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29

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T22733	DL-AP5 DL-2-氨基-5-膦酰基缬草酸	NMDAR	Neuroscience
	DL-AP5 是选择性 N-甲基-D-天冬氨酸 (NMDA) 受体拮抗剂的外消旋形式，具有抗惊厥作用。
T6831	Etretinate Retinoid,Tegison,Etretinato,Ethyl etrinoate,Ro 10-9359,依曲替酯	Apoptosis; Others	Apoptosis; Others
	Etretinate (Ro 10-9359) 是一种口服芳香族维甲酸，对牛皮癣和其他皮肤病综合征有效。它激活类视黄醇受体，引起细胞分化的诱导、细胞增殖的抑制和炎症细胞对组织浸润的抑制。
T34299	Retinaloxime trans-Retinaloxime
	Retinaloxime is a retinoid.
T38219	11-cis Retinal
	11-cis Retinal is a chromophore that binds to opsin in the mammalian visual system as an inverse agonist forming the inactive conformation of rhodopsin. When 11-cis retinal absorbs a photon of light, it isomerizes to form all-trans retinal beginning the phototransduction cycle, which is the basis for mammalian vision. A G121L mutation in opsin allows 11-cis retinal to bind as a partial agonist and activate rhodopsin in the absence of light. In a moth model of carotenoid deficiency-induced low vi...
T29395	3-Diazirinophenylretinal
	3-Diazirinophenylretinal is a bioactive chemical.
T8600	N-ACETYLTRYPTAMINE	Melatonin Receptor	GPCR/G Protein
	N-Acetyltryptamine 是视网膜褪黑素受体的部分激动剂，可用于 5-羟色胺 N-乙酰转移酶活性的检测。
T8736	Cidofovir dihydrate HPMPC,(S)-HPMPC,GS 0504,西多福韦二水合物	Others	Others
	Cidofovir dihydrate (HPMPC) 是注射型巨细胞病毒 DNA 聚合酶抑制剂，通过选择性抑制病毒 DNA 聚合酶来抑制 CMV 复制，从而阻止病毒复制和转录。
T22530	6-Chloromelatonin	Melatonin Receptor; Dopamine Receptor	GPCR/G Protein; Neuroscience
	6-Chloromelatonin 是一种有效的褪黑素受体 (melatonin receptor) 激动剂，是一种5-甲氧基吲哚化合物，可竞争兔视网膜中相同的突触前褪黑激素受体位点，可抑制[3H]多巴胺的钙依赖性释放具有比褪黑素更高的代谢稳定性。6-Chloromelatonin 竞争 [3H] 褪黑素与 MT2 受体结合 (pKi=9.77)，可能用于研究与抑郁症相关的失眠和睡眠障碍。
T35505	(±)11-HDHA
	(±)11-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. DHA is metabolized to 11(S)-HDHA by human platelets and canine retina. In addition to 11(S)-HDHA, 14(S)-HDHA is also produced by platelets. 11(S)-HDHA was shown to be an inhibitor of U-46619-induced human platelet aggregation and rabbit and rat aortic smooth muscle contraction with IC50 values of about 50, 4.7, and 7.5 μM, respe...
T68125	(Rac)-PD0299685 (Rac)-PF-299685	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	(Rac)-PD0299685 是一种有效的电压依赖性钙通道抑制剂，可用于研究视网膜相关疾病。
T35512	(±)16-HDHA
	(±)16-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. (±)16-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.
T36607	(±)8-HDHA
	(±)8-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. (±)8-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.
T35508	(±)13-HDHA
	(±)13-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Fresh water hydra was shown to metabolize DHA to 13(R)-HDHA, presumably via the 11R-lipoxygenase activity. (±)13-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.
T78197	5-Fluoromethylornithine dihydrochloride 5-FMOrn dihydrochloride
	5-Fluoromethylornithine (5-FMOrn) dihydrochloride 是一种特异性且不可逆的 L-Ornithine:2-oxoacid aminotransferase (OAT) 抑制剂，常用于探索回旋状脉络膜视网膜萎缩。
T38216	1-Palmitoyl-2-Oleoyl-3-Arachidonoyl-rac-glycerol
	1-Palmitoyl-2-oleoyl-3-arachidonoyl-rac-glycerol is a triacylglycerol that contains palmitic acid , oleic acid , and arachidonic acid at the sn-1, sn-2, and sn-3 positions, respectively. It has been found in lipid extracts from whole rat retina.1
T37532	Docosahexaenoyl Glycine
	The ω-3 polyunsaturated fatty acids (PUFAs) found in fish oils provide cardiovascular benefits. Docosahexaenoic acid (DHA), a C22:6 PUFA, is the most abundant ω-3 fatty acid in neural tissues, especially in the retina and brain. It can be synthesized from other dietary ω-3 PUFAs or taken as a nutritional supplement. Docosahexaenoyl glycine consists of DHA with glycine attached at its carboxy terminus.
T36602	(±)4-HDHA
	(±)4-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Enzymatic transformation of DHA by RBL-1 cells also produces 4-HDHA. However, the enzymatic product is most likely the S-isomer. (±)4-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.
T36606	(±)7-HDHA
	(±)7-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Enzymatic transformation of DHA by RBL-1 cells and human neutrophils also produces 7-HDHA. However, the enzymatic product is most likely the S-isomer. (±)7-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.
TP1464	Risuteganib hydrochloride
