated polyunsaturated fatty acid (PUFA) that has been found inC. officinalisseed oil and has anticancer activity.1,2,3It inhibits the growth of Caco-2 cells when used at concentrations ranging from 10 to 50 μM.28(E),10(E),12(Z)-Octadecatrienoic acid (10 μM) induces formation of thiobarbituric acid reactive substances (TBARS) and apoptosis in DLD-1 colorectal adenocarcinoma cells.3It also inhibits prostaglandin biosynthesis in sheep vesicular gland...
T80262	SMAP-18
	SMAP-18是一种具有高生物活性的18氨基酸残基肽酰胺，为SMAP-29 (羊髓系抗菌肽-29) 的缩短版本。SMAP-29对假单胞菌菌株、其他革兰氏阴性菌及多重耐药病原体有很强的抗菌作用。SMAP-18相较于母体SMAP-29，表现出更高的细胞选择性，因其降低了溶血活性同时保留了抗菌能力。
T83826	1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin 1,2,3,6,7,8-HxCDD,PCDD 67
	1,2,3,6,7,8-六氯二苯并-p-二噁英是一种多氯代二苯并二噁英（PCDD）。它是芳香烃受体（AhR; EC50s分别为5.4和9.3 nM，在4和8小时的报告检测中）的激动剂。1,2,3,6,7,8-六氯二苯并-p-二噁英（0.5和2 µg/kg）降低了小鼠对羊红血球的抗体产生。在动物饲料和靠近市政废物焚烧炉的空气中均有发现。
T36855	Phomopsinamine
	Phomopsinamine is an inhibitor of microtubule polymerization and a derivative of phomopsin A .1It inhibits the rate and extent of polymerization of tubulin isolated from ovine brain (IC50s = 0.53 and 0.59 μM, respectively). 1.Lacey, E., Edgar, J.A., and Culvenor, C.C.Interaction of phomopsin A and related compounds with purified sheep brain tubulinBiochem. Pharmacol.36(13)2133-2138(1987)
T38309	LL-37 amide (trifluoroacetate salt)
	LL-37 is a cationic and α-helical antimicrobial peptide expressed in human bone marrow, testis, granulocytes, and gingival epithelium and is upregulated in psoriatic lesions. It inhibits growth of Gram-positive E. coli D21 and Gram-negative B. megatarium in a concentration-dependent manner and LL-37 expression is induced in A549 epithelial cells, alveolar macrophages, neutrophils, and monocyte-derived macrophages following M. tuberculosis infection. LL-37 binds sheep erythrocytes coated with S. ...
T71055	Albendazole-d7
	Albendazole-d7 is intended for use as an internal standard for the quantification of albendazole by GC- or LC-MS. Albendazole is an orally bioavailable benzimidazole anthelmintic that is active against a variety of helminths, including liver flukes, tapeworms, and roundworms. It eliminates Trichostrongylus in the fourth stomach of cattle and sheep when orally administered at doses ranging from 2.5 to 10 mg/kg as well as other species in the fourth stomach and the small and large intestine. Alben...
T38100	Betamethasone 21-phosphate (sodium salt hydrate)
	Betamethasone 21-phosphate is a synthetic glucocorticoid.1It prevents increases in macrophage and eosinophil numbers in bronchoalveolar lavage fluid (BALF) and decreases in blood leukocyte numbers in a guinea pig model of parainfluenza-3 viral infection when administered at a dose of 8 mg/kg but does not prevent airway hyperresponsiveness after infection.2Betamethasone 21-phosphate inhibits cell infiltration into the aqueous humor in a rat model of endotoxin-induced uveitis when administered top...
T66029	3,4-Dehydro-L-proline
	The leguminous shrub,Leucaena leucocephala(Leucaena) is wide‐spread in tropical and subtropical agricultural systems and provides a ready source of protein for livestock. However, the presence of mimosine, a non‐protein, amino acid comprising about 12% of the dry matter in growing tips ofLeucaena, is toxic to animals. Mimosine is degraded rapidly in the rumen to produce 3,4‐dihydroxypyridine (3,4‐DHP) and 2,3‐dihydroxypyridine (2,3‐DHP), both of which remain toxic to animals[1]. 3,4-DHP, as a de...

