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Search Results for " rantes "

11

抑制剂 & 化合物

1

天然产物

6

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T76567	Met-RANTES (human)
	Met-RANTES (human) 为一部分CCR5拮抗剂，能够降低血液单核细胞向肝脏浸润的程度。
T21938	AS-041164	PI3K	PI3K/Akt/mTOR signaling
	AS-041164 是选择性的，具有口服活性的PI3Kγ亚型抑制剂，IC50=70 nM。它对 PI3Kα (IC50:240 μM)，PI3Kβ (IC50:1.45 μM) 和 PI3Kδ (IC50:1.70 μM) 的活性较低。它具有抗炎活性。
T6016	Maraviroc Celsentri,马拉维若,UK-427857,Selzentry	HIV Protease; CCR	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Maraviroc (Selzentry) 是一种 C-C 趋化因子受体 5 拮抗剂，具有抑制HIV 的活性。
T4674	SB297006 SB 297006	CCR	Immunology/Inflammation; Microbiology/Virology
	SB297006 是一种CCR3拮抗剂，IC50为39 nM。它能够显著抑制 CCL11 处理的神经祖细胞的增殖和神经球形成。
T24735	RP-23618
	RP-23618 is a non-peptidic antagonist of RANTES.
T16973	TAK-220	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	TAK-220 is a selective and orally bioavailable CCR5 antagonist (IC50s: 3.5 nM and 1.4 nM for inhibition on the binding of RANTES and MIP-1α to CCR5, respectively).
T35452	β-Defensin-3 (human) (trifluoroacetate salt)
	β-Defensin-3 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It inhibits the growth of the periodontopathogenic and cariogenic bacteria F. nucleatum, S. mutans, S. sobrinus, S. salivarius, and L. casei (MICs = 12.5-100 mg/l). It also inhibits the growth of S. aureus, S. pyogenes, P. aeruginosa, E. coli, and C. albicans. β-Defensin-3 stimulates gene expression and production of IL-6, IL-10, CXC...
T35453	β-Defensin-4 (human) (trifluoroacetate salt)
	β-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It induces migration of monocytes in vitro when used at a concentration of 10 nM but does not affect migration of neutrophils and eosinophils. β-Defensin-4 (30 μg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes. It also stimulates calcium mobilization, migration, and pro...
T35451	β-Defensin-2 (human) (trifluoroacetate salt)
	β-Defensin-2 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1It inhibits the growth of periodontopathogenic and cariogenic bacteria, includingP. gingivalisandS. salivarius.2β-Defensin-2 (30 μg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes.3It also stimulates calcium mobilization, migration, and proliferation of keratinocytes whe...
T7499	TAK-779 Takeda 779	HIV Protease; CXCR; CCR	Autophagy; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	TAK-779 (Takeda 779) 是一种非肽类CCR5和CXCR3 拮抗剂，对CCR5的Ki 值为 1.1 nM，并选择性抑制R5 HIV-1。
T14845	BX471 hydrochloride ZK-811752 hydrochloride	Others	Others
	BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist (Ki: 1 nM for human CCR1). It shows 250-fold selectivity for CCR1 over CCR2, CCR5, and CXCR4.

化合物

Met-RANTES (human)

Cat.No: T76567

Cat.No: T21938

Target: PI3K

Cat.No: T6016

Synonym: Celsentri,马拉维若,UK-427857,Selzentry

Target: HIV Protease, CCR

Cat.No: T4674

Synonym: SB 297006

Target: CCR

Cat.No: T24735

Cat.No: T16973

Target: HIV Protease

β-Defensin-3 (human) (trifluoroacetate salt)

Cat.No: T35452

β-Defensin-4 (human) (trifluoroacetate salt)

Cat.No: T35453

β-Defensin-2 (human) (trifluoroacetate salt)

Cat.No: T35451

Cat.No: T7499

Synonym: Takeda 779

Target: HIV Protease, CXCR, CCR

BX471 hydrochloride

Cat.No: T14845

Synonym: ZK-811752 hydrochloride

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN1347	8-Prenylkaempferol 去甲脱水淫羊藿黄素	p38 MAPK; NF-κB; PI3K	MAPK; NF-κB; PI3K/Akt/mTOR signaling
	8-Prenylkaempferol is an effective agent for attenuating pro-inflammatory NO induction, it may be an anti-inflammatory agent for suppressing influenza A virus-induced RANTES production acts by blocking PI3K-mediated transcriptional activation of NF-κB and