	Risuteganib hydrochloride is an anti-integrin that downregulates oxidative stress and restores homeostasis, and targets three integrin receptors that are implicated in dry age-related macular degeneration (AMD) in order to restore homeostasis in the retin
TP2199	Rhodopsin peptide	Others	Others
	Rhodopsin peptide is a peptide with the sequence H2N-Val-Ser-Lys-Thr-Glu-Thr-Ser-Gln-Val-Ala-Pro-Ala-OH, MW= 1217.33. Rhodopsin is a biological pigment in photoreceptor cells of the retina that is responsible for the first events in the perception of ligh
T35504	(±)10-HDHA
	(±)10-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro.[1][2] It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes.[3][4][5] (±)10-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid. Reference：[1]. VanRollins, M., and Murphy, R.C. Autooxidation of docosahexaenoic acid: Analysis of ten isomers of hydroxydocosahexaenoate. J. Lipid Res. 25(5), 507-517 (1984).[2]. Reynaud, ...
T37259	14(S)-HDHA
	Docosahexaenoic acid is a nutritionally-derived ω-3 fatty acid that is abundant in the brain and the retina and is thought to be important in early development and for therapeutic approaches to inflammatory disorders and cancer. 14(S)-HDHA is an oxygenation product of DHA that serves as a precursor to maresin 1 , an anti-inflammatory, pro-resolving mediator that prevents polymorphonuclear neutrophil (PMN) infiltration and stimulates macrophage phagocytosis. At doses as low as 0.2 ng/mouse 14(S)-...
T81311	RASP-IN-1
	RASP-IN-1（compound A）作为一种抗黄斑变性的亲脂性化合物，在兔视网膜中展现生物活性。通过IP途径给予小鼠14C-RASP-IN-1（10 mg/kg）后30分钟，测得其眼杯的最大浓度（Cmax）为14.36 μg/g。
TP1749	IRBP (1-20), human
	IRBP (1-20), human is the 1-20 fragment of interphotoreceptor retinoid binding protein (IRBP).This peptide is a 1 to 20 amino acid fragment of the interphotoreceptor retinoid binding protein (IRBP). IRBP is a 140-kDa glycolipoprotein residing in the inter
T36601	(±)17-HDHA
	(±)17-HDHA is an autoxidation product of docosahexaenoic acid in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. 17(S)-HDHA could be produced by enzymatic oxidation of DHA using soybean lipoxygenase (LO) and is the putative product of mammalian 15-LOs. 17(S)-HDHA was shown to be an inhibitor of U-46619 -induced rabbit and rat aortic smooth muscle contraction with IC50 values of 4.9 and 7.2 μM, respectively. (±)17-HDHA is a potential marker of ox...
T37503	Maresin 2 3R,14S-diHDHA
	Docosahexaenoic acid is an ω-3 fatty acid that is abundant in the brain and the retina and is known to be important in early development.[1] [2] Maresin 2 (MaR2) is a 13R,14S-dihydroxy DHA formed by recombinant human macrophage 12-lipoxygenase and soluble epoxide hydrolase co-incubated with DHA. [3] At 1 ng/mouse, MaR2 was shown to reduce neutrophil infiltration by 40% in a mouse model of peritonitis, and at 10 pM, MaR2 can enhance human macrophage phagocytosis of zymosan A by 90%. [3] Analytica...
T35509	(±)14-HDHA
	(±)14-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. DHA is metabolized to 14(S)-HDHA by human platelets along with 11(S)-HDHA. 14(S)-HDoHE is also produced by salmon gills upon stimulation with calcium ionophore. 14(S)-HDHA was shown to be an inhibitor of U-46619-induced human platelet aggregation and rabbit and rat aortic smooth muscle contraction with IC50 values of about 70, 3...
T35497	(±)7(8)-EpDPA
	Docosahexaenoic acid is the most abundant ω-3 fatty acid in neural tissues, especially in the brain and retina. (±)7(8)-EpDPA is an epoxide derivative of DHA that is generated by the action of cytochrome P450 epoxygenases. It is naturally occurring in plasma and brain and spinal cord tissues and is increased following dietary supplementation with ω-3 fatty acids. (±)7(8)-EpDPA and other epoxy metabolites of DHA modulate receptor and channel activities to evoke diverse effects, such as promoting ...
T35578	Phosphatidylserines (sodium salt) Phosphatidylserines (sodium salt),L-α-Phosphatidylserine
	Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina. It is anionic and found mainly on the inner leaflet of the cell membrane. It is biosynthesized from phosphatidylcholine or phosphatidylethanolamine by phosphatidyl synthase 1 (PSS1) or PSS2, respectively, in the endoplasmic reticulum (ER) and can be reversibly converted back by the same enzymes. It can also be irre...