化合物

Cat.No: TP1638

Cyclic somatostatin Acetate(38916-34-6(free base))

Cat.No: TP1035L

Synonym: Somatostatin (sheep), monoacetate (salt),Somatostatin-14,SRIF-14,monoacetate (salt)

Target: Others

SMAP 29 (ovine) TFA

Cat.No: T83738

Synonym: Sheep Myeloid Antimicrobial Peptide 29

Cyclic somatostatin

Cat.No: TP1035

Synonym: SRIF-14,合成生长抑素,环状生长激素抑制素,Somatostatin-14

Target: Others

Chloroquinoxaline sulfonamide

Cat.No: T14953

Synonym: NSC-339004,Chloroquinoxaline

Target: Topoisomerase

Cat.No: T30596

Synonym: BAY-VA 4059,Dirian,BAY-VA-4059,BAY-VA4059

Target: Parasite

Cat.No: T3361

Synonym: 坎苯达唑,Bonlam,MK-905,Novazole

Target: Others

Cat.No: T15272

Target: Parasite

Cat.No: T35258

Synonym: YM 638,YM-16638,YM16638

Target: LTR

Cat.No: T1137

Synonym: 克洛索隆,L631529,MK401,氯舒隆

Target: ATPase, Antibiotic, Parasite

Cat.No: T7724

Synonym: RWJ-20485,RWJ20485,ORF20485,替泊沙林,ORF-20485,RWJ 20485,ORF 20485

Target: Lipoxygenase, COX

Cat.No: T22415

Target: Parasite

Cat.No: T67959

Target: Thrombin, Serine Protease

Cat.No: T20826

Synonym: Salithion

Cat.No: TP2378

Synonym: NSC-291838,NSC291838,NSC 291838

MMP-12 Inhibitor

Cat.No: T60083

Synonym: MMP12,MMP408

Target: MMP

Cat.No: T2214

Target: Others

[Tyr0] Corticotropin Releasing Factor, ovine

Cat.No: T83484

Val-Gly-Ser-Glu

Cat.No: T80882

Synonym: NSC 350591

Cat.No: T22189

1a,1b-dihomo Prostaglandin E2

Cat.No: T36045

Synonym: 1a,1b-dihomo Prostaglandin E2

Cat.No: T26751

Synonym: BBR-2160,BBR2160

8(E),10(E),12(Z)-Octadecatrienoic Acid

Cat.No: T36887

Cat.No: T80262

1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin

Cat.No: T83826

Synonym: 1,2,3,6,7,8-HxCDD,PCDD 67

Cat.No: T36855

LL-37 amide (trifluoroacetate salt)

Cat.No: T38309

Cat.No: T71055

Betamethasone 21-phosphate (sodium salt hydrate)

Cat.No: T38100

3,4-Dehydro-L-proline

Cat.No: T66029

Cat. No.	Product Name	Target	Signaling Pathways
T3238	Lanolin 绵羊油,羊毛脂,wool grease,wool wax	Others	Others
	Lanolin (wool wax) 是一种从绵羊毛获得的黄色脂肪。它能够在母乳喂养期间疼痛，破裂的乳头局部应用。
T5265	Phenylacetylglutamine NSC 203800,N-苯乙酰基-L-谷氨酰胺,Phenyl-Ac-Gln-OH,Phenylacetyl-L-glutamine	Others; Endogenous Metabolite	Metabolism; Others
	Phenylacetylglutamine (NSC 203800) 是结肠微生物的代谢物，源于氨基酸发酵。
T5625	Zearalenone 玉米,Mycotoxin F2,玉米烯酮,RAL,F2 toxin,Toxin F2	Others	Others
	Zearalenone (F2 toxin) 是真菌毒素，主要由食物和饲料中的 Fusarium 产生。它会引起幼龄母猪乳房发育早熟或其它雌激素效应。它在猪、牛、羊体内具有雌激素活性，急性毒性低。
T1157	Moxidectin milbemycin B,CL301423,莫昔克丁,莫西菌素	GluCls; Antibiotic; Parasite	Microbiology/Virology
	Moxidectin (CL301423) 是可用于预防和控制心丝虫和蛔虫的一种驱虫剂。

天然产物

Cat.No: T3238

Synonym: 绵羊油,羊毛脂,wool grease,wool wax

Target: Others

Phenylacetylglutamine

Cat.No: T5265

Synonym: NSC 203800,N-苯乙酰基-L-谷氨酰胺,Phenyl-Ac-Gln-OH,Phenylacetyl-L-glutamine

Target: Others, Endogenous Metabolite

Cat.No: T5625

Synonym: 玉米,Mycotoxin F2,玉米烯酮,RAL,F2 toxin,Toxin F2

Target: Others

Cat.No: T1157

Synonym: milbemycin B,CL301423,莫昔克丁,莫西菌素

Target: GluCls, Antibiotic, Parasite

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