天然产物

8-Prenylkaempferol

Cat.No: TN1347

Synonym: 去甲脱水淫羊藿黄素

Target: p38 MAPK, NF-κB, PI3K

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00009	CCL5 Protein, Human, Recombinant (His & Avi), Biotinylated RANTES,SIS-δ,D17S136E,TCP228,eoCP,SIS-delta,SCYA5,C...	Human	E. coli
	The CCR5 and the CCL5 ligand have been detected in some hematological malignancies, lymphomas, and a great number of solid tumors, but extensive studies on the role of the CCL5/CCR axis were performed only in a limited number of cancers. CCL5 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in E. coli expression system with N-His-Avi tag. The predicted molecular weight is 10.89 kDa and the accession number is P13501.
TMPK-00008	CCL5 Protein, Mouse, Recombinant (hFc) D17S136E,RANTES,SCYA5,SIS-δ,Ccl5,SISd,eoCP,MuRa...	Mouse	HEK293 Cells
	The CCR5 and the CCL5 ligand have been detected in some hematological malignancies, lymphomas, and a great number of solid tumors, but extensive studies on the role of the CCL5/CCR axis were performed only in a limited number of cancers. CCL5 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 35.2 kDa and the accession number is P30882.
TMPY-04214	CCL5 Protein, Human, Recombinant SISd,TCP228,chemokine (C-C motif) ligand 5,RANTES,S...	Human	E. coli
	CCL5 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 8 kDa and the accession number is D0EI67.
TMPJ-00993	CCL5 Protein, Rat, Recombinant (E. coli, His) Small-inducible cytokine A5,SIS-δ,C-C motif chemokine 5,T-ce...	Rat	E. coli
	C-C motif chemokine 5(CCL5) is a β-chemokine that plays a primary role in the inflammatory immune response by means of its ability to attract and activate leukocytes. CCL5 is secreted by many cell types at inflammatory sites, and it exerts a wide range of activities through the receptors CCR1, CCR3, CCR4, and CCR5. Inflammatory responses can be impaired by the sequestration of CCL5 by the cytomegalovirus protein US28. Oligomerization of CCL5 on glycosaminoglycans is required for CCR1mediated leu...
TMPY-01072	CCL5 Protein, Human, Recombinant (His & mucin) D17S136E,SCYA5,SIS-δ,SISd,SIS-delta,RANTES,chemokin...	Human	HEK293 Cells
	CCL5 Protein, Human, Recombinant (His & mucin) is expressed in HEK293 mammalian cells with His and mucin tag. The predicted molecular weight is 34 kDa and the accession number is D0EI67.
TMPJ-00018	CCL16 Protein, Human, Recombinant NCC-4,Lymphocyte and Monocyte Chemoattractant,LMC,NCC4,HCC-4...	Human	E. coli
	CCL16 is a member of CC chemokine family. CCL16 cDNA encodes a 120 amino acid peptide along with a 23 amino acids signal peptide that is cleaved to generate 97 amino acid protein. CCL16 is distantly related to other CC chemokines, showing less than 30% sequence identity. CCL16 elicits its effects on cells by interacting with cell surface chemokine receptors such as CCR1, CCR2, CCR5 and CCR8. Recombinant CCL16 has been shown to chemoattract human monocytes and THP1 cells but not resting lymphocyt...

重组蛋白

CCL5 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00009

Species: Human

Expression System: E. coli

CCL5 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00008

Species: Mouse

Expression System: HEK293 Cells

CCL5 Protein, Human, Recombinant

Cat.No: TMPY-04214

Species: Human

Expression System: E. coli

CCL5 Protein, Rat, Recombinant (E. coli, His)

Cat.No: TMPJ-00993

Species: Rat

Expression System: E. coli

CCL5 Protein, Human, Recombinant (His & mucin)

Cat.No: TMPY-01072

Species: Human

Expression System: HEK293 Cells

CCL16 Protein, Human, Recombinant

Cat.No: TMPJ-00018

Species: Human

Expression System: E. coli

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