化合物

Cat.No: T22733

Synonym: DL-2-氨基-5-膦酰基缬草酸

Target: NMDAR

Cat.No: T6831

Synonym: Retinoid,Tegison,Etretinato,Ethyl etrinoate,Ro 10-9359,依曲替酯

Target: Apoptosis, Others

Cat.No: T34299

Synonym: trans-Retinaloxime

11-cis Retinal

Cat.No: T38219

3-Diazirinophenylretinal

Cat.No: T29395

N-ACETYLTRYPTAMINE

Cat.No: T8600

Target: Melatonin Receptor

Cidofovir dihydrate

Cat.No: T8736

Synonym: HPMPC,(S)-HPMPC,GS 0504,西多福韦二水合物

Target: Others

6-Chloromelatonin

Cat.No: T22530

Target: Melatonin Receptor, Dopamine Receptor

Cat.No: T35505

(Rac)-PD0299685

Cat.No: T68125

Synonym: (Rac)-PF-299685

Target: Calcium Channel

Cat.No: T35512

Cat.No: T36607

Cat.No: T35508

5-Fluoromethylornithine dihydrochloride

Cat.No: T78197

Synonym: 5-FMOrn dihydrochloride

1-Palmitoyl-2-Oleoyl-3-Arachidonoyl-rac-glycerol

Cat.No: T38216

Docosahexaenoyl Glycine

Cat.No: T37532

Cat.No: T36602

Cat.No: T36606

Risuteganib hydrochloride

Cat.No: TP1464

Rhodopsin peptide

Cat.No: TP2199

Target: Others

Cat.No: T35504

Cat.No: T37259

Cat.No: T81311

IRBP (1-20), human

Cat.No: TP1749

Cat.No: T36601

Cat.No: T37503

Synonym: 3R,14S-diHDHA

Cat.No: T35509

Cat.No: T35497

Phosphatidylserines (sodium salt)

