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Cat. No.	Product Name	Target	Signaling Pathways
T6948	Pluripotin SC1	ERK; Raf; S6 Kinase	MAPK; PI3K/Akt/mTOR signaling
	Pluripotin (SC1) 是ERK1和RasGAP 的双重抑制剂，KD 分别为 98 和 212 nM。它还抑制RSK1、RSK2、RSK3和RSK4，IC50分别为 0.5、2.5、3.3 和 10.0 μM。
T9743	FEN1-IN-SC13	Others	Others
	FEN1-IN-SC13 是有效的DNA 片段化核酸内切酶 1 抑制剂。
T6207	SC144	Apoptosis; Interleukin	Apoptosis; Immunology/Inflammation
	SC144 是一种口服活性 gp130 抑制剂。它结合 gp130，诱导 gp130 磷酸化(S782) 和去糖基化，消除 Stat3 磷酸化和核易位，进一步抑制下游靶基因的表达。它对 gp130 配体触发的信号转导有明显的抑制作用，可诱导人卵巢癌细胞凋亡。
T25885	NSC12404 CID 224134,CID224134,CID-224134,NSC 12404,NSC-12404
	NSC-12404 is a selective non-lipid LPA2/3 agonist.
T16351	NSC16168	Estrogen/progestogen Receptor	Endocrinology/Hormones
	NSC16168 inhibits DNA repair and potentiates CDDP efficacy in cancer. NSC16168 is a specific ERCC1-XPF inhibitor (IC50: 0.42 μM).
T33752	NSC190488
	NSC190488 is a bioactive chemical.
T41260	SC144 hydrochloride
	SC144 hydrochloride 是首创的口服活性gp130 (IL6-beta)抑制剂。SC144 hydrochloride 结合 gp130，诱导 gp130 磷酸化(S782) 和去糖基化，消除 Stat3 磷酸化和核易位，进而抑制下游靶基因的表达。SC144 hydrochloride 对 gp130 配体触发的信号转导显示有效的抑制作用。SC144 hydrochloride 诱导人卵巢癌细胞凋亡。
T61177	NSC114126
	NSC114126 is a highly effective and orally bioavailable inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR-TK). This compound exhibits robust antiproliferative properties, making it a promising candidate for further investigation in the field of cancer research [1].
T28203	NSC156529 NSC-156529,NSC 156529
	NSC156529 downregulates AKT1 signaling. NSC156529 efficiently decreases the proliferation of human cancer cells in vitro, and substantially inhibits the growth of prostate tumor xenografts in vivo.
T33749	NSC107392 NSC 107392,NSC-107392
	NSC107392 is a substrate of ABCG2.
T71527	NSC145366
	NSC145366 is an inhibitor of Hsp90 activities which targets the Hsp90 C-terminal domain to induce allosteric inhibition and selective client downregulation. NSC145366 increases Hsp90 oligomerization resulting in allosteric inhibition of NTD ATPase activity (IC50=119μM) but does not compete with NTD or CTD-ATP binding.
T78203	NSC194598
	NSC194598是一种p53 DNA结合抑制剂，其体外和体内抑制p53序列特异性DNA结合的IC50值分别约为180 nM和2-40 μM。在人甲状腺髓样癌TT细胞中，NSC194598能够干扰突变RET基因的转录激活。该化合物可应用于研究放射及化学疗法对正常组织造成的急性毒性。
T62722	SC13
	SC13 是一种新型的 mitragynine 类似物，具有低效Muopioid receptor 激动作用，具有麻醉作用和较轻的不良反应。
T69141	NSC1008
	NSC1008 is an inhibitor of the Ras Converting Enzyme 1 (Rce1) protease that disrupts Ras membrane localization in human cells.
T33751	NSC145021 NSC-145021,NSC 145021
	NSC145021 is a bioactive chemical.
T33750	NSC127916 NSC 127916,NSC-127916
	NSC127916 is a bioactive chemical.
T81640	NSC15520
	NSC15520是一种小分子RPA抑制剂，特异性结合RPA的N端DNA结合域(DBD)，阻断其与p53或RAD9的相互作用。它还能够抑制双链DNA(dsDNA)寡核苷酸的螺旋不稳定性，影响DNA复制、修复、重组及损伤反应信号。
T28201	NSC1011 NSC 1011,NSC-1011
	NSC1011 is an inhibitor of ras converting enzyme 1 (Rce1).
T68637	NSC13987
	NSC13987 is an inhibitor of Nef-calnexin interaction.
T12114	MSC1094308	p97	Ubiquitination
	MSC1094308 is a reversible and allosteric inhibitor of the type II AAA ATPase.
T69893	NSC109131
	NSC109131 is an inhibitor of human tyrosyl-DNA phosphodiesterase 1 (TDP1).
T24549	NSC114792 NSC-114792,NSC 114792
	NSC114792 is a selective JAK3 inhibitor.
T12260	NSC117079	Others	Others
	NSC117079 is an inhibitor of PHLPP.
T25884	NSC103054 NSC-103054,NSC 103054
	NSC103054 is an ABCG2 transporter function inhibitor.
T24548	NSC10010 hydrochloride NSC#10010,NSC 10010,NSC# 10010,NSC#-10010,NSC-10010
	NSC10010 hydrochloride is an effective growth inhibitor for gammaherpesvirus-associated B-lymphomas. It acts through activation of both the NF-κB and c-Myc-mediated signaling pathways.
T60095	CCF0058981	SARS-CoV	Microbiology/Virology
	CCF0058981 (CCF981) 是3-氯苯基类似物，是一种非共价 SARS-CoV-2 3CLpro(SC2)抑制剂，IC50为 68 nM。CCF0058981 抑制 SC1 (SARS-CoV-1 3CLpro)，IC50为 19 nM。CCF0058981 具有抗病毒功效，具有用于 COVID-19 研究的潜力。

化合物

Cat.No: T6948

Synonym: SC1

Target: ERK, Raf, S6 Kinase

Cat.No: T9743

Target: Others

Cat.No: T6207

Target: Apoptosis, Interleukin

Cat.No: T25885

Synonym: CID 224134,CID224134,CID-224134,NSC 12404,NSC-12404

Cat.No: T16351

Target: Estrogen/progestogen Receptor

Cat.No: T33752

SC144 hydrochloride

Cat.No: T41260

Cat.No: T61177

Cat.No: T28203

Synonym: NSC-156529,NSC 156529

Cat.No: T33749

Synonym: NSC 107392,NSC-107392

Cat.No: T71527

Cat.No: T78203

Cat.No: T62722

Cat.No: T69141

Cat.No: T33751

Synonym: NSC-145021,NSC 145021

Cat.No: T33750

Synonym: NSC 127916,NSC-127916

Cat.No: T81640

Cat.No: T28201

Synonym: NSC 1011,NSC-1011

Cat.No: T68637

Cat.No: T12114

Target: p97

Cat.No: T69893

Cat.No: T24549

Synonym: NSC-114792,NSC 114792

Cat.No: T12260

Target: Others

Cat.No: T25884

Synonym: NSC-103054,NSC 103054

NSC10010 hydrochloride

Cat.No: T24548

Synonym: NSC#10010,NSC 10010,NSC# 10010,NSC#-10010,NSC-10010

Cat.No: T60095

Target: SARS-CoV

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