12
7
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2628 |
RI-2
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
RI-2 是一种可逆的RAD51抑制剂,IC50值为 44.17 μM,可抑制人体细胞中的同源重组修复。 | |||
T2276 |
RI-1
RI-1; 3-氯-1-(3,4-二氯苯基)-4-(4-吗啉基)-1H-吡咯-2,5-二酮,RI1,RAD51 inhibitor 1 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
RI-1 (RAD51 inhibitor 1) 是一种选择性 RAD51的抑制剂,IC50值为 5-30 μM,可以破坏人类细胞中的同源重组。它在半胱氨酸 319 处与 RAD51 蛋白表面共价结合,并通过直接结合到 RAD51 细丝中蛋白质亚基之间的界面的蛋白质表面来灭活 RAD51。 | |||
T9523 |
TGFβRI-IN-3
|
TGF-beta/Smad | Stem Cells |
TGFβRI-IN-3 抑制TGFβR1,IC50为 0.79 nM,是对 MAP4K4 的选择性2000 倍。TGFβRI-IN-3 是一种高选择性的 TGFβR1 抑制剂,在免疫肿瘤中具有潜在的应用。 | |||
T39615L |
P8RI acetate
|
Integrin | Cytoskeletal Signaling |
P8RI acetate 是 CD31 的仿生肽和 CD3 的激动剂。 P8RI acetate 通过恢复 CD31 抑制途径显示出免疫抑制作用。 | |||
T39615 |
P8RI
D-P8RI |
||
P8RI (D-P8RI) is a CD31 biomimetic peptide and agonist that specifically targets the juxtamembrane amino acid sequence of the ectodomain of CD31. By restoring the CD31 inhibitory pathway, P8RI exhibits immunosuppressive properties. | |||
T37140 |
5'-O-DMT-rI
|
||
5’-O-DMT-Ri can be used in the synthesis of oligoribonucleotides[1]. [1]. Kadokura M. Synthesis of 4-thiouridine, 6-thioinosine, and 6-thioguanosine 3’,5’-O-bisphosphates as donor molecules for RNA ligation and their application to the synthesis of photoactivatable TMG-capped U1 snRNA fragments. J Org Chem. 2000 Aug 25;65(17):5104-13. | |||
T73493 |
RI-962
|
RIP kinase | Apoptosis; NF-κB |
RI-962 是一种针对受体相互作用蛋白激酶 1 (RIPK1) 的高效选择性抑制剂,具有35.0 nM的IC50。本化合物主要用于神经系统疾病和炎症性疾病研究领域。 | |||
T62559 | TGFβRI-IN-4 | ||
TGFβRI-IN-4 是一种高效的、口服具有活力的 TGFβ 受体 I 型激酶 (TGFβRI) 抑制剂,能够作用于 ALK5 (IC50: 44 nM) 和 NIH3T3 (IC50: 42.5 nM)。TGFβRI-IN-4 在异种移植瘤模型中,能够抑制肿瘤生长和肿瘤重量。 | |||
T60931 |
TGFβRI-IN-5
|
||
TGFβRI-IN-5 (Compound 4b) 是 TGFβRI 的有效抑制剂,IC50值为 0.08 μM。TGFβRI-IN-5 对所有测试细胞系的均显示出显著的抗癌活性,可增强细胞凋亡并抑制细胞周期的 G2/M 期。 | |||
T72976 |
TGFβRI-IN-6
|
||
TGFβRI-IN-6 是一种有效的TGFβRI 抑制剂,IC50值为 0.55 nM。TGFβRI-IN-6 具有增强抗肿瘤免疫力的潜力。 | |||
T38676 |
5'-O-DMT-2'-O-TBDMS-rI
|
||
5'-O-DMT-2'-O-TBDMS-rI is a modified nucleoside utilized in the synthetic process of deoxyribonucleic acid (DNA) or nucleic acid. | |||
TP2129 |
RI-STAD 2
|
||
AKAP disruptor. Selectively binds PKA-RI with high affinity (KD values are 6.2 and 12.1 nM for the RIα and β subunits, respectively) and blocks its interaction with AKAP. Inhibits type I PKA-mediated phosphorylation in live cells. Cell permeable. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-05084 |
Fc epsilon RI Protein, Human, Recombinant
alpha polypeptide,FcERI,α polypeptide,Fc fragment of IgE, hi... |
Human | HEK293 Cells |
Fc epsilon RI Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 21 kDa and the accession number is P12319. | |||
TMPY-03054 |
Fc epsilon RI Protein, Human, Recombinant (His)
Fc ε RI,α polypeptide,Fc fragment of IgE, high affinity I, r... |
Human | HEK293 Cells |
Fc epsilon RI Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.5 kDa and the accession number is P12319. | |||
TMPY-05207 |
PRKAR1A Protein, Mouse, Recombinant (His)
1300018C22Rik,protein kinase, cAMP-dependent, regulatory, ty... |
Mouse | Baculovirus Insect Cells |
PRKAR1A Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 44.6 kDa and the accession number is Q9DBC7. | |||
TMPY-03064 |
Fc epsilon RI Protein, Mouse, Recombinant (hFc)
α polypeptide,FcERI,Fc ε RI,Fcr-5,alpha polypeptide,Fce1a,Fc... |
Mouse | HEK293 Cells |
Fc epsilon RI Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48 kDa and the accession number is P20489. | |||
TMPK-00149 |
Fc epsilon RI alpha/FCER1a Protein, Human, Recombinant (His)
Fc-ε RI-α,Fc-epsilon RI-alpha,FCER1A,Fc-epsilon RI-α,FCE1A,F... |
Human | HEK293 Cells |
Known susceptibility genes to atopy and asthma have been identified by linkage or associations with clinical phenotypes, including total serum IgE levels. IgE-mediated sensitivity reactions require a high-affinity IgE receptor (FcepsilonRI), which immobilizes the immunoglobulin on the surface of the effector cells, mostly mast cells and basophils. Similarly to the previously investigated beta subunit of the receptor, FCER1A is a good candidate for a quantitative trait locus (QTL) in allergic dis... | |||
TMPK-00241 |
Fc gamma RI/CD64 Protein, Human, Recombinant (His & Avi), Biotinylated
FcERI,CD64,FLJ18345,IGFR1,Fc gamma RI,Fcgr,Fcr,Fc γ RI/CD64,... |
Human | HEK293 Cells |
The Fc gamma Rs have been divided into three classes based on close relationships in their extracellular domains; these groups are designated Fc gamma RI (also known as CD64), Fc gamma RII (CD32), and Fc gamma RIII (CD16). Each group may be encoded by multiple genes and exist in different isoforms depending on species and cell type. Fc gamma RI/CD64 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight i... | |||
TMPK-00240 |
Fc gamma RI/CD64 Protein, Human, Recombinant (His & Avi)
FcgRI,IGFR1,FCE1A,FCGR1A,Fc-γ RIA,Fc gamma RI,Fc-gamma RIA,F... |
Human | HEK293 Cells |
The Fc gamma Rs have been divided into three classes based on close relationships in their extracellular domains; these groups are designated Fc gamma RI (also known as CD64), Fc gamma RII (CD32), and Fc gamma RIII (CD16). Each group may be encoded by multiple genes and exist in different isoforms depending on species and cell type. Fc gamma RI/CD64 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 33.5 kDa and... |