Cat.No: T35578

Synonym: Phosphatidylserines (sodium salt),L-α-Phosphatidylserine

Cat. No.	Product Name	Target	Signaling Pathways
T5256	All-trans-retinal 视黄醛,All trans-Retinal,Retinaldehyde,Vitamin A aldehyde	Others; Endogenous Metabolite	Metabolism; Others
	All-trans-retinal (Vitamin A aldehyde) 是视网膜中维生素A 代谢物之一。生理条件下，它再生为视觉发色团，11-顺式-视黄醛。
T19169	9-cis-Retinal	Others	Others
	9-cis-Retinal is a natural retinoid. Dietary 9-cis-β-carotene generates 9-cis-retinoids via cleavage into 9-cis-retinal. 9-cis Retinal binds to CRBP-I and CRBP-II (Kds: 8 nM and 5 nM). It expedites differentiation and maturation of rod photoreceptors in r
T5369	Docosahexaenoic Acid Cervonic acid,DHA	Others; Endogenous Metabolite	Metabolism; Others
	Docosahexaenoic Acid 是一种ω-3脂肪酸，在脑和视网膜中较为丰富，且能够直接从鱼油和母乳中获得。
T3394	Timosaponin BII 知母皂苷BII,Prototimosaponin A III	Beta Amyloid; Others; BACE	Neuroscience; Others
	Timosaponin BII (Prototimosaponin A III) 是一种甾体皂苷，发现于知母根茎中，具有神经保护、抗炎和抗氧化作用。
T1183	Retinol all-trans-Retinol,视黄醇,Vitamin A,Vitamin A1,Alphalin	Others	Others
	Retinol (Alphalin) 及其衍生物，在视网膜的代谢功能、上皮组织的生长和分化、骨骼的生长、生殖和免疫反应中起重要作用。膳食维生素 A 来源于植物中发现的多种类胡萝卜素。它富含肝脏、蛋黄和乳制品的脂肪成分。
T4S0969	Obtusifolin 决明蒽醌,决明蒽醌；美决明子素	Antioxidant; NF-κB	NF-κB; oxidation-reduction
	Obtusifolin 是分离自决明子的种子中，能够抑制NF-kB 通路，调节气道上皮细胞中 MUC5AC 粘蛋白的基因表达和产生。它通过靶向甲状旁腺激素相关蛋白来抑制邻苯二甲酸酯诱导的乳腺癌骨转移。
T0937	Riboflavin Vitamin B2,维生素B2,E101	Endogenous Metabolite	Metabolism
	Riboflavin (E101)，一种人内源性代谢物，是极易吸收的微量营养素。
T35577	Phosphatidylserines (bovine)
	Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina. It is anionic and found mainly on the inner leaflet of the cell membrane. It is biosynthesized from phosphatidylcholine or phosphatidylethanolamine by phosphatidyl synthase 1 (PSS1) or PSS2, respectively, in the endoplasmic reticulum and can be reversibly converted back by the same enzymes. It can also be irreversi...

天然产物

All-trans-retinal

Cat.No: T5256

Synonym: 视黄醛,All trans-Retinal,Retinaldehyde,Vitamin A aldehyde

Target: Others, Endogenous Metabolite

9-cis-Retinal

Cat.No: T19169

Target: Others

Docosahexaenoic Acid

Cat.No: T5369

Synonym: Cervonic acid,DHA

Target: Others, Endogenous Metabolite

Timosaponin BII

Cat.No: T3394

Synonym: 知母皂苷BII,Prototimosaponin A III

Target: Beta Amyloid, Others, BACE

Cat.No: T1183

Synonym: all-trans-Retinol,视黄醇,Vitamin A,Vitamin A1,Alphalin

Target: Others

Cat.No: T4S0969

Synonym: 决明蒽醌,决明蒽醌；美决明子素

Target: Antioxidant, NF-κB

Cat.No: T0937

Synonym: Vitamin B2,维生素B2,E101

Target: Endogenous Metabolite

Phosphatidylserines (bovine)

Cat.No: T35577

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